IGFBP4

Functionⁱ

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

GO - Molecular functionⁱ

insulin-like growth factor I binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
insulin-like growth factor II binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
signaling receptor binding
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 24431302

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 1377672
cellular protein metabolic process Source: Reactome
DNA metabolic process
Source: ProtInc
Traceable author statementⁱ
- 1377672
inflammatory response Source: Ensembl
negative regulation of canonical Wnt signaling pathway
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 24431302
positive regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
positive regulation of MAPK cascade Source: Ensembl
post-translational protein modification Source: Reactome
regulation of cell growth Source: Ensembl
regulation of glucose metabolic process Source: Ensembl
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 1377672
skeletal system development
Source: ProtInc
Traceable author statementⁱ
- 1377672
type B pancreatic cell proliferation Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Growth factor binding

Molecular function

Growth factor binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:ENSG00000141753-MONOMER
Reactomeⁱ	R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I31.952

MEROPSⁱ

I31.952

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Insulin-like growth factor-binding protein 4 Short name: IBP-4 Short name: IGF-binding protein 4 Short name: IGFBP-4
Gene namesⁱ	Name:IGFBP4 Synonyms:IBP4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000141753.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5473 IGFBP4
MIMⁱ	146733 gene
neXtProtⁱ	NX_P22692

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3487
Open Targets More...OpenTargetsⁱ	ENSG00000141753
PharmGKBⁱ	PA29706

Chemistry databases

ChEMBLⁱ	CHEMBL2310

ChEMBLⁱ

CHEMBL2310

Polymorphism and mutation databases

BioMutaⁱ	IGFBP4
DMDMⁱ	124065

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	3 PublicationsAdd BLAST		21
ChainⁱPRO_0000014382	22 – 258	Insulin-like growth factor-binding protein 4Add BLAST		237

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	27 ↔ 53	2 Publications
Disulfide bondⁱ	30 ↔ 55	2 Publications
Disulfide bondⁱ	38 ↔ 59	2 Publications
Disulfide bondⁱ	44 ↔ 56	2 Publications
Disulfide bondⁱ	67 ↔ 80	2 Publications
Disulfide bondⁱ	74 ↔ 100	2 Publications
Glycosylationⁱ	125	N-linked (GlcNAc...) asparagine1 PublicationSequence analysis	1
Disulfide bondⁱ	131 ↔ 138	PROSITE-ProRule annotation2 Publications
Disulfide bondⁱ	174 ↔ 204	2 Publications
Disulfide bondⁱ	215 ↔ 226	2 Publications
Disulfide bondⁱ	228 ↔ 249	2 Publications
Modified residueⁱ	255	Phosphoserine; by FAM20C1 Publication	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	P22692
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P22692
PaxDbⁱ	P22692
PeptideAtlas More...PeptideAtlasⁱ	P22692
PRIDEⁱ	P22692
ProteomicsDBⁱ	54018

PTM databases

iPTMnetⁱ	P22692
PhosphoSitePlusⁱ	P22692

Miscellaneous databases

PMAP-CutDBⁱ	P22692

PMAP-CutDBⁱ

P22692

Expressionⁱ

Inductionⁱ

By forskolin and N6,O2'dibutyryl adenosine 3',5'-cyclic monophosphate, but not by 1,9 dideoxyforskolin.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000141753 Expressed in 215 organ(s), highest expression level in decidua
CleanExⁱ	HS_IGFBP4
ExpressionAtlasⁱ	P22692 baseline and differential
Genevisibleⁱ	P22692 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA066240

HPAⁱ

HPA066240

Interactionⁱ

Subunit structureⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
IGF1	P05019	7	EBI-2831948,EBI-7902275

With

Entry

#Exp.

IntAct

Notes

IGF1

P05019

7

EBI-2831948,EBI-7902275

GO - Molecular functionⁱ

insulin-like growth factor I binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
insulin-like growth factor II binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
signaling receptor binding
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 24431302

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109708, 9 interactors
Database of interacting proteins More...DIPⁱ	DIP-48432N
IntActⁱ	P22692, 8 interactors
Molecular INTeraction database More...MINTⁱ	P22692
STRINGⁱ	9606.ENSP00000269593

Chemistry databases

BindingDBⁱ

P22692

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	32 – 36	Combined sources	5
Beta strandⁱ	45 – 49	Combined sources	5
Beta strandⁱ	56 – 59	Combined sources	4
Beta strandⁱ	69 – 71	Combined sources	3
Beta strandⁱ	78 – 81	Combined sources	4
Helixⁱ	89 – 94	Combined sources	6
Beta strandⁱ	98 – 102	Combined sources	5
Helixⁱ	103 – 110	Combined sources	8
Helixⁱ	173 – 186	Combined sources	14
Helixⁱ	195 – 198	Combined sources	4
Beta strandⁱ	208 – 210	Combined sources	3
Beta strandⁱ	212 – 215	Combined sources	4
Beta strandⁱ	226 – 229	Combined sources	4
Turnⁱ	231 – 233	Combined sources	3
Helixⁱ	244 – 246	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P22692
SMRⁱ	P22692
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P22692

EvolutionaryTraceⁱ

P22692

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	23 – 103	IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST		81
Domainⁱ	171 – 249	Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST		79

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IKZ1 Eukaryota ENOG4111HXV LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074457
HOGENOMⁱ	HOG000253012
HOVERGENⁱ	HBG002631
InParanoidⁱ	P22692
OMAⁱ	KGMPCGV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EIN
PhylomeDBⁱ	P22692
TreeFamⁱ	TF331211

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00191 TY, 1 hit
Gene3Dⁱ	4.10.800.10, 1 hit
InterProⁱ	View protein in InterPro IPR009030 Growth_fac_rcpt_cys_sf IPR022327 IGFBP-4 IPR000867 IGFBP-like IPR009168 IGFBP1-6 IPR022321 IGFBP_1-6_chordata IPR017891 Insulin_GF-bd_Cys-rich_CS IPR000716 Thyroglobulin_1 IPR036857 Thyroglobulin_1_sf
PANTHERⁱ	PTHR11551 PTHR11551, 1 hit PTHR11551:SF7 PTHR11551:SF7, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00219 IGFBP, 1 hit PF00086 Thyroglobulin_1, 1 hit
PRINTSⁱ	PR01976 IGFBPFAMILY PR01980 IGFBPFAMILY4
SMARTⁱ	View protein in SMART SM00121 IB, 1 hit SM00211 TY, 1 hit
SUPFAMⁱ	SSF57184 SSF57184, 1 hit SSF57610 SSF57610, 1 hit
PROSITEⁱ	View protein in PROSITE PS00222 IGFBP_N_1, 1 hit PS51323 IGFBP_N_2, 1 hit PS00484 THYROGLOBULIN_1_1, 1 hit PS51162 THYROGLOBULIN_1_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P22692-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPLCLVAAL LLAAGPGPSL GDEAIHCPPC SEEKLARCRP PVGCEELVRE 
        60         70         80         90        100
PGCGCCATCA LGLGMPCGVY TPRCGSGLRC YPPRGVEKPL HTLMHGQGVC 
       110        120        130        140        150
MELAEIEAIQ ESLQPSDKDE GDHPNNSFSP CSAHDRRCLQ KHFAKIRDRS 
       160        170        180        190        200
TSGGKMKVNG APREDARPVP QGSCQSELHR ALERLAASQS RTHEDLYIIP 
       210        220        230        240        250
IPNCDRNGNF HPKQCHPALD GQRGKCWCVD RKTGVKLPGG LEPKGELDCH 

QLADSFRE

Length:258

Mass (Da):27,934

Last modified:March 1, 1992 - v2

Checksum:ⁱ5E8F4638D99F0A94

GO

Isoform 2 (identifier: P22692-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-100: Missing.

« Hide

        10         20         30         40         50
MELAEIEAIQ ESLQPSDKDE GDHPNNSFSP CSAHDRRCLQ KHFAKIRDRS 
        60         70         80         90        100
TSGGKMKVNG APREDARPVP QGSCQSELHR ALERLAASQS RTHEDLYIIP 
       110        120        130        140        150
IPNCDRNGNF HPKQCHPALD GQRGKCWCVD RKTGVKLPGG LEPKGELDCH 

QLADSFRE

Note: No experimental confirmation available.

Show »

Length:158

Mass (Da):17,635

Checksum:ⁱF31375031D835A1E

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	51	P → A in M38177 (PubMed:1707125).Curated	1
Sequence conflictⁱ	51	P → A in AAA62670 (PubMed:9048882).Curated	1
Sequence conflictⁱ	51	P → A AA sequence (PubMed:1709585).Curated	1
Sequence conflictⁱ	160	G → E in AAV38694 (Ref. 7) Curated	1
Sequence conflictⁱ	198	I → F in M38177 (PubMed:1707125).Curated	1
Sequence conflictⁱ	198	I → F in AAA62670 (PubMed:9048882).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_011906	42	V → G. Corresponds to variant dbSNP:rs599199Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_057034	1 – 100	Missing in isoform 2. 1 PublicationAdd BLAST		100

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M38177 mRNA No translation available. M62403 mRNA Translation: AAB06189.1 U20982 Genomic DNA Translation: AAA62670.1 Y12508 Genomic DNA Translation: CAA73110.1 AK304572 mRNA Translation: BAG65363.1 BT019891 mRNA Translation: AAV38694.1 BT019892 mRNA Translation: AAV38695.1 AY442346 Genomic DNA Translation: AAR05443.1 AC018629 Genomic DNA No translation available. CH471152 Genomic DNA Translation: EAW60664.1 BC016041 mRNA Translation: AAH16041.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11367.1 [P22692-1]
PIRⁱ	G01662 B37252
NCBI Reference Sequences More...RefSeqⁱ	NP_001543.2, NM_001552.2 [P22692-1]
UniGeneⁱ	Hs.462998

Genome annotation databases

Ensemblⁱ	ENST00000269593; ENSP00000269593; ENSG00000141753 [P22692-1]
GeneIDⁱ	3487
KEGGⁱ	hsa:3487
UCSC genome browser More...UCSCⁱ	uc002hus.4 human [P22692-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P22692	Insulin-like growth factor binding protein 4, isoform CRA_a		HUMAN		258	UniRef100_P22692
Insulin-like growth factor-binding protein 4		MACMU		258
Insulin-like growth factor binding protein 4		PANTR		258
Uncharacterized protein		CERAT		258
Uncharacterized protein		CHLSB		258
+12

Protein	Similar proteins		Species	Score	Length	Source
P22692	Insulin-like growth factor-binding protein 4		PIG		259	UniRef90_P22692
Insulin-like growth factor-binding protein 4		BOVIN		258
Insulin-like growth factor-binding protein 4		MOUSE		254
Insulin-like growth factor-binding protein 4		RAT		254
Insulin-like growth factor binding protein 4, isoform CRA_a		HUMAN		258
+110

Protein	Similar proteins		Species	Score	Length	Source
P22692	Insulin-like growth factor-binding protein 4		PIG		259	UniRef50_P22692
Insulin-like growth factor-binding protein 4		BOVIN		258
Insulin-like growth factor-binding protein 4		MOUSE		254
Insulin-like growth factor-binding protein 4		RAT		254
Insulin-like growth factor binding protein 4, isoform CRA_a		HUMAN		258
+111

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M38177 mRNA No translation available. M62403 mRNA Translation: AAB06189.1 U20982 Genomic DNA Translation: AAA62670.1 Y12508 Genomic DNA Translation: CAA73110.1 AK304572 mRNA Translation: BAG65363.1 BT019891 mRNA Translation: AAV38694.1 BT019892 mRNA Translation: AAV38695.1 AY442346 Genomic DNA Translation: AAR05443.1 AC018629 Genomic DNA No translation available. CH471152 Genomic DNA Translation: EAW60664.1 BC016041 mRNA Translation: AAH16041.1
CCDSⁱ	CCDS11367.1 [P22692-1]
PIRⁱ	G01662 B37252
RefSeqⁱ	NP_001543.2, NM_001552.2 [P22692-1]
UniGeneⁱ	Hs.462998

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1WQJ	X-ray	1.60	B	24-103	[»]
	2DSP	X-ray	2.50	B	22-113	[»]
	2DSQ	X-ray	2.80	A/B	22-113	[»]
	2DSR	X-ray	2.10	B	24-103	[»]
				G	172-253	[»]
ProteinModelPortalⁱ	P22692
SMRⁱ	P22692
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109708, 9 interactors
DIPⁱ	DIP-48432N
IntActⁱ	P22692, 8 interactors
MINTⁱ	P22692
STRINGⁱ	9606.ENSP00000269593

Chemistry databases

BindingDBⁱ	P22692
ChEMBLⁱ	CHEMBL2310

Protein family/group databases

MEROPSⁱ	I31.952

MEROPSⁱ

I31.952

PTM databases

iPTMnetⁱ	P22692
PhosphoSitePlusⁱ	P22692

Polymorphism and mutation databases

BioMutaⁱ	IGFBP4
DMDMⁱ	124065

Proteomic databases

EPDⁱ	P22692
MaxQBⁱ	P22692
PaxDbⁱ	P22692
PeptideAtlasⁱ	P22692
PRIDEⁱ	P22692
ProteomicsDBⁱ	54018

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3487
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000269593; ENSP00000269593; ENSG00000141753 [P22692-1]
GeneIDⁱ	3487
KEGGⁱ	hsa:3487
UCSCⁱ	uc002hus.4 human [P22692-1]

Organism-specific databases

CTDⁱ	3487
DisGeNETⁱ	3487
EuPathDBⁱ	HostDB:ENSG00000141753.6
GeneCardsⁱ	IGFBP4
HGNCⁱ	HGNC:5473 IGFBP4
HPAⁱ	HPA066240
MIMⁱ	146733 gene
neXtProtⁱ	NX_P22692
OpenTargetsⁱ	ENSG00000141753
PharmGKBⁱ	PA29706
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IKZ1 Eukaryota ENOG4111HXV LUCA
GeneTreeⁱ	ENSGT00550000074457
HOGENOMⁱ	HOG000253012
HOVERGENⁱ	HBG002631
InParanoidⁱ	P22692
OMAⁱ	KGMPCGV
OrthoDBⁱ	EOG091G0EIN
PhylomeDBⁱ	P22692
TreeFamⁱ	TF331211

Enzyme and pathway databases

BioCycⁱ	MetaCyc:ENSG00000141753-MONOMER
Reactomeⁱ	R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275 Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRSⁱ	IGFBP4 human
EvolutionaryTraceⁱ	P22692
GeneWikiⁱ	IGFBP4
GenomeRNAiⁱ	3487
PMAP-CutDBⁱ	P22692
Protein Ontology More...PROⁱ	PR:P22692
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000141753 Expressed in 215 organ(s), highest expression level in decidua
CleanExⁱ	HS_IGFBP4
ExpressionAtlasⁱ	P22692 baseline and differential
Genevisibleⁱ	P22692 HS

Family and domain databases

CDDⁱ	cd00191 TY, 1 hit
Gene3Dⁱ	4.10.800.10, 1 hit
InterProⁱ	View protein in InterPro IPR009030 Growth_fac_rcpt_cys_sf IPR022327 IGFBP-4 IPR000867 IGFBP-like IPR009168 IGFBP1-6 IPR022321 IGFBP_1-6_chordata IPR017891 Insulin_GF-bd_Cys-rich_CS IPR000716 Thyroglobulin_1 IPR036857 Thyroglobulin_1_sf
PANTHERⁱ	PTHR11551 PTHR11551, 1 hit PTHR11551:SF7 PTHR11551:SF7, 1 hit
Pfamⁱ	View protein in Pfam PF00219 IGFBP, 1 hit PF00086 Thyroglobulin_1, 1 hit
PRINTSⁱ	PR01976 IGFBPFAMILY PR01980 IGFBPFAMILY4
SMARTⁱ	View protein in SMART SM00121 IB, 1 hit SM00211 TY, 1 hit
SUPFAMⁱ	SSF57184 SSF57184, 1 hit SSF57610 SSF57610, 1 hit
PROSITEⁱ	View protein in PROSITE PS00222 IGFBP_N_1, 1 hit PS51323 IGFBP_N_2, 1 hit PS00484 THYROGLOBULIN_1_1, 1 hit PS51162 THYROGLOBULIN_1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IBP4_HUMAN
Accessionⁱ	P22692Primary (citable) accession number: P22692 Secondary accession number(s): A0N9W2 , B4E351, Q5U012, Q9UCL6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
	Last sequence update:	March 1, 1992
	Last modified:	November 7, 2018
	This is version 186 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P22692 (IBP4_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Insulin-like growth factor-binding protein 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Endoplasmic reticulum

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ