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Protein

Mercuric resistance operon regulatory protein

Gene

merR

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury MerR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a potent transcriptional activator, while remaining bound to the mer site.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi79Mercury1
Metal bindingi114Mercury1
Metal bindingi123Mercury1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi5 – 24H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processMercuric resistance, Transcription, Transcription regulation
LigandMercury, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mercuric resistance operon regulatory protein
Gene namesi
Name:merR
Encoded oniPlasmid pI2580 Publication
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000981421 – 135Mercuric resistance operon regulatory proteinAdd BLAST135

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP22874
SMRiP22874
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 71HTH merR-typePROSITE-ProRule annotationAdd BLAST71

Family and domain databases

CDDicd04783 HTH_MerR1, 1 hit
InterProiView protein in InterPro
IPR009061 DNA-bd_dom_put_sf
IPR011794 MerR
IPR000551 MerR-type_HTH_dom
PfamiView protein in Pfam
PF13411 MerR_1, 1 hit
PRINTSiPR00040 HTHMERR
SMARTiView protein in SMART
SM00422 HTH_MERR, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
TIGRFAMsiTIGR02051 MerR, 1 hit
PROSITEiView protein in PROSITE
PS00552 HTH_MERR_1, 1 hit
PS50937 HTH_MERR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P22874-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGMKISELAK ACDVNKETVR YYERKGLIAG PPRNESGYRI YSEETADRVR
60 70 80 90 100
FIKRMKELDF SLKEIHLLFG VVDQDGERCK DMYAFTVQKT KEIERKVQGL
110 120 130
LRIQRLLEEL KEKCPDEKAM YTCPIIETLM GGPDK
Length:135
Mass (Da):15,741
Last modified:August 1, 1991 - v1
Checksum:iFDC1A852621D4F82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29436 Genomic DNA Translation: AAA98241.1
PIRiA29504
RefSeqiWP_000525462.1, NZ_PKSE01000054.1
YP_006937597.1, NC_013319.1
YP_006937784.1, NC_013323.1
YP_006938299.1, NC_013337.1
YP_006938632.1, NC_013347.1
YP_006938794.1, NC_013352.1

Genome annotation databases

GeneIDi13874745
13874936
13875466
13875809
13875975

Similar proteinsi

Entry informationi

Entry nameiMERR_STAAU
AccessioniPrimary (citable) accession number: P22874
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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