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UniProtKB - P22814 (RUNT_DROME)

Entry version 181 (12 Aug 2020)
Sequence version 2 (25 Oct 2005)
Previous versions | rss
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Protein

Segmentation protein Runt

Gene

run

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a pivotal role in regulating the expression of other pair-rule genes such as eve, ftz, and h.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Pair-rule protein, Segmentation polarity protein
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-549127, Organic cation transport
R-DME-8878166, Transcriptional regulation by RUNX2
R-DME-8931987, RUNX1 regulates estrogen receptor mediated transcription
R-DME-8934593, Regulation of RUNX1 Expression and Activity
R-DME-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-DME-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-DME-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-DME-8939245, RUNX1 regulates transcription of genes involved in BCR signaling
R-DME-8939246, RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
R-DME-8939247, RUNX1 regulates transcription of genes involved in interleukin signaling
R-DME-8939902, Regulation of RUNX2 expression and activity
R-DME-8940973, RUNX2 regulates osteoblast differentiation
R-DME-8941326, RUNX2 regulates bone development
R-DME-9018519, Estrogen-dependent gene expression

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P22814

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Segmentation protein Runt
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:run
ORF Names:CG1849
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0003300, run

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001746641 – 510Segmentation protein RuntAdd BLAST510

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P22814

PRoteomics IDEntifications database

More...PRIDEi		P22814

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in embryonic central and peripheral nervous system.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Most abundantly expressed at the blastoderm stage of embryogenesis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0003300, Expressed in embryo and 57 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P22814, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P22814, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		59347, 19 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P22814

Protein interaction database and analysis system

More...IntActi		P22814, 7 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0076971

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P22814

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini106 – 234RuntPROSITE-ProRule annotationAdd BLAST129

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi18 – 58Ala-richAdd BLAST41
Compositional biasi254 – 385Ala-richAdd BLAST132

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3982, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_041058_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P22814

KEGG Orthology (KO)

More...KOi		K20213

Identification of Orthologs from Complete Genome Data

More...OMAi		PATPYAM

Database of Orthologous Groups

More...OrthoDBi		1130963at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P22814

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.720, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000040, AML1_Runt
IPR008967, p53-like_TF_DNA-bd
IPR012346, p53/RUNT-type_TF_DNA-bd_sf
IPR013524, Runt_dom

The PANTHER Classification System

More...PANTHERi		PTHR11950, PTHR11950, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00853, Runt, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00967, ONCOGENEAML1

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49417, SSF49417, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51062, RUNT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P22814-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHLPAGPTMV ANNTQVLAAA AAAAAAAAAA VAQGPGPQQS SNATTASAIA 
        60         70         80         90        100
INPAQSLANT STHSASSTGS STPDLSTNNT SSSSNATTSP QNSAKMPSSM 
       110        120        130        140        150
TDMFASLHEM LQEYHGELAQ TGSPSILCSA LPNHWRSNKS LPGAFKVIAL 
       160        170        180        190        200
DDVPDGTLVS IKCGNDENYC GELRNCTTTM KNQVAKFNDL RFVGRSGRGK 
       210        220        230        240        250
SFTLTITIAT YPVQIASYSK AIKVTVDGPR EPRSKQSYGY PHPGAFNPFM 
       260        270        280        290        300
LNPAWLDAAY MTYGYADYFR HQAAAQAAQV HHPALAKSSA SSVSPNPNPS 
       310        320        330        340        350
VATSSSSAVQ PSEYPHPAAA VAAAAGQPAA MMPSPPGAAP ATPYAIPQFP 
       360        370        380        390        400
FNHVAAAAAA KAATPHAFHP YNFAAAAGLR ARNAALHHQS EPVHVSPASS 
       410        420        430        440        450
RPSSSSPTQQ HVLLKLNTSI ETSSIHEQSA SDGDSDDEQI DVVKSEFDLD 
       460        470        480        490        500
KSLDVAPLRM RCDLKAPSAM KPLYHESGPG AVANSRQPSP ETTTKIKSAA 
       510
VQQKTVWRPY
Length:510
Mass (Da):53,209
Last modified:October 25, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC32B1D344433362E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X2JEJ3X2JEJ3_DROME
Runt, isoform C
run 1, 13.1, 2, AA33, Dmel\CG1849
510Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9NHG0M9NHG0_DROME
Runt, isoform B
run 1, 13.1, 2, AA33, Dmel\CG1849
507Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18Missing in CAA39817 (PubMed:2249771).Curated1
Sequence conflicti153V → W in CAA39817 (PubMed:2249771).Curated1
Sequence conflicti231 – 236EPRSKQ → DPR in AAM51942 (Ref. 5) Curated6
Sequence conflicti329A → S in CAA39817 (PubMed:2249771).Curated1
Sequence conflicti329A → S in AAC27776 (PubMed:10368951).Curated1
Sequence conflicti329A → S in AAC27777 (PubMed:10368951).Curated1
Sequence conflicti329A → S in AAC27778 (PubMed:10368951).Curated1
Sequence conflicti329A → S in AAC27779 (PubMed:10368951).Curated1
Sequence conflicti329A → S in AAC27780 (PubMed:10368951).Curated1
Sequence conflicti329A → S in AAC27781 (PubMed:10368951).Curated1
Sequence conflicti329A → S in AAC27782 (PubMed:10368951).Curated1
Sequence conflicti329A → S in AAC27783 (PubMed:10368951).Curated1
Sequence conflicti329A → S in AAC27784 (PubMed:10368951).Curated1
Sequence conflicti329A → S in AAC27785 (PubMed:10368951).Curated1
Sequence conflicti329A → S in AAC27786 (PubMed:10368951).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti32A → P. 1
Natural varianti44T → A in strain: OK17, OK94, Z42, Z55, Z64 and Z74. 1
Natural varianti315P → S in strain: OK94. 1
Natural varianti469A → S in strain: Z27, OK13, OK5 and Z16. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X56432 mRNA Translation: CAA39817.1
AF077070 Genomic DNA Translation: AAC27776.1
AF077071 Genomic DNA Translation: AAC27777.1
AF077072 Genomic DNA Translation: AAC27778.1
AF077073 Genomic DNA Translation: AAC27779.1
AF077074 Genomic DNA Translation: AAC27780.1
AF077075 Genomic DNA Translation: AAC27781.1
AF077076 Genomic DNA Translation: AAC27782.1
AF077077 Genomic DNA Translation: AAC27783.1
AF077078 Genomic DNA Translation: AAC27784.1
AF077079 Genomic DNA Translation: AAC27785.1
AF077080 Genomic DNA Translation: AAC27786.1
AE014298 Genomic DNA Translation: AAF50886.1
AY121615 mRNA Translation: AAM51942.2
BT029257 mRNA Translation: ABK30894.1
AY459923 Genomic DNA Translation: AAS16109.1
AY459924 Genomic DNA Translation: AAS16110.1
AY459925 Genomic DNA Translation: AAS16111.1
AY459926 Genomic DNA Translation: AAS16112.1
AY459927 Genomic DNA Translation: AAS16113.1
AY459928 Genomic DNA Translation: AAS16114.1
AY459929 Genomic DNA Translation: AAS16115.1
AY459930 Genomic DNA Translation: AAS16116.1
AY459931 Genomic DNA Translation: AAS16117.1
AY459932 Genomic DNA Translation: AAS16118.1
AY459933 Genomic DNA Translation: AAS16119.1
AY459934 Genomic DNA Translation: AAS16120.1
AY459935 Genomic DNA Translation: AAS16121.1
AY459936 Genomic DNA Translation: AAS16122.1
AY459937 Genomic DNA Translation: AAS16123.1
AY459938 Genomic DNA Translation: AAS16124.1
AY459939 Genomic DNA Translation: AAS16125.1
AY459940 Genomic DNA Translation: AAS16126.1
AY459941 Genomic DNA Translation: AAS16127.1
AY459942 Genomic DNA Translation: AAS16128.1
AY459943 Genomic DNA Translation: AAS16129.1
AY459944 Genomic DNA Translation: AAS16130.1
AY459945 Genomic DNA Translation: AAS16131.1
AY459946 Genomic DNA Translation: AAS16132.1
AY459947 Genomic DNA Translation: AAS16133.1
AY459948 Genomic DNA Translation: AAS16134.1
AY459949 Genomic DNA Translation: AAS16135.1
AY459950 Genomic DNA Translation: AAS16136.1
AY459951 Genomic DNA Translation: AAS16137.1
AY459952 Genomic DNA Translation: AAS16138.1
AY459953 Genomic DNA Translation: AAS16139.1
AY459954 Genomic DNA Translation: AAS16140.1
AY459955 Genomic DNA Translation: AAS16141.1
AY459956 Genomic DNA Translation: AAS16142.1
AY459957 Genomic DNA Translation: AAS16143.1
AY459958 Genomic DNA Translation: AAS16144.1
AY459959 Genomic DNA Translation: AAS16145.1
AY459960 Genomic DNA Translation: AAS16146.1
AY459961 Genomic DNA Translation: AAS16147.1
AY459962 Genomic DNA Translation: AAS16148.1
AY459963 Genomic DNA Translation: AAS16149.1
AY459964 Genomic DNA Translation: AAS16150.1
AY459965 Genomic DNA Translation: AAS16151.1
AY459966 Genomic DNA Translation: AAS16152.1
AY459967 Genomic DNA Translation: AAS16153.1
AY459968 Genomic DNA Translation: AAS16154.1
AY459969 Genomic DNA Translation: AAS16155.1
AY459970 Genomic DNA Translation: AAS16156.1
AY459971 Genomic DNA Translation: AAS16157.1
AY459972 Genomic DNA Translation: AAS16158.1
AY459973 Genomic DNA Translation: AAS16159.1
AY459974 Genomic DNA Translation: AAS16160.1
AY459975 Genomic DNA Translation: AAS16161.1
AY459976 Genomic DNA Translation: AAS16162.1
AY459977 Genomic DNA Translation: AAS16163.1
AY459978 Genomic DNA Translation: AAS16164.1
AY459979 Genomic DNA Translation: AAS16165.1
AY459980 Genomic DNA Translation: AAS16166.1
AY459981 Genomic DNA Translation: AAS16167.1
AY459982 Genomic DNA Translation: AAS16168.1
AY459983 Genomic DNA Translation: AAS16169.1
AY459984 Genomic DNA Translation: AAS16170.1
AY459985 Genomic DNA Translation: AAS16171.1
AY459986 Genomic DNA Translation: AAS16172.1
AY459987 Genomic DNA Translation: AAS16173.1
AY459988 Genomic DNA Translation: AAS16174.1
AY459989 Genomic DNA Translation: AAS16175.1
AY459990 Genomic DNA Translation: AAS16176.1
AY459991 Genomic DNA Translation: AAS16177.1
AY459992 Genomic DNA Translation: AAS16178.1
AY459993 Genomic DNA Translation: AAS16179.1
AY459994 Genomic DNA Translation: AAS16180.1
AY459995 Genomic DNA Translation: AAS16181.1
AY459996 Genomic DNA Translation: AAS16182.1
AY459997 Genomic DNA Translation: AAS16183.1
AY459998 Genomic DNA Translation: AAS16184.1
AY459999 Genomic DNA Translation: AAS16185.1
AY460000 Genomic DNA Translation: AAS16186.1
AY460001 Genomic DNA Translation: AAS16187.1
AY460002 Genomic DNA Translation: AAS16188.1
AY460003 Genomic DNA Translation: AAS16189.1
AY460004 Genomic DNA Translation: AAS16190.1
AY460005 Genomic DNA Translation: AAS16191.1
AY460006 Genomic DNA Translation: AAS16192.1
AY460007 Genomic DNA Translation: AAS16193.1
AY460008 Genomic DNA Translation: AAS16194.1
AY460009 Genomic DNA Translation: AAS16195.1
AY460010 Genomic DNA Translation: AAS16196.1
AY460011 Genomic DNA Translation: AAS16197.1
AY460012 Genomic DNA Translation: AAS16198.1
AY460013 Genomic DNA Translation: AAS16199.1
AY460014 Genomic DNA Translation: AAS16200.1
AY460015 Genomic DNA Translation: AAS16201.1
AY460016 Genomic DNA Translation: AAS16202.1
AY460017 Genomic DNA Translation: AAS16203.1
AY460018 Genomic DNA Translation: AAS16204.1
AY460019 Genomic DNA Translation: AAS16205.1
AY460020 Genomic DNA Translation: AAS16206.1
AY460021 Genomic DNA Translation: AAS16207.1
AY460022 Genomic DNA Translation: AAS16208.1
AY460023 Genomic DNA Translation: AAS16209.1
AY460024 Genomic DNA Translation: AAS16210.1
AY460025 Genomic DNA Translation: AAS16211.1
AY460026 Genomic DNA Translation: AAS16212.1
AY460027 Genomic DNA Translation: AAS16213.1
AY460028 Genomic DNA Translation: AAS16214.1
AY460029 Genomic DNA Translation: AAS16215.1
AY460030 Genomic DNA Translation: AAS16216.1
AY460031 Genomic DNA Translation: AAS16217.1
AY460032 Genomic DNA Translation: AAS16218.1
AY460033 Genomic DNA Translation: AAS16219.1
AY460034 Genomic DNA Translation: AAS16220.1
AY460035 Genomic DNA Translation: AAS16221.1
AY460036 Genomic DNA Translation: AAS16222.1
AY460037 Genomic DNA Translation: AAS16223.1
AY460038 Genomic DNA Translation: AAS16224.1
AY460039 Genomic DNA Translation: AAS16225.1
AY460040 Genomic DNA Translation: AAS16226.1
AY460041 Genomic DNA Translation: AAS16227.1
AY460042 Genomic DNA Translation: AAS16228.1
AY460043 Genomic DNA Translation: AAS16229.1
AY460044 Genomic DNA Translation: AAS16230.1
AY460045 Genomic DNA Translation: AAS16231.1
AY460046 Genomic DNA Translation: AAS16232.1
AY460047 Genomic DNA Translation: AAS16233.1
AY460048 Genomic DNA Translation: AAS16234.1
AY460049 Genomic DNA Translation: AAS16235.1
AY460050 Genomic DNA Translation: AAS16236.1
AY460051 Genomic DNA Translation: AAS16237.1
AY460052 Genomic DNA Translation: AAS16238.1
AY460053 Genomic DNA Translation: AAS16239.1
AY460054 Genomic DNA Translation: AAS16240.1
AY460055 Genomic DNA Translation: AAS16241.1
AY460056 Genomic DNA Translation: AAS16242.1
AY460057 Genomic DNA Translation: AAS16243.1
AY460058 Genomic DNA Translation: AAS16244.1
AY460059 Genomic DNA Translation: AAS16245.1
AY460060 Genomic DNA Translation: AAS16246.1
AY460061 Genomic DNA Translation: AAS16247.1
AY460062 Genomic DNA Translation: AAS16248.1
AY460063 Genomic DNA Translation: AAS16249.1
AY460064 Genomic DNA Translation: AAS16250.1
AY460065 Genomic DNA Translation: AAS16251.1
AY460066 Genomic DNA Translation: AAS16252.1
AY460067 Genomic DNA Translation: AAS16253.1
AY460068 Genomic DNA Translation: AAS16254.1
AY460069 Genomic DNA Translation: AAS16255.1
AY460070 Genomic DNA Translation: AAS16256.1
AY460071 Genomic DNA Translation: AAS16257.1
AY460072 Genomic DNA Translation: AAS16258.1
AY460073 Genomic DNA Translation: AAS16259.1
AY460074 Genomic DNA Translation: AAS16260.1
AY460075 Genomic DNA Translation: AAS16261.1

Protein sequence database of the Protein Information Resource

More...PIRi		A36392

NCBI Reference Sequences

More...RefSeqi		NP_001285501.1, NM_001298572.1
NP_523424.2, NM_078700.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0077279; FBpp0076971; FBgn0003300
FBtr0345922; FBpp0311837; FBgn0003300

Database of genes from NCBI RefSeq genomes

More...GeneIDi		33059

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG1849

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56432 mRNA Translation: CAA39817.1
AF077070 Genomic DNA Translation: AAC27776.1
AF077071 Genomic DNA Translation: AAC27777.1
AF077072 Genomic DNA Translation: AAC27778.1
AF077073 Genomic DNA Translation: AAC27779.1
AF077074 Genomic DNA Translation: AAC27780.1
AF077075 Genomic DNA Translation: AAC27781.1
AF077076 Genomic DNA Translation: AAC27782.1
AF077077 Genomic DNA Translation: AAC27783.1
AF077078 Genomic DNA Translation: AAC27784.1
AF077079 Genomic DNA Translation: AAC27785.1
AF077080 Genomic DNA Translation: AAC27786.1
AE014298 Genomic DNA Translation: AAF50886.1
AY121615 mRNA Translation: AAM51942.2
BT029257 mRNA Translation: ABK30894.1
AY459923 Genomic DNA Translation: AAS16109.1
AY459924 Genomic DNA Translation: AAS16110.1
AY459925 Genomic DNA Translation: AAS16111.1
AY459926 Genomic DNA Translation: AAS16112.1
AY459927 Genomic DNA Translation: AAS16113.1
AY459928 Genomic DNA Translation: AAS16114.1
AY459929 Genomic DNA Translation: AAS16115.1
AY459930 Genomic DNA Translation: AAS16116.1
AY459931 Genomic DNA Translation: AAS16117.1
AY459932 Genomic DNA Translation: AAS16118.1
AY459933 Genomic DNA Translation: AAS16119.1
AY459934 Genomic DNA Translation: AAS16120.1
AY459935 Genomic DNA Translation: AAS16121.1
AY459936 Genomic DNA Translation: AAS16122.1
AY459937 Genomic DNA Translation: AAS16123.1
AY459938 Genomic DNA Translation: AAS16124.1
AY459939 Genomic DNA Translation: AAS16125.1
AY459940 Genomic DNA Translation: AAS16126.1
AY459941 Genomic DNA Translation: AAS16127.1
AY459942 Genomic DNA Translation: AAS16128.1
AY459943 Genomic DNA Translation: AAS16129.1
AY459944 Genomic DNA Translation: AAS16130.1
AY459945 Genomic DNA Translation: AAS16131.1
AY459946 Genomic DNA Translation: AAS16132.1
AY459947 Genomic DNA Translation: AAS16133.1
AY459948 Genomic DNA Translation: AAS16134.1
AY459949 Genomic DNA Translation: AAS16135.1
AY459950 Genomic DNA Translation: AAS16136.1
AY459951 Genomic DNA Translation: AAS16137.1
AY459952 Genomic DNA Translation: AAS16138.1
AY459953 Genomic DNA Translation: AAS16139.1
AY459954 Genomic DNA Translation: AAS16140.1
AY459955 Genomic DNA Translation: AAS16141.1
AY459956 Genomic DNA Translation: AAS16142.1
AY459957 Genomic DNA Translation: AAS16143.1
AY459958 Genomic DNA Translation: AAS16144.1
AY459959 Genomic DNA Translation: AAS16145.1
AY459960 Genomic DNA Translation: AAS16146.1
AY459961 Genomic DNA Translation: AAS16147.1
AY459962 Genomic DNA Translation: AAS16148.1
AY459963 Genomic DNA Translation: AAS16149.1
AY459964 Genomic DNA Translation: AAS16150.1
AY459965 Genomic DNA Translation: AAS16151.1
AY459966 Genomic DNA Translation: AAS16152.1
AY459967 Genomic DNA Translation: AAS16153.1
AY459968 Genomic DNA Translation: AAS16154.1
AY459969 Genomic DNA Translation: AAS16155.1
AY459970 Genomic DNA Translation: AAS16156.1
AY459971 Genomic DNA Translation: AAS16157.1
AY459972 Genomic DNA Translation: AAS16158.1
AY459973 Genomic DNA Translation: AAS16159.1
AY459974 Genomic DNA Translation: AAS16160.1
AY459975 Genomic DNA Translation: AAS16161.1
AY459976 Genomic DNA Translation: AAS16162.1
AY459977 Genomic DNA Translation: AAS16163.1
AY459978 Genomic DNA Translation: AAS16164.1
AY459979 Genomic DNA Translation: AAS16165.1
AY459980 Genomic DNA Translation: AAS16166.1
AY459981 Genomic DNA Translation: AAS16167.1
AY459982 Genomic DNA Translation: AAS16168.1
AY459983 Genomic DNA Translation: AAS16169.1
AY459984 Genomic DNA Translation: AAS16170.1
AY459985 Genomic DNA Translation: AAS16171.1
AY459986 Genomic DNA Translation: AAS16172.1
AY459987 Genomic DNA Translation: AAS16173.1
AY459988 Genomic DNA Translation: AAS16174.1
AY459989 Genomic DNA Translation: AAS16175.1
AY459990 Genomic DNA Translation: AAS16176.1
AY459991 Genomic DNA Translation: AAS16177.1
AY459992 Genomic DNA Translation: AAS16178.1
AY459993 Genomic DNA Translation: AAS16179.1
AY459994 Genomic DNA Translation: AAS16180.1
AY459995 Genomic DNA Translation: AAS16181.1
AY459996 Genomic DNA Translation: AAS16182.1
AY459997 Genomic DNA Translation: AAS16183.1
AY459998 Genomic DNA Translation: AAS16184.1
AY459999 Genomic DNA Translation: AAS16185.1
AY460000 Genomic DNA Translation: AAS16186.1
AY460001 Genomic DNA Translation: AAS16187.1
AY460002 Genomic DNA Translation: AAS16188.1
AY460003 Genomic DNA Translation: AAS16189.1
AY460004 Genomic DNA Translation: AAS16190.1
AY460005 Genomic DNA Translation: AAS16191.1
AY460006 Genomic DNA Translation: AAS16192.1
AY460007 Genomic DNA Translation: AAS16193.1
AY460008 Genomic DNA Translation: AAS16194.1
AY460009 Genomic DNA Translation: AAS16195.1
AY460010 Genomic DNA Translation: AAS16196.1
AY460011 Genomic DNA Translation: AAS16197.1
AY460012 Genomic DNA Translation: AAS16198.1
AY460013 Genomic DNA Translation: AAS16199.1
AY460014 Genomic DNA Translation: AAS16200.1
AY460015 Genomic DNA Translation: AAS16201.1
AY460016 Genomic DNA Translation: AAS16202.1
AY460017 Genomic DNA Translation: AAS16203.1
AY460018 Genomic DNA Translation: AAS16204.1
AY460019 Genomic DNA Translation: AAS16205.1
AY460020 Genomic DNA Translation: AAS16206.1
AY460021 Genomic DNA Translation: AAS16207.1
AY460022 Genomic DNA Translation: AAS16208.1
AY460023 Genomic DNA Translation: AAS16209.1
AY460024 Genomic DNA Translation: AAS16210.1
AY460025 Genomic DNA Translation: AAS16211.1
AY460026 Genomic DNA Translation: AAS16212.1
AY460027 Genomic DNA Translation: AAS16213.1
AY460028 Genomic DNA Translation: AAS16214.1
AY460029 Genomic DNA Translation: AAS16215.1
AY460030 Genomic DNA Translation: AAS16216.1
AY460031 Genomic DNA Translation: AAS16217.1
AY460032 Genomic DNA Translation: AAS16218.1
AY460033 Genomic DNA Translation: AAS16219.1
AY460034 Genomic DNA Translation: AAS16220.1
AY460035 Genomic DNA Translation: AAS16221.1
AY460036 Genomic DNA Translation: AAS16222.1
AY460037 Genomic DNA Translation: AAS16223.1
AY460038 Genomic DNA Translation: AAS16224.1
AY460039 Genomic DNA Translation: AAS16225.1
AY460040 Genomic DNA Translation: AAS16226.1
AY460041 Genomic DNA Translation: AAS16227.1
AY460042 Genomic DNA Translation: AAS16228.1
AY460043 Genomic DNA Translation: AAS16229.1
AY460044 Genomic DNA Translation: AAS16230.1
AY460045 Genomic DNA Translation: AAS16231.1
AY460046 Genomic DNA Translation: AAS16232.1
AY460047 Genomic DNA Translation: AAS16233.1
AY460048 Genomic DNA Translation: AAS16234.1
AY460049 Genomic DNA Translation: AAS16235.1
AY460050 Genomic DNA Translation: AAS16236.1
AY460051 Genomic DNA Translation: AAS16237.1
AY460052 Genomic DNA Translation: AAS16238.1
AY460053 Genomic DNA Translation: AAS16239.1
AY460054 Genomic DNA Translation: AAS16240.1
AY460055 Genomic DNA Translation: AAS16241.1
AY460056 Genomic DNA Translation: AAS16242.1
AY460057 Genomic DNA Translation: AAS16243.1
AY460058 Genomic DNA Translation: AAS16244.1
AY460059 Genomic DNA Translation: AAS16245.1
AY460060 Genomic DNA Translation: AAS16246.1
AY460061 Genomic DNA Translation: AAS16247.1
AY460062 Genomic DNA Translation: AAS16248.1
AY460063 Genomic DNA Translation: AAS16249.1
AY460064 Genomic DNA Translation: AAS16250.1
AY460065 Genomic DNA Translation: AAS16251.1
AY460066 Genomic DNA Translation: AAS16252.1
AY460067 Genomic DNA Translation: AAS16253.1
AY460068 Genomic DNA Translation: AAS16254.1
AY460069 Genomic DNA Translation: AAS16255.1
AY460070 Genomic DNA Translation: AAS16256.1
AY460071 Genomic DNA Translation: AAS16257.1
AY460072 Genomic DNA Translation: AAS16258.1
AY460073 Genomic DNA Translation: AAS16259.1
AY460074 Genomic DNA Translation: AAS16260.1
AY460075 Genomic DNA Translation: AAS16261.1
PIRiA36392
RefSeqiNP_001285501.1, NM_001298572.1
NP_523424.2, NM_078700.4

3D structure databases

SMRiP22814
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi59347, 19 interactors
ELMiP22814
IntActiP22814, 7 interactors
STRINGi7227.FBpp0076971

Proteomic databases

PaxDbiP22814
PRIDEiP22814

Genome annotation databases

EnsemblMetazoaiFBtr0077279; FBpp0076971; FBgn0003300
FBtr0345922; FBpp0311837; FBgn0003300
GeneIDi33059
KEGGidme:Dmel_CG1849

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		33059
FlyBaseiFBgn0003300, run

Phylogenomic databases

eggNOGiKOG3982, Eukaryota
HOGENOMiCLU_041058_1_0_1
InParanoidiP22814
KOiK20213
OMAiPATPYAM
OrthoDBi1130963at2759
PhylomeDBiP22814

Enzyme and pathway databases

ReactomeiR-DME-549127, Organic cation transport
R-DME-8878166, Transcriptional regulation by RUNX2
R-DME-8931987, RUNX1 regulates estrogen receptor mediated transcription
R-DME-8934593, Regulation of RUNX1 Expression and Activity
R-DME-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-DME-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-DME-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-DME-8939245, RUNX1 regulates transcription of genes involved in BCR signaling
R-DME-8939246, RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
R-DME-8939247, RUNX1 regulates transcription of genes involved in interleukin signaling
R-DME-8939902, Regulation of RUNX2 expression and activity
R-DME-8940973, RUNX2 regulates osteoblast differentiation
R-DME-8941326, RUNX2 regulates bone development
R-DME-9018519, Estrogen-dependent gene expression
SignaLinkiP22814

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		33059, 0 hits in 5 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		run, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		33059

Protein Ontology

More...PROi		PR:P22814

Gene expression databases

BgeeiFBgn0003300, Expressed in embryo and 57 other tissues
ExpressionAtlasiP22814, baseline and differential
GenevisibleiP22814, DM

Family and domain databases

Gene3Di2.60.40.720, 1 hit
InterProiView protein in InterPro
IPR000040, AML1_Runt
IPR008967, p53-like_TF_DNA-bd
IPR012346, p53/RUNT-type_TF_DNA-bd_sf
IPR013524, Runt_dom
PANTHERiPTHR11950, PTHR11950, 1 hit
PfamiView protein in Pfam
PF00853, Runt, 1 hit
PRINTSiPR00967, ONCOGENEAML1
SUPFAMiSSF49417, SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS51062, RUNT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRUNT_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22814
Secondary accession number(s): A0AVT9
, O76551, Q6SD78, Q7KPD6, Q8MRF4, Q9TVG1, Q9TVZ7, Q9TZQ9, Q9TZR0, Q9VRB6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: October 25, 2005
Last modified: August 12, 2020
This is version 181 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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