SLC2A5

Functionⁱ

Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:8333543). Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905). Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake (By similarity).By similarity2 Publications

Activity regulationⁱ

The uptake of 2-deoxyglucose is inhibited by cytochalasin B.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	32	FructoseBy similarity	1
Binding siteⁱ	167	FructoseBy similarity	1
Binding siteⁱ	288	FructoseBy similarity	1
Binding siteⁱ	387	FructoseBy similarity	1

GO - Molecular functionⁱ

fructose binding Source: UniProtKB
fructose transmembrane transporter activity
Source: UniProtKB
Inferred from direct assayⁱ
- 8333543
glucose transmembrane transporter activity
Source: ProtInc
Traceable author statementⁱ
- 1695905

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

carbohydrate metabolic process
Source: ProtInc
Traceable author statementⁱ
- 1634504
cellular response to fructose stimulus Source: UniProtKB
fructose import across plasma membrane
Source: UniProtKB
Inferred from direct assayⁱ
- 8333543
fructose transmembrane transport
Source: ProtInc
Traceable author statementⁱ
- 1634504
glucose transmembrane transport
Source: ProtInc
Traceable author statementⁱ
- 1695905
intestinal hexose absorption Source: Reactome
neutrophil degranulation Source: Reactome
regulation of systemic arterial blood pressure mediated by a chemical signal Source: UniProtKB
response to fructose Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Sugar transport, Transport

Biological process

Sugar transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6798695 Neutrophil degranulation R-HSA-8981373 Intestinal hexose absorption

Reactomeⁱ

R-HSA-6798695 Neutrophil degranulation
R-HSA-8981373 Intestinal hexose absorption

Protein family/group databases

TCDBⁱ	2.A.1.1.13 the major facilitator superfamily (mfs)

TCDBⁱ

2.A.1.1.13 the major facilitator superfamily (mfs)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Solute carrier family 2, facilitated glucose transporter member 5 Alternative name(s): Fructose transporter Glucose transporter type 5, small intestine Short name: GLUT-5
Gene namesⁱ	Name:SLC2A5 Synonyms:GLUT5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000142583.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11010 SLC2A5
MIMⁱ	138230 gene
neXtProtⁱ	NX_P22732

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 18	CytoplasmicBy similarityAdd BLAST	18
Transmembraneⁱ	19 – 39	Helical; Name=1By similarityAdd BLAST	21
Topological domainⁱ	40 – 68	ExtracellularBy similarityAdd BLAST	29
Transmembraneⁱ	69 – 91	Helical; Name=2By similarityAdd BLAST	23
Topological domainⁱ	92 – 98	CytoplasmicBy similarity	7
Transmembraneⁱ	99 – 119	Helical; Name=3By similarityAdd BLAST	21
Topological domainⁱ	120 – 126	ExtracellularBy similarity	7
Transmembraneⁱ	127 – 149	Helical; Name=4By similarityAdd BLAST	23
Topological domainⁱ	150 – 161	CytoplasmicBy similarityAdd BLAST	12
Transmembraneⁱ	162 – 182	Helical; Name=5By similarityAdd BLAST	21
Topological domainⁱ	183 – 192	ExtracellularBy similarity	10
Transmembraneⁱ	193 – 213	Helical; Name=6By similarityAdd BLAST	21
Topological domainⁱ	214 – 277	CytoplasmicBy similarityAdd BLAST	64
Transmembraneⁱ	278 – 298	Helical; Name=7By similarityAdd BLAST	21
Topological domainⁱ	299 – 313	ExtracellularBy similarityAdd BLAST	15
Transmembraneⁱ	314 – 334	Helical; Name=8By similarityAdd BLAST	21
Topological domainⁱ	335 – 342	CytoplasmicBy similarity	8
Transmembraneⁱ	343 – 363	Helical; Name=9By similarityAdd BLAST	21
Topological domainⁱ	364 – 371	ExtracellularBy similarity	8
Transmembraneⁱ	372 – 394	Helical; Name=10By similarityAdd BLAST	23
Topological domainⁱ	395 – 412	CytoplasmicBy similarityAdd BLAST	18
Transmembraneⁱ	413 – 433	Helical; Name=11By similarityAdd BLAST	21
Topological domainⁱ	434 – 439	ExtracellularBy similarity	6
Transmembraneⁱ	440 – 460	Helical; Name=12By similarityAdd BLAST	21
Topological domainⁱ	461 – 501	CytoplasmicBy similarityAdd BLAST	41

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6518
Open Targets More...OpenTargetsⁱ	ENSG00000142583
PharmGKBⁱ	PA35880

Chemistry databases

ChEMBLⁱ	CHEMBL5875
Drug and drug target database More...DrugBankⁱ	DB09502 Fludeoxyglucose F-18

Polymorphism and mutation databases

BioMutaⁱ	SLC2A5
DMDMⁱ	121764

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000050369	1 – 501	Solute carrier family 2, facilitated glucose transporter member 5Add BLAST		501

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources		1
Glycosylationⁱ	51	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Acetylation, Glycoprotein

Proteomic databases

PaxDbⁱ	P22732
PeptideAtlas More...PeptideAtlasⁱ	P22732
PRIDEⁱ	P22732
ProteomicsDBⁱ	54029 54030 [P22732-2]

PTM databases

iPTMnetⁱ	P22732
PhosphoSitePlusⁱ	P22732

Expressionⁱ

Tissue specificityⁱ

Detected in skeletal muscle, and in jejunum brush border membrane and basolateral membrane (at protein level) (PubMed:7619085). Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose tissue.2 Publications

Inductionⁱ

By forskolin in Caco-2 cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000142583 Expressed in 186 organ(s), highest expression level in jejunal mucosa
CleanExⁱ	HS_SLC2A5
ExpressionAtlasⁱ	P22732 baseline and differential
Genevisibleⁱ	P22732 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA005449

HPAⁱ

HPA005449

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	112409, 13 interactors
IntActⁱ	P22732, 15 interactors
STRINGⁱ	9606.ENSP00000366641

Chemistry databases

BindingDBⁱ

P22732

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P22732
SMRⁱ	P22732
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	296 – 298	Fructose bindingBy similarity		3
Regionⁱ	419 – 420	Fructose bindingBy similarity		2

Sequence similaritiesⁱ

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0569 Eukaryota COG0477 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119022
HOGENOMⁱ	HOG000202871
HOVERGENⁱ	HBG014816
InParanoidⁱ	P22732
KEGG Orthology (KO) More...KOⁱ	K08143
OMAⁱ	FTKMNKV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0A9K
PhylomeDBⁱ	P22732
TreeFamⁱ	TF313762

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06174 MFS, 1 hit
InterProⁱ	View protein in InterPro IPR002442 Fru_transpt_5 IPR020846 MFS_dom IPR005828 MFS_sugar_transport-like IPR036259 MFS_trans_sf IPR003663 Sugar/inositol_transpt IPR005829 Sugar_transporter_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00083 Sugar_tr, 1 hit
PRINTSⁱ	PR01194 GLUCTRSPORT5 PR00171 SUGRTRNSPORT
SUPFAMⁱ	SSF103473 SSF103473, 1 hit
TIGRFAMsⁱ	TIGR00879 SP, 1 hit
PROSITEⁱ	View protein in PROSITE PS50850 MFS, 1 hit PS00216 SUGAR_TRANSPORT_1, 1 hit PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P22732-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEQQDQSMKE GRLTLVLALA TLIAAFGSSF QYGYNVAAVN SPALLMQQFY 
        60         70         80         90        100
NETYYGRTGE FMEDFPLTLL WSVTVSMFPF GGFIGSLLVG PLVNKFGRKG 
       110        120        130        140        150
ALLFNNIFSI VPAILMGCSR VATSFELIII SRLLVGICAG VSSNVVPMYL 
       160        170        180        190        200
GELAPKNLRG ALGVVPQLFI TVGILVAQIF GLRNLLANVD GWPILLGLTG 
       210        220        230        240        250
VPAALQLLLL PFFPESPRYL LIQKKDEAAA KKALQTLRGW DSVDREVAEI 
       260        270        280        290        300
RQEDEAEKAA GFISVLKLFR MRSLRWQLLS IIVLMGGQQL SGVNAIYYYA 
       310        320        330        340        350
DQIYLSAGVP EEHVQYVTAG TGAVNVVMTF CAVFVVELLG RRLLLLLGFS 
       360        370        380        390        400
ICLIACCVLT AALALQDTVS WMPYISIVCV ISYVIGHALG PSPIPALLIT 
       410        420        430        440        450
EIFLQSSRPS AFMVGGSVHW LSNFTVGLIF PFIQEGLGPY SFIVFAVICL 
       460        470        480        490        500
LTTIYIFLIV PETKAKTFIE INQIFTKMNK VSEVYPEKEE LKELPPVTSE 

Q

Length:501

Mass (Da):54,974

Last modified:August 1, 1991 - v1

Checksum:ⁱ090B12F529C7B857

GO

Isoform 2 (identifier: P22732-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
192-501: WPILLGLTGV...KELPPVTSEQ → EFRTSREHPH...LGGPSCPEPT

« Hide

        10         20         30         40         50
MEQQDQSMKE GRLTLVLALA TLIAAFGSSF QYGYNVAAVN SPALLMQQFY 
        60         70         80         90        100
NETYYGRTGE FMEDFPLTLL WSVTVSMFPF GGFIGSLLVG PLVNKFGRKG 
       110        120        130        140        150
ALLFNNIFSI VPAILMGCSR VATSFELIII SRLLVGICAG VSSNVVPMYL 
       160        170        180        190        200
GELAPKNLRG ALGVVPQLFI TVGILVAQIF GLRNLLANVD GEFRTSREHP 
       210        220        230        240 
HPFTTTLGPL LVFQSHHHRT GLSADWSLLT GWMSLGGPSC PEPT

Show »

Length:244

Mass (Da):26,519

Checksum:ⁱ310B5F011D6CEA71

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7EJZ0	K7EJZ0_HUMAN	Solute carrier family 2, facilitate... Solute carrier family 2, facilitated glucose transporter member 5	SLC2A5	166	Annotation score:
K7EIT1	K7EIT1_HUMAN	Solute carrier family 2, facilitate... Solute carrier family 2, facilitated glucose transporter member 5	SLC2A5	190	Annotation score:
K7EQI3	K7EQI3_HUMAN	Solute carrier family 2, facilitate... Solute carrier family 2, facilitated glucose transporter member 5	SLC2A5	139	Annotation score:
K7EJR1	K7EJR1_HUMAN	Solute carrier family 2, facilitate... Solute carrier family 2, facilitated glucose transporter member 5	SLC2A5	81	Annotation score:

Sequence cautionⁱ

The sequence AAB60641 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	202	P → G in AAB60641 (PubMed:8037665).Curated		1

Mass spectrometryⁱ

Molecular mass is 54973.98 Da from positions 1 - 501. Determined by MALDI. 1 Publication

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_042031	192 – 501	WPILL…VTSEQ → EFRTSREHPHPFTTTLGPLL VFQSHHHRTGLSADWSLLTG WMSLGGPSCPEPT in isoform 2. 2 PublicationsAdd BLAST		310

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M55531 mRNA Translation: AAA52570.1 U11843 U11842 Genomic DNA Translation: AAB60641.1 Sequence problems. AK289849 mRNA Translation: BAF82538.1 AK290398 mRNA Translation: BAF83087.1 AL158048 Genomic DNA No translation available. CH471130 Genomic DNA Translation: EAW71610.1 BC001692 mRNA Translation: AAH01692.1 BC001820 mRNA Translation: AAH01820.1 BC035878 mRNA Translation: AAH35878.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44054.1 [P22732-2] CCDS99.1 [P22732-1]
PIRⁱ	A36629 G02864
NCBI Reference Sequences More...RefSeqⁱ	NP_001129057.1, NM_001135585.1 [P22732-2] NP_001315548.1, NM_001328619.1 [P22732-1] NP_003030.1, NM_003039.2 [P22732-1] XP_005263548.1, XM_005263491.3 XP_016857622.1, XM_017002133.1 XP_016857623.1, XM_017002134.1 XP_016857624.1, XM_017002135.1 XP_016857625.1, XM_017002136.1 XP_016857626.1, XM_017002137.1 XP_016857627.1, XM_017002138.1 XP_016857629.1, XM_017002140.1 XP_016857630.1, XM_017002141.1
UniGeneⁱ	Hs.530003

Genome annotation databases

Ensemblⁱ	ENST00000377414; ENSP00000366631; ENSG00000142583 [P22732-2] ENST00000377424; ENSP00000366641; ENSG00000142583 [P22732-1]
GeneIDⁱ	6518
KEGGⁱ	hsa:6518
UCSC genome browser More...UCSCⁱ	uc001apo.4 human [P22732-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P22732	Solute carrier family 2, facilitated glucose transporter member 5 (Fragment)		HUMAN		139	UniRef100_P22732
SLC2A5 isoform 3 (Fragment)		PANTR		139
SLC2A5 isoform 10 (Fragment)		PONAB		81
Solute carrier family 2, facilitated glucose transporter member 5 (Fragment)		HUMAN		166
Solute carrier family 2, facilitated glucose transporter member 5 (Fragment)		HUMAN		190
+5
P22732-2	Testicular tissue protein Li 81		HUMAN		244	UniRef100_A0A140VJK5
Solute carrier family 2 member 5		GORGO		224

Protein	Similar proteins		Species	Score	Length	Source
P22732	Solute carrier family 2, facilitated glucose transporter member 5		PONAB		501	UniRef90_P22732
Solute carrier family 2, facilitated glucose transporter member 5 (Fragment)		HUMAN		139
SLC2A5 isoform 3 (Fragment)		PANTR		139
Uncharacterized protein		MACMU		503
Uncharacterized protein		CERAT		502
+49
P22732-2	Uncharacterized protein		NOMLE		261	UniRef90_G1RDG8
SLC2A5 isoform 3 (Fragment)		PONAB		245
Uncharacterized protein		MANLE		245
Uncharacterized protein		CALJA		244
SLC2A5 isoform 10		PANTR		244
+5

Protein	Similar proteins		Species	Score	Length	Source
P22732	Solute carrier family 2, facilitated glucose transporter member 5	)	RAT		502	UniRef50_P43427
Solute carrier family 2, facilitated glucose transporter member 5		SHEEP		501
Solute carrier family 2, facilitated glucose transporter member 5	)	BOVIN		501
Solute carrier family 2, facilitated glucose transporter member 7	)	HUMAN		512
Solute carrier family 2, facilitated glucose transporter member 5		MOUSE		501
+482
P22732-2	Uncharacterized protein		NOMLE		261	UniRef50_G1RDG8
SLC2A5 isoform 3 (Fragment)		PONAB		245
Uncharacterized protein		MANLE		245
Testicular tissue protein Li 81		HUMAN		244
Solute carrier family 2 member 5		GORGO		224
+10

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M55531 mRNA Translation: AAA52570.1 U11843 U11842 Genomic DNA Translation: AAB60641.1 Sequence problems. AK289849 mRNA Translation: BAF82538.1 AK290398 mRNA Translation: BAF83087.1 AL158048 Genomic DNA No translation available. CH471130 Genomic DNA Translation: EAW71610.1 BC001692 mRNA Translation: AAH01692.1 BC001820 mRNA Translation: AAH01820.1 BC035878 mRNA Translation: AAH35878.1
CCDSⁱ	CCDS44054.1 [P22732-2] CCDS99.1 [P22732-1]
PIRⁱ	A36629 G02864
RefSeqⁱ	NP_001129057.1, NM_001135585.1 [P22732-2] NP_001315548.1, NM_001328619.1 [P22732-1] NP_003030.1, NM_003039.2 [P22732-1] XP_005263548.1, XM_005263491.3 XP_016857622.1, XM_017002133.1 XP_016857623.1, XM_017002134.1 XP_016857624.1, XM_017002135.1 XP_016857625.1, XM_017002136.1 XP_016857626.1, XM_017002137.1 XP_016857627.1, XM_017002138.1 XP_016857629.1, XM_017002140.1 XP_016857630.1, XM_017002141.1
UniGeneⁱ	Hs.530003

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1YG1	model	-	A	1-501	[»]
ProteinModelPortalⁱ	P22732
SMRⁱ	P22732
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112409, 13 interactors
IntActⁱ	P22732, 15 interactors
STRINGⁱ	9606.ENSP00000366641

Chemistry databases

BindingDBⁱ	P22732
ChEMBLⁱ	CHEMBL5875
DrugBankⁱ	DB09502 Fludeoxyglucose F-18

Protein family/group databases

TCDBⁱ	2.A.1.1.13 the major facilitator superfamily (mfs)

TCDBⁱ

2.A.1.1.13 the major facilitator superfamily (mfs)

PTM databases

iPTMnetⁱ	P22732
PhosphoSitePlusⁱ	P22732

Polymorphism and mutation databases

BioMutaⁱ	SLC2A5
DMDMⁱ	121764

Proteomic databases

PaxDbⁱ	P22732
PeptideAtlasⁱ	P22732
PRIDEⁱ	P22732
ProteomicsDBⁱ	54029 54030 [P22732-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6518
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000377414; ENSP00000366631; ENSG00000142583 [P22732-2] ENST00000377424; ENSP00000366641; ENSG00000142583 [P22732-1]
GeneIDⁱ	6518
KEGGⁱ	hsa:6518
UCSCⁱ	uc001apo.4 human [P22732-1]

Organism-specific databases

CTDⁱ	6518
DisGeNETⁱ	6518
EuPathDBⁱ	HostDB:ENSG00000142583.17
GeneCardsⁱ	SLC2A5
HGNCⁱ	HGNC:11010 SLC2A5
HPAⁱ	HPA005449
MIMⁱ	138230 gene
neXtProtⁱ	NX_P22732
OpenTargetsⁱ	ENSG00000142583
PharmGKBⁱ	PA35880
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0569 Eukaryota COG0477 LUCA
GeneTreeⁱ	ENSGT00760000119022
HOGENOMⁱ	HOG000202871
HOVERGENⁱ	HBG014816
InParanoidⁱ	P22732
KOⁱ	K08143
OMAⁱ	FTKMNKV
OrthoDBⁱ	EOG091G0A9K
PhylomeDBⁱ	P22732
TreeFamⁱ	TF313762

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6798695 Neutrophil degranulation R-HSA-8981373 Intestinal hexose absorption

Reactomeⁱ

R-HSA-6798695 Neutrophil degranulation
R-HSA-8981373 Intestinal hexose absorption

Miscellaneous databases

ChiTaRSⁱ	SLC2A5 human
GenomeRNAiⁱ	6518
Protein Ontology More...PROⁱ	PR:P22732
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000142583 Expressed in 186 organ(s), highest expression level in jejunal mucosa
CleanExⁱ	HS_SLC2A5
ExpressionAtlasⁱ	P22732 baseline and differential
Genevisibleⁱ	P22732 HS

Family and domain databases

CDDⁱ	cd06174 MFS, 1 hit
InterProⁱ	View protein in InterPro IPR002442 Fru_transpt_5 IPR020846 MFS_dom IPR005828 MFS_sugar_transport-like IPR036259 MFS_trans_sf IPR003663 Sugar/inositol_transpt IPR005829 Sugar_transporter_CS
Pfamⁱ	View protein in Pfam PF00083 Sugar_tr, 1 hit
PRINTSⁱ	PR01194 GLUCTRSPORT5 PR00171 SUGRTRNSPORT
SUPFAMⁱ	SSF103473 SSF103473, 1 hit
TIGRFAMsⁱ	TIGR00879 SP, 1 hit
PROSITEⁱ	View protein in PROSITE PS50850 MFS, 1 hit PS00216 SUGAR_TRANSPORT_1, 1 hit PS00217 SUGAR_TRANSPORT_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GTR5_HUMAN
Accessionⁱ	P22732Primary (citable) accession number: P22732 Secondary accession number(s): Q14770, Q5T977, Q8IVB3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
	Last sequence update:	August 1, 1991
	Last modified:	October 10, 2018
	This is version 186 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P22732 (GTR5_HUMAN)

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Solute carrier family 2, facilitated glucose transporter member 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Mass spectrometryⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ