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Entry version 195 (02 Jun 2021)
Sequence version 2 (01 Jun 1994)
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Protein

Cytochrome P450 7A1

Gene

CYP7A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (PubMed:11013305, PubMed:12077124, PubMed:19965590, PubMed:2384150, PubMed:21813643).

Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:2384150, PubMed:11013305, PubMed:12077124, PubMed:19965590, PubMed:21813643).

Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting step in cholesterol catabolism and bile acid biosynthesis (PubMed:12077124, PubMed:19965590, PubMed:2384150).

7-alpha hydroxylates several oxysterols, including 4beta-hydroxycholesterol and 24-hydroxycholesterol (PubMed:11013305, PubMed:12077124).

Catalyzes the oxidation of the 7,8 double bond of 7-dehydrocholesterol and lathosterol with direct and predominant formation of the 7-keto derivatives (PubMed:21813643).

5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

heme1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 3.7 min(-1) with 5alpha-cholest-7-en-3beta-ol (lathosterol) as substrate. kcat is 2.2 min(-1) with cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol) as substrate.1 Publication
  1. KM=3 µM for cholesterol1 Publication
  2. KM=6 µM for 24-hydroxycholesterol1 Publication
  3. KM=1.8 µM for 5alpha-cholest-7-en-3beta-ol (lathosterol)1 Publication
  4. KM=1.1 µM for cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol)1 Publication
  1. Vmax=0.184 nmol/min/nmol enzyme toward cholesterol1 Publication
  2. Vmax=0.087 nmol/min/nmol enzyme toward 4beta-hydroxycholesterol1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: bile acid biosynthesis

This protein is involved in the pathway bile acid biosynthesis, which is part of Lipid metabolism.3 Publications
View all proteins of this organism that are known to be involved in the pathway bile acid biosynthesis and in Lipid metabolism.

Pathwayi: cholesterol degradation

This protein is involved in the pathway cholesterol degradation, which is part of Steroid metabolism.3 Publications
View all proteins of this organism that are known to be involved in the pathway cholesterol degradation and in Steroid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi444Iron (heme axial ligand)Combined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processCholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS09659-MONOMER

BRENDA Comprehensive Enzyme Information System

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BRENDAi
1.14.14.23, 2681

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P22680

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-192105, Synthesis of bile acids and bile salts
R-HSA-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-193807, Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-HSA-1989781, PPARA activates gene expression
R-HSA-211976, Endogenous sterols

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P22680

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P22680

UniPathway: a resource for the exploration and annotation of metabolic pathways

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UniPathwayi
UPA00221
UPA01058

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001200

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome P450 7A11 Publication
Alternative name(s):
24-hydroxycholesterol 7-alpha-hydroxylase1 Publication (EC:1.14.14.261 Publication)
CYPVII
Cholesterol 7-alpha-hydroxylase1 Publication
Cholesterol 7-alpha-monooxygenase (EC:1.14.14.231 Publication)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CYP7A11 PublicationImported
Synonyms:CYP7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2651, CYP7A1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
118455, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P22680

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000167910.3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4 – 24HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1581

MalaCards human disease database

More...
MalaCardsi
CYP7A1

Open Targets

More...
OpenTargetsi
ENSG00000167910

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
209902, Hypercholesterolemia due to cholesterol 7alpha-hydroxylase deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA132

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P22680, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1851

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CYP7A1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
544084

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000519011 – 504Cytochrome P450 7A1Add BLAST504

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P22680

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P22680

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P22680

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P22680

PeptideAtlas

More...
PeptideAtlasi
P22680

PRoteomics IDEntifications database

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PRIDEi
P22680

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
54016

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P22680

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P22680

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in liver.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by glucose and by cholestyramine. Down-regulated by chenodeoxycholic acid.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167910, Expressed in liver and 24 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P22680, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000167910, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

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STRINGi
9606.ENSP00000301645

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P22680, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1504
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P22680

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P22680

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0684, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000153141

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_018012_1_3_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P22680

Identification of Orthologs from Complete Genome Data

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OMAi
VCCCLWL

Database of Orthologous Groups

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OrthoDBi
864748at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P22680

TreeFam database of animal gene trees

More...
TreeFami
TF105090

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.630.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR030681, Cholesterol_7a_monooxygenase
IPR001128, Cyt_P450
IPR017972, Cyt_P450_CS
IPR024204, Cyt_P450_CYP7A1-type
IPR002403, Cyt_P450_E_grp-IV
IPR036396, Cyt_P450_sf

The PANTHER Classification System

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PANTHERi
PTHR24304:SF1, PTHR24304:SF1, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00067, p450, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF500625, Cytochrome_CYP7A1, 1 hit
PIRSF000047, Cytochrome_CYPVIIA1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00465, EP450IV

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48264, SSF48264, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00086, CYTOCHROME_P450, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P22680-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMTTSLIWGI AIAACCCLWL ILGIRRRQTG EPPLENGLIP YLGCALQFGA
60 70 80 90 100
NPLEFLRANQ RKHGHVFTCK LMGKYVHFIT NPLSYHKVLC HGKYFDWKKF
110 120 130 140 150
HFATSAKAFG HRSIDPMDGN TTENINDTFI KTLQGHALNS LTESMMENLQ
160 170 180 190 200
RIMRPPVSSN SKTAAWVTEG MYSFCYRVMF EAGYLTIFGR DLTRRDTQKA
210 220 230 240 250
HILNNLDNFK QFDKVFPALV AGLPIHMFRT AHNAREKLAE SLRHENLQKR
260 270 280 290 300
ESISELISLR MFLNDTLSTF DDLEKAKTHL VVLWASQANT IPATFWSLFQ
310 320 330 340 350
MIRNPEAMKA ATEEVKRTLE NAGQKVSLEG NPICLSQAEL NDLPVLDSII
360 370 380 390 400
KESLRLSSAS LNIRTAKEDF TLHLEDGSYN IRKDDIIALY PQLMHLDPEI
410 420 430 440 450
YPDPLTFKYD RYLDENGKTK TTFYCNGLKL KYYYMPFGSG ATICPGRLFA
460 470 480 490 500
IHEIKQFLIL MLSYFELELI EGQAKCPPLD QSRAGLGILP PLNDIEFKYK

FKHL
Length:504
Mass (Da):57,661
Last modified:June 1, 1994 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD8067E0FF6342949
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti385D → S in CAA39568 (PubMed:2384150).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05915286H → N. Corresponds to variant dbSNP:rs62621283EnsemblClinVar.1
Natural variantiVAR_001259100F → S1 Publication1
Natural variantiVAR_018376233N → S1 PublicationCorresponds to variant dbSNP:rs8192874Ensembl.1
Natural variantiVAR_018377347D → N2 PublicationsCorresponds to variant dbSNP:rs8192875Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X56088 mRNA Translation: CAA39568.1
M93133 mRNA Translation: AAA58435.1
BC101777 mRNA Translation: AAI01778.1
BC112184 mRNA Translation: AAI12185.1
L13460 Genomic DNA Translation: AAA61350.1
M89647 Genomic DNA Translation: AAA58423.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6171.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S29818, JH0659

NCBI Reference Sequences

More...
RefSeqi
NP_000771.2, NM_000780.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000301645; ENSP00000301645; ENSG00000167910

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1581

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1581

UCSC genome browser

More...
UCSCi
uc003xtm.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Cholesterol-7 alpha-hydroxylase entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56088 mRNA Translation: CAA39568.1
M93133 mRNA Translation: AAA58435.1
BC101777 mRNA Translation: AAI01778.1
BC112184 mRNA Translation: AAI12185.1
L13460 Genomic DNA Translation: AAA61350.1
M89647 Genomic DNA Translation: AAA58423.1
CCDSiCCDS6171.1
PIRiS29818, JH0659
RefSeqiNP_000771.2, NM_000780.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DAXX-ray2.15A/B25-503[»]
3SN5X-ray2.75A/B25-503[»]
3V8DX-ray1.90A/B25-503[»]
SMRiP22680
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000301645

Chemistry databases

ChEMBLiCHEMBL1851
SwissLipidsiSLP:000001200

PTM databases

iPTMnetiP22680
PhosphoSitePlusiP22680

Genetic variation databases

BioMutaiCYP7A1
DMDMi544084

Proteomic databases

EPDiP22680
jPOSTiP22680
MassIVEiP22680
PaxDbiP22680
PeptideAtlasiP22680
PRIDEiP22680
ProteomicsDBi54016

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2602, 151 antibodies

The DNASU plasmid repository

More...
DNASUi
1581

Genome annotation databases

EnsembliENST00000301645; ENSP00000301645; ENSG00000167910
GeneIDi1581
KEGGihsa:1581
UCSCiuc003xtm.5, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1581
DisGeNETi1581

GeneCards: human genes, protein and diseases

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GeneCardsi
CYP7A1
HGNCiHGNC:2651, CYP7A1
HPAiENSG00000167910, Tissue enriched (liver)
MalaCardsiCYP7A1
MIMi118455, gene
neXtProtiNX_P22680
OpenTargetsiENSG00000167910
Orphaneti209902, Hypercholesterolemia due to cholesterol 7alpha-hydroxylase deficiency
PharmGKBiPA132
VEuPathDBiHostDB:ENSG00000167910.3

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0684, Eukaryota
GeneTreeiENSGT00940000153141
HOGENOMiCLU_018012_1_3_1
InParanoidiP22680
OMAiVCCCLWL
OrthoDBi864748at2759
PhylomeDBiP22680
TreeFamiTF105090

Enzyme and pathway databases

UniPathwayiUPA00221
UPA01058
BioCyciMetaCyc:HS09659-MONOMER
BRENDAi1.14.14.23, 2681
PathwayCommonsiP22680
ReactomeiR-HSA-192105, Synthesis of bile acids and bile salts
R-HSA-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-193807, Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-HSA-1989781, PPARA activates gene expression
R-HSA-211976, Endogenous sterols
SABIO-RKiP22680
SIGNORiP22680

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
1581, 6 hits in 980 CRISPR screens
EvolutionaryTraceiP22680

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Cholesterol_7_alpha-hydroxylase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1581
PharosiP22680, Tbio

Protein Ontology

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PROi
PR:P22680
RNActiP22680, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000167910, Expressed in liver and 24 other tissues
GenevisibleiP22680, HS

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR030681, Cholesterol_7a_monooxygenase
IPR001128, Cyt_P450
IPR017972, Cyt_P450_CS
IPR024204, Cyt_P450_CYP7A1-type
IPR002403, Cyt_P450_E_grp-IV
IPR036396, Cyt_P450_sf
PANTHERiPTHR24304:SF1, PTHR24304:SF1, 1 hit
PfamiView protein in Pfam
PF00067, p450, 1 hit
PIRSFiPIRSF500625, Cytochrome_CYP7A1, 1 hit
PIRSF000047, Cytochrome_CYPVIIA1, 1 hit
PRINTSiPR00465, EP450IV
SUPFAMiSSF48264, SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086, CYTOCHROME_P450, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCP7A1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22680
Secondary accession number(s): P78454, Q3MIL8, Q7KZ19
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: June 1, 1994
Last modified: June 2, 2021
This is version 195 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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