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UniProtKB - P22732 (GTR5_HUMAN)

Protein

Solute carrier family 2, facilitated glucose transporter member 5

Gene

SLC2A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:8333543). Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905). Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake (By similarity).By similarity2 Publications

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

The uptake of 2-deoxyglucose is inhibited by cytochalasin B.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei32FructoseBy similarity1
Binding sitei167FructoseBy similarity1
Binding sitei288FructoseBy similarity1
Binding sitei387FructoseBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • fructose binding Source: UniProtKB
  • fructose transmembrane transporter activity Source: UniProtKB
  • glucose transmembrane transporter activity Source: ProtInc
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6798695 Neutrophil degranulation
R-HSA-8981373 Intestinal hexose absorption

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.1.1.13 the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 5
Alternative name(s):
Fructose transporter
Glucose transporter type 5, small intestine
Short name:
GLUT-5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC2A5
Synonyms:GLUT5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000142583.17

Human Gene Nomenclature Database

More...HGNCi		HGNC:11010 SLC2A5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		138230 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P22732

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 18CytoplasmicBy similarityAdd BLAST18
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei19 – 39Helical; Name=1By similarityAdd BLAST21
Topological domaini40 – 68ExtracellularBy similarityAdd BLAST29
Transmembranei69 – 91Helical; Name=2By similarityAdd BLAST23
Topological domaini92 – 98CytoplasmicBy similarity7
Transmembranei99 – 119Helical; Name=3By similarityAdd BLAST21
Topological domaini120 – 126ExtracellularBy similarity7
Transmembranei127 – 149Helical; Name=4By similarityAdd BLAST23
Topological domaini150 – 161CytoplasmicBy similarityAdd BLAST12
Transmembranei162 – 182Helical; Name=5By similarityAdd BLAST21
Topological domaini183 – 192ExtracellularBy similarity10
Transmembranei193 – 213Helical; Name=6By similarityAdd BLAST21
Topological domaini214 – 277CytoplasmicBy similarityAdd BLAST64
Transmembranei278 – 298Helical; Name=7By similarityAdd BLAST21
Topological domaini299 – 313ExtracellularBy similarityAdd BLAST15
Transmembranei314 – 334Helical; Name=8By similarityAdd BLAST21
Topological domaini335 – 342CytoplasmicBy similarity8
Transmembranei343 – 363Helical; Name=9By similarityAdd BLAST21
Topological domaini364 – 371ExtracellularBy similarity8
Transmembranei372 – 394Helical; Name=10By similarityAdd BLAST23
Topological domaini395 – 412CytoplasmicBy similarityAdd BLAST18
Transmembranei413 – 433Helical; Name=11By similarityAdd BLAST21
Topological domaini434 – 439ExtracellularBy similarity6
Transmembranei440 – 460Helical; Name=12By similarityAdd BLAST21
Topological domaini461 – 501CytoplasmicBy similarityAdd BLAST41

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		6518

Open Targets

More...OpenTargetsi		ENSG00000142583

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35880

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5875

Drug and drug target database

More...DrugBanki		DB09502 Fludeoxyglucose F-18

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC2A5

Domain mapping of disease mutations (DMDM)

More...DMDMi		121764

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000503691 – 501Solute carrier family 2, facilitated glucose transporter member 5Add BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P22732

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P22732

PeptideAtlas

More...PeptideAtlasi		P22732

PRoteomics IDEntifications database

More...PRIDEi		P22732

ProteomicsDB human proteome resource

More...ProteomicsDBi		54029
54030 [P22732-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P22732

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P22732

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in skeletal muscle, and in jejunum brush border membrane and basolateral membrane (at protein level) (PubMed:7619085). Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose tissue.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By forskolin in Caco-2 cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000142583 Expressed in 186 organ(s), highest expression level in jejunal mucosa

CleanEx database of gene expression profiles

More...CleanExi		HS_SLC2A5

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P22732 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P22732 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA005449

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		112409, 13 interactors

Protein interaction database and analysis system

More...IntActi		P22732, 15 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000366641

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P22732

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YG1model-A1-501[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P22732

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P22732

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni296 – 298Fructose bindingBy similarity3
Regioni419 – 420Fructose bindingBy similarity2

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0569 Eukaryota
COG0477 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156846

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000202871

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG014816

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P22732

KEGG Orthology (KO)

More...KOi		K08143

Identification of Orthologs from Complete Genome Data

More...OMAi		FTKMNKV

Database of Orthologous Groups

More...OrthoDBi		326501at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P22732

TreeFam database of animal gene trees

More...TreeFami		TF313762

Family and domain databases

Conserved Domains Database

More...CDDi		cd06174 MFS, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002442 Fru_transpt_5
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00083 Sugar_tr, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01194 GLUCTRSPORT5
PR00171 SUGRTRNSPORT

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103473 SSF103473, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00879 SP, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P22732-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEQQDQSMKE GRLTLVLALA TLIAAFGSSF QYGYNVAAVN SPALLMQQFY 
        60         70         80         90        100
NETYYGRTGE FMEDFPLTLL WSVTVSMFPF GGFIGSLLVG PLVNKFGRKG 
       110        120        130        140        150
ALLFNNIFSI VPAILMGCSR VATSFELIII SRLLVGICAG VSSNVVPMYL 
       160        170        180        190        200
GELAPKNLRG ALGVVPQLFI TVGILVAQIF GLRNLLANVD GWPILLGLTG 
       210        220        230        240        250
VPAALQLLLL PFFPESPRYL LIQKKDEAAA KKALQTLRGW DSVDREVAEI 
       260        270        280        290        300
RQEDEAEKAA GFISVLKLFR MRSLRWQLLS IIVLMGGQQL SGVNAIYYYA 
       310        320        330        340        350
DQIYLSAGVP EEHVQYVTAG TGAVNVVMTF CAVFVVELLG RRLLLLLGFS 
       360        370        380        390        400
ICLIACCVLT AALALQDTVS WMPYISIVCV ISYVIGHALG PSPIPALLIT 
       410        420        430        440        450
EIFLQSSRPS AFMVGGSVHW LSNFTVGLIF PFIQEGLGPY SFIVFAVICL 
       460        470        480        490        500
LTTIYIFLIV PETKAKTFIE INQIFTKMNK VSEVYPEKEE LKELPPVTSE 

Q
Length:501
Mass (Da):54,974
Last modified:August 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i090B12F529C7B857
GO
Isoform 2 (identifier: P22732-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     192-501: WPILLGLTGV...KELPPVTSEQ → EFRTSREHPH...LGGPSCPEPT

Show »
Length:244
Mass (Da):26,519
Checksum:i310B5F011D6CEA71
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EJZ0K7EJZ0_HUMAN
Solute carrier family 2, facilitate...
SLC2A5
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EIT1K7EIT1_HUMAN
Solute carrier family 2, facilitate...
SLC2A5
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQI3K7EQI3_HUMAN
Solute carrier family 2, facilitate...
SLC2A5
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJR1K7EJR1_HUMAN
Solute carrier family 2, facilitate...
SLC2A5
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB60641 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti202P → G in AAB60641 (PubMed:8037665).Curated1

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 54973.98 Da from positions 1 - 501. Determined by MALDI. 1 Publication

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042031192 – 501WPILL…VTSEQ → EFRTSREHPHPFTTTLGPLL VFQSHHHRTGLSADWSLLTG WMSLGGPSCPEPT in isoform 2. 2 PublicationsAdd BLAST310

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M55531 mRNA Translation: AAA52570.1
U11843
, U05344, U11839, U11840, U11841, U11842 Genomic DNA Translation: AAB60641.1 Sequence problems.
AK289849 mRNA Translation: BAF82538.1
AK290398 mRNA Translation: BAF83087.1
AL158048 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71610.1
BC001692 mRNA Translation: AAH01692.1
BC001820 mRNA Translation: AAH01820.1
BC035878 mRNA Translation: AAH35878.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44054.1 [P22732-2]
CCDS99.1 [P22732-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A36629
G02864

NCBI Reference Sequences

More...RefSeqi		NP_001129057.1, NM_001135585.1 [P22732-2]
NP_001315548.1, NM_001328619.1 [P22732-1]
NP_003030.1, NM_003039.2 [P22732-1]
XP_005263548.1, XM_005263491.3
XP_016857622.1, XM_017002133.1
XP_016857623.1, XM_017002134.1
XP_016857624.1, XM_017002135.1
XP_016857625.1, XM_017002136.1
XP_016857626.1, XM_017002137.1
XP_016857627.1, XM_017002138.1
XP_016857629.1, XM_017002140.1
XP_016857630.1, XM_017002141.1

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.530003

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000377414; ENSP00000366631; ENSG00000142583 [P22732-2]
ENST00000377424; ENSP00000366641; ENSG00000142583 [P22732-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6518

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6518

UCSC genome browser

More...UCSCi		uc001apo.4 human [P22732-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55531 mRNA Translation: AAA52570.1
U11843
, U05344, U11839, U11840, U11841, U11842 Genomic DNA Translation: AAB60641.1 Sequence problems.
AK289849 mRNA Translation: BAF82538.1
AK290398 mRNA Translation: BAF83087.1
AL158048 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71610.1
BC001692 mRNA Translation: AAH01692.1
BC001820 mRNA Translation: AAH01820.1
BC035878 mRNA Translation: AAH35878.1
CCDSiCCDS44054.1 [P22732-2]
CCDS99.1 [P22732-1]
PIRiA36629
G02864
RefSeqiNP_001129057.1, NM_001135585.1 [P22732-2]
NP_001315548.1, NM_001328619.1 [P22732-1]
NP_003030.1, NM_003039.2 [P22732-1]
XP_005263548.1, XM_005263491.3
XP_016857622.1, XM_017002133.1
XP_016857623.1, XM_017002134.1
XP_016857624.1, XM_017002135.1
XP_016857625.1, XM_017002136.1
XP_016857626.1, XM_017002137.1
XP_016857627.1, XM_017002138.1
XP_016857629.1, XM_017002140.1
XP_016857630.1, XM_017002141.1
UniGeneiHs.530003

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YG1model-A1-501[»]
ProteinModelPortaliP22732
SMRiP22732
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112409, 13 interactors
IntActiP22732, 15 interactors
STRINGi9606.ENSP00000366641

Chemistry databases

BindingDBiP22732
ChEMBLiCHEMBL5875
DrugBankiDB09502 Fludeoxyglucose F-18

Protein family/group databases

TCDBi2.A.1.1.13 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiP22732
PhosphoSitePlusiP22732

Polymorphism and mutation databases

BioMutaiSLC2A5
DMDMi121764

Proteomic databases

jPOSTiP22732
PaxDbiP22732
PeptideAtlasiP22732
PRIDEiP22732
ProteomicsDBi54029
54030 [P22732-2]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		6518
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377414; ENSP00000366631; ENSG00000142583 [P22732-2]
ENST00000377424; ENSP00000366641; ENSG00000142583 [P22732-1]
GeneIDi6518
KEGGihsa:6518
UCSCiuc001apo.4 human [P22732-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6518
DisGeNETi6518
EuPathDBiHostDB:ENSG00000142583.17

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC2A5
HGNCiHGNC:11010 SLC2A5
HPAiHPA005449
MIMi138230 gene
neXtProtiNX_P22732
OpenTargetsiENSG00000142583
PharmGKBiPA35880

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0569 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00940000156846
HOGENOMiHOG000202871
HOVERGENiHBG014816
InParanoidiP22732
KOiK08143
OMAiFTKMNKV
OrthoDBi326501at2759
PhylomeDBiP22732
TreeFamiTF313762

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-8981373 Intestinal hexose absorption

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SLC2A5 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6518

Protein Ontology

More...PROi		PR:P22732

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000142583 Expressed in 186 organ(s), highest expression level in jejunal mucosa
CleanExiHS_SLC2A5
ExpressionAtlasiP22732 baseline and differential
GenevisibleiP22732 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002442 Fru_transpt_5
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR01194 GLUCTRSPORT5
PR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGTR5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22732
Secondary accession number(s): Q14770, Q5T977, Q8IVB3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: January 16, 2019
This is version 189 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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