UniProtKB - P22729 (LIVM_ECOLI)
Protein
High-affinity branched-chain amino acid transport system permease protein LivM
Gene
livM
Organism
Escherichia coli (strain K12)
Status
Functioni
Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane.
GO - Molecular functioni
- branched-chain amino acid transmembrane transporter activity Source: EcoCyc
- L-isoleucine transmembrane transporter activity Source: EcoCyc
- L-phenylalanine transmembrane transporter activity Source: EcoCyc
- L-valine transmembrane transporter activity Source: EcoCyc
GO - Biological processi
- branched-chain amino acid transport Source: EcoCyc
- isoleucine transmembrane transport Source: EcoCyc
- L-valine transmembrane transport Source: EcoCyc
- phenylalanine transport Source: EcoCyc
Keywordsi
Biological process | Amino-acid transport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:LIVM-MONOMER MetaCyc:LIVM-MONOMER |
Protein family/group databases
TCDBi | 3.A.1.4.1, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: High-affinity branched-chain amino acid transport system permease protein LivMAlternative name(s): LIV-I protein M |
Gene namesi | Name:livM Ordered Locus Names:b3456, JW3421 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Cell inner membrane 1 Publication; Multi-pass membrane protein 1 Publication
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 6 – 26 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 45 – 65 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 92 – 112 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 120 – 140 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 145 – 165 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 167 – 187 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 191 – 211 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 260 – 280 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 311 – 331 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 353 – 373 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 387 – 407 | HelicalSequence analysisAdd BLAST | 21 |
GO - Cellular componenti
- integral component of plasma membrane Source: EcoCyc
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000060062 | 1 – 425 | High-affinity branched-chain amino acid transport system permease protein LivMAdd BLAST | 425 |
Proteomic databases
PaxDbi | P22729 |
PRIDEi | P22729 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4262489, 17 interactors |
ComplexPortali | CPX-4316, Branched chain amino acid ABC transporter complex CPX-4317, Branched chain amino acid, leucine-specific ABC transporter complex |
STRINGi | 511145.b3456 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG4177, Bacteria |
HOGENOMi | CLU_031365_1_1_6 |
InParanoidi | P22729 |
PhylomeDBi | P22729 |
Family and domain databases
CDDi | cd06581, TM_PBP1_LivM_like, 1 hit |
InterProi | View protein in InterPro IPR001851, ABC_transp_permease IPR021807, LivHM_N IPR043428, LivM-like |
PANTHERi | PTHR30482, PTHR30482, 1 hit |
Pfami | View protein in Pfam PF02653, BPD_transp_2, 1 hit PF11862, DUF3382, 1 hit |
i Sequence
Sequence statusi: Complete.
P22729-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKPMHIAMAL LSAAMFFVLA GVFMGVQLEL DGTKLVVDTA SDVRWQWVFI
60 70 80 90 100
GTAVVFFFQL LRPAFQKGLK SVSGPKFILP AIDGSTVKQK LFLVALLVLA
110 120 130 140 150
VAWPFMVSRG TVDIATLTMI YIILGLGLNV VVGLSGLLVL GYGGFYAIGA
160 170 180 190 200
YTFALLNHYY GLGFWTCLPI AGLMAAAAGF LLGFPVLRLR GDYLAIVTLG
210 220 230 240 250
FGEIVRILLL NNTEITGGPN GISQIPKPTL FGLEFSRTAR EGGWDTFSNF
260 270 280 290 300
FGLKYDPSDR VIFLYLVALL LVVLSLFVIN RLLRMPLGRA WEALREDEIA
310 320 330 340 350
CRSLGLSPRR IKLTAFTISA AFAGFAGTLF AARQGFVSPE SFTFAESAFV
360 370 380 390 400
LAIVVLGGMG SQFAVILAAI LLVVSRELMR DFNEYSMLML GGLMVLMMIW
410 420
RPQGLLPMTR PQLKLKNGAA KGEQA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 150 – 178 | AYTFA…MAAAA → LHFCAAQSLLRLGLLDLPAD CWINGSGG in AAA83885 (PubMed:2195019).CuratedAdd BLAST | 29 | |
Sequence conflicti | 295 | R → G in AAA83885 (PubMed:2195019).Curated | 1 | |
Sequence conflicti | 411 | P → R in AAA83885 (PubMed:2195019).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05516 Genomic DNA Translation: AAA83885.1 U00039 Genomic DNA Translation: AAB18431.1 U00096 Genomic DNA Translation: AAC76481.1 AP009048 Genomic DNA Translation: BAE77837.1 |
PIRi | S47675 |
RefSeqi | NP_417913.1, NC_000913.3 WP_000803813.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC76481; AAC76481; b3456 BAE77837; BAE77837; BAE77837 |
GeneIDi | 947966 |
KEGGi | ecj:JW3421 eco:b3456 |
PATRICi | fig|1411691.4.peg.3270 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05516 Genomic DNA Translation: AAA83885.1 U00039 Genomic DNA Translation: AAB18431.1 U00096 Genomic DNA Translation: AAC76481.1 AP009048 Genomic DNA Translation: BAE77837.1 |
PIRi | S47675 |
RefSeqi | NP_417913.1, NC_000913.3 WP_000803813.1, NZ_LN832404.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4262489, 17 interactors |
ComplexPortali | CPX-4316, Branched chain amino acid ABC transporter complex CPX-4317, Branched chain amino acid, leucine-specific ABC transporter complex |
STRINGi | 511145.b3456 |
Protein family/group databases
TCDBi | 3.A.1.4.1, the atp-binding cassette (abc) superfamily |
Proteomic databases
PaxDbi | P22729 |
PRIDEi | P22729 |
Genome annotation databases
EnsemblBacteriai | AAC76481; AAC76481; b3456 BAE77837; BAE77837; BAE77837 |
GeneIDi | 947966 |
KEGGi | ecj:JW3421 eco:b3456 |
PATRICi | fig|1411691.4.peg.3270 |
Organism-specific databases
EchoBASEi | EB0536 |
Phylogenomic databases
eggNOGi | COG4177, Bacteria |
HOGENOMi | CLU_031365_1_1_6 |
InParanoidi | P22729 |
PhylomeDBi | P22729 |
Enzyme and pathway databases
BioCyci | EcoCyc:LIVM-MONOMER MetaCyc:LIVM-MONOMER |
Miscellaneous databases
PROi | PR:P22729 |
Family and domain databases
CDDi | cd06581, TM_PBP1_LivM_like, 1 hit |
InterProi | View protein in InterPro IPR001851, ABC_transp_permease IPR021807, LivHM_N IPR043428, LivM-like |
PANTHERi | PTHR30482, PTHR30482, 1 hit |
Pfami | View protein in Pfam PF02653, BPD_transp_2, 1 hit PF11862, DUF3382, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LIVM_ECOLI | |
Accessioni | P22729Primary (citable) accession number: P22729 Secondary accession number(s): Q2M7B9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1991 |
Last sequence update: | October 1, 1994 | |
Last modified: | December 2, 2020 | |
This is version 144 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families