NR4A1

Functionⁱ

Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury (By similarity).By similarity2 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	264 – 339	Nuclear receptorPROSITE-ProRule annotationAdd BLAST	76
Zinc fingerⁱ	267 – 287	NR C4-typePROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	303 – 327	NR C4-typePROSITE-ProRule annotationAdd BLAST	25

GO - Molecular functionⁱ

DNA binding Source: BHF-UCL
nuclear receptor activity
Source: ProtInc
Traceable author statementⁱ
- 2626032
protein heterodimerization activity Source: UniProtKB
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
sequence-specific DNA binding Source: InterPro
steroid hormone receptor activity Source: InterPro
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: UniProtKB
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell migration involved in sprouting angiogenesis
Source: BHF-UCL
Inferred from direct assayⁱ
- 18059339
cellular response to corticotropin-releasing hormone stimulus Source: UniProtKB
cellular response to fibroblast growth factor stimulus
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18059339
cellular response to vascular endothelial growth factor stimulus
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18059339
endothelial cell chemotaxis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18059339
fat cell differentiation Source: UniProtKB
negative regulation of cell cycle Source: UniProtKB
positive regulation of endothelial cell proliferation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18059339
positive regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 22427340
regulation of type B pancreatic cell proliferation Source: UniProtKB
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 2626032
transcription initiation from RNA polymerase II promoter Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Receptor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-198693 AKT phosphorylates targets in the nucleus R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer
SignaLinkⁱ	P22736
SIGNORⁱ	P22736

Protein family/group databases

MoonDBⁱ	P22736 Predicted

MoonDBⁱ

P22736 Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Nuclear receptor subfamily 4 group A member 1 Alternative name(s): Early response protein NAK1 Nuclear hormone receptor NUR/77 Short name: Nur77 Orphan nuclear receptor HMR Orphan nuclear receptor TR3 ST-59 Testicular receptor 3
Gene namesⁱ	Name:NR4A1 Synonyms:GFRP1, HMR, NAK1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000123358.19
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7980 NR4A1
MIMⁱ	139139 gene
neXtProtⁱ	NX_P22736

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	595	T → E: Strongly weakens interaction with STK11. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3164
Open Targets More...OpenTargetsⁱ	ENSG00000123358
PharmGKBⁱ	PA31761

Chemistry databases

ChEMBLⁱ	CHEMBL1293229

ChEMBLⁱ

CHEMBL1293229

Polymorphism and mutation databases

BioMutaⁱ	NR4A1
DMDMⁱ	127819

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000053715	1 – 598	Nuclear receptor subfamily 4 group A member 1Add BLAST		598

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	341	Phosphoserine; by PKABy similarity		1
Modified residueⁱ	351	PhosphoserineCombined sources1 Publication		1

Post-translational modificationⁱ

Phosphorylated at Ser-351 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli.1 Publication

Acetylated by p300/CBP, acetylation increases stability. Deacetylated by HDAC1.1 Publication

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P22736
PaxDbⁱ	P22736
PeptideAtlas More...PeptideAtlasⁱ	P22736
PRIDEⁱ	P22736
ProteomicsDBⁱ	54032 54033 [P22736-2]

PTM databases

iPTMnetⁱ	P22736
PhosphoSitePlusⁱ	P22736

Expressionⁱ

Tissue specificityⁱ

Fetal muscle and adult liver, brain and thyroid.

Inductionⁱ

By growth-stimulating agents.

Gene expression databases

Bgeeⁱ	ENSG00000123358 Expressed in 221 organ(s), highest expression level in right adrenal gland
CleanExⁱ	HS_NR4A1
ExpressionAtlasⁱ	P22736 baseline and differential
Genevisibleⁱ	P22736 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA059742 HPA070142

HPAⁱ

HPA059742
HPA070142

Interactionⁱ

Subunit structureⁱ

Binds DNA as a monomer (By similarity). Interacts with GADD45GIP1 (PubMed:15459248). Interacts with STK11 (PubMed:22983157). Interacts with IFI27 (PubMed:22427340).By similarity3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
	Q9WMX2	2	EBI-721550,EBI-9028517	From Hepatitis C virus genotype 1b (isolate Con1).
ANKIB1	Q9P2G1	2	EBI-721550,EBI-2687890
BCL2	P10415	7	EBI-721550,EBI-77694
BNIP3L	O60238	4	EBI-16085263,EBI-849893
CDKN2D	P55273	3	EBI-721550,EBI-745859
CUTA	O60888	2	EBI-721550,EBI-1051556
E2	P03120	3	EBI-721550,EBI-1779322	From Human papillomavirus type 16.
GK	P32189	3	EBI-721550,EBI-3926629
KRTAP10-5	P60370	3	EBI-721550,EBI-10172150
LONRF1	Q17RB8	3	EBI-721550,EBI-2341787
MAPK14	Q16539-1	5	EBI-16085263,EBI-15834191
MATR3	P43243	2	EBI-721550,EBI-352602
PGBD1	Q96JS3	3	EBI-12697871,EBI-10290053
PLXND1	Q9Y4D7	2	EBI-721550,EBI-310731
PRMT1	Q99873	6	EBI-721550,EBI-78738
RELA	Q04206	3	EBI-16085263,EBI-73886
SLC25A4	P12235	2	EBI-16085263,EBI-359074
STAT3	P40763	3	EBI-721550,EBI-518675
TP53	P04637	6	EBI-721550,EBI-366083
TUBB4A	P04350	2	EBI-721550,EBI-355007
VASP	P50552	2	EBI-721550,EBI-748201

GO - Molecular functionⁱ

protein heterodimerization activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109407, 100 interactors
Database of interacting proteins More...DIPⁱ	DIP-40392N
IntActⁱ	P22736, 107 interactors
Molecular INTeraction database More...MINTⁱ	P22736
STRINGⁱ	9606.ENSP00000353427

Chemistry databases

BindingDBⁱ

P22736

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	364 – 373	Combined sources	10
Helixⁱ	379 – 381	Combined sources	3
Beta strandⁱ	395 – 397	Combined sources	3
Helixⁱ	400 – 422	Combined sources	23
Helixⁱ	427 – 429	Combined sources	3
Helixⁱ	432 – 454	Combined sources	23
Helixⁱ	457 – 459	Combined sources	3
Beta strandⁱ	461 – 463	Combined sources	3
Beta strandⁱ	467 – 471	Combined sources	5
Helixⁱ	472 – 479	Combined sources	8
Helixⁱ	482 – 495	Combined sources	14
Helixⁱ	500 – 511	Combined sources	12
Helixⁱ	521 – 541	Combined sources	21
Turnⁱ	544 – 546	Combined sources	3
Helixⁱ	550 – 556	Combined sources	7
Helixⁱ	558 – 579	Combined sources	22
Helixⁱ	586 – 594	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	P22736
SMRⁱ	P22736
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P22736

EvolutionaryTraceⁱ

P22736

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	360 – 595	NR LBDPROSITE-ProRule annotationAdd BLAST		236

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	82 – 92	Poly-SerAdd BLAST		11
Compositional biasⁱ	583 – 586	Poly-Pro		4

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family. NR4 subfamily.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	267 – 287	NR C4-typePROSITE-ProRule annotationAdd BLAST		21
Zinc fingerⁱ	303 – 327	NR C4-typePROSITE-ProRule annotationAdd BLAST		25

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG4217 Eukaryota ENOG410YWNC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118887
HOGENOMⁱ	HOG000230925
HOVERGENⁱ	HBG052663
InParanoidⁱ	P22736
KEGG Orthology (KO) More...KOⁱ	K04465
PhylomeDBⁱ	P22736
TreeFamⁱ	TF315430

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR003071 Nuc_orp_HMR_rcpt IPR003070 Nuc_orph_rcpt IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR01285 HMRNUCRECPTR PR01284 NUCLEARECPTR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P22736-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPCIQAQYGT PAPSPGPRDH LASDPLTPEF IKPTMDLASP EAAPAAPTAL 
        60         70         80         90        100
PSFSTFMDGY TGEFDTFLYQ LPGTVQPCSS ASSSASSTSS SSATSPASAS 
       110        120        130        140        150
FKFEDFQVYG CYPGPLSGPV DEALSSSGSD YYGSPCSAPS PSTPSFQPPQ 
       160        170        180        190        200
LSPWDGSFGH FSPSQTYEGL RAWTEQLPKA SGPPQPPAFF SFSPPTGPSP 
       210        220        230        240        250
SLAQSPLKLF PSQATHQLGE GESYSMPTAF PGLAPTSPHL EGSGILDTPV 
       260        270        280        290        300
TSTKARSGAP GGSEGRCAVC GDNASCQHYG VRTCEGCKGF FKRTVQKNAK 
       310        320        330        340        350
YICLANKDCP VDKRRRNRCQ FCRFQKCLAV GMVKEVVRTD SLKGRRGRLP 
       360        370        380        390        400
SKPKQPPDAS PANLLTSLVR AHLDSGPSTA KLDYSKFQEL VLPHFGKEDA 
       410        420        430        440        450
GDVQQFYDLL SGSLEVIRKW AEKIPGFAEL SPADQDLLLE SAFLELFILR 
       460        470        480        490        500
LAYRSKPGEG KLIFCSGLVL HRLQCARGFG DWIDSILAFS RSLHSLLVDV 
       510        520        530        540        550
PAFACLSALV LITDRHGLQE PRRVEELQNR IASCLKEHVA AVAGEPQPAS 
       560        570        580        590 
CLSRLLGKLP ELRTLCTQGL QRIFYLKLED LVPPPPIIDK IFMDTLPF

Length:598

Mass (Da):64,463

Last modified:August 1, 1991 - v1

Checksum:ⁱ41DAAEA7C25FDA22

GO

Isoform 2 (identifier: P22736-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MWLAKACWSIQSEM

« Hide

        10         20         30         40         50
MWLAKACWSI QSEMPCIQAQ YGTPAPSPGP RDHLASDPLT PEFIKPTMDL 
        60         70         80         90        100
ASPEAAPAAP TALPSFSTFM DGYTGEFDTF LYQLPGTVQP CSSASSSASS 
       110        120        130        140        150
TSSSSATSPA SASFKFEDFQ VYGCYPGPLS GPVDEALSSS GSDYYGSPCS 
       160        170        180        190        200
APSPSTPSFQ PPQLSPWDGS FGHFSPSQTY EGLRAWTEQL PKASGPPQPP 
       210        220        230        240        250
AFFSFSPPTG PSPSLAQSPL KLFPSQATHQ LGEGESYSMP TAFPGLAPTS 
       260        270        280        290        300
PHLEGSGILD TPVTSTKARS GAPGGSEGRC AVCGDNASCQ HYGVRTCEGC 
       310        320        330        340        350
KGFFKRTVQK NAKYICLANK DCPVDKRRRN RCQFCRFQKC LAVGMVKEVV 
       360        370        380        390        400
RTDSLKGRRG RLPSKPKQPP DASPANLLTS LVRAHLDSGP STAKLDYSKF 
       410        420        430        440        450
QELVLPHFGK EDAGDVQQFY DLLSGSLEVI RKWAEKIPGF AELSPADQDL 
       460        470        480        490        500
LLESAFLELF ILRLAYRSKP GEGKLIFCSG LVLHRLQCAR GFGDWIDSIL 
       510        520        530        540        550
AFSRSLHSLL VDVPAFACLS ALVLITDRHG LQEPRRVEEL QNRIASCLKE 
       560        570        580        590        600
HVAAVAGEPQ PASCLSRLLG KLPELRTLCT QGLQRIFYLK LEDLVPPPPI 
       610 
IDKIFMDTLP F

Note: No experimental confirmation available.

Show »

Length:611

Mass (Da):65,998

Checksum:ⁱ21F3BC282AE6BE8D

GO

Isoform 3 (identifier: P22736-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
293-325: RTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQ → VPRSPRWGLLLEMERGWPHPIGTCGLPLGSPPS
326-598: Missing.

« Hide

        10         20         30         40         50
MPCIQAQYGT PAPSPGPRDH LASDPLTPEF IKPTMDLASP EAAPAAPTAL 
        60         70         80         90        100
PSFSTFMDGY TGEFDTFLYQ LPGTVQPCSS ASSSASSTSS SSATSPASAS 
       110        120        130        140        150
FKFEDFQVYG CYPGPLSGPV DEALSSSGSD YYGSPCSAPS PSTPSFQPPQ 
       160        170        180        190        200
LSPWDGSFGH FSPSQTYEGL RAWTEQLPKA SGPPQPPAFF SFSPPTGPSP 
       210        220        230        240        250
SLAQSPLKLF PSQATHQLGE GESYSMPTAF PGLAPTSPHL EGSGILDTPV 
       260        270        280        290        300
TSTKARSGAP GGSEGRCAVC GDNASCQHYG VRTCEGCKGF FKVPRSPRWG 
       310        320 
LLLEMERGWP HPIGTCGLPL GSPPS

Show »

Length:325

Mass (Da):33,754

Checksum:ⁱBCF2490A32A09175

GO

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5GXF0	F5GXF0_HUMAN	Nuclear receptor subfamily 4 group ... Nuclear receptor subfamily 4 group A member 1	NR4A1	652	Annotation score:
H3BT85	H3BT85_HUMAN	Nuclear receptor subfamily 4 group ... Nuclear receptor subfamily 4 group A member 1	NR4A1	302	Annotation score:
H3BPN8	H3BPN8_HUMAN	Nuclear receptor subfamily 4 group ... Nuclear receptor subfamily 4 group A member 1	NR4A1	150	Annotation score:
F8VVX9	F8VVX9_HUMAN	Nuclear receptor subfamily 4 group ... Nuclear receptor subfamily 4 group A member 1	NR4A1	148	Annotation score:
H3BSB9	H3BSB9_HUMAN	Nuclear receptor subfamily 4 group ... Nuclear receptor subfamily 4 group A member 1	NR4A1	119	Annotation score:
H3BSM8	H3BSM8_HUMAN	Nuclear receptor subfamily 4 group ... Nuclear receptor subfamily 4 group A member 1	NR4A1	78	Annotation score:
H3BQG5	H3BQG5_HUMAN	Nuclear receptor subfamily 4 group ... Nuclear receptor subfamily 4 group A member 1	NR4A1	120	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	253	T → I (PubMed:1651101).Curated	1
Sequence conflictⁱ	262	G → P in AAA36763 (PubMed:2626032).Curated	1
Sequence conflictⁱ	360	S → F in CAG32985 (Ref. 8) Curated	1
Sequence conflictⁱ	370	R → L in AAA36763 (PubMed:2626032).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_061534	26	L → V. Corresponds to variant dbSNP:rs1882118Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_043086	1	M → MWLAKACWSIQSEM in isoform 2. 1 Publication	1
Alternative sequenceⁱVSP_047769	293 – 325	RTVQK…FCRFQ → VPRSPRWGLLLEMERGWPHP IGTCGLPLGSPPS in isoform 3. 2 PublicationsAdd BLAST	33
Alternative sequenceⁱVSP_047770	326 – 598	Missing in isoform 3. 2 PublicationsAdd BLAST	273

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D49728 mRNA Translation: BAA08565.1 L13740 mRNA Translation: AAA36763.1 D85245 mRNA Translation: BAA12746.1 AK297526 mRNA Translation: BAG59929.1 HQ692855 mRNA Translation: ADZ17366.1 AB307717 mRNA Translation: BAH02308.1 BT007144 mRNA Translation: AAP35808.1 AK314437 mRNA Translation: BAG37048.1 CR456704 mRNA Translation: CAG32985.1 AC025259 Genomic DNA No translation available. CH471111 Genomic DNA Translation: EAW58222.1 CH471111 Genomic DNA Translation: EAW58224.1 CH471111 Genomic DNA Translation: EAW58225.1 BC016147 mRNA Translation: AAH16147.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS55828.1 [P22736-2] CCDS8818.1 [P22736-1]
PIRⁱ	A37251
NCBI Reference Sequences More...RefSeqⁱ	NP_001189162.1, NM_001202233.1 [P22736-2] NP_002126.2, NM_002135.4 [P22736-1] NP_775180.1, NM_173157.2 [P22736-1] XP_005268881.1, XM_005268824.3 [P22736-1] XP_006719426.1, XM_006719363.1 [P22736-1] XP_006719427.1, XM_006719364.3 [P22736-1]
UniGeneⁱ	Hs.524430 Hs.670088

Genome annotation databases

Ensemblⁱ	ENST00000243050; ENSP00000243050; ENSG00000123358 [P22736-1] ENST00000360284; ENSP00000353427; ENSG00000123358 [P22736-2] ENST00000394824; ENSP00000378301; ENSG00000123358 [P22736-1] ENST00000394825; ENSP00000378302; ENSG00000123358 [P22736-1] ENST00000548232; ENSP00000449587; ENSG00000123358 [P22736-3] ENST00000550082; ENSP00000449539; ENSG00000123358 [P22736-2]
GeneIDⁱ	3164
KEGGⁱ	hsa:3164
UCSC genome browser More...UCSCⁱ	uc001rzs.4 human [P22736-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P22736	Isoform 2 of Nuclear receptor subfamily 4 group A member 1		HUMAN		611	UniRef100_P22736
Nuclear receptor subfamily 4 group A member 1 (Fragment)		HUMAN		302
Nuclear receptor subfamily 4, group A, member 1, isoform CRA_d		HUMAN		598
UPI0000EE64F5		HUMAN		670

Protein	Similar proteins		Species	Score	Length	Source
P22736	Isoform 2 of Nuclear receptor subfamily 4 group A member 1		HUMAN		611	UniRef90_P22736
Uncharacterized protein		RHIBE		670
Uncharacterized protein		RHIRO		670
Uncharacterized protein		MACFA		670
Uncharacterized protein		CERAT		670
+98
P22736-3	NR4A1 isoform 18		PANTR		325	UniRef90_P22736-3
Uncharacterized protein		AOTNA		317
Uncharacterized protein		Cebus capucinus imitator		316
Nuclear receptor subfamily 4 group A member 1		SAIBB		316
Uncharacterized protein		MACMU		309

Protein	Similar proteins		Species	Score	Length	Source
P22736	Isoform 2 of Nuclear receptor subfamily 4 group A member 1		HUMAN		611	UniRef50_P22736
Uncharacterized protein		CERAT		670
Uncharacterized protein		MACFA		670
Uncharacterized protein		RHIBE		670
Uncharacterized protein		RHIRO		670
+114
P22736-3	NR4A1 isoform 18		PANTR		325	UniRef50_P22736-3
Uncharacterized protein		AOTNA		317
Uncharacterized protein		Cebus capucinus imitator		316
Nuclear receptor subfamily 4 group A member 1		SAIBB		316
Uncharacterized protein		MACMU		309
+2

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D49728 mRNA Translation: BAA08565.1 L13740 mRNA Translation: AAA36763.1 D85245 mRNA Translation: BAA12746.1 AK297526 mRNA Translation: BAG59929.1 HQ692855 mRNA Translation: ADZ17366.1 AB307717 mRNA Translation: BAH02308.1 BT007144 mRNA Translation: AAP35808.1 AK314437 mRNA Translation: BAG37048.1 CR456704 mRNA Translation: CAG32985.1 AC025259 Genomic DNA No translation available. CH471111 Genomic DNA Translation: EAW58222.1 CH471111 Genomic DNA Translation: EAW58224.1 CH471111 Genomic DNA Translation: EAW58225.1 BC016147 mRNA Translation: AAH16147.1
CCDSⁱ	CCDS55828.1 [P22736-2] CCDS8818.1 [P22736-1]
PIRⁱ	A37251
RefSeqⁱ	NP_001189162.1, NM_001202233.1 [P22736-2] NP_002126.2, NM_002135.4 [P22736-1] NP_775180.1, NM_173157.2 [P22736-1] XP_005268881.1, XM_005268824.3 [P22736-1] XP_006719426.1, XM_006719363.1 [P22736-1] XP_006719427.1, XM_006719364.3 [P22736-1]
UniGeneⁱ	Hs.524430 Hs.670088

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2QW4	X-ray	2.80	A/B/C/D	347-598	[»]
	3V3E	X-ray	2.06	A/B	351-598	[»]
	3V3Q	X-ray	2.22	A/B	351-598	[»]
	4JGV	X-ray	3.01	A/B	351-598	[»]
	4KZI	X-ray	2.41	A/B	351-598	[»]
	4KZJ	X-ray	2.12	A/B	351-598	[»]
	4KZM	X-ray	2.30	A/B	351-598	[»]
	4RE8	X-ray	2.16	A/B	351-598	[»]
	4REE	X-ray	2.37	A/B	351-598	[»]
	4REF	X-ray	2.10	A/B	351-598	[»]
	4RZE	X-ray	2.49	A/B	351-598	[»]
	4RZF	X-ray	1.99	A/B	351-598	[»]
	4RZG	X-ray	2.70	A/B	351-598	[»]
	4WHF	X-ray	2.27	A/B	351-598	[»]
	4WHG	X-ray	2.18	A/B	351-598	[»]
ProteinModelPortalⁱ	P22736
SMRⁱ	P22736
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109407, 100 interactors
DIPⁱ	DIP-40392N
IntActⁱ	P22736, 107 interactors
MINTⁱ	P22736
STRINGⁱ	9606.ENSP00000353427

Chemistry databases

BindingDBⁱ	P22736
ChEMBLⁱ	CHEMBL1293229

Protein family/group databases

MoonDBⁱ	P22736 Predicted

MoonDBⁱ

P22736 Predicted

PTM databases

iPTMnetⁱ	P22736
PhosphoSitePlusⁱ	P22736

Polymorphism and mutation databases

BioMutaⁱ	NR4A1
DMDMⁱ	127819

Proteomic databases

EPDⁱ	P22736
PaxDbⁱ	P22736
PeptideAtlasⁱ	P22736
PRIDEⁱ	P22736
ProteomicsDBⁱ	54032 54033 [P22736-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3164
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000243050; ENSP00000243050; ENSG00000123358 [P22736-1] ENST00000360284; ENSP00000353427; ENSG00000123358 [P22736-2] ENST00000394824; ENSP00000378301; ENSG00000123358 [P22736-1] ENST00000394825; ENSP00000378302; ENSG00000123358 [P22736-1] ENST00000548232; ENSP00000449587; ENSG00000123358 [P22736-3] ENST00000550082; ENSP00000449539; ENSG00000123358 [P22736-2]
GeneIDⁱ	3164
KEGGⁱ	hsa:3164
UCSCⁱ	uc001rzs.4 human [P22736-1]

Organism-specific databases

CTDⁱ	3164
DisGeNETⁱ	3164
EuPathDBⁱ	HostDB:ENSG00000123358.19
GeneCardsⁱ	NR4A1
H-InvDBⁱ	HIX0171621
HGNCⁱ	HGNC:7980 NR4A1
HPAⁱ	HPA059742 HPA070142
MIMⁱ	139139 gene
neXtProtⁱ	NX_P22736
OpenTargetsⁱ	ENSG00000123358
PharmGKBⁱ	PA31761
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4217 Eukaryota ENOG410YWNC LUCA
GeneTreeⁱ	ENSGT00760000118887
HOGENOMⁱ	HOG000230925
HOVERGENⁱ	HBG052663
InParanoidⁱ	P22736
KOⁱ	K04465
PhylomeDBⁱ	P22736
TreeFamⁱ	TF315430

Enzyme and pathway databases

Reactomeⁱ	R-HSA-198693 AKT phosphorylates targets in the nucleus R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer
SignaLinkⁱ	P22736
SIGNORⁱ	P22736

Miscellaneous databases

ChiTaRSⁱ	NR4A1 human
EvolutionaryTraceⁱ	P22736
GeneWikiⁱ	Nerve_Growth_factor_IB
GenomeRNAiⁱ	3164
Protein Ontology More...PROⁱ	PR:P22736
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000123358 Expressed in 221 organ(s), highest expression level in right adrenal gland
CleanExⁱ	HS_NR4A1
ExpressionAtlasⁱ	P22736 baseline and differential
Genevisibleⁱ	P22736 HS

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR003071 Nuc_orp_HMR_rcpt IPR003070 Nuc_orph_rcpt IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR01285 HMRNUCRECPTR PR01284 NUCLEARECPTR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NR4A1_HUMAN
Accessionⁱ	P22736Primary (citable) accession number: P22736 Secondary accession number(s): B4DML7 , Q15627, Q53Y00, Q6IBU8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
	Last sequence update:	August 1, 1991
	Last modified:	October 10, 2018
	This is version 203 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P22736 (NR4A1_HUMAN)

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Nuclear receptor subfamily 4 group A member 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

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GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ