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UniProtKB - P22732 (GTR5_HUMAN)

Entry version 202 (02 Dec 2020)
Sequence version 1 (01 Aug 1991)
Previous versions | rss
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Protein

Solute carrier family 2, facilitated glucose transporter member 5

Gene

SLC2A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:8333543, PubMed:16186102, PubMed:28083649). Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905). Essential for fructose uptake in the small intestine (By similarity). Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose (By similarity). Required for the development of high blood pressure in response to high dietary fructose intake (By similarity).By similarity4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

The uptake of 2-deoxyglucose is inhibited by cytochalasin B.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=30.1 mM for fructose1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei32FructoseBy similarity1
    Binding sitei167FructoseBy similarity1
    Binding sitei288FructoseBy similarity1
    Binding sitei387FructoseBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processSugar transport, Transport

    Enzyme and pathway databases

    Pathway Commons web resource for biological pathway data

    More...    PathwayCommonsi    		P22732

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-6798695, Neutrophil degranulation
    R-HSA-8981373, Intestinal hexose absorption

    Protein family/group databases

    Transport Classification Database

    More...    TCDBi    		2.A.1.1.13, the major facilitator superfamily (mfs)

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 5Curated
    Alternative name(s):
    Fructose transporterCurated
    Glucose transporter type 5, small intestine1 Publication
    Short name:
    GLUT-51 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SLC2A5Imported
    Synonyms:GLUT51 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

    Organism-specific databases

    Eukaryotic Pathogen and Host Database Resources

    More...    EuPathDBi    		HostDB:ENSG00000142583.17

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:11010, SLC2A5

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		138230, gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_P22732

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 18CytoplasmicBy similarityAdd BLAST18
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei19 – 39Helical; Name=1By similarityAdd BLAST21
    Topological domaini40 – 68ExtracellularBy similarityAdd BLAST29
    Transmembranei69 – 91Helical; Name=2By similarityAdd BLAST23
    Topological domaini92 – 98CytoplasmicBy similarity7
    Transmembranei99 – 119Helical; Name=3By similarityAdd BLAST21
    Topological domaini120 – 126ExtracellularBy similarity7
    Transmembranei127 – 149Helical; Name=4By similarityAdd BLAST23
    Topological domaini150 – 161CytoplasmicBy similarityAdd BLAST12
    Transmembranei162 – 182Helical; Name=5By similarityAdd BLAST21
    Topological domaini183 – 192ExtracellularBy similarity10
    Transmembranei193 – 213Helical; Name=6By similarityAdd BLAST21
    Topological domaini214 – 277CytoplasmicBy similarityAdd BLAST64
    Transmembranei278 – 298Helical; Name=7By similarityAdd BLAST21
    Topological domaini299 – 313ExtracellularBy similarityAdd BLAST15
    Transmembranei314 – 334Helical; Name=8By similarityAdd BLAST21
    Topological domaini335 – 342CytoplasmicBy similarity8
    Transmembranei343 – 363Helical; Name=9By similarityAdd BLAST21
    Topological domaini364 – 371ExtracellularBy similarity8
    Transmembranei372 – 394Helical; Name=10By similarityAdd BLAST23
    Topological domaini395 – 412CytoplasmicBy similarityAdd BLAST18
    Transmembranei413 – 433Helical; Name=11By similarityAdd BLAST21
    Topological domaini434 – 439ExtracellularBy similarity6
    Transmembranei440 – 460Helical; Name=12By similarityAdd BLAST21
    Topological domaini461 – 501CytoplasmicBy similarityAdd BLAST41

    Keywords - Cellular componenti

    Cell membrane, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		6518

    Open Targets

    More...    OpenTargetsi    		ENSG00000142583

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA35880

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		P22732, Tbio

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL5875

    Drug and drug target database

    More...    DrugBanki    		DB01914, D-glucose
    DB09502, Fludeoxyglucose (18F)
    DB09344, Invert sugar

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		SLC2A5

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		121764

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000503691 – 501Solute carrier family 2, facilitated glucose transporter member 5Add BLAST501

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1

    Keywords - PTMi

    Acetylation, Glycoprotein

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		P22732

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		P22732

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		P22732

    PeptideAtlas

    More...    PeptideAtlasi    		P22732

    PRoteomics IDEntifications database

    More...    PRIDEi    		P22732

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		54029 [P22732-1]
    54030 [P22732-2]

    PTM databases

    GlyGen: Computational and Informatics Resources for Glycoscience

    More...    GlyGeni    		P22732, 1 site

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		P22732

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		P22732

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Detected in skeletal muscle, and in jejunum brush border membrane and basolateral membrane (at protein level) (PubMed:7619085). Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose tissue.2 Publications

    <p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    By forskolin in Caco-2 cells.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000142583, Expressed in jejunal mucosa and 200 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		P22732, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		P22732, HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		ENSG00000142583, Tissue enhanced (bone marrow, intestine)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Hide details

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		112409, 24 interactors

    Protein interaction database and analysis system

    More...    IntActi    		P22732, 23 interactors

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000366641

    Chemistry databases

    BindingDB database of measured binding affinities

    More...    BindingDBi    		P22732

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		P22732, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		P22732

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    Protein Data Bank in Europe - Knowledge Base

    More...    PDBe-KBi    		Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni296 – 298Fructose bindingBy similarity3
    Regioni419 – 420Fructose bindingBy similarity2

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG0569, Eukaryota

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00940000156846

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_001265_30_5_1

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		P22732

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		GCIEFTG

    Database of Orthologous Groups

    More...    OrthoDBi    		326501at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		P22732

    TreeFam database of animal gene trees

    More...    TreeFami    		TF313762

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR002442, Fru_transpt_5
    IPR020846, MFS_dom
    IPR005828, MFS_sugar_transport-like
    IPR036259, MFS_trans_sf
    IPR003663, Sugar/inositol_transpt
    IPR005829, Sugar_transporter_CS

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF00083, Sugar_tr, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...    PRINTSi    		PR01194, GLUCTRSPORT5
    PR00171, SUGRTRNSPORT

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF103473, SSF103473, 1 hit

    TIGRFAMs; a protein family database

    More...    TIGRFAMsi    		TIGR00879, SP, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS50850, MFS, 1 hit
    PS00216, SUGAR_TRANSPORT_1, 1 hit
    PS00217, SUGAR_TRANSPORT_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: P22732-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MEQQDQSMKE GRLTLVLALA TLIAAFGSSF QYGYNVAAVN SPALLMQQFY 
            60         70         80         90        100
    NETYYGRTGE FMEDFPLTLL WSVTVSMFPF GGFIGSLLVG PLVNKFGRKG 
           110        120        130        140        150
    ALLFNNIFSI VPAILMGCSR VATSFELIII SRLLVGICAG VSSNVVPMYL 
           160        170        180        190        200
    GELAPKNLRG ALGVVPQLFI TVGILVAQIF GLRNLLANVD GWPILLGLTG 
           210        220        230        240        250
    VPAALQLLLL PFFPESPRYL LIQKKDEAAA KKALQTLRGW DSVDREVAEI 
           260        270        280        290        300
    RQEDEAEKAA GFISVLKLFR MRSLRWQLLS IIVLMGGQQL SGVNAIYYYA 
           310        320        330        340        350
    DQIYLSAGVP EEHVQYVTAG TGAVNVVMTF CAVFVVELLG RRLLLLLGFS 
           360        370        380        390        400
    ICLIACCVLT AALALQDTVS WMPYISIVCV ISYVIGHALG PSPIPALLIT 
           410        420        430        440        450
    EIFLQSSRPS AFMVGGSVHW LSNFTVGLIF PFIQEGLGPY SFIVFAVICL 
           460        470        480        490        500
    LTTIYIFLIV PETKAKTFIE INQIFTKMNK VSEVYPEKEE LKELPPVTSE 

    Q
    Length:501
    Mass (Da):54,974
    Last modified:August 1, 1991 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i090B12F529C7B857
    GO
    Isoform 2 (identifier: P22732-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         192-501: WPILLGLTGV...KELPPVTSEQ → EFRTSREHPH...LGGPSCPEPT

    Show »
    Length:244
    Mass (Da):26,519
    Checksum:i310B5F011D6CEA71
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    K7EJZ0K7EJZ0_HUMAN
    Fructose transporter
    SLC2A5
    		166Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    K7EIT1K7EIT1_HUMAN
    Fructose transporter
    SLC2A5
    		190Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    K7EQI3K7EQI3_HUMAN
    Solute carrier family 2, facilitate...
    SLC2A5
    		139Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    K7EJR1K7EJR1_HUMAN
    Solute carrier family 2, facilitate...
    SLC2A5
    		81Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAB60641 differs from that shown. Reason: Erroneous gene model prediction.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti202P → G in AAB60641 (PubMed:8037665).Curated1

    <p>This subsection of the 'Sequence' section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

    Molecular mass is 54973.98 Da. Determined by MALDI. 1 Publication

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_081827296I → V Polymorphism; does not affect fructose transport. 1 PublicationCorresponds to variant dbSNP:rs1451503051Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042031192 – 501WPILL…VTSEQ → EFRTSREHPHPFTTTLGPLL VFQSHHHRTGLSADWSLLTG WMSLGGPSCPEPT in isoform 2. 2 PublicationsAdd BLAST310

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		M55531 mRNA Translation: AAA52570.1
    U11843 U11842 Genomic DNA Translation: AAB60641.1 Sequence problems.
    AK289849 mRNA Translation: BAF82538.1
    AK290398 mRNA Translation: BAF83087.1
    AL158048 Genomic DNA No translation available.
    CH471130 Genomic DNA Translation: EAW71610.1
    BC001692 mRNA Translation: AAH01692.1
    BC001820 mRNA Translation: AAH01820.1
    BC035878 mRNA Translation: AAH35878.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS44054.1 [P22732-2]
    CCDS99.1 [P22732-1]

    Protein sequence database of the Protein Information Resource

    More...    PIRi    		A36629
    G02864

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001129057.1, NM_001135585.1 [P22732-2]
    NP_001315548.1, NM_001328619.1 [P22732-1]
    NP_003030.1, NM_003039.2 [P22732-1]
    XP_005263548.1, XM_005263491.3
    XP_016857622.1, XM_017002133.1
    XP_016857623.1, XM_017002134.1
    XP_016857624.1, XM_017002135.1
    XP_016857625.1, XM_017002136.1
    XP_016857626.1, XM_017002137.1
    XP_016857627.1, XM_017002138.1
    XP_016857629.1, XM_017002140.1
    XP_016857630.1, XM_017002141.1

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000377414; ENSP00000366631; ENSG00000142583 [P22732-2]
    ENST00000377424; ENSP00000366641; ENSG00000142583 [P22732-1]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		6518

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:6518

    UCSC genome browser

    More...    UCSCi    		uc001apo.4, human [P22732-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		M55531 mRNA Translation: AAA52570.1
    U11843 U11842 Genomic DNA Translation: AAB60641.1 Sequence problems.
    AK289849 mRNA Translation: BAF82538.1
    AK290398 mRNA Translation: BAF83087.1
    AL158048 Genomic DNA No translation available.
    CH471130 Genomic DNA Translation: EAW71610.1
    BC001692 mRNA Translation: AAH01692.1
    BC001820 mRNA Translation: AAH01820.1
    BC035878 mRNA Translation: AAH35878.1
    CCDSiCCDS44054.1 [P22732-2]
    CCDS99.1 [P22732-1]
    PIRiA36629
    G02864
    RefSeqiNP_001129057.1, NM_001135585.1 [P22732-2]
    NP_001315548.1, NM_001328619.1 [P22732-1]
    NP_003030.1, NM_003039.2 [P22732-1]
    XP_005263548.1, XM_005263491.3
    XP_016857622.1, XM_017002133.1
    XP_016857623.1, XM_017002134.1
    XP_016857624.1, XM_017002135.1
    XP_016857625.1, XM_017002136.1
    XP_016857626.1, XM_017002137.1
    XP_016857627.1, XM_017002138.1
    XP_016857629.1, XM_017002140.1
    XP_016857630.1, XM_017002141.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1YG1model-A1-501[»]
    SMRiP22732
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi112409, 24 interactors
    IntActiP22732, 23 interactors
    STRINGi9606.ENSP00000366641

    Chemistry databases

    BindingDBiP22732
    ChEMBLiCHEMBL5875
    DrugBankiDB01914, D-glucose
    DB09502, Fludeoxyglucose (18F)
    DB09344, Invert sugar

    Protein family/group databases

    TCDBi2.A.1.1.13, the major facilitator superfamily (mfs)

    PTM databases

    GlyGeniP22732, 1 site
    iPTMnetiP22732
    PhosphoSitePlusiP22732

    Polymorphism and mutation databases

    BioMutaiSLC2A5
    DMDMi121764

    Proteomic databases

    jPOSTiP22732
    MassIVEiP22732
    PaxDbiP22732
    PeptideAtlasiP22732
    PRIDEiP22732
    ProteomicsDBi54029 [P22732-1]
    54030 [P22732-2]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		1404, 399 antibodies

    The DNASU plasmid repository

    More...    DNASUi    		6518

    Genome annotation databases

    EnsembliENST00000377414; ENSP00000366631; ENSG00000142583 [P22732-2]
    ENST00000377424; ENSP00000366641; ENSG00000142583 [P22732-1]
    GeneIDi6518
    KEGGihsa:6518
    UCSCiuc001apo.4, human [P22732-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		6518
    DisGeNETi6518
    EuPathDBiHostDB:ENSG00000142583.17

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		SLC2A5
    HGNCiHGNC:11010, SLC2A5
    HPAiENSG00000142583, Tissue enhanced (bone marrow, intestine)
    MIMi138230, gene
    neXtProtiNX_P22732
    OpenTargetsiENSG00000142583
    PharmGKBiPA35880

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG0569, Eukaryota
    GeneTreeiENSGT00940000156846
    HOGENOMiCLU_001265_30_5_1
    InParanoidiP22732
    OMAiGCIEFTG
    OrthoDBi326501at2759
    PhylomeDBiP22732
    TreeFamiTF313762

    Enzyme and pathway databases

    PathwayCommonsiP22732
    ReactomeiR-HSA-6798695, Neutrophil degranulation
    R-HSA-8981373, Intestinal hexose absorption

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...    BioGRID-ORCSi    		6518, 6 hits in 839 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		SLC2A5, human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		6518
    PharosiP22732, Tbio

    Protein Ontology

    More...    PROi    		PR:P22732
    RNActiP22732, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000142583, Expressed in jejunal mucosa and 200 other tissues
    ExpressionAtlasiP22732, baseline and differential
    GenevisibleiP22732, HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR002442, Fru_transpt_5
    IPR020846, MFS_dom
    IPR005828, MFS_sugar_transport-like
    IPR036259, MFS_trans_sf
    IPR003663, Sugar/inositol_transpt
    IPR005829, Sugar_transporter_CS
    PfamiView protein in Pfam
    PF00083, Sugar_tr, 1 hit
    PRINTSiPR01194, GLUCTRSPORT5
    PR00171, SUGRTRNSPORT
    SUPFAMiSSF103473, SSF103473, 1 hit
    TIGRFAMsiTIGR00879, SP, 1 hit
    PROSITEiView protein in PROSITE
    PS50850, MFS, 1 hit
    PS00216, SUGAR_TRANSPORT_1, 1 hit
    PS00217, SUGAR_TRANSPORT_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGTR5_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22732
    Secondary accession number(s): Q14770, Q5T977, Q8IVB3
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: August 1, 1991
    Last modified: December 2, 2020
    This is version 202 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families
    5. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    6. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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