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Entry version 188 (03 Jul 2019)
Sequence version 1 (01 Aug 1991)
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Protein

mRNA decay activator protein ZFP36

Gene

Zfp36

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Zinc-finger RNA-binding protein that destabilizes numerous cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:10330172, PubMed:10706852, PubMed:10805719, PubMed:15014438, PubMed:15187092, PubMed:15634918, PubMed:17030620, PubMed:19188452, PubMed:20595389, PubMed:21078877, PubMed:22701344, PubMed:27193233). Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:21278420). Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation (PubMed:21278420). Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs (PubMed:21278420). Self regulates by destabilizing its own mRNA (PubMed:15187092, PubMed:17288565). Binds to 3'-UTR ARE of numerous mRNAs and of its own mRNA (PubMed:11533235, PubMed:15187092, PubMed:16508014, PubMed:17288565, PubMed:17971298, PubMed:20595389, PubMed:21078877, PubMed:21278420, PubMed:22701344, PubMed:27193233). Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages (PubMed:8630730, PubMed:9703499, PubMed:15014438, PubMed:16514065). Plays also a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response (By similarity). Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia (By similarity). Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (PubMed:22701344). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (By similarity). Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA (PubMed:25815583). Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs (By similarity). Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs (By similarity). May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro (By similarity). Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (By similarity). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing (PubMed:22844456). Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages (PubMed:22844456). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (By similarity). Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (By similarity).By similarity23 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri95 – 123C3H1-type 1PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri133 – 161C3H1-type 2PROSITE-ProRule annotationAdd BLAST29

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Ribonucleoprotein
Biological processmRNA transport, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
mRNA decay activator protein ZFP36Curated
Alternative name(s):
Growth factor-inducible nuclear protein NUP475Curated
TPA-induced sequence 111 Publication
Tristetraprolin1 Publication
Zinc finger protein 361 PublicationImported
Short name:
Zfp-361 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Zfp361 PublicationImported
Synonyms:Nup4751 Publication, Tis111 Publication, Tis11a, Ttp1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:99180 Zfp36

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Exosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice appear normal at birth, but within 1-8 weeks after birth they develop a complex syndrome of cachexia, arthritis, autoimmunity, myeloid hyperplasia and general inflammation (PubMed:8630730). Show precocious skeletal muscle satellite cell activation and increased satellite cell fusion into myofibers (PubMed:25815583). Show higher levels of tumor necrosis factor (TNF)-alpha mRNA and protein in macrophages and an excess of circulating TNF-alpha (PubMed:8630730, PubMed:9703499, PubMed:16508014). Show higher levels of granulocyte-macrophage colony-stimulating factor (GM-CSF) expression in macrophages and an excess of GM-CSF secretion upon lipopolysaccharide (LPS) stimulation (PubMed:10706852). Show higher levels of serine/threonine-protein kinase PLK3 expression in macrophages (PubMed:19188452). Show higher levels of interleukin IL2 expression in splenocytes and T lymphocytes and an excess of IL2 secretion upon T cell activation (PubMed:15634918). Show an increase in the stability of numerous mRNAs, such as TNF-alpha, GM-CSF, IL2 and PLK3 mRNAs (PubMed:9703499, PubMed:10706852, PubMed:15634918, PubMed:17030620, PubMed:19188452). Show an absence of ARE-containing transcript deadenylation (PubMed:10330172). Mice with a double knockout of ZFP36 and MAPKAPK2 show increased amounts of TNF in macrophages almost comparable to single ZFP36 knockout (PubMed:16508014).9 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi52S → A: Impairs phosphorylation by MAPKAPK2, decreases its stability and cytoplasmic localization, increases interaction with PPP2CA, inhibits binding to 14-3-3 proteins, but does not impair binding to ARE-containing transcripts, recruitment of mRNA decay factors and ZFP36-mediated deadenylation and decay of ARE-containing transcripts; when associated with A-178. 6 Publications1
Mutagenesisi64 – 66PPP → SSS: Abolished interaction with GIGYF2 and impaired TTP-mediated mRNA repression; when associated with 191-S--S-193. 1 Publication3
Mutagenesisi178S → A: Reduces both interaction with 14-3-3 proteins and YWHAB-induced cytoplasmic localization. Impairs phosphorylation by MAPKAPK2, decreases its stability and cytoplasmic localization, increases interaction with PPP2CA, inhibits binding to 14-3-3 proteins, but does not impair binding to ARE-containing transcripts, recruitment of mRNA decay factors and ZFP36-mediated deadenylation and decay of ARE-containing transcripts; when associated with A-52. 7 Publications1
Mutagenesisi191 – 193PPP → SSS: Abolished interaction with GIGYF2 and impaired TTP-mediated mRNA repression; when associated with 64-S--S-66. 1 Publication3
Mutagenesisi212 – 214PPP → SSS: Does not affect interaction with GIGYF2. 1 Publication3
Mutagenesisi303P → A: Stimulates interaction with SH3KBP1. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000891641 – 319mRNA decay activator protein ZFP36Add BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei52Phosphoserine; by MAPKAPK23 Publications1
Modified residuei58PhosphoserineBy similarity1
Modified residuei80Phosphoserine1 Publication1
Modified residuei82Phosphoserine1 Publication1
Modified residuei84PhosphothreonineBy similarity1
Modified residuei85Phosphoserine1 Publication1
Modified residuei178Phosphoserine; by MAPKAPK23 Publications1
Modified residuei189PhosphoserineBy similarity1
Modified residuei210PhosphoserineBy similarity1
Modified residuei220Phosphoserine; by MAPK1; in vitro1 Publication1
Modified residuei250Phosphothreonine1 Publication1
Modified residuei269PhosphoserineBy similarity1
Modified residuei289PhosphoserineBy similarity1
Modified residuei316Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated (PubMed:11533235). Phosphorylation at serine and/or threonine residues occurs in a p38 MAPK- and MAPKAPK2-dependent manner (PubMed:11533235). Phosphorylated by MAPKAPK2 at Ser-52 and Ser-178; phosphorylation increases its stability and cytoplasmic localization, promotes binding to 14-3-3 adapter proteins and inhibits the recruitment of cytoplasmic CCR4-NOT and PAN2-PAN3 deadenylase complexes to the mRNA decay machinery, thereby inhibiting ZFP36-induced ARE-containing mRNA deadenylation and decay processes (PubMed:15014438, PubMed:14688255, PubMed:16508014, PubMed:16508015, PubMed:17170118, PubMed:20595389, PubMed:21078877). Phosphorylation by MAPKAPK2 does not impair ARE-containing RNA-binding (PubMed:20595389, PubMed:21078877). Phosphorylated in a MAPKAPK2- and p38 MAPK-dependent manner upon skeletal muscle satellite cell activation; this phosphorylation inhibits ZFP36-mediated mRNA decay activity, and hence stabilizes MYOD1 mRNA (PubMed:25815583). Phosphorylated by MAPK1 upon mitogen stimulation (PubMed:7768935, PubMed:14688255). Phosphorylated at Ser-58 and Ser-85; these phosphorylations increase in a SH3KBP1-dependent manner (By similarity). Phosphorylated at serine and threonine residues in a pyruvate kinase PKM- and p38 MAPK-dependent manner (By similarity). Phosphorylation at Ser-52 may participate in the PKM-mediated degradation of ZFP36 in a p38 MAPK-dependent manner (By similarity). Dephosphorylated by serine/threonine phosphatase 2A at Ser-178 (PubMed:11533235, PubMed:17170118).By similarity10 Publications
Ubiquitinated; pyruvate kinase (PKM)-dependent ubiquitination leads to proteasomal degradation through a p38 MAPK signaling pathway.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P22893

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P22893

PeptideAtlas

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PeptideAtlasi
P22893

PRoteomics IDEntifications database

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PRIDEi
P22893

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P22893

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P22893

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in skeletal muscle satellite cells (PubMed:25815583). Strongly expressed in differentiated adipocytes compared to preadipocytes (at protein level) (PubMed:22701344). Expressed in embryonic stem cells (ESCs) (PubMed:24733888). Expressed in heart, placenta, kidney, intestine, liver, lung, thymus, fat and spleen (PubMed:2204625, PubMed:1699942).5 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated during adipocyte differentiation (PubMed:17288565, PubMed:22701344). Up-regulated transiently in response to fibroblast growth factor FGF4 in a MAPK-dependent manner in embryonic stem cells (ESCs) (PubMed:24733888). Up-regulated by interferons and/or lipopolysaccharide (LPS) in a STAT1- and p38 MAPK-dependent manner (PubMed:11533235, PubMed:16514065, PubMed:16508014, PubMed:16508015). Down-regulated in muscle satellite cells upon muscle injury (at protein level) (PubMed:25815583). Up-regulated by various mitogens (PubMed:7559666). Up-regulated by LPS and TNF-alpha (PubMed:9703499). Up-regulated by interferon IFN-gamma and/or LPS in a STAT1- and p38 MAPK-dependent manner (PubMed:15187092, PubMed:16514065). Up-regulated during adipocyte differentiation (PubMed:22701344). Up-regulated in keratinocytes during epidermal repair after wound healing (PubMed:20166898). Down-regulated during the conversion from quiescence to activated satellite cells upon muscle injury (PubMed:23046558, PubMed:25815583).13 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000044786 Expressed in 235 organ(s), highest expression level in subcutaneous adipose tissue

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P22893 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P22893 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with cytoplasmic CCR4-NOT and PAN2-PAN3 deadenylase complexes to trigger ARE-containing mRNA deadenylation and decay processes (PubMed:20595389, PubMed:21078877).

Part of a mRNA decay activation complex at least composed of poly(A)-specific exoribonucleases CNOT6, EXOSC2 and XRN1 and mRNA-decapping enzymes DCP1A and DCP2 (By similarity). Associates with the RNA exosome complex (By similarity).

Interacts (via phosphorylated form) with 14-3-3 proteins; these interactions promote exclusion of ZFP36 from cytoplasmic stress granules in response to arsenite treatment in a MAPKAPK2-dependent manner and does not prevent CCR4-NOT deadenylase complex recruitment or ZFP36-induced ARE-containing mRNA deadenylation and decay processes (PubMed:15014438, PubMed:20595389).

Interacts with 14-3-3 proteins; these interactions occur in response to rapamycin in an Akt-dependent manner (By similarity).

Interacts with AGO2 and AGO4 (By similarity).

Interacts (via C-terminus) with CNOT1; this interaction occurs in a RNA-independent manner and induces mRNA deadenylation (PubMed:21278420).

Interacts (via N-terminus) with CNOT6 (By similarity).

Interacts with CNOT6L (PubMed:21078877).

Interacts (via C-terminus) with CNOT7; this interaction occurs in a RNA-independent manner, induces mRNA deadenylation and is inhibited in a phosphorylation MAPKAPK2-dependent manner (PubMed:20595389, PubMed:21278420).

Interacts (via unphosphorylated form) with CNOT8; this interaction occurs in a RNA-independent manner and is inhibited in a phosphorylation MAPKAPK2-dependent manner (PubMed:20595389).

Interacts with DCP1A (By similarity).

Interacts (via N-terminus) with DCP2 (By similarity).

Interacts with EDC3 (By similarity).

Interacts (via N-terminus) with EXOSC2 (By similarity).

Interacts with heat shock 70 kDa proteins (By similarity).

Interacts with KHSRP; this interaction increases upon cytokine-induced treatment (By similarity).

Interacts with MAP3K4; this interaction enhances the association with SH3KBP1/CIN85 (By similarity).

Interacts with MAPKAPK2; this interaction occurs upon skeletal muscle satellite cell activation (PubMed:25815583).

Interacts with NCL (By similarity).

Interacts with NUP214; this interaction increases upon lipopolysaccharide (LPS) stimulation (By similarity).

Interacts with PABPC1; this interaction occurs in a RNA-dependent manner (PubMed:20595389, PubMed:21078877).

Interacts (via hypophosphorylated form) with PABPN1 (via RRM domain and C-terminal arginine-rich region); this interaction occurs in the nucleus in a RNA-independent manner, decreases in presence of single-stranded poly(A) RNA-oligomer and in a p38 MAPK-dependent-manner and inhibits nuclear poly(A) tail synthesis (PubMed:22844456).

Interacts with PAN2 (PubMed:21078877).

Interacts (via C3H1-type zinc finger domains) with PKM (By similarity).

Interacts (via C3H1-type zinc finger domains) with nuclear RNA poly(A) polymerase (PubMed:22844456).

Interacts with PPP2CA; this interaction occurs in LPS-stimulated cells and induces ZFP36 dephosphorylation, and hence may promote ARE-containing mRNAs decay (PubMed:17170118).

Interacts (via C-terminus) with PRR5L (via C-terminus); this interaction may accelerate ZFP36-mediated mRNA decay during stress (By similarity).

Interacts (via C-terminus) with SFN; this interaction occurs in a phosphorylation-dependent manner (PubMed:11886850).

Interacts (via extreme C-terminal region) with SH3KBP1/CIN85 (via SH3 domains); this interaction enhances MAP3K4-induced phosphorylation of ZFP36 at Ser-58 and Ser-85 and does not alter neither ZFP36 binding to ARE-containing transcripts nor TNF-alpha mRNA decay (By similarity).

Interacts with XRN1 (By similarity).

Interacts (via C-terminus and Ser-178 phosphorylated form) with YWHAB; this interaction occurs in a p38/MAPKAPK2-dependent manner, increases cytoplasmic localization of ZFP36 and protects ZFP36 from Ser-178 dephosphorylation by serine/threonine phosphatase 2A, and hence may be crucial for stabilizing ARE-containing mRNAs (PubMed:14688255, PubMed:17170118).

Interacts (via phosphorylated form) with YWHAE (PubMed:21078877).

Interacts (via C-terminus) with YWHAG; this interaction occurs in a phosphorylation-dependent manner (PubMed:11886850).

Interacts with YWHAH; this interaction occurs in a phosphorylation-dependent manner (PubMed:11886850).

Interacts with YWHAQ; this interaction occurs in a phosphorylation-dependent manner (PubMed:11886850).

Interacts with (via C-terminus) YWHAZ; this interaction occurs in a phosphorylation-dependent manner (PubMed:11886850). Does not interact with SH3KBP1 (PubMed:20221403).

Interacts (via the 4EHP-binding motif) with EIF4E2; the interaction is direct (By similarity).

Interacts (via P-P-P-P-G repeats) with GIGYF2; the interaction is direct (PubMed:26763119).

By similarity11 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
204658, 7 interactors

Protein interaction database and analysis system

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IntActi
P22893, 34 interactors

Molecular INTeraction database

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MINTi
P22893

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000057815

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1319
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P22893

Database of comparative protein structure models

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ModBasei
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Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P22893

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati63 – 67P-P-P-P-G5
Repeati190 – 194P-P-P-P-G5
Repeati211 – 215P-P-P-P-G5

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 166Necessary for localization of ARE-containing mRNAs to processing bodies (PBs)By similarityAdd BLAST166
Regioni1 – 92Necessary and sufficient for the association with mRNA decay enzymes and mRNA decay activationBy similarityAdd BLAST92
Regioni1 – 15Necessary for nuclear exportBy similarityAdd BLAST15
Regioni87 – 160Necessary for nuclear localizationBy similarityAdd BLAST74
Regioni89 – 165Necessary for RNA-bindingBy similarityAdd BLAST77
Regioni92 – 319Necessary for localization of ARE-containing mRNAs to processing bodies (PBs)By similarityAdd BLAST228
Regioni95 – 186Necessary for interaction with PABPN11 PublicationAdd BLAST92
Regioni166 – 319Necessary for mRNA decay activationBy similarityAdd BLAST154
Regioni305 – 319Interaction with CNOT1By similarityAdd BLAST15

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C3H1-type zinc finger domains are necessary for ARE-binding activity.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri95 – 123C3H1-type 1PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri133 – 161C3H1-type 2PROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1677 Eukaryota
COG5063 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000162360

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000233479

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P22893

KEGG Orthology (KO)

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KOi
K15308

Database of Orthologous Groups

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OrthoDBi
1541140at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P22893

TreeFam database of animal gene trees

More...
TreeFami
TF315463

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00642 zf-CCCH, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00356 ZnF_C3H1, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF90229 SSF90229, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50103 ZF_C3H1, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P22893-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLSAIYESL QSMSHDLSSD HGGTESLGGL WNINSDSIPS GVTSRLTGRS
60 70 80 90 100
TSLVEGRSCG WVPPPPGFAP LAPRPGPELS PSPTSPTATP TTSSRYKTEL
110 120 130 140 150
CRTYSESGRC RYGAKCQFAH GLGELRQANR HPKYKTELCH KFYLQGRCPY
160 170 180 190 200
GSRCHFIHNP TEDLALPGQP HVLRQSISFS GLPSGRRSSP PPPGFSGPSL
210 220 230 240 250
SSCSFSPSSS PPPPGDLPLS PSAFSAAPGT PVTRRDPNQA CCPSCRRSTT
260 270 280 290 300
PSTIWGPLGG LARSPSAHSL GSDPDDYASS GSSLGGSDSP VFEAGVFGPP
310
QTPAPPRRLP IFNRISVSE
Length:319
Mass (Da):33,613
Last modified:August 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i860DD6DDA80386F8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9DBE5Q9DBE5_MOUSE
mRNA decay activator protein ZFP36
Zfp36
307Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M57422 mRNA Translation: AAA40498.1
M58691 mRNA Translation: AAA39837.1
X14678 mRNA Translation: CAA32807.1 Sequence problems.
M58565 mRNA Translation: AAA72947.1
L42317 Genomic DNA Translation: AAC37676.1
BC021391 mRNA Translation: AAH21391.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS21041.1

Protein sequence database of the Protein Information Resource

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PIRi
A36600
S04743

NCBI Reference Sequences

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RefSeqi
NP_035886.1, NM_011756.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000051241; ENSMUSP00000057815; ENSMUSG00000044786

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22695

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:22695

UCSC genome browser

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UCSCi
uc009fys.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57422 mRNA Translation: AAA40498.1
M58691 mRNA Translation: AAA39837.1
X14678 mRNA Translation: CAA32807.1 Sequence problems.
M58565 mRNA Translation: AAA72947.1
L42317 Genomic DNA Translation: AAC37676.1
BC021391 mRNA Translation: AAH21391.1
CCDSiCCDS21041.1
PIRiA36600
S04743
RefSeqiNP_035886.1, NM_011756.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M9ONMR-A91-163[»]
SMRiP22893
ModBaseiSearch...

Protein-protein interaction databases

BioGridi204658, 7 interactors
IntActiP22893, 34 interactors
MINTiP22893
STRINGi10090.ENSMUSP00000057815

PTM databases

iPTMnetiP22893
PhosphoSitePlusiP22893

Proteomic databases

jPOSTiP22893
PaxDbiP22893
PeptideAtlasiP22893
PRIDEiP22893

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051241; ENSMUSP00000057815; ENSMUSG00000044786
GeneIDi22695
KEGGimmu:22695
UCSCiuc009fys.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7538
MGIiMGI:99180 Zfp36

Phylogenomic databases

eggNOGiKOG1677 Eukaryota
COG5063 LUCA
GeneTreeiENSGT00940000162360
HOGENOMiHOG000233479
InParanoidiP22893
KOiK15308
OrthoDBi1541140at2759
PhylomeDBiP22893
TreeFamiTF315463

Enzyme and pathway databases

ReactomeiR-MMU-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA

Miscellaneous databases

EvolutionaryTraceiP22893

Protein Ontology

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PROi
PR:P22893

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000044786 Expressed in 235 organ(s), highest expression level in subcutaneous adipose tissue
ExpressionAtlasiP22893 baseline and differential
GenevisibleiP22893 MM

Family and domain databases

InterProiView protein in InterPro
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf
PfamiView protein in Pfam
PF00642 zf-CCCH, 2 hits
SMARTiView protein in SMART
SM00356 ZnF_C3H1, 2 hits
SUPFAMiSSF90229 SSF90229, 2 hits
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTP_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22893
Secondary accession number(s): P11520
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: July 3, 2019
This is version 188 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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