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Protein

Protein Wnt-6

Gene

Wnt6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

GO - Molecular functioni

  • frizzled binding Source: GO_Central
  • signaling receptor binding Source: MGI

GO - Biological processi

  • animal organ morphogenesis Source: MGI
  • axis specification Source: MGI
  • branching involved in ureteric bud morphogenesis Source: MGI
  • cell-cell signaling Source: MGI
  • cell fate commitment Source: GO_Central
  • epithelial-mesenchymal cell signaling Source: MGI
  • nephron tubule development Source: MGI
  • nephron tubule formation Source: MGI
  • neuron differentiation Source: GO_Central
  • odontogenesis of dentin-containing tooth Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of tooth mineralization Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • signal transduction Source: MGI
  • Wnt signaling pathway Source: MGI

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-3238698 WNT ligand biogenesis and trafficking

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-6
Gene namesi
Name:Wnt6
Synonyms:Wnt-6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:98960 Wnt6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000004144124 – 364Protein Wnt-6Add BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi75 ↔ 86By similarity
Glycosylationi85N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi123 ↔ 131By similarity
Disulfide bondi133 ↔ 171By similarity
Disulfide bondi221 ↔ 235By similarity
Disulfide bondi223 ↔ 230By similarity
Lipidationi227O-palmitoleoyl serine; by PORCNBy similarity1
Disulfide bondi309 ↔ 324By similarity
Glycosylationi310N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi339 ↔ 354By similarity
Disulfide bondi341 ↔ 351By similarity
Disulfide bondi346 ↔ 347By similarity

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

MaxQBiP22727
PaxDbiP22727
PRIDEiP22727

PTM databases

PhosphoSitePlusiP22727

Expressioni

Tissue specificityi

Detected in ileum, colon and stomach (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000033227
CleanExiMM_WNT6
GenevisibleiP22727 MM

Interactioni

Subunit structurei

Interacts with PORCN.1 Publication

GO - Molecular functioni

  • frizzled binding Source: GO_Central
  • signaling receptor binding Source: MGI

Protein-protein interaction databases

BioGridi204579, 1 interactor
IntActiP22727, 1 interactor
STRINGi10090.ENSMUSP00000006716

Structurei

3D structure databases

ProteinModelPortaliP22727
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
GeneTreeiENSGT00760000118943
HOGENOMiHOG000039528
HOVERGENiHBG001595
InParanoidiP22727
KOiK00445
OMAiNGGQPQM
OrthoDBiEOG091G0OFF
TreeFamiTF105310

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR009143 Wnt6
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01845 WNT6PROTEIN
PR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22727-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPPVPSRLG LLLLLLCPAH VDGLWWAVGS PLVMDPTSIC RKARRLAGRQ
60 70 80 90 100
AELCQAEPEV VAELARGARL GVRECQFQFR FRRWNCSSHS KAFGRVLQQD
110 120 130 140 150
IRETAFVFAI TAAGASHAVT QACSMGELLQ CGCQAPRGRA PPRPSGLLGT
160 170 180 190 200
PGPPGPTGSP DASAAWEWGG CGDDVDFGDE KSRLFMDAQH KRGRGDIRAL
210 220 230 240 250
VQLHNNEAGR LAVRSHTRTE CKCHGLSGSC ALRTCWQKLP PFREVGARLL
260 270 280 290 300
ERFHGASRVM GTNDGKALLP AVRTLKPPGR ADLLYAADSP DFCAPNRRTG
310 320 330 340 350
SPGTRGRACN SSAPDLSGCD LLCCGRGHRQ ESVQLEENCL CRFHWCCVVQ
360
CHRCRVRKEL SLCL
Length:364
Mass (Da):39,656
Last modified:June 28, 2011 - v2
Checksum:i6F28CE191F98A0AC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti233R → S in AAA40569 (PubMed:2279700).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89800 mRNA Translation: AAA40569.1
AK133954 mRNA Translation: BAE21949.1
CH466548 Genomic DNA Translation: EDL00351.1
BC048700 mRNA Translation: AAH48700.1
CCDSiCCDS15056.1
PIRiF36470
RefSeqiNP_033552.2, NM_009526.3
XP_006495950.1, XM_006495887.3
XP_006495951.1, XM_006495888.3
UniGeneiMm.268282

Genome annotation databases

EnsembliENSMUST00000006716; ENSMUSP00000006716; ENSMUSG00000033227
GeneIDi22420
KEGGimmu:22420
UCSCiuc007bne.1 mouse

Similar proteinsi

Entry informationi

Entry nameiWNT6_MOUSE
AccessioniPrimary (citable) accession number: P22727
Secondary accession number(s): Q80ZM9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: June 28, 2011
Last modified: July 18, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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