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Protein

Protein Wnt-5b

Gene

Wnt5b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

GO - Molecular functioni

  • frizzled binding Source: GO_Central
  • signaling receptor binding Source: ParkinsonsUK-UCL

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-3238698 WNT ligand biogenesis and trafficking
R-MMU-4086400 PCP/CE pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-5b
Gene namesi
Name:Wnt5b
Synonyms:Wnt-5b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:98959 Wnt5b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000004143518 – 359Protein Wnt-5bAdd BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi83 ↔ 94By similarity
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi133 ↔ 141By similarity
Disulfide bondi143 ↔ 161By similarity
Disulfide bondi217 ↔ 231By similarity
Disulfide bondi219 ↔ 226By similarity
Lipidationi223O-palmitoleoyl serine; by PORCNBy similarity1
Glycosylationi291N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi304 ↔ 319By similarity
Glycosylationi305N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi334 ↔ 349By similarity
Disulfide bondi336 ↔ 346By similarity
Disulfide bondi341 ↔ 342By similarity

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

MaxQBiP22726
PaxDbiP22726
PRIDEiP22726

PTM databases

iPTMnetiP22726
PhosphoSitePlusiP22726

Expressioni

Gene expression databases

BgeeiENSMUSG00000030170 Expressed in 330 organ(s), highest expression level in epithelium of lens
CleanExiMM_WNT5B
ExpressionAtlasiP22726 baseline and differential
GenevisibleiP22726 MM

Interactioni

Subunit structurei

Interacts with PORCN.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204578, 1 interactor
STRINGi10090.ENSMUSP00000113188

Structurei

3D structure databases

ProteinModelPortaliP22726
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
GeneTreeiENSGT00760000118943
HOGENOMiHOG000039529
HOVERGENiHBG001595
InParanoidiP22726
KOiK00444
PhylomeDBiP22726
TreeFamiTF105310

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR026537 Wnt5b
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PTHR12027:SF87 PTHR12027:SF87, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P22726-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSLLLVVVA ALLSSWAQLL TDANSWWSLA LNPVQRPEMF IIGAQPVCSQ
60 70 80 90 100
LPGLSPGQRK LCQLYQEHMS YIGEGAKTGI RECQHQFRQR RWNCSTVDNT
110 120 130 140 150
SVFGRVMQIG SRETAFTYAV SAAGVVNAIS RACREGELST CGCSRAARPK
160 170 180 190 200
DLPRDWLWGG CGDNVEYGYR FAKEFVDARE REKNFAKGSE EQGRALMNLQ
210 220 230 240 250
NNEAGRRAVY KMADVACKCH GVSGSCSLKT CWLQLAEFRK VGDRLKEKYD
260 270 280 290 300
SAAAMRITRQ GKLELANSRF NQPTPEDLVY VDPSPDYCLR NETTGSLGTQ
310 320 330 340 350
GRLCNKTSEG MDGCELMCCG RGYDRFKSVQ VERCHCRFHW CCFVRCKKCT

EVVDQYVCK
Length:359
Mass (Da):40,343
Last modified:June 20, 2001 - v2
Checksum:i308ED393D3020DEB
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J1M1A0A0R4J1M1_MOUSE
Protein Wnt
Wnt5b mCG_131712
372Annotation score:
D3YTW9D3YTW9_MOUSE
Protein Wnt
Wnt5b
321Annotation score:

Sequence cautioni

The sequence AAA40568 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH10775 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89799 mRNA Translation: AAA40568.1 Different initiation.
BC010775 mRNA Translation: AAH10775.1 Different initiation.
BC051406 mRNA Translation: AAH51406.1
CCDSiCCDS20474.2
PIRiE36470
RefSeqiNP_001258686.1, NM_001271757.1
NP_001258687.1, NM_001271758.1
NP_033551.2, NM_009525.3
XP_006505987.1, XM_006505924.1
UniGeneiMm.321818

Genome annotation databases

EnsembliENSMUST00000117171; ENSMUSP00000113188; ENSMUSG00000030170
ENSMUST00000178696; ENSMUSP00000137065; ENSMUSG00000030170
GeneIDi22419
KEGGimmu:22419
UCSCiuc009dmg.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89799 mRNA Translation: AAA40568.1 Different initiation.
BC010775 mRNA Translation: AAH10775.1 Different initiation.
BC051406 mRNA Translation: AAH51406.1
CCDSiCCDS20474.2
PIRiE36470
RefSeqiNP_001258686.1, NM_001271757.1
NP_001258687.1, NM_001271758.1
NP_033551.2, NM_009525.3
XP_006505987.1, XM_006505924.1
UniGeneiMm.321818

3D structure databases

ProteinModelPortaliP22726
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204578, 1 interactor
STRINGi10090.ENSMUSP00000113188

PTM databases

iPTMnetiP22726
PhosphoSitePlusiP22726

Proteomic databases

MaxQBiP22726
PaxDbiP22726
PRIDEiP22726

Protocols and materials databases

DNASUi22419
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000117171; ENSMUSP00000113188; ENSMUSG00000030170
ENSMUST00000178696; ENSMUSP00000137065; ENSMUSG00000030170
GeneIDi22419
KEGGimmu:22419
UCSCiuc009dmg.3 mouse

Organism-specific databases

CTDi81029
MGIiMGI:98959 Wnt5b

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
GeneTreeiENSGT00760000118943
HOGENOMiHOG000039529
HOVERGENiHBG001595
InParanoidiP22726
KOiK00444
PhylomeDBiP22726
TreeFamiTF105310

Enzyme and pathway databases

ReactomeiR-MMU-3238698 WNT ligand biogenesis and trafficking
R-MMU-4086400 PCP/CE pathway

Miscellaneous databases

PROiPR:P22726
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030170 Expressed in 330 organ(s), highest expression level in epithelium of lens
CleanExiMM_WNT5B
ExpressionAtlasiP22726 baseline and differential
GenevisibleiP22726 MM

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR026537 Wnt5b
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PTHR12027:SF87 PTHR12027:SF87, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWNT5B_MOUSE
AccessioniPrimary (citable) accession number: P22726
Secondary accession number(s): Q91XF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: June 20, 2001
Last modified: November 7, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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