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Protein

Peptidyl-prolyl cis-trans isomerase ESS1

Gene

ESS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential PPIase specific for phosphoserine and phosphothreonine N-terminal to the proline residue. Required for efficient pre-mRNA 3'-end processing and transcription termination, probably by inducing conformational changes by proline-directed isomerization in the C-terminal domain (CTD) of RPB1, thereby altering cofactor binding with the RNA polymerase II transcription complex. Also targets the SIN3-RPD3 histone deacetylase complex (HDAC).

Miscellaneous

Present with 4401 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).1 Publication

Activity regulationi

Inhibited by 5-hydroxy-1,4-naphthoquinone (juglone), but not by FK506 or cyclosporin A.1 Publication

GO - Molecular functioni

  • peptidyl-prolyl cis-trans isomerase activity Source: SGD
  • RNA polymerase II complex binding Source: SGD

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase

Enzyme and pathway databases

BioCyciYEAST:YJR017C-MONOMER
ReactomeiR-SCE-6811555 PI5P Regulates TP53 Acetylation

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase ESS1 (EC:5.2.1.8)
Short name:
PPIase ESS1
Alternative name(s):
Parvulin ESS1
Processing/termination factor 1
Gene namesi
Name:ESS1
Synonyms:PIN1, PTF1
Ordered Locus Names:YJR017C
ORF Names:J1452
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

SGDiS000003778 ESS1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi120C → R: Abolishes PPIase activity. 1 Publication1
Mutagenesisi122S → P: Abolishes PPIase activity. 1 Publication1
Mutagenesisi127G → D in PTF1-2; decreases the catalytic efficiency 20-fold. 1 Publication1
Mutagenesisi162G → S in PTF1-5; decreases the catalytic efficiency 12-fold. 1 Publication1
Mutagenesisi164H → R: Abolishes PPIase activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001934331 – 170Peptidyl-prolyl cis-trans isomerase ESS1Add BLAST170

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei161PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP22696
PaxDbiP22696
PRIDEiP22696
TopDownProteomicsiP22696

PTM databases

iPTMnetiP22696

Interactioni

Subunit structurei

Interacts with the RNA polymerase II largest subunit (RPB1) and with the SIN1-RDP3 HDAC subunit SIN3.2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi33773, 1009 interactors
DIPiDIP-3856N
ELMiP22696
IntActiP22696, 115 interactors
MINTiP22696
STRINGi4932.YJR017C

Chemistry databases

BindingDBiP22696

Structurei

3D structure databases

ProteinModelPortaliP22696
SMRiP22696
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 43WWPROSITE-ProRule annotationAdd BLAST35
Domaini57 – 170PpiCPROSITE-ProRule annotationAdd BLAST114

Domaini

The WW domain binds to the phosphorylated tandem 7 residues repeats of RPB1.

Sequence similaritiesi

Belongs to the PpiC/parvulin rotamase family.Curated

Phylogenomic databases

GeneTreeiENSGT00640000091578
HOGENOMiHOG000275331
InParanoidiP22696
KOiK09578
OMAiDEVQCLH
OrthoDBiEOG092C4TRA

Family and domain databases

CDDicd00201 WW, 1 hit
InterProiView protein in InterPro
IPR000297 PPIase_PpiC
IPR023058 PPIase_PpiC_CS
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00639 Rotamase, 1 hit
PF00397 WW, 1 hit
SMARTiView protein in SMART
SM00456 WW, 1 hit
SUPFAMiSSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS01096 PPIC_PPIASE_1, 1 hit
PS50198 PPIC_PPIASE_2, 1 hit
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

P22696-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSDVASRTG LPTPWTVRYS KSKKREYFFN PETKHSQWEE PEGTNKDQLH
60 70 80 90 100
KHLRDHPVRV RCLHILIKHK DSRRPASHRS ENITISKQDA TDELKTLITR
110 120 130 140 150
LDDDSKTNSF EALAKERSDC SSYKRGGDLG WFGRGEMQPS FEDAAFQLKV
160 170
GEVSDIVESG SGVHVIKRVG
Length:170
Mass (Da):19,405
Last modified:October 25, 2005 - v3
Checksum:i18D3EC02E8395175
GO

Sequence cautioni

The sequence CAA60941 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA89541 differs from that shown. Reason: Erroneous initiation.Curated
The sequence described in PubMed:2648698 differs from that shown. Reason: Frameshift at position 127.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8R → S (PubMed:2648698).Curated1
Sequence conflicti17V → A (PubMed:2648698).Curated1
Sequence conflicti128D → G (PubMed:2648698).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85972 Genomic DNA Translation: CAA59961.1
X87611 Genomic DNA Translation: CAA60941.1 Different initiation.
Z49517 Genomic DNA Translation: CAA89541.1 Different initiation.
BK006943 Genomic DNA Translation: DAA08809.1
PIRiS52764
RefSeqiNP_012551.2, NM_001181675.1

Genome annotation databases

EnsemblFungiiYJR017C; YJR017C; YJR017C
GeneIDi853475
KEGGisce:YJR017C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85972 Genomic DNA Translation: CAA59961.1
X87611 Genomic DNA Translation: CAA60941.1 Different initiation.
Z49517 Genomic DNA Translation: CAA89541.1 Different initiation.
BK006943 Genomic DNA Translation: DAA08809.1
PIRiS52764
RefSeqiNP_012551.2, NM_001181675.1

3D structure databases

ProteinModelPortaliP22696
SMRiP22696
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33773, 1009 interactors
DIPiDIP-3856N
ELMiP22696
IntActiP22696, 115 interactors
MINTiP22696
STRINGi4932.YJR017C

Chemistry databases

BindingDBiP22696

PTM databases

iPTMnetiP22696

Proteomic databases

MaxQBiP22696
PaxDbiP22696
PRIDEiP22696
TopDownProteomicsiP22696

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJR017C; YJR017C; YJR017C
GeneIDi853475
KEGGisce:YJR017C

Organism-specific databases

SGDiS000003778 ESS1

Phylogenomic databases

GeneTreeiENSGT00640000091578
HOGENOMiHOG000275331
InParanoidiP22696
KOiK09578
OMAiDEVQCLH
OrthoDBiEOG092C4TRA

Enzyme and pathway databases

BioCyciYEAST:YJR017C-MONOMER
ReactomeiR-SCE-6811555 PI5P Regulates TP53 Acetylation

Miscellaneous databases

PROiPR:P22696

Family and domain databases

CDDicd00201 WW, 1 hit
InterProiView protein in InterPro
IPR000297 PPIase_PpiC
IPR023058 PPIase_PpiC_CS
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00639 Rotamase, 1 hit
PF00397 WW, 1 hit
SMARTiView protein in SMART
SM00456 WW, 1 hit
SUPFAMiSSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS01096 PPIC_PPIASE_1, 1 hit
PS50198 PPIC_PPIASE_2, 1 hit
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiESS1_YEAST
AccessioniPrimary (citable) accession number: P22696
Secondary accession number(s): D6VWJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: October 25, 2005
Last modified: November 7, 2018
This is version 177 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names
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Main funding by: National Institutes of Health

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