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UniProtKB - P22692 (IBP4_HUMAN)

Entry version 206 (29 Sep 2021)
Sequence version 2 (01 Mar 1992)
Previous versions | rss
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Protein

Insulin-like growth factor-binding protein 4

Gene

IGFBP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:ENSG00000141753-MONOMER

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P22692

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275, Post-translational protein phosphorylation

Protein family/group databases

MEROPS protease database

More...MEROPSi		I31.952

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 4
Short name:
IBP-4
Short name:
IGF-binding protein 4
Short name:
IGFBP-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IGFBP4
Synonyms:IBP4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:5473, IGFBP4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		146733, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P22692

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000141753

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3487

Open Targets

More...OpenTargetsi		ENSG00000141753

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29706

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P22692, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2310

Drug and drug target database

More...DrugBanki		DB01277, Mecasermin

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		IGFBP4

Domain mapping of disease mutations (DMDM)

More...DMDMi		124065

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 213 PublicationsAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001438222 – 258Insulin-like growth factor-binding protein 4Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi27 ↔ 532 Publications
Disulfide bondi30 ↔ 552 Publications
Disulfide bondi38 ↔ 592 Publications
Disulfide bondi44 ↔ 562 Publications
Disulfide bondi67 ↔ 802 Publications
Disulfide bondi74 ↔ 1002 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi125N-linked (GlcNAc...) asparagine1 PublicationSequence analysis1
Disulfide bondi131 ↔ 138PROSITE-ProRule annotation2 Publications
Disulfide bondi174 ↔ 2042 Publications
Disulfide bondi215 ↔ 2262 Publications
Disulfide bondi228 ↔ 2492 Publications
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei255Phosphoserine; by FAM20C1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P22692

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P22692

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P22692

MaxQB - The MaxQuant DataBase

More...MaxQBi		P22692

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P22692

PeptideAtlas

More...PeptideAtlasi		P22692

PRoteomics IDEntifications database

More...PRIDEi		P22692

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54018 [P22692-1]
5879

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P22692, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P22692

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P22692

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By forskolin and N6,O2'dibutyryl adenosine 3',5'-cyclic monophosphate, but not by 1,9 dideoxyforskolin.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000141753, Expressed in decidua and 228 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P22692, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P22692, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000141753, Tissue enhanced (ovary)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds IGF2 more than IGF1.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109708, 16 interactors

Database of interacting proteins

More...DIPi		DIP-48432N

Protein interaction database and analysis system

More...IntActi		P22692, 23 interactors

Molecular INTeraction database

More...MINTi		P22692

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000269593

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P22692

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P22692, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1258
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P22692

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P22692

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 103IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST81
Domaini171 – 249Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni149 – 172DisorderedSequence analysisAdd BLAST24

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QTC8, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159647

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_070833_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P22692

Identification of Orthologs from Complete Genome Data

More...OMAi		LDCHQAS

Database for complete collections of gene phylogenies

More...PhylomeDBi		P22692

TreeFam database of animal gene trees

More...TreeFami		TF331211

Family and domain databases

Conserved Domains Database

More...CDDi		cd00191, TY, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.800.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009030, Growth_fac_rcpt_cys_sf
IPR022327, IGFBP-4
IPR000867, IGFBP-like
IPR022321, IGFBP_1-6_chordata
IPR017891, Insulin_GF-bd_Cys-rich_CS
IPR000716, Thyroglobulin_1
IPR036857, Thyroglobulin_1_sf

The PANTHER Classification System

More...PANTHERi		PTHR11551:SF7, PTHR11551:SF7, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00219, IGFBP, 1 hit
PF00086, Thyroglobulin_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01976, IGFBPFAMILY
PR01980, IGFBPFAMILY4

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00121, IB, 1 hit
SM00211, TY, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57184, SSF57184, 1 hit
SSF57610, SSF57610, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00222, IGFBP_N_1, 1 hit
PS51323, IGFBP_N_2, 1 hit
PS00484, THYROGLOBULIN_1_1, 1 hit
PS51162, THYROGLOBULIN_1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P22692-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLPLCLVAAL LLAAGPGPSL GDEAIHCPPC SEEKLARCRP PVGCEELVRE 
        60         70         80         90        100
PGCGCCATCA LGLGMPCGVY TPRCGSGLRC YPPRGVEKPL HTLMHGQGVC 
       110        120        130        140        150
MELAEIEAIQ ESLQPSDKDE GDHPNNSFSP CSAHDRRCLQ KHFAKIRDRS 
       160        170        180        190        200
TSGGKMKVNG APREDARPVP QGSCQSELHR ALERLAASQS RTHEDLYIIP 
       210        220        230        240        250
IPNCDRNGNF HPKQCHPALD GQRGKCWCVD RKTGVKLPGG LEPKGELDCH 

QLADSFRE
Length:258
Mass (Da):27,934
Last modified:March 1, 1992 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5E8F4638D99F0A94
GO
Isoform 2 (identifier: P22692-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: Missing.

Show »
Length:158
Mass (Da):17,635
Checksum:iF31375031D835A1E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti51P → A in M38177 (PubMed:1707125).Curated1
Sequence conflicti51P → A in AAA62670 (PubMed:9048882).Curated1
Sequence conflicti51P → A AA sequence (PubMed:1709585).Curated1
Sequence conflicti160G → E in AAV38694 (Ref. 7) Curated1
Sequence conflicti198I → F in M38177 (PubMed:1707125).Curated1
Sequence conflicti198I → F in AAA62670 (PubMed:9048882).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01190642V → G. Corresponds to variant dbSNP:rs599199Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0570341 – 100Missing in isoform 2. 1 PublicationAdd BLAST100

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M38177 mRNA No translation available.
M62403 mRNA Translation: AAB06189.1
U20982 Genomic DNA Translation: AAA62670.1
Y12508 Genomic DNA Translation: CAA73110.1
AK304572 mRNA Translation: BAG65363.1
BT019891 mRNA Translation: AAV38694.1
BT019892 mRNA Translation: AAV38695.1
AY442346 Genomic DNA Translation: AAR05443.1
AC018629 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60664.1
BC016041 mRNA Translation: AAH16041.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11367.1 [P22692-1]

Protein sequence database of the Protein Information Resource

More...PIRi		G01662, B37252

NCBI Reference Sequences

More...RefSeqi		NP_001543.2, NM_001552.2 [P22692-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000269593; ENSP00000269593; ENSG00000141753 [P22692-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3487

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3487

UCSC genome browser

More...UCSCi		uc002hus.4, human [P22692-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M38177 mRNA No translation available.
M62403 mRNA Translation: AAB06189.1
U20982 Genomic DNA Translation: AAA62670.1
Y12508 Genomic DNA Translation: CAA73110.1
AK304572 mRNA Translation: BAG65363.1
BT019891 mRNA Translation: AAV38694.1
BT019892 mRNA Translation: AAV38695.1
AY442346 Genomic DNA Translation: AAR05443.1
AC018629 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60664.1
BC016041 mRNA Translation: AAH16041.1
CCDSiCCDS11367.1 [P22692-1]
PIRiG01662, B37252
RefSeqiNP_001543.2, NM_001552.2 [P22692-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WQJX-ray1.60B24-103[»]
2DSPX-ray2.50B22-113[»]
2DSQX-ray2.80A/B22-113[»]
2DSRX-ray2.10B24-103[»]
G172-253[»]
SMRiP22692
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109708, 16 interactors
DIPiDIP-48432N
IntActiP22692, 23 interactors
MINTiP22692
STRINGi9606.ENSP00000269593

Chemistry databases

BindingDBiP22692
ChEMBLiCHEMBL2310
DrugBankiDB01277, Mecasermin

Protein family/group databases

MEROPSiI31.952

PTM databases

GlyGeniP22692, 1 site
iPTMnetiP22692
PhosphoSitePlusiP22692

Genetic variation databases

BioMutaiIGFBP4
DMDMi124065

Proteomic databases

EPDiP22692
jPOSTiP22692
MassIVEiP22692
MaxQBiP22692
PaxDbiP22692
PeptideAtlasiP22692
PRIDEiP22692
ProteomicsDBi54018 [P22692-1]
5879

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		16491, 654 antibodies

The DNASU plasmid repository

More...DNASUi		3487

Genome annotation databases

EnsembliENST00000269593; ENSP00000269593; ENSG00000141753 [P22692-1]
GeneIDi3487
KEGGihsa:3487
UCSCiuc002hus.4, human [P22692-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3487
DisGeNETi3487

GeneCards: human genes, protein and diseases

More...GeneCardsi		IGFBP4
HGNCiHGNC:5473, IGFBP4
HPAiENSG00000141753, Tissue enhanced (ovary)
MIMi146733, gene
neXtProtiNX_P22692
OpenTargetsiENSG00000141753
PharmGKBiPA29706
VEuPathDBiHostDB:ENSG00000141753

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QTC8, Eukaryota
GeneTreeiENSGT00940000159647
HOGENOMiCLU_070833_3_0_1
InParanoidiP22692
OMAiLDCHQAS
PhylomeDBiP22692
TreeFamiTF331211

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000141753-MONOMER
PathwayCommonsiP22692
ReactomeiR-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275, Post-translational protein phosphorylation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3487, 5 hits in 1015 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		IGFBP4, human
EvolutionaryTraceiP22692

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		IGFBP4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3487
PharosiP22692, Tchem

Protein Ontology

More...PROi		PR:P22692
RNActiP22692, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000141753, Expressed in decidua and 228 other tissues
ExpressionAtlasiP22692, baseline and differential
GenevisibleiP22692, HS

Family and domain databases

CDDicd00191, TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030, Growth_fac_rcpt_cys_sf
IPR022327, IGFBP-4
IPR000867, IGFBP-like
IPR022321, IGFBP_1-6_chordata
IPR017891, Insulin_GF-bd_Cys-rich_CS
IPR000716, Thyroglobulin_1
IPR036857, Thyroglobulin_1_sf
PANTHERiPTHR11551:SF7, PTHR11551:SF7, 1 hit
PfamiView protein in Pfam
PF00219, IGFBP, 1 hit
PF00086, Thyroglobulin_1, 1 hit
PRINTSiPR01976, IGFBPFAMILY
PR01980, IGFBPFAMILY4
SMARTiView protein in SMART
SM00121, IB, 1 hit
SM00211, TY, 1 hit
SUPFAMiSSF57184, SSF57184, 1 hit
SSF57610, SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222, IGFBP_N_1, 1 hit
PS51323, IGFBP_N_2, 1 hit
PS00484, THYROGLOBULIN_1_1, 1 hit
PS51162, THYROGLOBULIN_1_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIBP4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22692
Secondary accession number(s): A0N9W2
, B4E351, Q5U012, Q9UCL6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: March 1, 1992
Last modified: September 29, 2021
This is version 206 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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