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Protein

Alcohol dehydrogenase 1

Gene
N/A
Organism
Pelophylax perezi (Perez's frog) (Rana perezi)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi46Zinc 1; catalyticBy similarity1
Metal bindingi68Zinc 1; catalyticBy similarity1
Metal bindingi98Zinc 2By similarity1
Metal bindingi101Zinc 2By similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi112Zinc 2By similarity1
Metal bindingi175Zinc 1; catalyticBy similarity1
Binding sitei224NADBy similarity1
Binding sitei229NADBy similarity1
Binding sitei370NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi200 – 205NADBy similarity6
Nucleotide bindingi293 – 295NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase, major
OrganismiPelophylax perezi (Perez's frog) (Rana perezi)
Taxonomic identifieri8403 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaePelophylax

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001606801 – 375Alcohol dehydrogenase 1Add BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

PTM databases

iPTMnetiP22797

Structurei

3D structure databases

ProteinModelPortaliP22797
SMRiP22797
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG000195

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P22797-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
ATAGKVIKCK AAVCWGPKQP LSIEEIEVAP PKRHEVRVKI VATGICRSDD
60 70 80 90 100
HVISGALSDM KFPVILGHEA AGVVESVGEG VTKFKPGDKV IPLFVPQCGE
110 120 130 140 150
CRCCKNPESN LCYKNDIGKY DGVLLDKTSR FTCKGKSIHN FISTSTFTEY
160 170 180 190 200
TVLDEIAVAK IHEDAPLEKV CLIGCGFSTG YGSAVNTGKV KPGSTCAVFG
210 220 230 240 250
LGGVGLSVII GCKVAGASRI IGVDLNSDKF TTAKECGATE CINPKDYNIP
260 270 280 290 300
IHEVLAKMTD DGVDYAFEVI GNTTVMTSAL SSSHFGCGKT VIVGLAPSSA
310 320 330 340 350
VMSFDPLLIL TGRILTGAVF GGWKSKDDVP KLVRDYLNKK FDFDPLITHY
360 370
MPFEKINEGF ELLRNGKSIR TILTF
Length:375
Mass (Da):40,185
Last modified:August 1, 1991 - v1
Checksum:i283E0A60E3339195
GO

Sequence databases

PIRiA38405
S11075

Similar proteinsi

Cross-referencesi

Sequence databases

PIRiA38405
S11075

3D structure databases

ProteinModelPortaliP22797
SMRiP22797
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP22797

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG000195

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADH1_PELPE
AccessioniPrimary (citable) accession number: P22797
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: November 22, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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