UniProtKB - P22736 (NR4A1_HUMAN)
Nuclear receptor subfamily 4 group A member 1
NR4A1
Functioni
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity).
May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury (By similarity).
By similarity2 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 264 – 339 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 76 | |
Zinc fingeri | 267 – 287 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 303 – 327 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- DNA binding Source: BHF-UCL
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- glucocorticoid receptor binding Source: GO_Central
- identical protein binding Source: Ensembl
- nuclear receptor activity Source: ProtInc
- protein heterodimerization activity Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- zinc ion binding Source: InterPro
GO - Biological processi
- apoptotic process Source: Ensembl
- cell migration involved in sprouting angiogenesis Source: BHF-UCL
- cellular response to corticotropin-releasing hormone stimulus Source: UniProtKB
- cellular response to fibroblast growth factor stimulus Source: BHF-UCL
- cellular response to vascular endothelial growth factor stimulus Source: BHF-UCL
- endothelial cell chemotaxis Source: BHF-UCL
- fat cell differentiation Source: UniProtKB
- negative regulation of cell cycle Source: UniProtKB
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
- neurotransmitter secretion involved in regulation of skeletal muscle contraction Source: Ensembl
- positive regulation of apoptotic process Source: Ensembl
- positive regulation of endothelial cell proliferation Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of type B pancreatic cell proliferation Source: UniProtKB
- response to amphetamine Source: Ensembl
- response to electrical stimulus Source: Ensembl
- response to lipopolysaccharide Source: Ensembl
- signal transduction Source: ProtInc
- skeletal muscle cell differentiation Source: Ensembl
Keywordsi
Molecular function | DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P22736 |
Reactomei | R-HSA-198693, AKT phosphorylates targets in the nucleus R-HSA-383280, Nuclear Receptor transcription pathway R-HSA-5674400, Constitutive Signaling by AKT1 E17K in Cancer |
SignaLinki | P22736 |
SIGNORi | P22736 |
Protein family/group databases
MoonDBi | P22736, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear receptor subfamily 4 group A member 1Alternative name(s): Early response protein NAK1 Nuclear hormone receptor NUR/77 Short name: Nur77 Orphan nuclear receptor HMR Orphan nuclear receptor TR3 ST-59 Testicular receptor 3 |
Gene namesi | Name:NR4A1 Synonyms:GFRP1, HMR, NAK1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7980, NR4A1 |
MIMi | 139139, gene |
neXtProti | NX_P22736 |
VEuPathDBi | HostDB:ENSG00000123358 |
Subcellular locationi
Nucleus
- Nucleus 5 Publications
Mitochondrion
- Mitochondrion 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 3 Publications
Note: Nuclear export to the cytoplasm is XPO1-mediated and positively regulated by IFI27 (PubMed:22427340). Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (PubMed:17761950).2 Publications
Cytosol
- cytosol Source: HPA
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Nucleus
- nuclear membrane Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: BHF-UCL
Other locations
- chromatin Source: NTNU_SB
- presynapse Source: GOC
- transcription regulator complex Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, Mitochondrion, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 1 – 50 | Missing : No impact on the interaction with RXRA. 1 PublicationAdd BLAST | 50 | |
Mutagenesisi | 299 – 361 | Missing : Loss of interaction with RXRA. 1 PublicationAdd BLAST | 63 | |
Mutagenesisi | 595 | T → E: Strongly weakens interaction with STK11. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 3164 |
OpenTargetsi | ENSG00000123358 |
PharmGKBi | PA31761 |
Miscellaneous databases
Pharosi | P22736, Tbio |
Chemistry databases
ChEMBLi | CHEMBL1293229 |
Genetic variation databases
BioMutai | NR4A1 |
DMDMi | 127819 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053715 | 1 – 598 | Nuclear receptor subfamily 4 group A member 1Add BLAST | 598 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 341 | Phosphoserine; by PKABy similarity | 1 | |
Modified residuei | 351 | PhosphoserineCombined sources1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P22736 |
jPOSTi | P22736 |
MassIVEi | P22736 |
MaxQBi | P22736 |
PaxDbi | P22736 |
PeptideAtlasi | P22736 |
PRIDEi | P22736 |
ProteomicsDBi | 54032 [P22736-1] 54033 [P22736-2] 60662 |
PTM databases
GlyGeni | P22736, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P22736 |
PhosphoSitePlusi | P22736 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000123358, Expressed in right adrenal gland and 236 other tissues |
ExpressionAtlasi | P22736, baseline and differential |
Genevisiblei | P22736, HS |
Organism-specific databases
HPAi | ENSG00000123358, Low tissue specificity |
Interactioni
Subunit structurei
Binds DNA as a monomer (By similarity).
Interacts with GADD45GIP1 (PubMed:15459248).
Interacts with STK11 (PubMed:22983157).
Interacts with IFI27 (PubMed:22427340). Heterodimer (via DNA-binding domain) with RXRA (via C-terminus); DNA-binding of the heterodimer is enhanced by 9-cis retinoic acid (PubMed:17761950, PubMed:15509776). Competes for the RXRA interaction with EP300 and thereby attenuates EP300 mediated acetylation of RXRA (PubMed:17761950).
By similarity5 PublicationsBinary interactionsi
P22736
Isoform 1 [P22736-1]
With | #Exp. | IntAct |
---|---|---|
BNIP3L [O60238] | 4 | EBI-16085263,EBI-849893 |
MAPK14 - isoform CSBP2 [Q16539-1] | 5 | EBI-16085263,EBI-15834191 |
RELA [Q04206] | 3 | EBI-16085263,EBI-73886 |
SLC25A4 [P12235] | 2 | EBI-16085263,EBI-359074 |
Isoform 2 [P22736-2]
With | #Exp. | IntAct |
---|---|---|
PGBD1 [Q96JS3] | 3 | EBI-12697871,EBI-10290053 |
GO - Molecular functioni
- glucocorticoid receptor binding Source: GO_Central
- identical protein binding Source: Ensembl
- protein heterodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 109407, 202 interactors |
DIPi | DIP-40392N |
IntActi | P22736, 111 interactors |
MINTi | P22736 |
STRINGi | 9606.ENSP00000440864 |
Chemistry databases
BindingDBi | P22736 |
Miscellaneous databases
RNActi | P22736, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P22736 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P22736 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 360 – 595 | NR LBDPROSITE-ProRule annotationAdd BLAST | 236 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 44 | DisorderedSequence analysisAdd BLAST | 44 | |
Regioni | 131 – 158 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 171 – 466 | Required for nuclear import1 PublicationAdd BLAST | 296 | |
Regioni | 177 – 206 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 221 – 265 | DisorderedSequence analysisAdd BLAST | 45 | |
Regioni | 299 – 361 | Required for the interaction with RXRA1 PublicationAdd BLAST | 63 | |
Regioni | 341 – 361 | DisorderedSequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 180 – 194 | Pro residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 267 – 287 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 303 – 327 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG4217, Eukaryota |
GeneTreei | ENSGT00950000183038 |
HOGENOMi | CLU_007368_14_2_1 |
InParanoidi | P22736 |
OMAi | MEVIRKW |
OrthoDBi | 454476at2759 |
PhylomeDBi | P22736 |
TreeFami | TF315430 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR003071, Nuc_orp_HMR_rcpt IPR003070, Nuc_orph_rcpt IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01285, HMRNUCRECPTR PR01284, NUCLEARECPTR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPCIQAQYGT PAPSPGPRDH LASDPLTPEF IKPTMDLASP EAAPAAPTAL
60 70 80 90 100
PSFSTFMDGY TGEFDTFLYQ LPGTVQPCSS ASSSASSTSS SSATSPASAS
110 120 130 140 150
FKFEDFQVYG CYPGPLSGPV DEALSSSGSD YYGSPCSAPS PSTPSFQPPQ
160 170 180 190 200
LSPWDGSFGH FSPSQTYEGL RAWTEQLPKA SGPPQPPAFF SFSPPTGPSP
210 220 230 240 250
SLAQSPLKLF PSQATHQLGE GESYSMPTAF PGLAPTSPHL EGSGILDTPV
260 270 280 290 300
TSTKARSGAP GGSEGRCAVC GDNASCQHYG VRTCEGCKGF FKRTVQKNAK
310 320 330 340 350
YICLANKDCP VDKRRRNRCQ FCRFQKCLAV GMVKEVVRTD SLKGRRGRLP
360 370 380 390 400
SKPKQPPDAS PANLLTSLVR AHLDSGPSTA KLDYSKFQEL VLPHFGKEDA
410 420 430 440 450
GDVQQFYDLL SGSLEVIRKW AEKIPGFAEL SPADQDLLLE SAFLELFILR
460 470 480 490 500
LAYRSKPGEG KLIFCSGLVL HRLQCARGFG DWIDSILAFS RSLHSLLVDV
510 520 530 540 550
PAFACLSALV LITDRHGLQE PRRVEELQNR IASCLKEHVA AVAGEPQPAS
560 570 580 590
CLSRLLGKLP ELRTLCTQGL QRIFYLKLED LVPPPPIIDK IFMDTLPF
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5GXF0 | F5GXF0_HUMAN | Nuclear receptor subfamily 4 group ... | NR4A1 | 652 | Annotation score: | ||
H3BT85 | H3BT85_HUMAN | Nuclear receptor subfamily 4 group ... | NR4A1 | 302 | Annotation score: | ||
H3BPN8 | H3BPN8_HUMAN | Nuclear receptor subfamily 4 group ... | NR4A1 | 150 | Annotation score: | ||
H3BSB9 | H3BSB9_HUMAN | Nuclear receptor subfamily 4 group ... | NR4A1 | 119 | Annotation score: | ||
F8VVX9 | F8VVX9_HUMAN | Nuclear receptor subfamily 4 group ... | NR4A1 | 148 | Annotation score: | ||
H3BSM8 | H3BSM8_HUMAN | Nuclear receptor subfamily 4 group ... | NR4A1 | 78 | Annotation score: | ||
H3BQG5 | H3BQG5_HUMAN | Nuclear receptor subfamily 4 group ... | NR4A1 | 120 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 253 | T → I (PubMed:1651101).Curated | 1 | |
Sequence conflicti | 262 | G → P in AAA36763 (PubMed:2626032).Curated | 1 | |
Sequence conflicti | 360 | S → F in CAG32985 (Ref. 8) Curated | 1 | |
Sequence conflicti | 370 | R → L in AAA36763 (PubMed:2626032).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061534 | 26 | L → V. Corresponds to variant dbSNP:rs1882118Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043086 | 1 | M → MWLAKACWSIQSEM in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_047769 | 293 – 325 | RTVQK…FCRFQ → VPRSPRWGLLLEMERGWPHP IGTCGLPLGSPPS in isoform 3. 2 PublicationsAdd BLAST | 33 | |
Alternative sequenceiVSP_047770 | 326 – 598 | Missing in isoform 3. 2 PublicationsAdd BLAST | 273 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D49728 mRNA Translation: BAA08565.1 L13740 mRNA Translation: AAA36763.1 D85245 mRNA Translation: BAA12746.1 AK297526 mRNA Translation: BAG59929.1 HQ692855 mRNA Translation: ADZ17366.1 AB307717 mRNA Translation: BAH02308.1 BT007144 mRNA Translation: AAP35808.1 AK314437 mRNA Translation: BAG37048.1 CR456704 mRNA Translation: CAG32985.1 AC025259 Genomic DNA No translation available. CH471111 Genomic DNA Translation: EAW58222.1 CH471111 Genomic DNA Translation: EAW58224.1 CH471111 Genomic DNA Translation: EAW58225.1 BC016147 mRNA Translation: AAH16147.1 |
CCDSi | CCDS55828.1 [P22736-2] CCDS8818.1 [P22736-1] |
PIRi | A37251 |
RefSeqi | NP_001189162.1, NM_001202233.1 [P22736-2] NP_002126.2, NM_002135.4 [P22736-1] NP_775180.1, NM_173157.2 [P22736-1] XP_005268881.1, XM_005268824.3 [P22736-1] XP_006719426.1, XM_006719363.1 [P22736-1] XP_006719427.1, XM_006719364.3 [P22736-1] |
Genome annotation databases
Ensembli | ENST00000243050; ENSP00000243050; ENSG00000123358 ENST00000360284; ENSP00000353427; ENSG00000123358 [P22736-2] ENST00000394824; ENSP00000378301; ENSG00000123358 ENST00000394825; ENSP00000378302; ENSG00000123358 ENST00000548232; ENSP00000449587; ENSG00000123358 [P22736-3] ENST00000550082; ENSP00000449539; ENSG00000123358 [P22736-2] |
GeneIDi | 3164 |
KEGGi | hsa:3164 |
MANE-Selecti | ENST00000394825.6; ENSP00000378302.1; NM_173157.3; NP_775180.1 |
UCSCi | uc001rzs.4, human [P22736-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D49728 mRNA Translation: BAA08565.1 L13740 mRNA Translation: AAA36763.1 D85245 mRNA Translation: BAA12746.1 AK297526 mRNA Translation: BAG59929.1 HQ692855 mRNA Translation: ADZ17366.1 AB307717 mRNA Translation: BAH02308.1 BT007144 mRNA Translation: AAP35808.1 AK314437 mRNA Translation: BAG37048.1 CR456704 mRNA Translation: CAG32985.1 AC025259 Genomic DNA No translation available. CH471111 Genomic DNA Translation: EAW58222.1 CH471111 Genomic DNA Translation: EAW58224.1 CH471111 Genomic DNA Translation: EAW58225.1 BC016147 mRNA Translation: AAH16147.1 |
CCDSi | CCDS55828.1 [P22736-2] CCDS8818.1 [P22736-1] |
PIRi | A37251 |
RefSeqi | NP_001189162.1, NM_001202233.1 [P22736-2] NP_002126.2, NM_002135.4 [P22736-1] NP_775180.1, NM_173157.2 [P22736-1] XP_005268881.1, XM_005268824.3 [P22736-1] XP_006719426.1, XM_006719363.1 [P22736-1] XP_006719427.1, XM_006719364.3 [P22736-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2QW4 | X-ray | 2.80 | A/B/C/D | 347-598 | [»] | |
3V3E | X-ray | 2.06 | A/B | 351-598 | [»] | |
3V3Q | X-ray | 2.22 | A/B | 351-598 | [»] | |
4JGV | X-ray | 3.01 | A/B | 351-598 | [»] | |
4KZI | X-ray | 2.41 | A/B | 351-598 | [»] | |
4KZJ | X-ray | 2.12 | A/B | 351-598 | [»] | |
4KZM | X-ray | 2.30 | A/B | 351-598 | [»] | |
4RE8 | X-ray | 2.16 | A/B | 351-598 | [»] | |
4REE | X-ray | 2.37 | A/B | 351-598 | [»] | |
4REF | X-ray | 2.10 | A/B | 351-598 | [»] | |
4RZE | X-ray | 2.49 | A/B | 351-598 | [»] | |
4RZF | X-ray | 1.99 | A/B | 351-598 | [»] | |
4RZG | X-ray | 2.70 | A/B | 351-598 | [»] | |
4WHF | X-ray | 2.27 | A/B | 351-598 | [»] | |
4WHG | X-ray | 2.18 | A/B | 351-598 | [»] | |
6KZ5 | X-ray | 4.45 | A/B | 351-598 | [»] | |
6LC1 | X-ray | 3.12 | A/D/G/J | 265-351 | [»] | |
SMRi | P22736 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109407, 202 interactors |
DIPi | DIP-40392N |
IntActi | P22736, 111 interactors |
MINTi | P22736 |
STRINGi | 9606.ENSP00000440864 |
Chemistry databases
BindingDBi | P22736 |
ChEMBLi | CHEMBL1293229 |
Protein family/group databases
MoonDBi | P22736, Predicted |
PTM databases
GlyGeni | P22736, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P22736 |
PhosphoSitePlusi | P22736 |
Genetic variation databases
BioMutai | NR4A1 |
DMDMi | 127819 |
Proteomic databases
EPDi | P22736 |
jPOSTi | P22736 |
MassIVEi | P22736 |
MaxQBi | P22736 |
PaxDbi | P22736 |
PeptideAtlasi | P22736 |
PRIDEi | P22736 |
ProteomicsDBi | 54032 [P22736-1] 54033 [P22736-2] 60662 |
Protocols and materials databases
Antibodypediai | 14466, 719 antibodies from 45 providers |
DNASUi | 3164 |
Genome annotation databases
Ensembli | ENST00000243050; ENSP00000243050; ENSG00000123358 ENST00000360284; ENSP00000353427; ENSG00000123358 [P22736-2] ENST00000394824; ENSP00000378301; ENSG00000123358 ENST00000394825; ENSP00000378302; ENSG00000123358 ENST00000548232; ENSP00000449587; ENSG00000123358 [P22736-3] ENST00000550082; ENSP00000449539; ENSG00000123358 [P22736-2] |
GeneIDi | 3164 |
KEGGi | hsa:3164 |
MANE-Selecti | ENST00000394825.6; ENSP00000378302.1; NM_173157.3; NP_775180.1 |
UCSCi | uc001rzs.4, human [P22736-1] |
Organism-specific databases
CTDi | 3164 |
DisGeNETi | 3164 |
GeneCardsi | NR4A1 |
HGNCi | HGNC:7980, NR4A1 |
HPAi | ENSG00000123358, Low tissue specificity |
MIMi | 139139, gene |
neXtProti | NX_P22736 |
OpenTargetsi | ENSG00000123358 |
PharmGKBi | PA31761 |
VEuPathDBi | HostDB:ENSG00000123358 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4217, Eukaryota |
GeneTreei | ENSGT00950000183038 |
HOGENOMi | CLU_007368_14_2_1 |
InParanoidi | P22736 |
OMAi | MEVIRKW |
OrthoDBi | 454476at2759 |
PhylomeDBi | P22736 |
TreeFami | TF315430 |
Enzyme and pathway databases
PathwayCommonsi | P22736 |
Reactomei | R-HSA-198693, AKT phosphorylates targets in the nucleus R-HSA-383280, Nuclear Receptor transcription pathway R-HSA-5674400, Constitutive Signaling by AKT1 E17K in Cancer |
SignaLinki | P22736 |
SIGNORi | P22736 |
Miscellaneous databases
BioGRID-ORCSi | 3164, 10 hits in 1065 CRISPR screens |
ChiTaRSi | NR4A1, human |
EvolutionaryTracei | P22736 |
GeneWikii | Nerve_Growth_factor_IB |
GenomeRNAii | 3164 |
Pharosi | P22736, Tbio |
PROi | PR:P22736 |
RNActi | P22736, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000123358, Expressed in right adrenal gland and 236 other tissues |
ExpressionAtlasi | P22736, baseline and differential |
Genevisiblei | P22736, HS |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR003071, Nuc_orp_HMR_rcpt IPR003070, Nuc_orph_rcpt IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01285, HMRNUCRECPTR PR01284, NUCLEARECPTR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NR4A1_HUMAN | |
Accessioni | P22736Primary (citable) accession number: P22736 Secondary accession number(s): B4DML7 Q6IBU8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1991 |
Last sequence update: | August 1, 1991 | |
Last modified: | February 23, 2022 | |
This is version 225 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families