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UniProtKB - P22727 (WNT6_MOUSE)
Protein
Protein Wnt-6
Gene
Wnt6
Organism
Mus musculus (Mouse)
Status
Functioni
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.
GO - Molecular functioni
- cytokine activity Source: GO_Central
- frizzled binding Source: GO_Central
- signaling receptor binding Source: MGI
GO - Biological processi
- animal organ morphogenesis Source: MGI
- axis specification Source: MGI
- branching involved in ureteric bud morphogenesis Source: MGI
- canonical Wnt signaling pathway Source: GO_Central
- cell-cell signaling Source: MGI
- cell fate commitment Source: GO_Central
- epithelial-mesenchymal cell signaling Source: MGI
- nephron tubule development Source: MGI
- nephron tubule formation Source: MGI
- neuron differentiation Source: GO_Central
- odontogenesis of dentin-containing tooth Source: MGI
- positive regulation of gene expression Source: MGI
- positive regulation of tooth mineralization Source: MGI
- positive regulation of transcription, DNA-templated Source: MGI
- signal transduction Source: MGI
- Wnt signaling pathway Source: MGI
Keywordsi
Molecular function | Developmental protein |
Biological process | Wnt signaling pathway |
Enzyme and pathway databases
Reactomei | R-MMU-3238698, WNT ligand biogenesis and trafficking |
Names & Taxonomyi
Protein namesi | Recommended name: Protein Wnt-6 |
Gene namesi | Name:Wnt6 Synonyms:Wnt-6 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98960, Wnt6 |
VEuPathDBi | HostDB:ENSMUSG00000033227 |
Subcellular locationi
Extracellular region or secreted
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- extracellular space Source: GO_Central
Other locations
- cell surface Source: BHF-UCL
- extracellular matrix Source: MGI
Keywords - Cellular componenti
Extracellular matrix, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000041441 | 24 – 364 | Protein Wnt-6Add BLAST | 341 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 75 ↔ 86 | By similarity | ||
Glycosylationi | 85 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 123 ↔ 131 | By similarity | ||
Disulfide bondi | 133 ↔ 171 | By similarity | ||
Disulfide bondi | 221 ↔ 235 | By similarity | ||
Disulfide bondi | 223 ↔ 230 | By similarity | ||
Lipidationi | 227 | O-palmitoleoyl serine; by PORCNBy similarity | 1 | |
Disulfide bondi | 293 ↔ 324 | By similarity | ||
Disulfide bondi | 309 ↔ 319 | By similarity | ||
Glycosylationi | 310 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 323 ↔ 363 | By similarity | ||
Disulfide bondi | 339 ↔ 354 | By similarity | ||
Disulfide bondi | 341 ↔ 351 | By similarity | ||
Disulfide bondi | 346 ↔ 347 | By similarity |
Post-translational modificationi
Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, LipoproteinProteomic databases
MaxQBi | P22727 |
PaxDbi | P22727 |
PRIDEi | P22727 |
ProteomicsDBi | 299774 |
PTM databases
GlyGeni | P22727, 2 sites |
PhosphoSitePlusi | P22727 |
Expressioni
Tissue specificityi
Detected in ileum, colon and stomach (at protein level).1 Publication
Gene expression databases
Bgeei | ENSMUSG00000033227, Expressed in molar tooth and 270 other tissues |
Genevisiblei | P22727, MM |
Interactioni
Subunit structurei
Interacts with PORCN.
1 PublicationGO - Molecular functioni
- cytokine activity Source: GO_Central
- frizzled binding Source: GO_Central
- signaling receptor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 204579, 1 interactor |
IntActi | P22727, 1 interactor |
STRINGi | 10090.ENSMUSP00000006716 |
Miscellaneous databases
RNActi | P22727, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 140 – 162 | DisorderedSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Belongs to the Wnt family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3913, Eukaryota |
GeneTreei | ENSGT00940000159281 |
HOGENOMi | CLU_033039_1_3_1 |
InParanoidi | P22727 |
OMAi | KAHMRRN |
OrthoDBi | 624528at2759 |
PhylomeDBi | P22727 |
TreeFami | TF105310 |
Family and domain databases
Gene3Di | 3.30.2460.20, 1 hit |
InterProi | View protein in InterPro IPR005817, Wnt IPR009143, Wnt6 IPR043158, Wnt_C IPR018161, Wnt_CS |
PANTHERi | PTHR12027, PTHR12027, 1 hit |
Pfami | View protein in Pfam PF00110, wnt, 1 hit |
PRINTSi | PR01845, WNT6PROTEIN PR01349, WNTPROTEIN |
SMARTi | View protein in SMART SM00097, WNT1, 1 hit |
PROSITEi | View protein in PROSITE PS00246, WNT1, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P22727-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLPPVPSRLG LLLLLLCPAH VDGLWWAVGS PLVMDPTSIC RKARRLAGRQ
60 70 80 90 100
AELCQAEPEV VAELARGARL GVRECQFQFR FRRWNCSSHS KAFGRVLQQD
110 120 130 140 150
IRETAFVFAI TAAGASHAVT QACSMGELLQ CGCQAPRGRA PPRPSGLLGT
160 170 180 190 200
PGPPGPTGSP DASAAWEWGG CGDDVDFGDE KSRLFMDAQH KRGRGDIRAL
210 220 230 240 250
VQLHNNEAGR LAVRSHTRTE CKCHGLSGSC ALRTCWQKLP PFREVGARLL
260 270 280 290 300
ERFHGASRVM GTNDGKALLP AVRTLKPPGR ADLLYAADSP DFCAPNRRTG
310 320 330 340 350
SPGTRGRACN SSAPDLSGCD LLCCGRGHRQ ESVQLEENCL CRFHWCCVVQ
360
CHRCRVRKEL SLCL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 233 | R → S in AAA40569 (PubMed:2279700).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M89800 mRNA Translation: AAA40569.1 AK133954 mRNA Translation: BAE21949.1 CH466548 Genomic DNA Translation: EDL00351.1 BC048700 mRNA Translation: AAH48700.1 |
CCDSi | CCDS15056.1 |
PIRi | F36470 |
RefSeqi | NP_033552.2, NM_009526.3 XP_006495950.1, XM_006495887.3 XP_006495951.1, XM_006495888.3 |
Genome annotation databases
Ensembli | ENSMUST00000006716; ENSMUSP00000006716; ENSMUSG00000033227 |
GeneIDi | 22420 |
KEGGi | mmu:22420 |
UCSCi | uc007bne.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M89800 mRNA Translation: AAA40569.1 AK133954 mRNA Translation: BAE21949.1 CH466548 Genomic DNA Translation: EDL00351.1 BC048700 mRNA Translation: AAH48700.1 |
CCDSi | CCDS15056.1 |
PIRi | F36470 |
RefSeqi | NP_033552.2, NM_009526.3 XP_006495950.1, XM_006495887.3 XP_006495951.1, XM_006495888.3 |
3D structure databases
SMRi | P22727 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 204579, 1 interactor |
IntActi | P22727, 1 interactor |
STRINGi | 10090.ENSMUSP00000006716 |
PTM databases
GlyGeni | P22727, 2 sites |
PhosphoSitePlusi | P22727 |
Proteomic databases
MaxQBi | P22727 |
PaxDbi | P22727 |
PRIDEi | P22727 |
ProteomicsDBi | 299774 |
Protocols and materials databases
Antibodypediai | 34291, 248 antibodies from 34 providers |
DNASUi | 22420 |
Genome annotation databases
Ensembli | ENSMUST00000006716; ENSMUSP00000006716; ENSMUSG00000033227 |
GeneIDi | 22420 |
KEGGi | mmu:22420 |
UCSCi | uc007bne.1, mouse |
Organism-specific databases
CTDi | 7475 |
MGIi | MGI:98960, Wnt6 |
VEuPathDBi | HostDB:ENSMUSG00000033227 |
Phylogenomic databases
eggNOGi | KOG3913, Eukaryota |
GeneTreei | ENSGT00940000159281 |
HOGENOMi | CLU_033039_1_3_1 |
InParanoidi | P22727 |
OMAi | KAHMRRN |
OrthoDBi | 624528at2759 |
PhylomeDBi | P22727 |
TreeFami | TF105310 |
Enzyme and pathway databases
Reactomei | R-MMU-3238698, WNT ligand biogenesis and trafficking |
Miscellaneous databases
BioGRID-ORCSi | 22420, 0 hits in 65 CRISPR screens |
PROi | PR:P22727 |
RNActi | P22727, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000033227, Expressed in molar tooth and 270 other tissues |
Genevisiblei | P22727, MM |
Family and domain databases
Gene3Di | 3.30.2460.20, 1 hit |
InterProi | View protein in InterPro IPR005817, Wnt IPR009143, Wnt6 IPR043158, Wnt_C IPR018161, Wnt_CS |
PANTHERi | PTHR12027, PTHR12027, 1 hit |
Pfami | View protein in Pfam PF00110, wnt, 1 hit |
PRINTSi | PR01845, WNT6PROTEIN PR01349, WNTPROTEIN |
SMARTi | View protein in SMART SM00097, WNT1, 1 hit |
PROSITEi | View protein in PROSITE PS00246, WNT1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | WNT6_MOUSE | |
Accessioni | P22727Primary (citable) accession number: P22727 Secondary accession number(s): Q80ZM9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1991 |
Last sequence update: | June 28, 2011 | |
Last modified: | February 23, 2022 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families