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Protein

Solute carrier family 2, facilitated glucose transporter member 5

Gene

SLC2A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:8333543). Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905). Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake (By similarity).By similarity2 Publications

Enzyme regulationi

The uptake of 2-deoxyglucose is inhibited by cytochalasin B.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei32FructoseBy similarity1
Binding sitei167FructoseBy similarity1
Binding sitei288FructoseBy similarity1
Binding sitei387FructoseBy similarity1

GO - Molecular functioni

  • fructose binding Source: UniProtKB
  • fructose transmembrane transporter activity Source: UniProtKB
  • glucose transmembrane transporter activity Source: ProtInc

GO - Biological processi

  • carbohydrate metabolic process Source: ProtInc
  • cellular response to fructose stimulus Source: UniProtKB
  • fructose import across plasma membrane Source: UniProtKB
  • fructose transmembrane transport Source: ProtInc
  • glucose transmembrane transport Source: ProtInc
  • intestinal hexose absorption Source: Reactome
  • neutrophil degranulation Source: Reactome
  • regulation of systemic arterial blood pressure mediated by a chemical signal Source: UniProtKB
  • response to fructose Source: UniProtKB

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-8981373 Intestinal hexose absorption

Protein family/group databases

TCDBi2.A.1.1.13 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 5
Alternative name(s):
Fructose transporter
Glucose transporter type 5, small intestine
Short name:
GLUT-5
Gene namesi
Name:SLC2A5
Synonyms:GLUT5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000142583.17
HGNCiHGNC:11010 SLC2A5
MIMi138230 gene
neXtProtiNX_P22732

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18CytoplasmicBy similarityAdd BLAST18
Transmembranei19 – 39Helical; Name=1By similarityAdd BLAST21
Topological domaini40 – 68ExtracellularBy similarityAdd BLAST29
Transmembranei69 – 91Helical; Name=2By similarityAdd BLAST23
Topological domaini92 – 98CytoplasmicBy similarity7
Transmembranei99 – 119Helical; Name=3By similarityAdd BLAST21
Topological domaini120 – 126ExtracellularBy similarity7
Transmembranei127 – 149Helical; Name=4By similarityAdd BLAST23
Topological domaini150 – 161CytoplasmicBy similarityAdd BLAST12
Transmembranei162 – 182Helical; Name=5By similarityAdd BLAST21
Topological domaini183 – 192ExtracellularBy similarity10
Transmembranei193 – 213Helical; Name=6By similarityAdd BLAST21
Topological domaini214 – 277CytoplasmicBy similarityAdd BLAST64
Transmembranei278 – 298Helical; Name=7By similarityAdd BLAST21
Topological domaini299 – 313ExtracellularBy similarityAdd BLAST15
Transmembranei314 – 334Helical; Name=8By similarityAdd BLAST21
Topological domaini335 – 342CytoplasmicBy similarity8
Transmembranei343 – 363Helical; Name=9By similarityAdd BLAST21
Topological domaini364 – 371ExtracellularBy similarity8
Transmembranei372 – 394Helical; Name=10By similarityAdd BLAST23
Topological domaini395 – 412CytoplasmicBy similarityAdd BLAST18
Transmembranei413 – 433Helical; Name=11By similarityAdd BLAST21
Topological domaini434 – 439ExtracellularBy similarity6
Transmembranei440 – 460Helical; Name=12By similarityAdd BLAST21
Topological domaini461 – 501CytoplasmicBy similarityAdd BLAST41

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6518
OpenTargetsiENSG00000142583
PharmGKBiPA35880

Chemistry databases

ChEMBLiCHEMBL5875
DrugBankiDB09502 Fludeoxyglucose F-18

Polymorphism and mutation databases

BioMutaiSLC2A5
DMDMi121764

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503691 – 501Solute carrier family 2, facilitated glucose transporter member 5Add BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

PaxDbiP22732
PeptideAtlasiP22732
PRIDEiP22732
ProteomicsDBi54029
54030 [P22732-2]

PTM databases

iPTMnetiP22732
PhosphoSitePlusiP22732

Expressioni

Tissue specificityi

Detected in skeletal muscle, and in jejunum brush border membrane and basolateral membrane (at protein level) (PubMed:7619085). Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose tissue.2 Publications

Inductioni

By forskolin in Caco-2 cells.1 Publication

Gene expression databases

BgeeiENSG00000142583
CleanExiHS_SLC2A5
ExpressionAtlasiP22732 baseline and differential
GenevisibleiP22732 HS

Organism-specific databases

HPAiHPA005449

Interactioni

Protein-protein interaction databases

BioGridi112409, 13 interactors
IntActiP22732, 15 interactors
STRINGi9606.ENSP00000366641

Chemistry databases

BindingDBiP22732

Structurei

3D structure databases

ProteinModelPortaliP22732
SMRiP22732
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni296 – 298Fructose bindingBy similarity3
Regioni419 – 420Fructose bindingBy similarity2

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000119022
HOGENOMiHOG000202871
HOVERGENiHBG014816
InParanoidiP22732
KOiK08143
OMAiFTKMNKV
OrthoDBiEOG091G0A9K
PhylomeDBiP22732
TreeFamiTF313762

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002442 Fru_transpt_5
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR01194 GLUCTRSPORT5
PR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P22732-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEQQDQSMKE GRLTLVLALA TLIAAFGSSF QYGYNVAAVN SPALLMQQFY
60 70 80 90 100
NETYYGRTGE FMEDFPLTLL WSVTVSMFPF GGFIGSLLVG PLVNKFGRKG
110 120 130 140 150
ALLFNNIFSI VPAILMGCSR VATSFELIII SRLLVGICAG VSSNVVPMYL
160 170 180 190 200
GELAPKNLRG ALGVVPQLFI TVGILVAQIF GLRNLLANVD GWPILLGLTG
210 220 230 240 250
VPAALQLLLL PFFPESPRYL LIQKKDEAAA KKALQTLRGW DSVDREVAEI
260 270 280 290 300
RQEDEAEKAA GFISVLKLFR MRSLRWQLLS IIVLMGGQQL SGVNAIYYYA
310 320 330 340 350
DQIYLSAGVP EEHVQYVTAG TGAVNVVMTF CAVFVVELLG RRLLLLLGFS
360 370 380 390 400
ICLIACCVLT AALALQDTVS WMPYISIVCV ISYVIGHALG PSPIPALLIT
410 420 430 440 450
EIFLQSSRPS AFMVGGSVHW LSNFTVGLIF PFIQEGLGPY SFIVFAVICL
460 470 480 490 500
LTTIYIFLIV PETKAKTFIE INQIFTKMNK VSEVYPEKEE LKELPPVTSE

Q
Length:501
Mass (Da):54,974
Last modified:August 1, 1991 - v1
Checksum:i090B12F529C7B857
GO
Isoform 2 (identifier: P22732-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     192-501: WPILLGLTGV...KELPPVTSEQ → EFRTSREHPH...LGGPSCPEPT

Show »
Length:244
Mass (Da):26,519
Checksum:i310B5F011D6CEA71
GO

Sequence cautioni

The sequence AAB60641 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti202P → G in AAB60641 (PubMed:8037665).Curated1

Mass spectrometryi

Molecular mass is 54973.98 Da from positions 1 - 501. Determined by MALDI. 1 Publication

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042031192 – 501WPILL…VTSEQ → EFRTSREHPHPFTTTLGPLL VFQSHHHRTGLSADWSLLTG WMSLGGPSCPEPT in isoform 2. 2 PublicationsAdd BLAST310

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55531 mRNA Translation: AAA52570.1
U11843
, U05344, U11839, U11840, U11841, U11842 Genomic DNA Translation: AAB60641.1 Sequence problems.
AK289849 mRNA Translation: BAF82538.1
AK290398 mRNA Translation: BAF83087.1
AL158048 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71610.1
BC001692 mRNA Translation: AAH01692.1
BC001820 mRNA Translation: AAH01820.1
BC035878 mRNA Translation: AAH35878.1
CCDSiCCDS44054.1 [P22732-2]
CCDS99.1 [P22732-1]
PIRiA36629
G02864
RefSeqiNP_001129057.1, NM_001135585.1 [P22732-2]
NP_001315548.1, NM_001328619.1 [P22732-1]
NP_003030.1, NM_003039.2 [P22732-1]
XP_005263548.1, XM_005263491.3 [P22732-1]
XP_016857622.1, XM_017002133.1 [P22732-1]
XP_016857623.1, XM_017002134.1 [P22732-1]
XP_016857624.1, XM_017002135.1 [P22732-1]
XP_016857625.1, XM_017002136.1 [P22732-1]
XP_016857626.1, XM_017002137.1 [P22732-1]
XP_016857627.1, XM_017002138.1 [P22732-1]
XP_016857629.1, XM_017002140.1 [P22732-1]
XP_016857630.1, XM_017002141.1 [P22732-1]
UniGeneiHs.530003

Genome annotation databases

EnsembliENST00000377414; ENSP00000366631; ENSG00000142583 [P22732-2]
ENST00000377424; ENSP00000366641; ENSG00000142583 [P22732-1]
GeneIDi6518
KEGGihsa:6518
UCSCiuc001apo.4 human [P22732-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGTR5_HUMAN
AccessioniPrimary (citable) accession number: P22732
Secondary accession number(s): Q14770, Q5T977, Q8IVB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: July 18, 2018
This is version 184 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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