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Entry version 211 (31 Jul 2019)
Sequence version 4 (15 Dec 2009)
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Protein

Lutropin-choriogonadotropic hormone receptor

Gene

LHCGR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for lutropin-choriogonadotropic hormone (PubMed:11847099). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-375281 Hormone ligand-binding receptors
R-HSA-418555 G alpha (s) signalling events

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P22888

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P22888

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lutropin-choriogonadotropic hormone receptor
Short name:
LH/CG-R
Alternative name(s):
Luteinizing hormone receptor
Short name:
LHR
Short name:
LSH-R
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LHCGR
Synonyms:LCGR, LGR2, LHRHR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6585 LHCGR

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
152790 gene+phenotype

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P22888

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini27 – 363ExtracellularSequence analysisAdd BLAST337
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei364 – 385Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini386 – 395CytoplasmicSequence analysis10
Transmembranei396 – 416Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini417 – 439ExtracellularSequence analysisAdd BLAST23
Transmembranei440 – 462Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini463 – 482CytoplasmicSequence analysisAdd BLAST20
Transmembranei483 – 505Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini506 – 525ExtracellularSequence analysisAdd BLAST20
Transmembranei526 – 549Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini550 – 570CytoplasmicSequence analysisAdd BLAST21
Transmembranei571 – 594Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini595 – 605ExtracellularSequence analysisAdd BLAST11
Transmembranei606 – 627Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini628 – 699CytoplasmicSequence analysisAdd BLAST72

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Familial male precocious puberty (FMPP)11 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionIn FMPP the receptor is constitutively activated.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_062338368L → P in FMPP; cells expressing the mutation display up to a 12-fold increase in basal cAMP production compared with cells expressing the same number of cell surface wild-type receptor indicating constitutive activation of the mutant receptor. 1 PublicationCorresponds to variant dbSNP:rs121912533EnsemblClinVar.1
Natural variantiVAR_003553373A → V in FMPP. 1 PublicationCorresponds to variant dbSNP:rs121912528EnsemblClinVar.1
Natural variantiVAR_003554398M → T in FMPP. 1 PublicationCorresponds to variant dbSNP:rs121912526EnsemblClinVar.1
Natural variantiVAR_010156457L → R in FMPP. 1 PublicationCorresponds to variant dbSNP:rs121912535EnsemblClinVar.1
Natural variantiVAR_010157542I → L in FMPP. Corresponds to variant dbSNP:rs121912531EnsemblClinVar.1
Natural variantiVAR_010159564D → G in FMPP. 1 PublicationCorresponds to variant dbSNP:rs121912540EnsemblClinVar.1
Natural variantiVAR_003555568A → V in FMPP. 2 PublicationsCorresponds to variant dbSNP:rs121912534EnsemblClinVar.1
Natural variantiVAR_003556571M → I in FMPP. 1 PublicationCorresponds to variant dbSNP:rs121912519EnsemblClinVar.1
Natural variantiVAR_003557572A → V in FMPP. 1 PublicationCorresponds to variant dbSNP:rs121912522EnsemblClinVar.1
Natural variantiVAR_010160575I → L in FMPP. 1
Natural variantiVAR_003558577T → I in FMPP. 2 PublicationsCorresponds to variant dbSNP:rs121912521EnsemblClinVar.1
Natural variantiVAR_010161578D → E in FMPP. 1
Natural variantiVAR_003559578D → G in FMPP. 2 PublicationsCorresponds to variant dbSNP:rs121912518EnsemblClinVar.1
Natural variantiVAR_010163578D → Y in FMPP. Corresponds to variant dbSNP:rs121912532EnsemblClinVar.1
Natural variantiVAR_010164581C → R in FMPP. 1
Luteinizing hormone resistance (LHR)10 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by unresponsiveness to luteinizing hormone, defective sexual development in males, and defective follicular development and ovulation, amenorrhea and infertility in females. Two forms of the disorder have been defined in males. Type 1 is a severe form characterized by complete 46,XY male pseudohermaphroditism, low testosterone and high luteinizing hormone levels, total lack of responsiveness to luteinizing and chorionic gonadotropin hormones, lack of breast development, and absent development of secondary male sex characteristics. Type 2, a milder form, displays a broader range of phenotypic expression ranging from micropenis to severe hypospadias.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_010154131C → R in LHR; Leydig cell hypoplasia type 2. 1 PublicationCorresponds to variant dbSNP:rs121912527EnsemblClinVar.1
Natural variantiVAR_062336144V → F in LHR; Leydig cell hypoplasia type 1; exhibits a marked impairment of human chorionic gonadotropin binding; shows the absence of the glycosylated cell surface form; the mutant receptor is retained in the endoplasmic reticulum; mutant receptors do not migrate to the cell surface. 1 PublicationCorresponds to variant dbSNP:rs121912539EnsemblClinVar.1
Natural variantiVAR_062337152I → T in LHR; reveals a marked impairment of human chorionic gonadotropin binding and signal transduction. 1 Publication1
Natural variantiVAR_010155343C → S in LHR; Leydig cell hypoplasia type 1; completely devoided of hormone-induced cAMP reporter gene activation; although initial translocation to the endoplasmic reticulum is normal translocation is halted or misrouted and the mutant does not reach the cell surface and cannot bind hormone. 1 PublicationCorresponds to variant dbSNP:rs121912536EnsemblClinVar.1
Natural variantiVAR_003552354E → K in LHR; Leydig cell hypoplasia type 1. 1 PublicationCorresponds to variant dbSNP:rs121912529EnsemblClinVar.1
Natural variantiVAR_062339502L → P in LHR; Leydig cell hypoplasia type 1; shows reduced cAMP production and ligand binding; receptor trafficking is not affected by the mutation. 1 PublicationCorresponds to variant dbSNP:rs121912538EnsemblClinVar.1
Natural variantiVAR_010158543C → R in LHR; Leydig cell hypoplasia type 1; completely devoided of hormone-induced cAMP reporter gene activation; although initial translocation to the endoplasmic reticulum is normal translocation is halted or misrouted and the mutant does not reach the cell surface and cannot bind hormone. 1 PublicationCorresponds to variant dbSNP:rs121912537EnsemblClinVar.1
Natural variantiVAR_003560593A → P in LHR; Leydig cell hypoplasia type 1; abolishes signal transduction. 1 PublicationCorresponds to variant dbSNP:rs121912520EnsemblClinVar.1
Natural variantiVAR_003561608 – 609Missing in LHR; Leydig cell hypoplasia type 1. 1 Publication2
Natural variantiVAR_003562616S → Y in LHR; Leydig cell hypoplasia type 1; micropenis. 1 PublicationCorresponds to variant dbSNP:rs121912525EnsemblClinVar.1
Natural variantiVAR_003563625I → K in LHR; Leydig cell hypoplasia type 2. 1 PublicationCorresponds to variant dbSNP:rs121912530EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi331Y → F: Reduces intracellular cAMP accumulation. 1 Publication1
Mutagenesisi333Y → F: No change in intracellular cAMP accumulation. 1 Publication1
Mutagenesisi643C → G: Loss of palmitoylation. 1 Publication1
Mutagenesisi644C → G: Loss of palmitoylation. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
3973

MalaCards human disease database

More...
MalaCardsi
LHCGR
MIMi152790 gene+phenotype
176410 phenotype
238320 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000138039

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
3000 Familial male-limited precocious puberty
96265 Leydig cell hypoplasia due to complete LH resistance
96266 Leydig cell hypoplasia due to partial LH resistance
619 NON RARE IN EUROPE: Primary ovarian failure

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30357

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1854

Drug and drug target database

More...
DrugBanki
DB06719 Buserelin
DB00050 Cetrorelix
DB09126 Chorionic Gonadotropin (Human)
DB00097 Chorionic Gonadotropin (Recombinant)
DB00014 Goserelin
DB00044 Lutropin alfa
DB00032 Menotropins

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
254

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
LHCGR

Domain mapping of disease mutations (DMDM)

More...
DMDMi
281185513

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001278027 – 699Lutropin-choriogonadotropic hormone receptorAdd BLAST673

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi174N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi291N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi299N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi313N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei331Sulfotyrosine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi439 ↔ 514PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi643S-palmitoyl cysteine1 Publication1
Lipidationi644S-palmitoyl cysteine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sulfated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Sulfation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P22888

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P22888

PeptideAtlas

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PeptideAtlasi
P22888

PRoteomics IDEntifications database

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PRIDEi
P22888

ProteomicsDB human proteome resource

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ProteomicsDBi
54043 [P22888-1]
54044 [P22888-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P22888

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P22888

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P22888

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Gonadal and thyroid cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000138039 Expressed in 67 organ(s), highest expression level in lower esophagus muscularis layer

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P22888 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P22888 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB009814

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110161, 4 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P22888

Molecular INTeraction database

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MINTi
P22888

STRING: functional protein association networks

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STRINGi
9606.ENSP00000294954

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P22888

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P22888

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 66LRRNTAdd BLAST40
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati96 – 115LRR 1Add BLAST20
Repeati124 – 145LRR 2Add BLAST22
Repeati149 – 171LRR 3Add BLAST23
Repeati175 – 196LRR 4Add BLAST22
Repeati198 – 220LRR 5Add BLAST23
Repeati223 – 244LRR 6Add BLAST22

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2087 Eukaryota
ENOG410XR1T LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157364

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000045902

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P22888

KEGG Orthology (KO)

More...
KOi
K04248

Identification of Orthologs from Complete Genome Data

More...
OMAi
KTLRCAP

Database of Orthologous Groups

More...
OrthoDBi
257031at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P22888

TreeFam database of animal gene trees

More...
TreeFami
TF316814

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR002131 Gphrmn_rcpt_fam
IPR026906 LRR_5
IPR032675 LRR_dom_sf
IPR002273 LSH_rcpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit
PF13306 LRR_5, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00373 GLYCHORMONER
PR00237 GPCRRHODOPSN
PR01144 LSHRECEPTOR

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: P22888-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKQRFSALQL LKLLLLLQPP LPRALREALC PEPCNCVPDG ALRCPGPTAG
60 70 80 90 100
LTRLSLAYLP VKVIPSQAFR GLNEVIKIEI SQIDSLERIE ANAFDNLLNL
110 120 130 140 150
SEILIQNTKN LRYIEPGAFI NLPRLKYLSI CNTGIRKFPD VTKVFSSESN
160 170 180 190 200
FILEICDNLH ITTIPGNAFQ GMNNESVTLK LYGNGFEEVQ SHAFNGTTLT
210 220 230 240 250
SLELKENVHL EKMHNGAFRG ATGPKTLDIS STKLQALPSY GLESIQRLIA
260 270 280 290 300
TSSYSLKKLP SRETFVNLLE ATLTYPSHCC AFRNLPTKEQ NFSHSISENF
310 320 330 340 350
SKQCESTVRK VNNKTLYSSM LAESELSGWD YEYGFCLPKT PRCAPEPDAF
360 370 380 390 400
NPCEDIMGYD FLRVLIWLIN ILAIMGNMTV LFVLLTSRYK LTVPRFLMCN
410 420 430 440 450
LSFADFCMGL YLLLIASVDS QTKGQYYNHA IDWQTGSGCS TAGFFTVFAS
460 470 480 490 500
ELSVYTLTVI TLERWHTITY AIHLDQKLRL RHAILIMLGG WLFSSLIAML
510 520 530 540 550
PLVGVSNYMK VSICFPMDVE TTLSQVYILT ILILNVVAFF IICACYIKIY
560 570 580 590 600
FAVRNPELMA TNKDTKIAKK MAILIFTDFT CMAPISFFAI SAAFKVPLIT
610 620 630 640 650
VTNSKVLLVL FYPINSCANP FLYAIFTKTF QRDFFLLLSK FGCCKRRAEL
660 670 680 690
YRRKDFSAYT SNCKNGFTGS NKPSQSTLKL STLHCQGTAL LDKTRYTEC
Length:699
Mass (Da):78,643
Last modified:December 15, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2E3D93F4621BA842
GO
Isoform Short (identifier: P22888-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-289: Missing.

Show »
Length:636
Mass (Da):71,615
Checksum:i969918F83E700C85
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ENI1E7ENI1_HUMAN
Lutropin-choriogonadotropic hormone...
LHCGR
672Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ESK4E7ESK4_HUMAN
Lutropin-choriogonadotropic hormone...
LHCGR
329Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EQB5E7EQB5_HUMAN
Lutropin-choriogonadotropic hormone...
LHCGR
325Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C226H7C226_HUMAN
Lutropin-choriogonadotropic hormone...
LHCGR
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti7A → P in AAA70231 (PubMed:2293030).Curated1
Sequence conflicti19P → A in AAA70231 (PubMed:2293030).Curated1
Sequence conflicti27 – 28EA → R in AAA70231 (PubMed:2293030).Curated2
Sequence conflicti44 – 51CPGPTAGL → APAPRPS in AAA70231 (PubMed:2293030).Curated8
Sequence conflicti68A → S in AAA70231 (PubMed:2293030).Curated1
Sequence conflicti124R → G in AAA59515 (PubMed:2244890).Curated1
Sequence conflicti124R → G in CAA59234 (PubMed:7556872).Curated1
Sequence conflicti262 – 263RE → KQ in AAA70231 (PubMed:2293030).Curated2
Sequence conflicti270E → R in AAA70231 (PubMed:2293030).Curated1
Sequence conflicti274T → H in AAA70231 (PubMed:2293030).Curated1
Sequence conflicti290Q → L in AAA70231 (PubMed:2293030).Curated1
Sequence conflicti311 – 323Missing in AAA70231 (PubMed:2293030).CuratedAdd BLAST13
Sequence conflicti448F → L in AAA70231 (PubMed:2293030).Curated1
Sequence conflicti540F → L in AAA70231 (PubMed:2293030).Curated1
Sequence conflicti649E → DP in AAA70231 (PubMed:2293030).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00354918Q → QLQ May be associated with earlier age of onset of breast cancer and poor prognosis. 2 Publications1
Natural variantiVAR_010154131C → R in LHR; Leydig cell hypoplasia type 2. 1 PublicationCorresponds to variant dbSNP:rs121912527EnsemblClinVar.1
Natural variantiVAR_062336144V → F in LHR; Leydig cell hypoplasia type 1; exhibits a marked impairment of human chorionic gonadotropin binding; shows the absence of the glycosylated cell surface form; the mutant receptor is retained in the endoplasmic reticulum; mutant receptors do not migrate to the cell surface. 1 PublicationCorresponds to variant dbSNP:rs121912539EnsemblClinVar.1
Natural variantiVAR_062337152I → T in LHR; reveals a marked impairment of human chorionic gonadotropin binding and signal transduction. 1 Publication1
Natural variantiVAR_003550284N → S1 Publication1
Natural variantiVAR_055922291N → S. Corresponds to variant dbSNP:rs12470652EnsemblClinVar.1
Natural variantiVAR_003551306S → N1 Publication1
Natural variantiVAR_060737312N → S2 PublicationsCorresponds to variant dbSNP:rs2293275EnsemblClinVar.1
Natural variantiVAR_010155343C → S in LHR; Leydig cell hypoplasia type 1; completely devoided of hormone-induced cAMP reporter gene activation; although initial translocation to the endoplasmic reticulum is normal translocation is halted or misrouted and the mutant does not reach the cell surface and cannot bind hormone. 1 PublicationCorresponds to variant dbSNP:rs121912536EnsemblClinVar.1
Natural variantiVAR_003552354E → K in LHR; Leydig cell hypoplasia type 1. 1 PublicationCorresponds to variant dbSNP:rs121912529EnsemblClinVar.1
Natural variantiVAR_062338368L → P in FMPP; cells expressing the mutation display up to a 12-fold increase in basal cAMP production compared with cells expressing the same number of cell surface wild-type receptor indicating constitutive activation of the mutant receptor. 1 PublicationCorresponds to variant dbSNP:rs121912533EnsemblClinVar.1
Natural variantiVAR_003553373A → V in FMPP. 1 PublicationCorresponds to variant dbSNP:rs121912528EnsemblClinVar.1
Natural variantiVAR_003554398M → T in FMPP. 1 PublicationCorresponds to variant dbSNP:rs121912526EnsemblClinVar.1
Natural variantiVAR_010156457L → R in FMPP. 1 PublicationCorresponds to variant dbSNP:rs121912535EnsemblClinVar.1
Natural variantiVAR_062339502L → P in LHR; Leydig cell hypoplasia type 1; shows reduced cAMP production and ligand binding; receptor trafficking is not affected by the mutation. 1 PublicationCorresponds to variant dbSNP:rs121912538EnsemblClinVar.1
Natural variantiVAR_010157542I → L in FMPP. Corresponds to variant dbSNP:rs121912531EnsemblClinVar.1
Natural variantiVAR_010158543C → R in LHR; Leydig cell hypoplasia type 1; completely devoided of hormone-induced cAMP reporter gene activation; although initial translocation to the endoplasmic reticulum is normal translocation is halted or misrouted and the mutant does not reach the cell surface and cannot bind hormone. 1 PublicationCorresponds to variant dbSNP:rs121912537EnsemblClinVar.1
Natural variantiVAR_010159564D → G in FMPP. 1 PublicationCorresponds to variant dbSNP:rs121912540EnsemblClinVar.1
Natural variantiVAR_035764564D → N in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_003555568A → V in FMPP. 2 PublicationsCorresponds to variant dbSNP:rs121912534EnsemblClinVar.1
Natural variantiVAR_003556571M → I in FMPP. 1 PublicationCorresponds to variant dbSNP:rs121912519EnsemblClinVar.1
Natural variantiVAR_003557572A → V in FMPP. 1 PublicationCorresponds to variant dbSNP:rs121912522EnsemblClinVar.1
Natural variantiVAR_010160575I → L in FMPP. 1
Natural variantiVAR_003558577T → I in FMPP. 2 PublicationsCorresponds to variant dbSNP:rs121912521EnsemblClinVar.1
Natural variantiVAR_010161578D → E in FMPP. 1
Natural variantiVAR_003559578D → G in FMPP. 2 PublicationsCorresponds to variant dbSNP:rs121912518EnsemblClinVar.1
Natural variantiVAR_010162578D → H in Leydig cell tumor; somatic mutation; causes receptor activation and precocious puberty. 1 PublicationCorresponds to variant dbSNP:rs121912532EnsemblClinVar.1
Natural variantiVAR_010163578D → Y in FMPP. Corresponds to variant dbSNP:rs121912532EnsemblClinVar.1
Natural variantiVAR_010164581C → R in FMPP. 1
Natural variantiVAR_003560593A → P in LHR; Leydig cell hypoplasia type 1; abolishes signal transduction. 1 PublicationCorresponds to variant dbSNP:rs121912520EnsemblClinVar.1
Natural variantiVAR_003561608 – 609Missing in LHR; Leydig cell hypoplasia type 1. 1 Publication2
Natural variantiVAR_003562616S → Y in LHR; Leydig cell hypoplasia type 1; micropenis. 1 PublicationCorresponds to variant dbSNP:rs121912525EnsemblClinVar.1
Natural variantiVAR_003563625I → K in LHR; Leydig cell hypoplasia type 2. 1 PublicationCorresponds to variant dbSNP:rs121912530EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001962227 – 289Missing in isoform Short. CuratedAdd BLAST63

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M63108 mRNA Translation: AAA59515.1
S57793 mRNA Translation: AAB19917.2
M73746 mRNA Translation: AAA70231.1
X84753
, X84754, X84755, X84756, X84757, X84758, X84759, X84760, X84761, X84762, X84763 Genomic DNA Translation: CAA59234.1
AC073082 Genomic DNA No translation available.
AC087816 Genomic DNA No translation available.
AF082076 Genomic DNA Translation: AAC98291.1
AF024642 Genomic DNA Translation: AAB88417.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1842.1 [P22888-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A36243 QRHUUT

NCBI Reference Sequences

More...
RefSeqi
NP_000224.2, NM_000233.3 [P22888-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000294954; ENSP00000294954; ENSG00000138039 [P22888-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3973

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3973

UCSC genome browser

More...
UCSCi
uc002rwu.5 human [P22888-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
Sequence-structure-function-analysis of glycoprotein hormone receptors

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63108 mRNA Translation: AAA59515.1
S57793 mRNA Translation: AAB19917.2
M73746 mRNA Translation: AAA70231.1
X84753
, X84754, X84755, X84756, X84757, X84758, X84759, X84760, X84761, X84762, X84763 Genomic DNA Translation: CAA59234.1
AC073082 Genomic DNA No translation available.
AC087816 Genomic DNA No translation available.
AF082076 Genomic DNA Translation: AAC98291.1
AF024642 Genomic DNA Translation: AAB88417.1
CCDSiCCDS1842.1 [P22888-1]
PIRiA36243 QRHUUT
RefSeqiNP_000224.2, NM_000233.3 [P22888-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LUTmodel-A51-232[»]
1XULmodel-C51-232[»]
SMRiP22888
ModBaseiSearch...

Protein-protein interaction databases

BioGridi110161, 4 interactors
CORUMiP22888
MINTiP22888
STRINGi9606.ENSP00000294954

Chemistry databases

BindingDBiP22888
ChEMBLiCHEMBL1854
DrugBankiDB06719 Buserelin
DB00050 Cetrorelix
DB09126 Chorionic Gonadotropin (Human)
DB00097 Chorionic Gonadotropin (Recombinant)
DB00014 Goserelin
DB00044 Lutropin alfa
DB00032 Menotropins
GuidetoPHARMACOLOGYi254

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiP22888
PhosphoSitePlusiP22888
SwissPalmiP22888

Polymorphism and mutation databases

BioMutaiLHCGR
DMDMi281185513

Proteomic databases

jPOSTiP22888
PaxDbiP22888
PeptideAtlasiP22888
PRIDEiP22888
ProteomicsDBi54043 [P22888-1]
54044 [P22888-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3973
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294954; ENSP00000294954; ENSG00000138039 [P22888-1]
GeneIDi3973
KEGGihsa:3973
UCSCiuc002rwu.5 human [P22888-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3973
DisGeNETi3973

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LHCGR
HGNCiHGNC:6585 LHCGR
HPAiCAB009814
MalaCardsiLHCGR
MIMi152790 gene+phenotype
176410 phenotype
238320 phenotype
neXtProtiNX_P22888
OpenTargetsiENSG00000138039
Orphaneti3000 Familial male-limited precocious puberty
96265 Leydig cell hypoplasia due to complete LH resistance
96266 Leydig cell hypoplasia due to partial LH resistance
619 NON RARE IN EUROPE: Primary ovarian failure
PharmGKBiPA30357

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2087 Eukaryota
ENOG410XR1T LUCA
GeneTreeiENSGT00940000157364
HOGENOMiHOG000045902
InParanoidiP22888
KOiK04248
OMAiKTLRCAP
OrthoDBi257031at2759
PhylomeDBiP22888
TreeFamiTF316814

Enzyme and pathway databases

ReactomeiR-HSA-375281 Hormone ligand-binding receptors
R-HSA-418555 G alpha (s) signalling events
SignaLinkiP22888
SIGNORiP22888

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Luteinizing_hormone/choriogonadotropin_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3973

Protein Ontology

More...
PROi
PR:P22888

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138039 Expressed in 67 organ(s), highest expression level in lower esophagus muscularis layer
ExpressionAtlasiP22888 baseline and differential
GenevisibleiP22888 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR002131 Gphrmn_rcpt_fam
IPR026906 LRR_5
IPR032675 LRR_dom_sf
IPR002273 LSH_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PF13306 LRR_5, 2 hits
PRINTSiPR00373 GLYCHORMONER
PR00237 GPCRRHODOPSN
PR01144 LSHRECEPTOR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLSHR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22888
Secondary accession number(s): Q14751, Q15996, Q9UEW9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: December 15, 2009
Last modified: July 31, 2019
This is version 211 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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