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UniProtKB - P22694 (KAPCB_HUMAN)

Entry version 216 (10 Feb 2021)
Sequence version 2 (23 Jan 2007)
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Protein

cAMP-dependent protein kinase catalytic subunit beta

Gene

PRKACB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:12420224, PubMed:21423175). Phosphorylates GPKOW which regulates its ability to bind RNA (PubMed:21880142).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by cAMP.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei73ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei167Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi50 – 58ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, cAMP, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.11.11, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P22694

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-111931, PKA-mediated phosphorylation of CREB
R-HSA-163358, PKA-mediated phosphorylation of key metabolic factors
R-HSA-163560, Triglyceride catabolism
R-HSA-163615, PKA activation
R-HSA-164378, PKA activation in glucagon signalling
R-HSA-180024, DARPP-32 events
R-HSA-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392517, Rap1 signalling
R-HSA-422356, Regulation of insulin secretion
R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-4420097, VEGFA-VEGFR2 Pathway
R-HSA-442720, CREB1 phosphorylation through the activation of Adenylate Cyclase
R-HSA-5610780, Degradation of GLI1 by the proteasome
R-HSA-5610783, Degradation of GLI2 by the proteasome
R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome
R-HSA-5610787, Hedgehog 'off' state
R-HSA-5621575, CD209 (DC-SIGN) signaling
R-HSA-5687128, MAPK6/MAPK4 signaling
R-HSA-8853659, RET signaling
R-HSA-8963896, HDL assembly
R-HSA-9010642, ROBO receptors bind AKAP5
R-HSA-9634600, Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production
R-HSA-9664323, FCGR3A-mediated IL10 synthesis
R-HSA-983231, Factors involved in megakaryocyte development and platelet production

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P22694

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P22694

SIGNOR Signaling Network Open Resource

More...SIGNORi		P22694

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
cAMP-dependent protein kinase catalytic subunit beta (EC:2.7.11.11)
Short name:
PKA C-beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRKACB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9381, PRKACB

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		176892, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P22694

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000142875.19

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		5567

Open Targets

More...OpenTargetsi		ENSG00000142875

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33749

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P22694, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2918

Drug and drug target database

More...DrugBanki		DB12010, Fostamatinib
DB02482, Phosphonothreonine

DrugCentral

More...DrugCentrali		P22694

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1477

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PRKACB

Domain mapping of disease mutations (DMDM)

More...DMDMi		125210

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000860602 – 351cAMP-dependent protein kinase catalytic subunit betaAdd BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine1 Publication1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei3Deamidated asparagineBy similarity1
Modified residuei11PhosphoserineBy similarity1
Modified residuei69PhosphotyrosineBy similarity1
Modified residuei140PhosphoserineBy similarity1
Modified residuei198PhosphothreonineBy similarity1
Modified residuei322PhosphoserineBy similarity1
Modified residuei331PhosphotyrosineBy similarity1
Modified residuei339PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively.By similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P22694

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P22694

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P22694

MaxQB - The MaxQuant DataBase

More...MaxQBi		P22694

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P22694

PeptideAtlas

More...PeptideAtlasi		P22694

PRoteomics IDEntifications database

More...PRIDEi		P22694

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		3296
54019 [P22694-1]
54020 [P22694-2]
54021 [P22694-3]
54022 [P22694-4]
54023 [P22694-5]
54024 [P22694-6]
54025 [P22694-7]
54026 [P22694-8]
54027 [P22694-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P22694

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P22694

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P22694

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P22694

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000142875, Expressed in caudate nucleus and 254 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P22694, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P22694, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000142875, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits (By similarity). The cAMP-dependent protein kinase catalytic subunit binds PJA2 (PubMed:21423175).

Interacts with GPKOW (PubMed:21880142).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111554, 104 interactors

Protein interaction database and analysis system

More...IntActi		P22694, 73 interactors

Molecular INTeraction database

More...MINTi		P22694

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000359719

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P22694

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P22694, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P22694

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini44 – 298Protein kinasePROSITE-ProRule annotationAdd BLAST255
Domaini299 – 351AGC-kinase C-terminalPROSITE-ProRule annotationAdd BLAST53

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0616, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161169

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000288_63_5_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P22694

Identification of Orthologs from Complete Genome Data

More...OMAi		SSLFDHY

Database of Orthologous Groups

More...OrthoDBi		963519at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P22694

TreeFam database of animal gene trees

More...TreeFami		TF313399

Family and domain databases

Conserved Domains Database

More...CDDi		cd14209, STKc_PKA, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000961, AGC-kinase_C
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
IPR044109, STKc_PKA

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00133, S_TK_X, 1 hit
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51285, AGC_KINASE_CTER, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (10+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 10 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 10 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P22694-1) [UniParc]FASTAAdd to basket
Also known as: Beta1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGNAATAKKG SEVESVKEFL AKAKEDFLKK WENPTQNNAG LEDFERKKTL 
        60         70         80         90        100
GTGSFGRVML VKHKATEQYY AMKILDKQKV VKLKQIEHTL NEKRILQAVN 
       110        120        130        140        150
FPFLVRLEYA FKDNSNLYMV MEYVPGGEMF SHLRRIGRFS EPHARFYAAQ 
       160        170        180        190        200
IVLTFEYLHS LDLIYRDLKP ENLLIDHQGY IQVTDFGFAK RVKGRTWTLC 
       210        220        230        240        250
GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAAGYPPFF ADQPIQIYEK 
       260        270        280        290        300
IVSGKVRFPS HFSSDLKDLL RNLLQVDLTK RFGNLKNGVS DIKTHKWFAT 
       310        320        330        340        350
TDWIAIYQRK VEAPFIPKFR GSGDTSNFDD YEEEDIRVSI TEKCAKEFGE 

F
Length:351
Mass (Da):40,623
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5C7443FBBA1C9BEC
GO
Isoform 2 (identifier: P22694-2) [UniParc]FASTAAdd to basket
Also known as: Beta2

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MGNAATAKKGSEVESV → MAAYREPPCN...EHTALWDRSM

Show »
Length:398
Mass (Da):46,236
Checksum:i49EFAF3E426468FC
GO
Isoform 3 (identifier: P22694-3) [UniParc]FASTAAdd to basket
Also known as: Beta3

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: Missing.
     13-16: VESV → MGLL

Note: Incomplete sequence.Curated
Show »
Length:339
Mass (Da):39,477
Checksum:iAD0D54B6EEB01501
GO
Isoform 4 (identifier: P22694-4) [UniParc]FASTAAdd to basket
Also known as: Beta4

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.
     14-14: E → M

Note: Incomplete sequence.Curated
Show »
Length:338
Mass (Da):39,379
Checksum:iCFB30E746FD025F5
GO
Isoform 5 (identifier: P22694-5) [UniParc]FASTAAdd to basket
Also known as: Beta4ab

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MGNAATAKKGSEVE → MSARKSSDASACSSSEI

Note: Incomplete sequence.Curated
Show »
Length:354
Mass (Da):40,947
Checksum:i7BB4E4E199E5B0B4
GO
Isoform 6 (identifier: P22694-6) [UniParc]FASTAAdd to basket
Also known as: Beta4abc

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MGNAATAKKGSEVES → MSARKSSDASACSSSEISDSF

Show »
Length:357
Mass (Da):41,296
Checksum:iFC923359146B9466
GO
Isoform 7 (identifier: P22694-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MGNAATAKKGSEVE → MGLSRKSSDASACSSSEI

Show »
Length:355
Mass (Da):41,046
Checksum:i02D5CA2B459BDDF1
GO
Isoform 8 (identifier: P22694-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     256-257: VR → NF
     258-351: Missing.

Show »
Length:257
Mass (Da):29,696
Checksum:i38FCBB18E1BF2761
GO
Isoform 9 (identifier: P22694-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MGNAATAKKGSEVES → MGLSRKSSDASACSSSEISDSF

Show »
Length:358
Mass (Da):41,395
Checksum:iB5E2A85075455EBA
GO
Isoform 10 (identifier: P22694-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MGNAATAKKGSEVE → MSARKSSDASACSSSEI
     79-111: Missing.

Show »
Length:321
Mass (Da):36,979
Checksum:i7FF5EB27D1706E88
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WVC4A0A087WVC4_HUMAN
cAMP-dependent protein kinase
PRKACB
338Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MS54A0A0A0MS54_HUMAN
cAMP-dependent protein kinase
PRKACB
357Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1APF9B1APF9_HUMAN
cAMP-dependent protein kinase catal...
PRKACB
245Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1APG3B1APG3_HUMAN
cAMP-dependent protein kinase catal...
PRKACB
264Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1APF7B1APF7_HUMAN
cAMP-dependent protein kinase catal...
PRKACB
186Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1APF8B1APF8_HUMAN
cAMP-dependent protein kinase catal...
PRKACB
214Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1APG0B1APG0_HUMAN
cAMP-dependent protein kinase catal...
PRKACB
206Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1APG1B1APG1_HUMAN
cAMP-dependent protein kinase catal...
PRKACB
197Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1APG2B1APG2_HUMAN
cAMP-dependent protein kinase catal...
PRKACB
209Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92426 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti80V → G in CAI56774 (Ref. 3) Curated1
Sequence conflicti159H → N in AAH35058 (PubMed:15489334).Curated1
Sequence conflicti163L → I in AAH35058 (PubMed:15489334).Curated1
Sequence conflicti233A → V in CAI56774 (Ref. 3) Curated1
Sequence conflicti261H → N in AAH35058 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_040594106R → Q1 PublicationCorresponds to variant dbSNP:rs36117118Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0173641 – 16MGNAA…EVESV → MAAYREPPCNQYTGTTTALQ KLEGFASRLFHRHSKGTAHD QKTALENDSLHFSEHTALWD RSM in isoform 2. 2 PublicationsAdd BLAST16
Alternative sequenceiVSP_0173651 – 15MGNAA…SEVES → MSARKSSDASACSSSEISDS F in isoform 6. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_0433721 – 15MGNAA…SEVES → MGLSRKSSDASACSSSEISD SF in isoform 9. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_0173661 – 14MGNAA…GSEVE → MSARKSSDASACSSSEI in isoform 5 and isoform 10. 2 PublicationsAdd BLAST14
Alternative sequenceiVSP_0173671 – 14MGNAA…GSEVE → MGLSRKSSDASACSSSEI in isoform 7. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_0173681 – 13Missing in isoform 4. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_0173691 – 12Missing in isoform 3. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_01737013 – 16VESV → MGLL in isoform 3. 2 Publications4
Alternative sequenceiVSP_01737114E → M in isoform 4. 1 Publication1
Alternative sequenceiVSP_04623879 – 111Missing in isoform 10. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_036556256 – 257VR → NF in isoform 8. 1 Publication2
Alternative sequenceiVSP_036557258 – 351Missing in isoform 8. 1 PublicationAdd BLAST94

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M34181 mRNA Translation: AAA60170.1
BX537705 mRNA Translation: CAD97818.1
BX641026 mRNA Translation: CAE46017.1
AB209189 mRNA Translation: BAD92426.1 Sequence problems.
CR936631 mRNA Translation: CAI56774.1
AK091420 mRNA Translation: BAG52356.1
AK296482 mRNA Translation: BAG59122.1
AK304375 mRNA Translation: BAG65213.1
DQ667174 Genomic DNA Translation: ABG25919.1
AL359504 Genomic DNA No translation available.
AL450063 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73248.1
BC016285 mRNA Translation: AAH16285.1
BC035058 mRNA Translation: AAH35058.1
AY927364 mRNA Translation: AAX19487.1
AY927365 mRNA Translation: AAX19488.1
AY927366 mRNA Translation: AAX19489.1
AY927367 mRNA Translation: AAX19490.1
AY927368 mRNA Translation: AAX19491.1
AF538872 Genomic DNA Translation: AAN16454.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS55609.1 [P22694-9]
CCDS55610.1 [P22694-7]
CCDS55611.1 [P22694-10]
CCDS691.1 [P22694-1]
CCDS692.1 [P22694-8]
CCDS693.1 [P22694-2]
CCDS72813.1 [P22694-3]
CCDS72815.1 [P22694-6]

Protein sequence database of the Protein Information Resource

More...PIRi		A34724, OKHUCB

NCBI Reference Sequences

More...RefSeqi		NP_001229786.1, NM_001242857.2 [P22694-9]
NP_001229787.1, NM_001242858.2 [P22694-3]
NP_001229788.1, NM_001242859.2 [P22694-7]
NP_001229789.1, NM_001242860.2 [P22694-6]
NP_001229790.1, NM_001242861.2 [P22694-10]
NP_001229791.1, NM_001242862.2
NP_001287844.1, NM_001300915.1
NP_001287845.1, NM_001300916.1
NP_001287846.1, NM_001300917.1
NP_002722.1, NM_002731.3 [P22694-1]
NP_891993.1, NM_182948.3 [P22694-2]
NP_997461.1, NM_207578.2 [P22694-8]
XP_005271076.1, XM_005271019.1
XP_006710821.1, XM_006710758.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000370682; ENSP00000359716; ENSG00000142875 [P22694-7]
ENST00000370685; ENSP00000359719; ENSG00000142875 [P22694-2]
ENST00000370688; ENSP00000359722; ENSG00000142875 [P22694-8]
ENST00000370689; ENSP00000359723; ENSG00000142875 [P22694-1]
ENST00000394839; ENSP00000378315; ENSG00000142875 [P22694-10]
ENST00000446538; ENSP00000401252; ENSG00000142875 [P22694-9]
ENST00000610703; ENSP00000481980; ENSG00000142875 [P22694-3]
ENST00000614872; ENSP00000479722; ENSG00000142875 [P22694-6]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5567

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5567

UCSC genome browser

More...UCSCi		uc001dji.4, human [P22694-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34181 mRNA Translation: AAA60170.1
BX537705 mRNA Translation: CAD97818.1
BX641026 mRNA Translation: CAE46017.1
AB209189 mRNA Translation: BAD92426.1 Sequence problems.
CR936631 mRNA Translation: CAI56774.1
AK091420 mRNA Translation: BAG52356.1
AK296482 mRNA Translation: BAG59122.1
AK304375 mRNA Translation: BAG65213.1
DQ667174 Genomic DNA Translation: ABG25919.1
AL359504 Genomic DNA No translation available.
AL450063 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73248.1
BC016285 mRNA Translation: AAH16285.1
BC035058 mRNA Translation: AAH35058.1
AY927364 mRNA Translation: AAX19487.1
AY927365 mRNA Translation: AAX19488.1
AY927366 mRNA Translation: AAX19489.1
AY927367 mRNA Translation: AAX19490.1
AY927368 mRNA Translation: AAX19491.1
AF538872 Genomic DNA Translation: AAN16454.1
CCDSiCCDS55609.1 [P22694-9]
CCDS55610.1 [P22694-7]
CCDS55611.1 [P22694-10]
CCDS691.1 [P22694-1]
CCDS692.1 [P22694-8]
CCDS693.1 [P22694-2]
CCDS72813.1 [P22694-3]
CCDS72815.1 [P22694-6]
PIRiA34724, OKHUCB
RefSeqiNP_001229786.1, NM_001242857.2 [P22694-9]
NP_001229787.1, NM_001242858.2 [P22694-3]
NP_001229788.1, NM_001242859.2 [P22694-7]
NP_001229789.1, NM_001242860.2 [P22694-6]
NP_001229790.1, NM_001242861.2 [P22694-10]
NP_001229791.1, NM_001242862.2
NP_001287844.1, NM_001300915.1
NP_001287845.1, NM_001300916.1
NP_001287846.1, NM_001300917.1
NP_002722.1, NM_002731.3 [P22694-1]
NP_891993.1, NM_182948.3 [P22694-2]
NP_997461.1, NM_207578.2 [P22694-8]
XP_005271076.1, XM_005271019.1
XP_006710821.1, XM_006710758.1

3D structure databases

SMRiP22694
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi111554, 104 interactors
IntActiP22694, 73 interactors
MINTiP22694
STRINGi9606.ENSP00000359719

Chemistry databases

BindingDBiP22694
ChEMBLiCHEMBL2918
DrugBankiDB12010, Fostamatinib
DB02482, Phosphonothreonine
DrugCentraliP22694
GuidetoPHARMACOLOGYi1477

PTM databases

iPTMnetiP22694
MetOSiteiP22694
PhosphoSitePlusiP22694
SwissPalmiP22694

Genetic variation databases

BioMutaiPRKACB
DMDMi125210

Proteomic databases

EPDiP22694
jPOSTiP22694
MassIVEiP22694
MaxQBiP22694
PaxDbiP22694
PeptideAtlasiP22694
PRIDEiP22694
ProteomicsDBi3296
54019 [P22694-1]
54020 [P22694-2]
54021 [P22694-3]
54022 [P22694-4]
54023 [P22694-5]
54024 [P22694-6]
54025 [P22694-7]
54026 [P22694-8]
54027 [P22694-9]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4160, 384 antibodies

The DNASU plasmid repository

More...DNASUi		5567

Genome annotation databases

EnsembliENST00000370682; ENSP00000359716; ENSG00000142875 [P22694-7]
ENST00000370685; ENSP00000359719; ENSG00000142875 [P22694-2]
ENST00000370688; ENSP00000359722; ENSG00000142875 [P22694-8]
ENST00000370689; ENSP00000359723; ENSG00000142875 [P22694-1]
ENST00000394839; ENSP00000378315; ENSG00000142875 [P22694-10]
ENST00000446538; ENSP00000401252; ENSG00000142875 [P22694-9]
ENST00000610703; ENSP00000481980; ENSG00000142875 [P22694-3]
ENST00000614872; ENSP00000479722; ENSG00000142875 [P22694-6]
GeneIDi5567
KEGGihsa:5567
UCSCiuc001dji.4, human [P22694-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5567
DisGeNETi5567

GeneCards: human genes, protein and diseases

More...GeneCardsi		PRKACB
HGNCiHGNC:9381, PRKACB
HPAiENSG00000142875, Tissue enhanced (brain)
MIMi176892, gene
neXtProtiNX_P22694
OpenTargetsiENSG00000142875
PharmGKBiPA33749
VEuPathDBiHostDB:ENSG00000142875.19

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0616, Eukaryota
GeneTreeiENSGT00940000161169
HOGENOMiCLU_000288_63_5_1
InParanoidiP22694
OMAiSSLFDHY
OrthoDBi963519at2759
PhylomeDBiP22694
TreeFamiTF313399

Enzyme and pathway databases

BRENDAi2.7.11.11, 2681
PathwayCommonsiP22694
ReactomeiR-HSA-111931, PKA-mediated phosphorylation of CREB
R-HSA-163358, PKA-mediated phosphorylation of key metabolic factors
R-HSA-163560, Triglyceride catabolism
R-HSA-163615, PKA activation
R-HSA-164378, PKA activation in glucagon signalling
R-HSA-180024, DARPP-32 events
R-HSA-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392517, Rap1 signalling
R-HSA-422356, Regulation of insulin secretion
R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-4420097, VEGFA-VEGFR2 Pathway
R-HSA-442720, CREB1 phosphorylation through the activation of Adenylate Cyclase
R-HSA-5610780, Degradation of GLI1 by the proteasome
R-HSA-5610783, Degradation of GLI2 by the proteasome
R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome
R-HSA-5610787, Hedgehog 'off' state
R-HSA-5621575, CD209 (DC-SIGN) signaling
R-HSA-5687128, MAPK6/MAPK4 signaling
R-HSA-8853659, RET signaling
R-HSA-8963896, HDL assembly
R-HSA-9010642, ROBO receptors bind AKAP5
R-HSA-9634600, Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production
R-HSA-9664323, FCGR3A-mediated IL10 synthesis
R-HSA-983231, Factors involved in megakaryocyte development and platelet production
SABIO-RKiP22694
SignaLinkiP22694
SIGNORiP22694

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5567, 7 hits in 901 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PRKACB, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PRKACB

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5567
PharosiP22694, Tchem

Protein Ontology

More...PROi		PR:P22694
RNActiP22694, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000142875, Expressed in caudate nucleus and 254 other tissues
ExpressionAtlasiP22694, baseline and differential
GenevisibleiP22694, HS

Family and domain databases

CDDicd14209, STKc_PKA, 1 hit
InterProiView protein in InterPro
IPR000961, AGC-kinase_C
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
IPR044109, STKc_PKA
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00133, S_TK_X, 1 hit
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285, AGC_KINASE_CTER, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKAPCB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22694
Secondary accession number(s): B1APG4
, B4DKB0, B4E2Q1, Q14VH1, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0, Q96B09
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: January 23, 2007
Last modified: February 10, 2021
This is version 216 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human variants curated from literature reports
    Index of human variants curated from literature reports
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with genetic variants
    List of human entries with genetic variants
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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