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UniProtKB - P22694 (KAPCB_HUMAN)

Protein

cAMP-dependent protein kinase catalytic subunit beta

Gene

PRKACB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:12420224, PubMed:21423175). Phosphorylates GPKOW which regulates its ability to bind RNA (PubMed:21880142).3 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+

Activity regulationi

Activated by cAMP.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei73ATPPROSITE-ProRule annotation1
Active sitei167Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi50 – 58ATPPROSITE-ProRule annotation9

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, cAMP, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.11 2681
ReactomeiR-HSA-111931 PKA-mediated phosphorylation of CREB
R-HSA-163358 PKA-mediated phosphorylation of key metabolic factors
R-HSA-163560 Triglyceride catabolism
R-HSA-163615 PKA activation
R-HSA-164378 PKA activation in glucagon signalling
R-HSA-180024 DARPP-32 events
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392517 Rap1 signalling
R-HSA-422356 Regulation of insulin secretion
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-442720 CREB phosphorylation through the activation of Adenylate Cyclase
R-HSA-5610780 Degradation of GLI1 by the proteasome
R-HSA-5610783 Degradation of GLI2 by the proteasome
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome
R-HSA-5610787 Hedgehog 'off' state
R-HSA-5621575 CD209 (DC-SIGN) signaling
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-70171 Glycolysis
R-HSA-8853659 RET signaling
R-HSA-8963896 HDL assembly
R-HSA-9010642 ROBO receptors bind AKAP5
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
SABIO-RKiP22694
SignaLinkiP22694
SIGNORiP22694

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-dependent protein kinase catalytic subunit beta (EC:2.7.11.11)
Short name:
PKA C-beta
Gene namesi
Name:PRKACB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000142875.19
HGNCiHGNC:9381 PRKACB
MIMi176892 gene
neXtProtiNX_P22694

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5567
OpenTargetsiENSG00000142875
PharmGKBiPA33749

Chemistry databases

ChEMBLiCHEMBL2918
DrugBankiDB02482 Phosphonothreonine
GuidetoPHARMACOLOGYi1477

Polymorphism and mutation databases

BioMutaiPRKACB
DMDMi125210

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000860602 – 351cAMP-dependent protein kinase catalytic subunit betaAdd BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Modified residuei3Deamidated asparagineBy similarity1
Modified residuei11PhosphoserineBy similarity1
Modified residuei69PhosphotyrosineBy similarity1
Modified residuei140PhosphoserineBy similarity1
Modified residuei198PhosphothreonineBy similarity1
Modified residuei322PhosphoserineBy similarity1
Modified residuei331PhosphotyrosineBy similarity1
Modified residuei339PhosphoserineBy similarity1

Post-translational modificationi

Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively.By similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiP22694
MaxQBiP22694
PaxDbiP22694
PeptideAtlasiP22694
PRIDEiP22694
ProteomicsDBi54019
54020 [P22694-2]
54021 [P22694-3]
54022 [P22694-4]
54023 [P22694-5]
54024 [P22694-6]
54025 [P22694-7]
54026 [P22694-8]
54027 [P22694-9]

PTM databases

iPTMnetiP22694
PhosphoSitePlusiP22694
SwissPalmiP22694

Expressioni

Tissue specificityi

Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain.1 Publication

Gene expression databases

BgeeiENSG00000142875 Expressed in 242 organ(s), highest expression level in caudate nucleus
ExpressionAtlasiP22694 baseline and differential
GenevisibleiP22694 HS

Organism-specific databases

HPAiCAB010363
HPA029754
HPA071185

Interactioni

Subunit structurei

A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits (By similarity). The cAMP-dependent protein kinase catalytic subunit binds PJA2 (PubMed:21423175). Interacts with GPKOW (PubMed:21880142).By similarity2 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi111554, 90 interactors
IntActiP22694, 46 interactors
MINTiP22694
STRINGi9606.ENSP00000359719

Chemistry databases

BindingDBiP22694

Structurei

3D structure databases

ProteinModelPortaliP22694
SMRiP22694
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 298Protein kinasePROSITE-ProRule annotationAdd BLAST255
Domaini299 – 351AGC-kinase C-terminalAdd BLAST53

Sequence similaritiesi

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.Curated

Phylogenomic databases

eggNOGiKOG0616 Eukaryota
ENOG410XPQQ LUCA
GeneTreeiENSGT00810000125385
HOGENOMiHOG000233033
HOVERGENiHBG108317
InParanoidiP22694
KOiK04345
OMAiLFMIMDY
OrthoDBiEOG091G10O8
PhylomeDBiP22694
TreeFamiTF313399

Family and domain databases

InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR039811 cAMP/cGMP-dep_PK
IPR011009 Kinase-like_dom_sf
IPR039083 PKA_C-beta
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24353 PTHR24353, 1 hit
PTHR24353:SF116 PTHR24353:SF116, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (10+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 10 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 10 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P22694-1) [UniParc]FASTAAdd to basket
Also known as: Beta1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGNAATAKKG SEVESVKEFL AKAKEDFLKK WENPTQNNAG LEDFERKKTL 
        60         70         80         90        100
GTGSFGRVML VKHKATEQYY AMKILDKQKV VKLKQIEHTL NEKRILQAVN 
       110        120        130        140        150
FPFLVRLEYA FKDNSNLYMV MEYVPGGEMF SHLRRIGRFS EPHARFYAAQ 
       160        170        180        190        200
IVLTFEYLHS LDLIYRDLKP ENLLIDHQGY IQVTDFGFAK RVKGRTWTLC 
       210        220        230        240        250
GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAAGYPPFF ADQPIQIYEK 
       260        270        280        290        300
IVSGKVRFPS HFSSDLKDLL RNLLQVDLTK RFGNLKNGVS DIKTHKWFAT 
       310        320        330        340        350
TDWIAIYQRK VEAPFIPKFR GSGDTSNFDD YEEEDIRVSI TEKCAKEFGE 

F
Length:351
Mass (Da):40,623
Last modified:January 23, 2007 - v2
Checksum:i5C7443FBBA1C9BEC
GO
Isoform 2 (identifier: P22694-2) [UniParc]FASTAAdd to basket
Also known as: Beta2

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MGNAATAKKGSEVESV → MAAYREPPCN...EHTALWDRSM

Show »
Length:398
Mass (Da):46,236
Checksum:i49EFAF3E426468FC
GO
Isoform 3 (identifier: P22694-3) [UniParc]FASTAAdd to basket
Also known as: Beta3

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: Missing.
     13-16: VESV → MGLL

Note: Incomplete sequence.
Show »
Length:339
Mass (Da):39,477
Checksum:iAD0D54B6EEB01501
GO
Isoform 4 (identifier: P22694-4) [UniParc]FASTAAdd to basket
Also known as: Beta4

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.
     14-14: E → M

Note: Incomplete sequence.
Show »
Length:338
Mass (Da):39,379
Checksum:iCFB30E746FD025F5
GO
Isoform 5 (identifier: P22694-5) [UniParc]FASTAAdd to basket
Also known as: Beta4ab

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MGNAATAKKGSEVE → MSARKSSDASACSSSEI

Note: Incomplete sequence.
Show »
Length:354
Mass (Da):40,947
Checksum:i7BB4E4E199E5B0B4
GO
Isoform 6 (identifier: P22694-6) [UniParc]FASTAAdd to basket
Also known as: Beta4abc

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MGNAATAKKGSEVES → MSARKSSDASACSSSEISDSF

Show »
Length:357
Mass (Da):41,296
Checksum:iFC923359146B9466
GO
Isoform 7 (identifier: P22694-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MGNAATAKKGSEVE → MGLSRKSSDASACSSSEI

Note: No experimental confirmation available.
Show »
Length:355
Mass (Da):41,046
Checksum:i02D5CA2B459BDDF1
GO
Isoform 8 (identifier: P22694-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     256-257: VR → NF
     258-351: Missing.

Show »
Length:257
Mass (Da):29,696
Checksum:i38FCBB18E1BF2761
GO
Isoform 9 (identifier: P22694-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MGNAATAKKGSEVES → MGLSRKSSDASACSSSEISDSF

Note: No experimental confirmation available.
Show »
Length:358
Mass (Da):41,395
Checksum:iB5E2A85075455EBA
GO
Isoform 10 (identifier: P22694-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MGNAATAKKGSEVE → MSARKSSDASACSSSEI
     79-111: Missing.

Note: No experimental confirmation available.
Show »
Length:321
Mass (Da):36,979
Checksum:i7FF5EB27D1706E88
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WVC4A0A087WVC4_HUMAN
cAMP-dependent protein kinase catal...
PRKACB
338Annotation score:
A0A0A0MS54A0A0A0MS54_HUMAN
cAMP-dependent protein kinase catal...
PRKACB
357Annotation score:
B1APG3B1APG3_HUMAN
cAMP-dependent protein kinase catal...
PRKACB
264Annotation score:
B1APF9B1APF9_HUMAN
cAMP-dependent protein kinase catal...
PRKACB
245Annotation score:
B1APF8B1APF8_HUMAN
cAMP-dependent protein kinase catal...
PRKACB
214Annotation score:
B1APF7B1APF7_HUMAN
cAMP-dependent protein kinase catal...
PRKACB
186Annotation score:
B1APG0B1APG0_HUMAN
cAMP-dependent protein kinase catal...
PRKACB
206Annotation score:
B1APG2B1APG2_HUMAN
cAMP-dependent protein kinase catal...
PRKACB
209Annotation score:
B1APG1B1APG1_HUMAN
cAMP-dependent protein kinase catal...
PRKACB
197Annotation score:

Sequence cautioni

The sequence BAD92426 differs from that shown. Reason: Frameshift at position 322.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti80V → G in CAI56774 (Ref. 3) Curated1
Sequence conflicti159H → N in AAH35058 (PubMed:15489334).Curated1
Sequence conflicti163L → I in AAH35058 (PubMed:15489334).Curated1
Sequence conflicti233A → V in CAI56774 (Ref. 3) Curated1
Sequence conflicti261H → N in AAH35058 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_040594106R → Q1 PublicationCorresponds to variant dbSNP:rs36117118Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0173641 – 16MGNAA…EVESV → MAAYREPPCNQYTGTTTALQ KLEGFASRLFHRHSKGTAHD QKTALENDSLHFSEHTALWD RSM in isoform 2. 2 PublicationsAdd BLAST16
Alternative sequenceiVSP_0173651 – 15MGNAA…SEVES → MSARKSSDASACSSSEISDS F in isoform 6. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_0433721 – 15MGNAA…SEVES → MGLSRKSSDASACSSSEISD SF in isoform 9. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_0173661 – 14MGNAA…GSEVE → MSARKSSDASACSSSEI in isoform 5 and isoform 10. 2 PublicationsAdd BLAST14
Alternative sequenceiVSP_0173671 – 14MGNAA…GSEVE → MGLSRKSSDASACSSSEI in isoform 7. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_0173681 – 13Missing in isoform 4. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_0173691 – 12Missing in isoform 3. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_01737013 – 16VESV → MGLL in isoform 3. 2 Publications4
Alternative sequenceiVSP_01737114E → M in isoform 4. 1 Publication1
Alternative sequenceiVSP_04623879 – 111Missing in isoform 10. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_036556256 – 257VR → NF in isoform 8. 1 Publication2
Alternative sequenceiVSP_036557258 – 351Missing in isoform 8. 1 PublicationAdd BLAST94

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34181 mRNA Translation: AAA60170.1
BX537705 mRNA Translation: CAD97818.1
BX641026 mRNA Translation: CAE46017.1
AB209189 mRNA Translation: BAD92426.1 Sequence problems.
CR936631 mRNA Translation: CAI56774.1
AK091420 mRNA Translation: BAG52356.1
AK296482 mRNA Translation: BAG59122.1
AK304375 mRNA Translation: BAG65213.1
DQ667174 Genomic DNA Translation: ABG25919.1
AL359504 Genomic DNA No translation available.
AL450063 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73248.1
BC016285 mRNA Translation: AAH16285.1
BC035058 mRNA Translation: AAH35058.1
AY927364 mRNA Translation: AAX19487.1
AY927365 mRNA Translation: AAX19488.1
AY927366 mRNA Translation: AAX19489.1
AY927367 mRNA Translation: AAX19490.1
AY927368 mRNA Translation: AAX19491.1
AF538872 Genomic DNA Translation: AAN16454.1
CCDSiCCDS55609.1 [P22694-9]
CCDS55610.1 [P22694-7]
CCDS55611.1 [P22694-10]
CCDS691.1 [P22694-1]
CCDS692.1 [P22694-8]
CCDS693.1 [P22694-2]
CCDS72813.1 [P22694-3]
CCDS72815.1 [P22694-6]
PIRiA34724 OKHUCB
RefSeqiNP_001229786.1, NM_001242857.2 [P22694-9]
NP_001229787.1, NM_001242858.2 [P22694-3]
NP_001229788.1, NM_001242859.2 [P22694-7]
NP_001229789.1, NM_001242860.2 [P22694-6]
NP_001229790.1, NM_001242861.2 [P22694-10]
NP_001229791.1, NM_001242862.2
NP_001287844.1, NM_001300915.1
NP_001287845.1, NM_001300916.1
NP_001287846.1, NM_001300917.1
NP_002722.1, NM_002731.3 [P22694-1]
NP_891993.1, NM_182948.3 [P22694-2]
NP_997461.1, NM_207578.2 [P22694-8]
XP_005271076.1, XM_005271019.1 [P22694-4]
XP_006710821.1, XM_006710758.1 [P22694-5]
UniGeneiHs.487325

Genome annotation databases

EnsembliENST00000370682; ENSP00000359716; ENSG00000142875 [P22694-7]
ENST00000370685; ENSP00000359719; ENSG00000142875 [P22694-2]
ENST00000370688; ENSP00000359722; ENSG00000142875 [P22694-8]
ENST00000370689; ENSP00000359723; ENSG00000142875 [P22694-1]
ENST00000394839; ENSP00000378315; ENSG00000142875 [P22694-10]
ENST00000446538; ENSP00000401252; ENSG00000142875 [P22694-9]
ENST00000610703; ENSP00000481980; ENSG00000142875 [P22694-3]
ENST00000614872; ENSP00000479722; ENSG00000142875 [P22694-6]
GeneIDi5567
KEGGihsa:5567
UCSCiuc001dji.4 human [P22694-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34181 mRNA Translation: AAA60170.1
BX537705 mRNA Translation: CAD97818.1
BX641026 mRNA Translation: CAE46017.1
AB209189 mRNA Translation: BAD92426.1 Sequence problems.
CR936631 mRNA Translation: CAI56774.1
AK091420 mRNA Translation: BAG52356.1
AK296482 mRNA Translation: BAG59122.1
AK304375 mRNA Translation: BAG65213.1
DQ667174 Genomic DNA Translation: ABG25919.1
AL359504 Genomic DNA No translation available.
AL450063 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73248.1
BC016285 mRNA Translation: AAH16285.1
BC035058 mRNA Translation: AAH35058.1
AY927364 mRNA Translation: AAX19487.1
AY927365 mRNA Translation: AAX19488.1
AY927366 mRNA Translation: AAX19489.1
AY927367 mRNA Translation: AAX19490.1
AY927368 mRNA Translation: AAX19491.1
AF538872 Genomic DNA Translation: AAN16454.1
CCDSiCCDS55609.1 [P22694-9]
CCDS55610.1 [P22694-7]
CCDS55611.1 [P22694-10]
CCDS691.1 [P22694-1]
CCDS692.1 [P22694-8]
CCDS693.1 [P22694-2]
CCDS72813.1 [P22694-3]
CCDS72815.1 [P22694-6]
PIRiA34724 OKHUCB
RefSeqiNP_001229786.1, NM_001242857.2 [P22694-9]
NP_001229787.1, NM_001242858.2 [P22694-3]
NP_001229788.1, NM_001242859.2 [P22694-7]
NP_001229789.1, NM_001242860.2 [P22694-6]
NP_001229790.1, NM_001242861.2 [P22694-10]
NP_001229791.1, NM_001242862.2
NP_001287844.1, NM_001300915.1
NP_001287845.1, NM_001300916.1
NP_001287846.1, NM_001300917.1
NP_002722.1, NM_002731.3 [P22694-1]
NP_891993.1, NM_182948.3 [P22694-2]
NP_997461.1, NM_207578.2 [P22694-8]
XP_005271076.1, XM_005271019.1 [P22694-4]
XP_006710821.1, XM_006710758.1 [P22694-5]
UniGeneiHs.487325

3D structure databases

ProteinModelPortaliP22694
SMRiP22694
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111554, 90 interactors
IntActiP22694, 46 interactors
MINTiP22694
STRINGi9606.ENSP00000359719

Chemistry databases

BindingDBiP22694
ChEMBLiCHEMBL2918
DrugBankiDB02482 Phosphonothreonine
GuidetoPHARMACOLOGYi1477

PTM databases

iPTMnetiP22694
PhosphoSitePlusiP22694
SwissPalmiP22694

Polymorphism and mutation databases

BioMutaiPRKACB
DMDMi125210

Proteomic databases

EPDiP22694
MaxQBiP22694
PaxDbiP22694
PeptideAtlasiP22694
PRIDEiP22694
ProteomicsDBi54019
54020 [P22694-2]
54021 [P22694-3]
54022 [P22694-4]
54023 [P22694-5]
54024 [P22694-6]
54025 [P22694-7]
54026 [P22694-8]
54027 [P22694-9]

Protocols and materials databases

DNASUi5567
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370682; ENSP00000359716; ENSG00000142875 [P22694-7]
ENST00000370685; ENSP00000359719; ENSG00000142875 [P22694-2]
ENST00000370688; ENSP00000359722; ENSG00000142875 [P22694-8]
ENST00000370689; ENSP00000359723; ENSG00000142875 [P22694-1]
ENST00000394839; ENSP00000378315; ENSG00000142875 [P22694-10]
ENST00000446538; ENSP00000401252; ENSG00000142875 [P22694-9]
ENST00000610703; ENSP00000481980; ENSG00000142875 [P22694-3]
ENST00000614872; ENSP00000479722; ENSG00000142875 [P22694-6]
GeneIDi5567
KEGGihsa:5567
UCSCiuc001dji.4 human [P22694-1]

Organism-specific databases

CTDi5567
DisGeNETi5567
EuPathDBiHostDB:ENSG00000142875.19
GeneCardsiPRKACB
HGNCiHGNC:9381 PRKACB
HPAiCAB010363
HPA029754
HPA071185
MIMi176892 gene
neXtProtiNX_P22694
OpenTargetsiENSG00000142875
PharmGKBiPA33749
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0616 Eukaryota
ENOG410XPQQ LUCA
GeneTreeiENSGT00810000125385
HOGENOMiHOG000233033
HOVERGENiHBG108317
InParanoidiP22694
KOiK04345
OMAiLFMIMDY
OrthoDBiEOG091G10O8
PhylomeDBiP22694
TreeFamiTF313399

Enzyme and pathway databases

BRENDAi2.7.11.11 2681
ReactomeiR-HSA-111931 PKA-mediated phosphorylation of CREB
R-HSA-163358 PKA-mediated phosphorylation of key metabolic factors
R-HSA-163560 Triglyceride catabolism
R-HSA-163615 PKA activation
R-HSA-164378 PKA activation in glucagon signalling
R-HSA-180024 DARPP-32 events
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392517 Rap1 signalling
R-HSA-422356 Regulation of insulin secretion
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-442720 CREB phosphorylation through the activation of Adenylate Cyclase
R-HSA-5610780 Degradation of GLI1 by the proteasome
R-HSA-5610783 Degradation of GLI2 by the proteasome
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome
R-HSA-5610787 Hedgehog 'off' state
R-HSA-5621575 CD209 (DC-SIGN) signaling
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-70171 Glycolysis
R-HSA-8853659 RET signaling
R-HSA-8963896 HDL assembly
R-HSA-9010642 ROBO receptors bind AKAP5
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
SABIO-RKiP22694
SignaLinkiP22694
SIGNORiP22694

Miscellaneous databases

ChiTaRSiPRKACB human
GeneWikiiPRKACB
GenomeRNAii5567
PROiPR:P22694
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000142875 Expressed in 242 organ(s), highest expression level in caudate nucleus
ExpressionAtlasiP22694 baseline and differential
GenevisibleiP22694 HS

Family and domain databases

InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR039811 cAMP/cGMP-dep_PK
IPR011009 Kinase-like_dom_sf
IPR039083 PKA_C-beta
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24353 PTHR24353, 1 hit
PTHR24353:SF116 PTHR24353:SF116, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKAPCB_HUMAN
AccessioniPrimary (citable) accession number: P22694
Secondary accession number(s): B1APG4
, B4DKB0, B4E2Q1, Q14VH1, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0, Q96B09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 200 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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