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Protein

Transposase from transposon Tn916

Gene

Int-Tn

Organism
Enterococcus faecalis (Streptococcus faecalis)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei378O-(3'-phospho-DNA)-tyrosine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA integration, DNA recombination, Viral genome integration, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Transposase from transposon Tn916
Alternative name(s):
Integrase
Gene namesi
Name:Int-Tn
OrganismiEnterococcus faecalis (Streptococcus faecalis)
Taxonomic identifieri1351 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001975591 – 405Transposase from transposon Tn916Add BLAST405

Structurei

Secondary structure

1405
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP22886
SMRiP22886
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22886

Family & Domainsi

Sequence similaritiesi

Belongs to the 'phage' integrase family.Curated

Family and domain databases

Gene3Di1.10.150.130, 1 hit
1.10.443.10, 1 hit
InterProiView protein in InterPro
IPR016177 DNA-bd_dom_sf
IPR011010 DNA_brk_join_enz
IPR013762 Integrase-like_cat_sf
IPR002104 Integrase_catalytic
IPR010998 Integrase_recombinase_N
IPR004191 Integrase_Tn916-type_DNA-bd_N
IPR025269 SAM-like_dom
PfamiView protein in Pfam
PF02920 Integrase_DNA, 1 hit
PF13102 Phage_int_SAM_5, 1 hit
PF00589 Phage_integrase, 1 hit
SUPFAMiSSF54171 SSF54171, 1 hit
SSF56349 SSF56349, 1 hit

Sequencei

Sequence statusi: Complete.

P22886-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEKRRDNRG RILKTGESQR KDGRYLYKYI DSFGEPQFVY SWKLVATDRV
60 70 80 90 100
PAGKRDCISL REKIAELQKD IHDGIDVVGK KMTLCQLYAK QNAQRPKVRK
110 120 130 140 150
NTETGRKYLM DILKKDKLGV RSIDSIKPSD AKEWAIRMSE NGYAYQTINN
160 170 180 190 200
YKRSLKASFY IAIQDDCVRK NPFDFQLKAV LDDDTVPKTV LTEEQEEKLL
210 220 230 240 250
AFAKADKTYS KNYDEILILL KTGLRISEFG GLTLPDLDFE NRLVNIDHQL
260 270 280 290 300
LRDTEIGYYI ETPKTKSGER QVPMVEEAYQ AFKRVLANRK NDKRVEIDGY
310 320 330 340 350
SDFLFLNRKN YPKVASDYNG MMKGLVKKYN KYNEDKLPHI TPHSLRHTFC
360 370 380 390 400
TNYANAGMNP KALQYIMGHA NIAMTLNYYA HATFDSAMAE MKRLNKEKQQ

ERLVA
Length:405
Mass (Da):47,050
Last modified:August 1, 1991 - v1
Checksum:i33E7AF825154E619
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37184 Genomic DNA Translation: AAA19427.1
U09422 Genomic DNA Translation: AAB60030.1
RefSeqiWP_010785527.1, NZ_NSJS01000002.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37184 Genomic DNA Translation: AAA19427.1
U09422 Genomic DNA Translation: AAB60030.1
RefSeqiWP_010785527.1, NZ_NSJS01000002.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B69NMR-A3-71[»]
1BB8NMR-A3-73[»]
1TN9NMR-A3-71[»]
2BB8NMR-A3-73[»]
ProteinModelPortaliP22886
SMRiP22886
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP22886

Family and domain databases

Gene3Di1.10.150.130, 1 hit
1.10.443.10, 1 hit
InterProiView protein in InterPro
IPR016177 DNA-bd_dom_sf
IPR011010 DNA_brk_join_enz
IPR013762 Integrase-like_cat_sf
IPR002104 Integrase_catalytic
IPR010998 Integrase_recombinase_N
IPR004191 Integrase_Tn916-type_DNA-bd_N
IPR025269 SAM-like_dom
PfamiView protein in Pfam
PF02920 Integrase_DNA, 1 hit
PF13102 Phage_int_SAM_5, 1 hit
PF00589 Phage_integrase, 1 hit
SUPFAMiSSF54171 SSF54171, 1 hit
SSF56349 SSF56349, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTNR6_ENTFL
AccessioniPrimary (citable) accession number: P22886
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: January 31, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Transposable element

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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