livM

Functionⁱ

Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane.

GO - Molecular functionⁱ

branched-chain amino acid transmembrane transporter activity
Source: EcoCyc
Inferred from direct assayⁱ
- 14702302
L-isoleucine transmembrane transporter activity
Source: EcoCyc
Inferred from direct assayⁱ
- 14702302
L-phenylalanine transmembrane transporter activity
Source: EcoCyc
Inferred from direct assayⁱ
- 14702302
L-valine transmembrane transporter activity
Source: EcoCyc
Inferred from direct assayⁱ
- 14702302

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

branched-chain amino acid transport
Source: EcoCyc
Inferred from direct assayⁱ
- 14702302
isoleucine transmembrane transport
Source: EcoCyc
Inferred from direct assayⁱ
- 14702302
L-valine transmembrane transport
Source: EcoCyc
Inferred from direct assayⁱ
- 14702302
phenylalanine transport
Source: EcoCyc
Inferred from direct assayⁱ
- 14702302

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Amino-acid transport, Transport

Biological process

Amino-acid transport, Transport

Enzyme and pathway databases

BioCycⁱ	EcoCyc:LIVM-MONOMER MetaCyc:LIVM-MONOMER

BioCycⁱ

EcoCyc:LIVM-MONOMER
MetaCyc:LIVM-MONOMER

Protein family/group databases

TCDBⁱ	3.A.1.4.1 the atp-binding cassette (abc) superfamily

TCDBⁱ

3.A.1.4.1 the atp-binding cassette (abc) superfamily

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: High-affinity branched-chain amino acid transport system permease protein LivM Alternative name(s): LIV-I protein M
Gene namesⁱ	Name:livM Ordered Locus Names:b3456, JW3421
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG10541 livM

EcoGeneⁱ

EG10541 livM

Subcellular locationⁱ

Cell inner membrane
1 Publication
Manual assertion based on experiment inⁱ
- Ref.5
  "Global topology analysis of the Escherichia coli inner membrane proteome."
  Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
  Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION.
; Multi-pass membrane protein
1 Publication
Manual assertion based on experiment inⁱ
- Ref.5
  "Global topology analysis of the Escherichia coli inner membrane proteome."
  Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
  Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION.

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	6 – 26	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	45 – 65	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	92 – 112	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	120 – 140	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	145 – 165	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	167 – 187	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	191 – 211	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	260 – 280	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	311 – 331	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	353 – 373	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	387 – 407	HelicalSequence analysisAdd BLAST	21

GO - Cellular componentⁱ

integral component of plasma membrane
Source: EcoCyc
Inferred from sequence modelⁱ
- 2195019
plasma membrane
Source: EcoCyc
Inferred from direct assayⁱ
- 15919996

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell inner membrane, Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000060062	1 – 425	High-affinity branched-chain amino acid transport system permease protein LivMAdd BLAST		425

Proteomic databases

PaxDbⁱ	P22729
PRIDEⁱ	P22729

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	4262489, 17 interactors
STRINGⁱ	316385.ECDH10B_3630

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P22729
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG4105CF8 Bacteria COG4177 LUCA
HOGENOMⁱ	HOG000202415
InParanoidⁱ	P22729
KEGG Orthology (KO) More...KOⁱ	K01998
PhylomeDBⁱ	P22729

Family and domain databases

InterProⁱ	View protein in InterPro IPR001851 ABC_transp_permease IPR021807 LivHM_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02653 BPD_transp_2, 1 hit PF11862 DUF3382, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P22729-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKPMHIAMAL LSAAMFFVLA GVFMGVQLEL DGTKLVVDTA SDVRWQWVFI 
        60         70         80         90        100
GTAVVFFFQL LRPAFQKGLK SVSGPKFILP AIDGSTVKQK LFLVALLVLA 
       110        120        130        140        150
VAWPFMVSRG TVDIATLTMI YIILGLGLNV VVGLSGLLVL GYGGFYAIGA 
       160        170        180        190        200
YTFALLNHYY GLGFWTCLPI AGLMAAAAGF LLGFPVLRLR GDYLAIVTLG 
       210        220        230        240        250
FGEIVRILLL NNTEITGGPN GISQIPKPTL FGLEFSRTAR EGGWDTFSNF 
       260        270        280        290        300
FGLKYDPSDR VIFLYLVALL LVVLSLFVIN RLLRMPLGRA WEALREDEIA 
       310        320        330        340        350
CRSLGLSPRR IKLTAFTISA AFAGFAGTLF AARQGFVSPE SFTFAESAFV 
       360        370        380        390        400
LAIVVLGGMG SQFAVILAAI LLVVSRELMR DFNEYSMLML GGLMVLMMIW 
       410        420 
RPQGLLPMTR PQLKLKNGAA KGEQA

Length:425

Mass (Da):46,269

Last modified:October 1, 1994 - v2

Checksum:ⁱF9658D0E5FCE987F

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	150 – 178	AYTFA…MAAAA → LHFCAAQSLLRLGLLDLPAD CWINGSGG in AAA83885 (PubMed:2195019).CuratedAdd BLAST	29
Sequence conflictⁱ	295	R → G in AAA83885 (PubMed:2195019).Curated	1
Sequence conflictⁱ	411	P → R in AAA83885 (PubMed:2195019).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J05516 Genomic DNA Translation: AAA83885.1 U00039 Genomic DNA Translation: AAB18431.1 U00096 Genomic DNA Translation: AAC76481.1 AP009048 Genomic DNA Translation: BAE77837.1
PIRⁱ	S47675
NCBI Reference Sequences More...RefSeqⁱ	NP_417913.1, NC_000913.3 WP_000803813.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC76481; AAC76481; b3456 BAE77837; BAE77837; BAE77837
GeneIDⁱ	947966
KEGGⁱ	ecj:JW3421 eco:b3456
PATRICⁱ	fig\|1411691.4.peg.3270

Protein	Similar proteins		Species	Score	Length	Source
P22729	Branched-chain amino acid ABC transporter permease		Shigella sp.		425	UniRef100_P22729
Branched-chain amino acid ABC transporter permease		ECOLX		425
Branched-chain amino acid transport system / permease component family protein		Escherichia coli 1-110-08_S3_C1		425
Branched-chain amino acid transport system / permease component family protein		Escherichia coli 2-210-07_S3_C3		425
Branched-chain amino acid transport system / permease component family protein		Escherichia coli DEC6A		425
+12

Protein	Similar proteins		Species	Score	Length	Source
P22729	High-affinity branched-chain amino acid transport system permease protein LivM		SALTY		425	UniRef90_P22729
Branched-chain amino acid ABC transporter permease		Shigella sp.		425
Branched-chain amino acid ABC transporter permease		ECOLX		425
Branched-chain amino acid transport system / permease component family protein		Escherichia coli 1-110-08_S3_C1		425
Branched-chain amino acid transport system / permease component family protein		Escherichia coli 2-210-07_S3_C3		425
+1405

Protein	Similar proteins		Species	Score	Length	Source
P22729	High-affinity branched-chain amino acid transport system permease protein LivM		SALTY		425	UniRef50_P22729
High-affinity branched-chain amino acid transport system permease protein BraE		PSEAE		417
Branched-chain amino acid ABC transporter permease		Shigella sp.		425
Branched-chain amino acid ABC transporter permease		ECOLX		425
Branched-chain amino acid transport system / permease component family protein		Escherichia coli 1-110-08_S3_C1		425
+3301

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J05516 Genomic DNA Translation: AAA83885.1 U00039 Genomic DNA Translation: AAB18431.1 U00096 Genomic DNA Translation: AAC76481.1 AP009048 Genomic DNA Translation: BAE77837.1
PIRⁱ	S47675
RefSeqⁱ	NP_417913.1, NC_000913.3 WP_000803813.1, NZ_LN832404.1

3D structure databases

ProteinModelPortalⁱ	P22729
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4262489, 17 interactors
STRINGⁱ	316385.ECDH10B_3630

Protein family/group databases

TCDBⁱ	3.A.1.4.1 the atp-binding cassette (abc) superfamily

TCDBⁱ

3.A.1.4.1 the atp-binding cassette (abc) superfamily

Proteomic databases

PaxDbⁱ	P22729
PRIDEⁱ	P22729

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC76481; AAC76481; b3456 BAE77837; BAE77837; BAE77837
GeneIDⁱ	947966
KEGGⁱ	ecj:JW3421 eco:b3456
PATRICⁱ	fig\|1411691.4.peg.3270

Organism-specific databases

EchoBASEⁱ	EB0536
EcoGeneⁱ	EG10541 livM

Phylogenomic databases

eggNOGⁱ	ENOG4105CF8 Bacteria COG4177 LUCA
HOGENOMⁱ	HOG000202415
InParanoidⁱ	P22729
KOⁱ	K01998
PhylomeDBⁱ	P22729

Enzyme and pathway databases

BioCycⁱ	EcoCyc:LIVM-MONOMER MetaCyc:LIVM-MONOMER

BioCycⁱ

EcoCyc:LIVM-MONOMER
MetaCyc:LIVM-MONOMER

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P22729

PROⁱ

PR:P22729

Family and domain databases

InterProⁱ	View protein in InterPro IPR001851 ABC_transp_permease IPR021807 LivHM_N
Pfamⁱ	View protein in Pfam PF02653 BPD_transp_2, 1 hit PF11862 DUF3382, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LIVM_ECOLI
Accessionⁱ	P22729Primary (citable) accession number: P22729 Secondary accession number(s): Q2M7B9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
	Last sequence update:	October 1, 1994
	Last modified:	November 7, 2018
	This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P22729 (LIVM_ECOLI)

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High-affinity branched-chain amino acid transport system permease protein LivM

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ