Wnt6

Functionⁱ

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

GO - Molecular functionⁱ

frizzled binding Source: GO_Central
signaling receptor binding
Source: MGI
Traceable author statementⁱ
- 9889131

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

animal organ morphogenesis
Source: MGI
Traceable author statementⁱ
- 9889131
axis specification
Source: MGI
Inferred from direct assayⁱ
- 11948913
branching involved in ureteric bud morphogenesis
Source: MGI
Inferred from genetic interactionⁱ
- 11948913
cell-cell signaling
Source: MGI
Traceable author statementⁱ
- 9889131
cell fate commitment Source: GO_Central
epithelial-mesenchymal cell signaling
Source: MGI
Inferred from direct assayⁱ
- 11948913
nephron tubule development
Source: MGI
Inferred from direct assayⁱ
- 11948913
nephron tubule formation
Source: MGI
Inferred from direct assayⁱ
- 11948913
neuron differentiation Source: GO_Central
odontogenesis of dentin-containing tooth Source: MGI
positive regulation of gene expression
Source: MGI
Inferred from direct assayⁱ
- 11948913
- 11973284
positive regulation of tooth mineralization Source: MGI
positive regulation of transcription, DNA-templated
Source: MGI
Inferred from direct assayⁱ
- 9356179
signal transduction
Source: MGI
Traceable author statementⁱ
- 9889131
Wnt signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 11948913
- 11973284

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Wnt signaling pathway

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3238698 WNT ligand biogenesis and trafficking

Reactomeⁱ

R-MMU-3238698 WNT ligand biogenesis and trafficking

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein Wnt-6
Gene namesⁱ	Name:Wnt6 Synonyms:Wnt-6
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:98960 Wnt6

Keywords - Cellular componentⁱ

Extracellular matrix, Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 23	Sequence analysisAdd BLAST		23
ChainⁱPRO_0000041441	24 – 364	Protein Wnt-6Add BLAST		341

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	75 ↔ 86	By similarity
Glycosylationⁱ	85	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	123 ↔ 131	By similarity
Disulfide bondⁱ	133 ↔ 171	By similarity
Disulfide bondⁱ	221 ↔ 235	By similarity
Disulfide bondⁱ	223 ↔ 230	By similarity
Lipidationⁱ	227	O-palmitoleoyl serine; by PORCNBy similarity	1
Disulfide bondⁱ	309 ↔ 324	By similarity
Glycosylationⁱ	310	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	339 ↔ 354	By similarity
Disulfide bondⁱ	341 ↔ 351	By similarity
Disulfide bondⁱ	346 ↔ 347	By similarity

Post-translational modificationⁱ

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P22727
PaxDbⁱ	P22727
PRIDEⁱ	P22727

PTM databases

PhosphoSitePlusⁱ	P22727

PhosphoSitePlusⁱ

P22727

Expressionⁱ

Tissue specificityⁱ

Detected in ileum, colon and stomach (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000033227 Expressed in 250 organ(s), highest expression level in molar tooth
CleanExⁱ	MM_WNT6
Genevisibleⁱ	P22727 MM

Interactionⁱ

Subunit structureⁱ

Interacts with PORCN.1 Publication

GO - Molecular functionⁱ

frizzled binding Source: GO_Central
signaling receptor binding
Source: MGI
Traceable author statementⁱ
- 9889131

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	204579, 1 interactor
IntActⁱ	P22727, 1 interactor
STRINGⁱ	10090.ENSMUSP00000006716

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P22727
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the Wnt family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG3913 Eukaryota ENOG410XQZ1 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118943
HOGENOMⁱ	HOG000039528
HOVERGENⁱ	HBG001595
InParanoidⁱ	P22727
KEGG Orthology (KO) More...KOⁱ	K00445
OMAⁱ	NGGQPQM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0OFF
TreeFamⁱ	TF105310

Family and domain databases

InterProⁱ	View protein in InterPro IPR005817 Wnt IPR009143 Wnt6 IPR018161 Wnt_CS
PANTHERⁱ	PTHR12027 PTHR12027, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00110 wnt, 1 hit
PRINTSⁱ	PR01845 WNT6PROTEIN PR01349 WNTPROTEIN
SMARTⁱ	View protein in SMART SM00097 WNT1, 1 hit
PROSITEⁱ	View protein in PROSITE PS00246 WNT1, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P22727-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLPPVPSRLG LLLLLLCPAH VDGLWWAVGS PLVMDPTSIC RKARRLAGRQ 
        60         70         80         90        100
AELCQAEPEV VAELARGARL GVRECQFQFR FRRWNCSSHS KAFGRVLQQD 
       110        120        130        140        150
IRETAFVFAI TAAGASHAVT QACSMGELLQ CGCQAPRGRA PPRPSGLLGT 
       160        170        180        190        200
PGPPGPTGSP DASAAWEWGG CGDDVDFGDE KSRLFMDAQH KRGRGDIRAL 
       210        220        230        240        250
VQLHNNEAGR LAVRSHTRTE CKCHGLSGSC ALRTCWQKLP PFREVGARLL 
       260        270        280        290        300
ERFHGASRVM GTNDGKALLP AVRTLKPPGR ADLLYAADSP DFCAPNRRTG 
       310        320        330        340        350
SPGTRGRACN SSAPDLSGCD LLCCGRGHRQ ESVQLEENCL CRFHWCCVVQ 
       360 
CHRCRVRKEL SLCL

Length:364

Mass (Da):39,656

Last modified:June 28, 2011 - v2

Checksum:ⁱ6F28CE191F98A0AC

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	233	R → S in AAA40569 (PubMed:2279700).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M89800 mRNA Translation: AAA40569.1 AK133954 mRNA Translation: BAE21949.1 CH466548 Genomic DNA Translation: EDL00351.1 BC048700 mRNA Translation: AAH48700.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS15056.1
PIRⁱ	F36470
NCBI Reference Sequences More...RefSeqⁱ	NP_033552.2, NM_009526.3 XP_006495950.1, XM_006495887.3 XP_006495951.1, XM_006495888.3
UniGeneⁱ	Mm.268282

Genome annotation databases

Ensemblⁱ	ENSMUST00000006716; ENSMUSP00000006716; ENSMUSG00000033227
GeneIDⁱ	22420
KEGGⁱ	mmu:22420
UCSC genome browser More...UCSCⁱ	uc007bne.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P22727	Protein Wnt-6		HUMAN		365	UniRef90_P22727
Protein Wnt		Florida manatee		448
Protein Wnt		RHIRO		369
Protein Wnt		RHIBE		338
Protein Wnt		OTOGA		368
+93

Protein	Similar proteins		Species	Score	Length	Source
P22727	Protein Wnt-6		HUMAN		365	UniRef50_P22727
Protein Wnt		Florida manatee		448
Protein Wnt		RHIRO		369
Protein Wnt		RHIBE		338
Protein Wnt		OTOGA		368
+225

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M89800 mRNA Translation: AAA40569.1 AK133954 mRNA Translation: BAE21949.1 CH466548 Genomic DNA Translation: EDL00351.1 BC048700 mRNA Translation: AAH48700.1
CCDSⁱ	CCDS15056.1
PIRⁱ	F36470
RefSeqⁱ	NP_033552.2, NM_009526.3 XP_006495950.1, XM_006495887.3 XP_006495951.1, XM_006495888.3
UniGeneⁱ	Mm.268282

3D structure databases

ProteinModelPortalⁱ	P22727
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	204579, 1 interactor
IntActⁱ	P22727, 1 interactor
STRINGⁱ	10090.ENSMUSP00000006716

PTM databases

PhosphoSitePlusⁱ	P22727

PhosphoSitePlusⁱ

P22727

Proteomic databases

MaxQBⁱ	P22727
PaxDbⁱ	P22727
PRIDEⁱ	P22727

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000006716; ENSMUSP00000006716; ENSMUSG00000033227
GeneIDⁱ	22420
KEGGⁱ	mmu:22420
UCSCⁱ	uc007bne.1 mouse

Organism-specific databases

CTDⁱ	7475
MGIⁱ	MGI:98960 Wnt6

Phylogenomic databases

eggNOGⁱ	KOG3913 Eukaryota ENOG410XQZ1 LUCA
GeneTreeⁱ	ENSGT00760000118943
HOGENOMⁱ	HOG000039528
HOVERGENⁱ	HBG001595
InParanoidⁱ	P22727
KOⁱ	K00445
OMAⁱ	NGGQPQM
OrthoDBⁱ	EOG091G0OFF
TreeFamⁱ	TF105310

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3238698 WNT ligand biogenesis and trafficking

Reactomeⁱ

R-MMU-3238698 WNT ligand biogenesis and trafficking

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P22727
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000033227 Expressed in 250 organ(s), highest expression level in molar tooth
CleanExⁱ	MM_WNT6
Genevisibleⁱ	P22727 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR005817 Wnt IPR009143 Wnt6 IPR018161 Wnt_CS
PANTHERⁱ	PTHR12027 PTHR12027, 1 hit
Pfamⁱ	View protein in Pfam PF00110 wnt, 1 hit
PRINTSⁱ	PR01845 WNT6PROTEIN PR01349 WNTPROTEIN
SMARTⁱ	View protein in SMART SM00097 WNT1, 1 hit
PROSITEⁱ	View protein in PROSITE PS00246 WNT1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	WNT6_MOUSE
Accessionⁱ	P22727Primary (citable) accession number: P22727 Secondary accession number(s): Q80ZM9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
	Last sequence update:	June 28, 2011
	Last modified:	September 12, 2018
	This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P22727 (WNT6_MOUSE)

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Protein Wnt-6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Endoplasmic reticulum

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ