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UniProtKB - P22729 (LIVM_ECOLI)

Entry version 143 (07 Oct 2020)
Sequence version 2 (01 Oct 1994)
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Protein

High-affinity branched-chain amino acid transport system permease protein LivM

Gene

livM

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:LIVM-MONOMER
MetaCyc:LIVM-MONOMER

Protein family/group databases

Transport Classification Database

More...TCDBi		3.A.1.4.1, the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
High-affinity branched-chain amino acid transport system permease protein LivM
Alternative name(s):
LIV-I protein M
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:livM
Ordered Locus Names:b3456, JW3421
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Transmembranei311 – 331HelicalSequence analysisAdd BLAST21
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21
Transmembranei387 – 407HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000600621 – 425High-affinity branched-chain amino acid transport system permease protein LivMAdd BLAST425

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P22729

PRoteomics IDEntifications database

More...PRIDEi		P22729

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4262489, 17 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-4316, Branched chain amino acid ABC transporter complex
CPX-4317, Branched chain amino acid, leucine-specific ABC transporter complex

STRING: functional protein association networks

More...STRINGi		511145.b3456

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG4177, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_031365_1_1_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P22729

KEGG Orthology (KO)

More...KOi		K01998

Database for complete collections of gene phylogenies

More...PhylomeDBi		P22729

Family and domain databases

Conserved Domains Database

More...CDDi		cd06581, TM_PBP1_LivM_like, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001851, ABC_transp_permease
IPR021807, LivHM_N
IPR043428, LivM-like

The PANTHER Classification System

More...PANTHERi		PTHR30482, PTHR30482, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02653, BPD_transp_2, 1 hit
PF11862, DUF3382, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P22729-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPMHIAMAL LSAAMFFVLA GVFMGVQLEL DGTKLVVDTA SDVRWQWVFI 
        60         70         80         90        100
GTAVVFFFQL LRPAFQKGLK SVSGPKFILP AIDGSTVKQK LFLVALLVLA 
       110        120        130        140        150
VAWPFMVSRG TVDIATLTMI YIILGLGLNV VVGLSGLLVL GYGGFYAIGA 
       160        170        180        190        200
YTFALLNHYY GLGFWTCLPI AGLMAAAAGF LLGFPVLRLR GDYLAIVTLG 
       210        220        230        240        250
FGEIVRILLL NNTEITGGPN GISQIPKPTL FGLEFSRTAR EGGWDTFSNF 
       260        270        280        290        300
FGLKYDPSDR VIFLYLVALL LVVLSLFVIN RLLRMPLGRA WEALREDEIA 
       310        320        330        340        350
CRSLGLSPRR IKLTAFTISA AFAGFAGTLF AARQGFVSPE SFTFAESAFV 
       360        370        380        390        400
LAIVVLGGMG SQFAVILAAI LLVVSRELMR DFNEYSMLML GGLMVLMMIW 
       410        420 
RPQGLLPMTR PQLKLKNGAA KGEQA
Length:425
Mass (Da):46,269
Last modified:October 1, 1994 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF9658D0E5FCE987F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti150 – 178AYTFA…MAAAA → LHFCAAQSLLRLGLLDLPAD CWINGSGG in AAA83885 (PubMed:2195019).CuratedAdd BLAST29
Sequence conflicti295R → G in AAA83885 (PubMed:2195019).Curated1
Sequence conflicti411P → R in AAA83885 (PubMed:2195019).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J05516 Genomic DNA Translation: AAA83885.1
U00039 Genomic DNA Translation: AAB18431.1
U00096 Genomic DNA Translation: AAC76481.1
AP009048 Genomic DNA Translation: BAE77837.1

Protein sequence database of the Protein Information Resource

More...PIRi		S47675

NCBI Reference Sequences

More...RefSeqi		NP_417913.1, NC_000913.3
WP_000803813.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC76481; AAC76481; b3456
BAE77837; BAE77837; BAE77837

Database of genes from NCBI RefSeq genomes

More...GeneIDi		947966

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW3421
eco:b3456

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.3270

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05516 Genomic DNA Translation: AAA83885.1
U00039 Genomic DNA Translation: AAB18431.1
U00096 Genomic DNA Translation: AAC76481.1
AP009048 Genomic DNA Translation: BAE77837.1
PIRiS47675
RefSeqiNP_417913.1, NC_000913.3
WP_000803813.1, NZ_LN832404.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4262489, 17 interactors
ComplexPortaliCPX-4316, Branched chain amino acid ABC transporter complex
CPX-4317, Branched chain amino acid, leucine-specific ABC transporter complex
STRINGi511145.b3456

Protein family/group databases

TCDBi3.A.1.4.1, the atp-binding cassette (abc) superfamily

Proteomic databases

PaxDbiP22729
PRIDEiP22729

Genome annotation databases

EnsemblBacteriaiAAC76481; AAC76481; b3456
BAE77837; BAE77837; BAE77837
GeneIDi947966
KEGGiecj:JW3421
eco:b3456
PATRICifig|1411691.4.peg.3270

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB0536

Phylogenomic databases

eggNOGiCOG4177, Bacteria
HOGENOMiCLU_031365_1_1_6
InParanoidiP22729
KOiK01998
PhylomeDBiP22729

Enzyme and pathway databases

BioCyciEcoCyc:LIVM-MONOMER
MetaCyc:LIVM-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P22729

Family and domain databases

CDDicd06581, TM_PBP1_LivM_like, 1 hit
InterProiView protein in InterPro
IPR001851, ABC_transp_permease
IPR021807, LivHM_N
IPR043428, LivM-like
PANTHERiPTHR30482, PTHR30482, 1 hit
PfamiView protein in Pfam
PF02653, BPD_transp_2, 1 hit
PF11862, DUF3382, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLIVM_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22729
Secondary accession number(s): Q2M7B9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: October 1, 1994
Last modified: October 7, 2020
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families
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