UniProtKB - P22692 (IBP4_HUMAN)
Protein
Insulin-like growth factor-binding protein 4
Gene
IGFBP4
Organism
Homo sapiens (Human)
Status
Functioni
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
GO - Molecular functioni
- insulin-like growth factor I binding Source: GO_Central
- insulin-like growth factor II binding Source: GO_Central
- signaling receptor binding Source: ParkinsonsUK-UCL
GO - Biological processi
- cellular protein metabolic process Source: Reactome
- inflammatory response Source: Ensembl
- negative regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
- positive regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
- positive regulation of MAPK cascade Source: Ensembl
- post-translational protein modification Source: Reactome
- regulation of cell growth Source: Ensembl
- regulation of glucose metabolic process Source: Ensembl
- regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
- signal transduction Source: ProtInc
- type B pancreatic cell proliferation Source: Ensembl
Keywordsi
Molecular function | Growth factor binding |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000141753-MONOMER |
PathwayCommonsi | P22692 |
Reactomei | R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation |
Protein family/group databases
MEROPSi | I31.952 |
Names & Taxonomyi
Protein namesi | Recommended name: Insulin-like growth factor-binding protein 4Short name: IBP-4 Short name: IGF-binding protein 4 Short name: IGFBP-4 |
Gene namesi | Name:IGFBP4 Synonyms:IBP4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5473, IGFBP4 |
MIMi | 146733, gene |
neXtProti | NX_P22692 |
VEuPathDBi | HostDB:ENSG00000141753.6 |
Subcellular locationi
Extracellular region or secreted
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 3487 |
OpenTargetsi | ENSG00000141753 |
PharmGKBi | PA29706 |
Miscellaneous databases
Pharosi | P22692, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2310 |
DrugBanki | DB01277, Mecasermin |
Genetic variation databases
BioMutai | IGFBP4 |
DMDMi | 124065 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | 3 PublicationsAdd BLAST | 21 | |
ChainiPRO_0000014382 | 22 – 258 | Insulin-like growth factor-binding protein 4Add BLAST | 237 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 27 ↔ 53 | 2 Publications | ||
Disulfide bondi | 30 ↔ 55 | 2 Publications | ||
Disulfide bondi | 38 ↔ 59 | 2 Publications | ||
Disulfide bondi | 44 ↔ 56 | 2 Publications | ||
Disulfide bondi | 67 ↔ 80 | 2 Publications | ||
Disulfide bondi | 74 ↔ 100 | 2 Publications | ||
Glycosylationi | 125 | N-linked (GlcNAc...) asparagine1 PublicationSequence analysis | 1 | |
Disulfide bondi | 131 ↔ 138 | PROSITE-ProRule annotation2 Publications | ||
Disulfide bondi | 174 ↔ 204 | 2 Publications | ||
Disulfide bondi | 215 ↔ 226 | 2 Publications | ||
Disulfide bondi | 228 ↔ 249 | 2 Publications | ||
Modified residuei | 255 | Phosphoserine; by FAM20C1 Publication | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | P22692 |
jPOSTi | P22692 |
MassIVEi | P22692 |
MaxQBi | P22692 |
PaxDbi | P22692 |
PeptideAtlasi | P22692 |
PRIDEi | P22692 |
ProteomicsDBi | 54018 [P22692-1] 5879 |
PTM databases
GlyGeni | P22692, 1 site |
iPTMneti | P22692 |
PhosphoSitePlusi | P22692 |
Expressioni
Inductioni
By forskolin and N6,O2'dibutyryl adenosine 3',5'-cyclic monophosphate, but not by 1,9 dideoxyforskolin.1 Publication
Gene expression databases
Bgeei | ENSG00000141753, Expressed in decidua and 227 other tissues |
ExpressionAtlasi | P22692, baseline and differential |
Genevisiblei | P22692, HS |
Organism-specific databases
HPAi | ENSG00000141753, Tissue enhanced (ovary) |
Interactioni
Subunit structurei
Binds IGF2 more than IGF1.
2 PublicationsBinary interactionsi
Hide detailsP22692
GO - Molecular functioni
- insulin-like growth factor I binding Source: GO_Central
- insulin-like growth factor II binding Source: GO_Central
- signaling receptor binding Source: ParkinsonsUK-UCL
Protein-protein interaction databases
BioGRIDi | 109708, 16 interactors |
DIPi | DIP-48432N |
IntActi | P22692, 23 interactors |
MINTi | P22692 |
STRINGi | 9606.ENSP00000269593 |
Chemistry databases
BindingDBi | P22692 |
Miscellaneous databases
RNActi | P22692, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P22692 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P22692 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 103 | IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST | 81 | |
Domaini | 171 – 249 | Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST | 79 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QTC8, Eukaryota |
GeneTreei | ENSGT00940000159647 |
HOGENOMi | CLU_070833_3_0_1 |
InParanoidi | P22692 |
OMAi | GLCMELA |
PhylomeDBi | P22692 |
TreeFami | TF331211 |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR022327, IGFBP-4 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
PANTHERi | PTHR11551:SF7, PTHR11551:SF7, 1 hit |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01980, IGFBPFAMILY4 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: P22692-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLPLCLVAAL LLAAGPGPSL GDEAIHCPPC SEEKLARCRP PVGCEELVRE
60 70 80 90 100
PGCGCCATCA LGLGMPCGVY TPRCGSGLRC YPPRGVEKPL HTLMHGQGVC
110 120 130 140 150
MELAEIEAIQ ESLQPSDKDE GDHPNNSFSP CSAHDRRCLQ KHFAKIRDRS
160 170 180 190 200
TSGGKMKVNG APREDARPVP QGSCQSELHR ALERLAASQS RTHEDLYIIP
210 220 230 240 250
IPNCDRNGNF HPKQCHPALD GQRGKCWCVD RKTGVKLPGG LEPKGELDCH
QLADSFRE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 51 | P → A in M38177 (PubMed:1707125).Curated | 1 | |
Sequence conflicti | 51 | P → A in AAA62670 (PubMed:9048882).Curated | 1 | |
Sequence conflicti | 51 | P → A AA sequence (PubMed:1709585).Curated | 1 | |
Sequence conflicti | 160 | G → E in AAV38694 (Ref. 7) Curated | 1 | |
Sequence conflicti | 198 | I → F in M38177 (PubMed:1707125).Curated | 1 | |
Sequence conflicti | 198 | I → F in AAA62670 (PubMed:9048882).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_011906 | 42 | V → G. Corresponds to variant dbSNP:rs599199Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_057034 | 1 – 100 | Missing in isoform 2. 1 PublicationAdd BLAST | 100 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M38177 mRNA No translation available. M62403 mRNA Translation: AAB06189.1 U20982 Genomic DNA Translation: AAA62670.1 Y12508 Genomic DNA Translation: CAA73110.1 AK304572 mRNA Translation: BAG65363.1 BT019891 mRNA Translation: AAV38694.1 BT019892 mRNA Translation: AAV38695.1 AY442346 Genomic DNA Translation: AAR05443.1 AC018629 Genomic DNA No translation available. CH471152 Genomic DNA Translation: EAW60664.1 BC016041 mRNA Translation: AAH16041.1 |
CCDSi | CCDS11367.1 [P22692-1] |
PIRi | G01662, B37252 |
RefSeqi | NP_001543.2, NM_001552.2 [P22692-1] |
Genome annotation databases
Ensembli | ENST00000269593; ENSP00000269593; ENSG00000141753 [P22692-1] |
GeneIDi | 3487 |
KEGGi | hsa:3487 |
UCSCi | uc002hus.4, human [P22692-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M38177 mRNA No translation available. M62403 mRNA Translation: AAB06189.1 U20982 Genomic DNA Translation: AAA62670.1 Y12508 Genomic DNA Translation: CAA73110.1 AK304572 mRNA Translation: BAG65363.1 BT019891 mRNA Translation: AAV38694.1 BT019892 mRNA Translation: AAV38695.1 AY442346 Genomic DNA Translation: AAR05443.1 AC018629 Genomic DNA No translation available. CH471152 Genomic DNA Translation: EAW60664.1 BC016041 mRNA Translation: AAH16041.1 |
CCDSi | CCDS11367.1 [P22692-1] |
PIRi | G01662, B37252 |
RefSeqi | NP_001543.2, NM_001552.2 [P22692-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1WQJ | X-ray | 1.60 | B | 24-103 | [»] | |
2DSP | X-ray | 2.50 | B | 22-113 | [»] | |
2DSQ | X-ray | 2.80 | A/B | 22-113 | [»] | |
2DSR | X-ray | 2.10 | B | 24-103 | [»] | |
G | 172-253 | [»] | ||||
SMRi | P22692 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109708, 16 interactors |
DIPi | DIP-48432N |
IntActi | P22692, 23 interactors |
MINTi | P22692 |
STRINGi | 9606.ENSP00000269593 |
Chemistry databases
BindingDBi | P22692 |
ChEMBLi | CHEMBL2310 |
DrugBanki | DB01277, Mecasermin |
Protein family/group databases
MEROPSi | I31.952 |
PTM databases
GlyGeni | P22692, 1 site |
iPTMneti | P22692 |
PhosphoSitePlusi | P22692 |
Genetic variation databases
BioMutai | IGFBP4 |
DMDMi | 124065 |
Proteomic databases
EPDi | P22692 |
jPOSTi | P22692 |
MassIVEi | P22692 |
MaxQBi | P22692 |
PaxDbi | P22692 |
PeptideAtlasi | P22692 |
PRIDEi | P22692 |
ProteomicsDBi | 54018 [P22692-1] 5879 |
Protocols and materials databases
Antibodypediai | 16491, 632 antibodies |
DNASUi | 3487 |
Genome annotation databases
Ensembli | ENST00000269593; ENSP00000269593; ENSG00000141753 [P22692-1] |
GeneIDi | 3487 |
KEGGi | hsa:3487 |
UCSCi | uc002hus.4, human [P22692-1] |
Organism-specific databases
CTDi | 3487 |
DisGeNETi | 3487 |
GeneCardsi | IGFBP4 |
HGNCi | HGNC:5473, IGFBP4 |
HPAi | ENSG00000141753, Tissue enhanced (ovary) |
MIMi | 146733, gene |
neXtProti | NX_P22692 |
OpenTargetsi | ENSG00000141753 |
PharmGKBi | PA29706 |
VEuPathDBi | HostDB:ENSG00000141753.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTC8, Eukaryota |
GeneTreei | ENSGT00940000159647 |
HOGENOMi | CLU_070833_3_0_1 |
InParanoidi | P22692 |
OMAi | GLCMELA |
PhylomeDBi | P22692 |
TreeFami | TF331211 |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000141753-MONOMER |
PathwayCommonsi | P22692 |
Reactomei | R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation |
Miscellaneous databases
BioGRID-ORCSi | 3487, 3 hits in 871 CRISPR screens |
ChiTaRSi | IGFBP4, human |
EvolutionaryTracei | P22692 |
GeneWikii | IGFBP4 |
GenomeRNAii | 3487 |
Pharosi | P22692, Tchem |
PROi | PR:P22692 |
RNActi | P22692, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000141753, Expressed in decidua and 227 other tissues |
ExpressionAtlasi | P22692, baseline and differential |
Genevisiblei | P22692, HS |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR022327, IGFBP-4 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
PANTHERi | PTHR11551:SF7, PTHR11551:SF7, 1 hit |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01980, IGFBPFAMILY4 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IBP4_HUMAN | |
Accessioni | P22692Primary (citable) accession number: P22692 Secondary accession number(s): A0N9W2 Q9UCL6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1991 |
Last sequence update: | March 1, 1992 | |
Last modified: | February 10, 2021 | |
This is version 203 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references