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Protein

Carboxypeptidase N subunit 2

Gene

CPN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • enzyme regulator activity Source: UniProtKB
  • metallocarboxypeptidase activity Source: Reactome

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-977606 Regulation of Complement cascade

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Carboxypeptidase N subunit 2
Alternative name(s):
Carboxypeptidase N 83 kDa chain
Carboxypeptidase N large subunit
Carboxypeptidase N polypeptide 2
Carboxypeptidase N regulatory subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CPN2
Synonyms:ACBP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000178772.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2313 CPN2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603104 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P22792

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1370

Open Targets

More...
OpenTargetsi
ENSG00000178772

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26830

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CPN2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
334302917

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002098922 – 545Carboxypeptidase N subunit 2Add BLAST524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi228N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi348N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi359N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi518N-linked (GlcNAc...) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Whether or not any Cys residues participate in intrachain bonds is unknown, but they do not form interchain disulfide bonds with the 50 kDa catalytic subunit.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P22792

PeptideAtlas

More...
PeptideAtlasi
P22792

PRoteomics IDEntifications database

More...
PRIDEi
P22792

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54038

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1068

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P22792

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P22792

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000178772 Expressed in 67 organ(s), highest expression level in right lobe of liver

CleanEx database of gene expression profiles

More...
CleanExi
HS_CPN2

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P22792 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA004732

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Tetramer of two catalytic chains and two glycosylated inactive chains.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107762, 3 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P22792

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000319464

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P22792

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P22792

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 49LRRNTAdd BLAST28
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati98 – 119LRR 1Add BLAST22
Repeati122 – 143LRR 2Add BLAST22
Repeati146 – 167LRR 3Add BLAST22
Repeati170 – 191LRR 4Add BLAST22
Repeati194 – 215LRR 5Add BLAST22
Repeati218 – 239LRR 6Add BLAST22
Repeati242 – 263LRR 7Add BLAST22
Repeati266 – 287LRR 8Add BLAST22
Repeati290 – 311LRR 9Add BLAST22
Repeati314 – 335LRR 10Add BLAST22
Repeati338 – 359LRR 11Add BLAST22
Repeati362 – 383LRR 12Add BLAST22
Domaini395 – 447LRRCTAdd BLAST53

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619 Eukaryota
COG4886 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163072

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000294123

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG050814

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P22792

KEGG Orthology (KO)

More...
KOi
K13023

Identification of Orthologs from Complete Genome Data

More...
OMAi
WQCDCHL

Database of Orthologous Groups

More...
OrthoDBi
EOG091G057B

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P22792

TreeFam database of animal gene trees

More...
TreeFami
TF351124

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13855 LRR_8, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 12 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P22792-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPGAWLLWT SLLLLARPAQ PCPMGCDCFV QEVFCSDEEL ATVPLDIPPY
60 70 80 90 100
TKNIIFVETS FTTLETRAFG SNPNLTKVVF LNTQLCQFRP DAFGGLPRLE
110 120 130 140 150
DLEVTGSSFL NLSTNIFSNL TSLGKLTLNF NMLEALPEGL FQHLAALESL
160 170 180 190 200
HLQGNQLQAL PRRLFQPLTH LKTLNLAQNL LAQLPEELFH PLTSLQTLKL
210 220 230 240 250
SNNALSGLPQ GVFGKLGSLQ ELFLDSNNIS ELPPQVFSQL FCLERLWLQR
260 270 280 290 300
NAITHLPLSI FASLGNLTFL SLQWNMLRVL PAGLFAHTPC LVGLSLTHNQ
310 320 330 340 350
LETVAEGTFA HLSNLRSLML SYNAITHLPA GIFRDLEELV KLYLGSNNLT
360 370 380 390 400
ALHPALFQNL SKLELLSLSK NQLTTLPEGI FDTNYNLFNL ALHGNPWQCD
410 420 430 440 450
CHLAYLFNWL QQYTDRLLNI QTYCAGPAYL KGQVVPALNE KQLVCPVTRD
460 470 480 490 500
HLGFQVTWPD ESKAGGSWDL AVQERAARSQ CTYSNPEGTV VLACDQAQCR
510 520 530 540
WLNVQLSPQQ GSLGLQYNAS QEWDLRSSCG SLRLTVSIEA RAAGP
Length:545
Mass (Da):60,557
Last modified:May 31, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i221AAF04413665AF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti156Q → R in AAH42334 (PubMed:15489334).Curated1
Sequence conflicti509Q → W in AAH31569 (PubMed:15489334).Curated1
Sequence conflicti509Q → W in AAH42334 (PubMed:15489334).Curated1
Sequence conflicti509Q → W in AAI37399 (PubMed:15489334).Curated1
Sequence conflicti509Q → W in AAI37404 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019722305A → T. Corresponds to variant dbSNP:rs3732477Ensembl.1
Natural variantiVAR_065186509Q → R1 PublicationCorresponds to variant dbSNP:rs4974538Ensembl.1
Natural variantiVAR_019721536V → M1 PublicationCorresponds to variant dbSNP:rs11711157Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J05158 mRNA Translation: AAA51921.2
AC125362 Genomic DNA No translation available.
AC174158 Genomic DNA No translation available.
BC031569 mRNA Translation: AAH31569.2
BC042334 mRNA Translation: AAH42334.2
BC137398 mRNA Translation: AAI37399.1
BC137403 mRNA Translation: AAI37404.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33920.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A34901

NCBI Reference Sequences

More...
RefSeqi
NP_001073982.3, NM_001080513.3
NP_001278917.1, NM_001291988.1
XP_005269337.1, XM_005269280.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.528368

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000323830; ENSP00000319464; ENSG00000178772
ENST00000429275; ENSP00000402232; ENSG00000178772

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1370

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1370

UCSC genome browser

More...
UCSCi
uc003fts.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05158 mRNA Translation: AAA51921.2
AC125362 Genomic DNA No translation available.
AC174158 Genomic DNA No translation available.
BC031569 mRNA Translation: AAH31569.2
BC042334 mRNA Translation: AAH42334.2
BC137398 mRNA Translation: AAI37399.1
BC137403 mRNA Translation: AAI37404.1
CCDSiCCDS33920.1
PIRiA34901
RefSeqiNP_001073982.3, NM_001080513.3
NP_001278917.1, NM_001291988.1
XP_005269337.1, XM_005269280.4
UniGeneiHs.528368

3D structure databases

ProteinModelPortaliP22792
SMRiP22792
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107762, 3 interactors
CORUMiP22792
STRINGi9606.ENSP00000319464

PTM databases

GlyConnecti1068
iPTMnetiP22792
PhosphoSitePlusiP22792

Polymorphism and mutation databases

BioMutaiCPN2
DMDMi334302917

Proteomic databases

PaxDbiP22792
PeptideAtlasiP22792
PRIDEiP22792
ProteomicsDBi54038

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323830; ENSP00000319464; ENSG00000178772
ENST00000429275; ENSP00000402232; ENSG00000178772
GeneIDi1370
KEGGihsa:1370
UCSCiuc003fts.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1370
DisGeNETi1370
EuPathDBiHostDB:ENSG00000178772.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CPN2

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0030813
HGNCiHGNC:2313 CPN2
HPAiHPA004732
MIMi603104 gene
neXtProtiNX_P22792
OpenTargetsiENSG00000178772
PharmGKBiPA26830

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000163072
HOGENOMiHOG000294123
HOVERGENiHBG050814
InParanoidiP22792
KOiK13023
OMAiWQCDCHL
OrthoDBiEOG091G057B
PhylomeDBiP22792
TreeFamiTF351124

Enzyme and pathway databases

ReactomeiR-HSA-977606 Regulation of Complement cascade

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CPN2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CPN2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1370

Protein Ontology

More...
PROi
PR:P22792

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000178772 Expressed in 67 organ(s), highest expression level in right lobe of liver
CleanExiHS_CPN2
GenevisibleiP22792 HS

Family and domain databases

Gene3Di3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 12 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 11 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCPN2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22792
Secondary accession number(s): B2RPE7, Q86SU4, Q8N5V4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: May 31, 2011
Last modified: December 5, 2018
This is version 171 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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