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Protein

Insulin-like growth factor-binding protein 4

Gene

IGFBP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

GO - Molecular functioni

  • insulin-like growth factor I binding Source: GO_Central
  • insulin-like growth factor II binding Source: GO_Central
  • signaling receptor binding Source: ParkinsonsUK-UCL

GO - Biological processi

Keywordsi

Molecular functionGrowth factor binding

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000141753-MONOMER
ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPSiI31.952

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 4
Short name:
IBP-4
Short name:
IGF-binding protein 4
Short name:
IGFBP-4
Gene namesi
Name:IGFBP4
Synonyms:IBP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000141753.6
HGNCiHGNC:5473 IGFBP4
MIMi146733 gene
neXtProtiNX_P22692

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3487
OpenTargetsiENSG00000141753
PharmGKBiPA29706

Chemistry databases

ChEMBLiCHEMBL2310

Polymorphism and mutation databases

BioMutaiIGFBP4
DMDMi124065

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 213 PublicationsAdd BLAST21
ChainiPRO_000001438222 – 258Insulin-like growth factor-binding protein 4Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 532 Publications
Disulfide bondi30 ↔ 552 Publications
Disulfide bondi38 ↔ 592 Publications
Disulfide bondi44 ↔ 562 Publications
Disulfide bondi67 ↔ 802 Publications
Disulfide bondi74 ↔ 1002 Publications
Glycosylationi125N-linked (GlcNAc...) asparagine1 PublicationSequence analysis1
Disulfide bondi131 ↔ 138PROSITE-ProRule annotation2 Publications
Disulfide bondi174 ↔ 2042 Publications
Disulfide bondi215 ↔ 2262 Publications
Disulfide bondi228 ↔ 2492 Publications
Modified residuei255Phosphoserine; by FAM20C1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP22692
MaxQBiP22692
PaxDbiP22692
PeptideAtlasiP22692
PRIDEiP22692
ProteomicsDBi54018

PTM databases

iPTMnetiP22692
PhosphoSitePlusiP22692

Miscellaneous databases

PMAP-CutDBiP22692

Expressioni

Inductioni

By forskolin and N6,O2'dibutyryl adenosine 3',5'-cyclic monophosphate, but not by 1,9 dideoxyforskolin.1 Publication

Gene expression databases

BgeeiENSG00000141753 Expressed in 215 organ(s), highest expression level in decidua
CleanExiHS_IGFBP4
ExpressionAtlasiP22692 baseline and differential
GenevisibleiP22692 HS

Organism-specific databases

HPAiHPA066240

Interactioni

Subunit structurei

Binds IGF2 more than IGF1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
IGF1P050197EBI-2831948,EBI-7902275

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109708, 9 interactors
DIPiDIP-48432N
IntActiP22692, 8 interactors
MINTiP22692
STRINGi9606.ENSP00000269593

Chemistry databases

BindingDBiP22692

Structurei

Secondary structure

1258
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP22692
SMRiP22692
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22692

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 103IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST81
Domaini171 – 249Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST79

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKZ1 Eukaryota
ENOG4111HXV LUCA
GeneTreeiENSGT00550000074457
HOGENOMiHOG000253012
HOVERGENiHBG002631
InParanoidiP22692
OMAiKGMPCGV
OrthoDBiEOG091G0EIN
PhylomeDBiP22692
TreeFamiTF331211

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR022327 IGFBP-4
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PTHR11551:SF7 PTHR11551:SF7, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01980 IGFBPFAMILY4
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P22692-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLPLCLVAAL LLAAGPGPSL GDEAIHCPPC SEEKLARCRP PVGCEELVRE
60 70 80 90 100
PGCGCCATCA LGLGMPCGVY TPRCGSGLRC YPPRGVEKPL HTLMHGQGVC
110 120 130 140 150
MELAEIEAIQ ESLQPSDKDE GDHPNNSFSP CSAHDRRCLQ KHFAKIRDRS
160 170 180 190 200
TSGGKMKVNG APREDARPVP QGSCQSELHR ALERLAASQS RTHEDLYIIP
210 220 230 240 250
IPNCDRNGNF HPKQCHPALD GQRGKCWCVD RKTGVKLPGG LEPKGELDCH

QLADSFRE
Length:258
Mass (Da):27,934
Last modified:March 1, 1992 - v2
Checksum:i5E8F4638D99F0A94
GO
Isoform 2 (identifier: P22692-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: Missing.

Note: No experimental confirmation available.
Show »
Length:158
Mass (Da):17,635
Checksum:iF31375031D835A1E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51P → A in M38177 (PubMed:1707125).Curated1
Sequence conflicti51P → A in AAA62670 (PubMed:9048882).Curated1
Sequence conflicti51P → A AA sequence (PubMed:1709585).Curated1
Sequence conflicti160G → E in AAV38694 (Ref. 7) Curated1
Sequence conflicti198I → F in M38177 (PubMed:1707125).Curated1
Sequence conflicti198I → F in AAA62670 (PubMed:9048882).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01190642V → G. Corresponds to variant dbSNP:rs599199Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0570341 – 100Missing in isoform 2. 1 PublicationAdd BLAST100

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M38177 mRNA No translation available.
M62403 mRNA Translation: AAB06189.1
U20982 Genomic DNA Translation: AAA62670.1
Y12508 Genomic DNA Translation: CAA73110.1
AK304572 mRNA Translation: BAG65363.1
BT019891 mRNA Translation: AAV38694.1
BT019892 mRNA Translation: AAV38695.1
AY442346 Genomic DNA Translation: AAR05443.1
AC018629 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60664.1
BC016041 mRNA Translation: AAH16041.1
CCDSiCCDS11367.1 [P22692-1]
PIRiG01662 B37252
RefSeqiNP_001543.2, NM_001552.2 [P22692-1]
UniGeneiHs.462998

Genome annotation databases

EnsembliENST00000269593; ENSP00000269593; ENSG00000141753 [P22692-1]
GeneIDi3487
KEGGihsa:3487
UCSCiuc002hus.4 human [P22692-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M38177 mRNA No translation available.
M62403 mRNA Translation: AAB06189.1
U20982 Genomic DNA Translation: AAA62670.1
Y12508 Genomic DNA Translation: CAA73110.1
AK304572 mRNA Translation: BAG65363.1
BT019891 mRNA Translation: AAV38694.1
BT019892 mRNA Translation: AAV38695.1
AY442346 Genomic DNA Translation: AAR05443.1
AC018629 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60664.1
BC016041 mRNA Translation: AAH16041.1
CCDSiCCDS11367.1 [P22692-1]
PIRiG01662 B37252
RefSeqiNP_001543.2, NM_001552.2 [P22692-1]
UniGeneiHs.462998

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WQJX-ray1.60B24-103[»]
2DSPX-ray2.50B22-113[»]
2DSQX-ray2.80A/B22-113[»]
2DSRX-ray2.10B24-103[»]
G172-253[»]
ProteinModelPortaliP22692
SMRiP22692
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109708, 9 interactors
DIPiDIP-48432N
IntActiP22692, 8 interactors
MINTiP22692
STRINGi9606.ENSP00000269593

Chemistry databases

BindingDBiP22692
ChEMBLiCHEMBL2310

Protein family/group databases

MEROPSiI31.952

PTM databases

iPTMnetiP22692
PhosphoSitePlusiP22692

Polymorphism and mutation databases

BioMutaiIGFBP4
DMDMi124065

Proteomic databases

EPDiP22692
MaxQBiP22692
PaxDbiP22692
PeptideAtlasiP22692
PRIDEiP22692
ProteomicsDBi54018

Protocols and materials databases

DNASUi3487
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269593; ENSP00000269593; ENSG00000141753 [P22692-1]
GeneIDi3487
KEGGihsa:3487
UCSCiuc002hus.4 human [P22692-1]

Organism-specific databases

CTDi3487
DisGeNETi3487
EuPathDBiHostDB:ENSG00000141753.6
GeneCardsiIGFBP4
HGNCiHGNC:5473 IGFBP4
HPAiHPA066240
MIMi146733 gene
neXtProtiNX_P22692
OpenTargetsiENSG00000141753
PharmGKBiPA29706
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKZ1 Eukaryota
ENOG4111HXV LUCA
GeneTreeiENSGT00550000074457
HOGENOMiHOG000253012
HOVERGENiHBG002631
InParanoidiP22692
OMAiKGMPCGV
OrthoDBiEOG091G0EIN
PhylomeDBiP22692
TreeFamiTF331211

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000141753-MONOMER
ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRSiIGFBP4 human
EvolutionaryTraceiP22692
GeneWikiiIGFBP4
GenomeRNAii3487
PMAP-CutDBiP22692
PROiPR:P22692
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141753 Expressed in 215 organ(s), highest expression level in decidua
CleanExiHS_IGFBP4
ExpressionAtlasiP22692 baseline and differential
GenevisibleiP22692 HS

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR022327 IGFBP-4
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PTHR11551:SF7 PTHR11551:SF7, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01980 IGFBPFAMILY4
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIBP4_HUMAN
AccessioniPrimary (citable) accession number: P22692
Secondary accession number(s): A0N9W2
, B4E351, Q5U012, Q9UCL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: March 1, 1992
Last modified: November 7, 2018
This is version 186 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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