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Entry version 180 (13 Feb 2019)
Sequence version 2 (01 Jun 1994)
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Protein

Cholesterol 7-alpha-monooxygenase

Gene

CYP7A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

heme1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

    1. Vmax=0.184 nmol/min/nmol enzyme toward cholesterol1 Publication
    2. Vmax=0.087 nmol/min/nmol enzyme toward 4beta-hydroxycholesterol1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: bile acid biosynthesis

    This protein is involved in the pathway bile acid biosynthesis, which is part of Lipid metabolism.2 Publications
    View all proteins of this organism that are known to be involved in the pathway bile acid biosynthesis and in Lipid metabolism.

    Pathwayi: cholesterol degradation

    This protein is involved in the pathway cholesterol degradation, which is part of Steroid metabolism.2 Publications
    View all proteins of this organism that are known to be involved in the pathway cholesterol degradation and in Steroid metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi444Iron (heme axial ligand)1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionMonooxygenase, Oxidoreductase
    Biological processCholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism
    LigandHeme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS09659-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    1.14.13.17 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-192105 Synthesis of bile acids and bile salts
    R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
    R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
    R-HSA-1989781 PPARA activates gene expression
    R-HSA-211976 Endogenous sterols

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P22680

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    P22680

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00221

    UPA01058

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000001200

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Cholesterol 7-alpha-monooxygenase (EC:1.14.14.231 Publication)
    Alternative name(s):
    CYPVII
    Cholesterol 7-alpha-hydroxylase
    Cytochrome P450 7A1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:CYP7A1
    Synonyms:CYP7
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000167910.3

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:2651 CYP7A1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    118455 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P22680

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    1581

    MalaCards human disease database

    More...
    MalaCardsi
    CYP7A1

    Open Targets

    More...
    OpenTargetsi
    ENSG00000167910

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    209902 Hypercholesterolemia due to cholesterol 7alpha-hydroxylase deficiency

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA132

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    CYP7A1

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    544084

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000519011 – 504Cholesterol 7-alpha-monooxygenaseAdd BLAST504

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    P22680

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P22680

    PeptideAtlas

    More...
    PeptideAtlasi
    P22680

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P22680

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    54016

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P22680

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P22680

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Detected in liver.1 Publication

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Up-regulated by glucose and by cholestyramine. Down-regulated by chenodeoxycholic acid.2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000167910 Expressed in 17 organ(s), highest expression level in liver

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P22680 HS

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000301645

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1504
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3DAXX-ray2.15A/B25-503[»]
    3SN5X-ray2.75A/B25-503[»]
    3V8DX-ray1.90A/B25-503[»]

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    P22680

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P22680

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P22680

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0684 Eukaryota
    COG2124 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000153141

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000231026

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG051100

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P22680

    KEGG Orthology (KO)

    More...
    KOi
    K00489

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    HGHVFTC

    Database of Orthologous Groups

    More...
    OrthoDBi
    864748at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P22680

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF105090

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.630.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR030681 Cholesterol_7a_monooxygenase
    IPR001128 Cyt_P450
    IPR017972 Cyt_P450_CS
    IPR024204 Cyt_P450_CYP7A1-type
    IPR002403 Cyt_P450_E_grp-IV
    IPR036396 Cyt_P450_sf

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR24304:SF1 PTHR24304:SF1, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00067 p450, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF500625 Cytochrome_CYP7A1, 1 hit
    PIRSF000047 Cytochrome_CYPVIIA1, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00465 EP450IV

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF48264 SSF48264, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00086 CYTOCHROME_P450, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    P22680-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MMTTSLIWGI AIAACCCLWL ILGIRRRQTG EPPLENGLIP YLGCALQFGA
    60 70 80 90 100
    NPLEFLRANQ RKHGHVFTCK LMGKYVHFIT NPLSYHKVLC HGKYFDWKKF
    110 120 130 140 150
    HFATSAKAFG HRSIDPMDGN TTENINDTFI KTLQGHALNS LTESMMENLQ
    160 170 180 190 200
    RIMRPPVSSN SKTAAWVTEG MYSFCYRVMF EAGYLTIFGR DLTRRDTQKA
    210 220 230 240 250
    HILNNLDNFK QFDKVFPALV AGLPIHMFRT AHNAREKLAE SLRHENLQKR
    260 270 280 290 300
    ESISELISLR MFLNDTLSTF DDLEKAKTHL VVLWASQANT IPATFWSLFQ
    310 320 330 340 350
    MIRNPEAMKA ATEEVKRTLE NAGQKVSLEG NPICLSQAEL NDLPVLDSII
    360 370 380 390 400
    KESLRLSSAS LNIRTAKEDF TLHLEDGSYN IRKDDIIALY PQLMHLDPEI
    410 420 430 440 450
    YPDPLTFKYD RYLDENGKTK TTFYCNGLKL KYYYMPFGSG ATICPGRLFA
    460 470 480 490 500
    IHEIKQFLIL MLSYFELELI EGQAKCPPLD QSRAGLGILP PLNDIEFKYK

    FKHL
    Length:504
    Mass (Da):57,661
    Last modified:June 1, 1994 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD8067E0FF6342949
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti385D → S in CAA39568 (PubMed:2384150).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05915286H → N. Corresponds to variant dbSNP:rs62621283Ensembl.1
    Natural variantiVAR_001259100F → S1 Publication1
    Natural variantiVAR_018376233N → S1 PublicationCorresponds to variant dbSNP:rs8192874Ensembl.1
    Natural variantiVAR_018377347D → N2 PublicationsCorresponds to variant dbSNP:rs8192875Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    X56088 mRNA Translation: CAA39568.1
    M93133 mRNA Translation: AAA58435.1
    BC101777 mRNA Translation: AAI01778.1
    BC112184 mRNA Translation: AAI12185.1
    L13460 Genomic DNA Translation: AAA61350.1
    M89647 Genomic DNA Translation: AAA58423.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS6171.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    S29818 JH0659

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_000771.2, NM_000780.3

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.1644

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000301645; ENSP00000301645; ENSG00000167910

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    1581

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:1581

    UCSC genome browser

    More...
    UCSCi
    uc003xtm.5 human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    Wikipedia

    Cholesterol-7 alpha-hydroxylase entry

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X56088 mRNA Translation: CAA39568.1
    M93133 mRNA Translation: AAA58435.1
    BC101777 mRNA Translation: AAI01778.1
    BC112184 mRNA Translation: AAI12185.1
    L13460 Genomic DNA Translation: AAA61350.1
    M89647 Genomic DNA Translation: AAA58423.1
    CCDSiCCDS6171.1
    PIRiS29818 JH0659
    RefSeqiNP_000771.2, NM_000780.3
    UniGeneiHs.1644

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3DAXX-ray2.15A/B25-503[»]
    3SN5X-ray2.75A/B25-503[»]
    3V8DX-ray1.90A/B25-503[»]
    ProteinModelPortaliP22680
    SMRiP22680
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    STRINGi9606.ENSP00000301645

    Chemistry databases

    SwissLipidsiSLP:000001200

    PTM databases

    iPTMnetiP22680
    PhosphoSitePlusiP22680

    Polymorphism and mutation databases

    BioMutaiCYP7A1
    DMDMi544084

    Proteomic databases

    EPDiP22680
    PaxDbiP22680
    PeptideAtlasiP22680
    PRIDEiP22680
    ProteomicsDBi54016

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000301645; ENSP00000301645; ENSG00000167910
    GeneIDi1581
    KEGGihsa:1581
    UCSCiuc003xtm.5 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    1581
    DisGeNETi1581
    EuPathDBiHostDB:ENSG00000167910.3

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    CYP7A1
    HGNCiHGNC:2651 CYP7A1
    MalaCardsiCYP7A1
    MIMi118455 gene
    neXtProtiNX_P22680
    OpenTargetsiENSG00000167910
    Orphaneti209902 Hypercholesterolemia due to cholesterol 7alpha-hydroxylase deficiency
    PharmGKBiPA132

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG0684 Eukaryota
    COG2124 LUCA
    GeneTreeiENSGT00940000153141
    HOGENOMiHOG000231026
    HOVERGENiHBG051100
    InParanoidiP22680
    KOiK00489
    OMAiHGHVFTC
    OrthoDBi864748at2759
    PhylomeDBiP22680
    TreeFamiTF105090

    Enzyme and pathway databases

    UniPathwayi
    UPA00221

    UPA01058

    BioCyciMetaCyc:HS09659-MONOMER
    BRENDAi1.14.13.17 2681
    ReactomeiR-HSA-192105 Synthesis of bile acids and bile salts
    R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
    R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
    R-HSA-1989781 PPARA activates gene expression
    R-HSA-211976 Endogenous sterols
    SABIO-RKiP22680
    SIGNORiP22680

    Miscellaneous databases

    EvolutionaryTraceiP22680

    The Gene Wiki collection of pages on human genes and proteins

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    GeneWikii
    Cholesterol_7_alpha-hydroxylase

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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    GenomeRNAii
    1581

    Protein Ontology

    More...
    PROi
    PR:P22680

    The Stanford Online Universal Resource for Clones and ESTs

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    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000167910 Expressed in 17 organ(s), highest expression level in liver
    GenevisibleiP22680 HS

    Family and domain databases

    Gene3Di1.10.630.10, 1 hit
    InterProiView protein in InterPro
    IPR030681 Cholesterol_7a_monooxygenase
    IPR001128 Cyt_P450
    IPR017972 Cyt_P450_CS
    IPR024204 Cyt_P450_CYP7A1-type
    IPR002403 Cyt_P450_E_grp-IV
    IPR036396 Cyt_P450_sf
    PANTHERiPTHR24304:SF1 PTHR24304:SF1, 1 hit
    PfamiView protein in Pfam
    PF00067 p450, 1 hit
    PIRSFiPIRSF500625 Cytochrome_CYP7A1, 1 hit
    PIRSF000047 Cytochrome_CYPVIIA1, 1 hit
    PRINTSiPR00465 EP450IV
    SUPFAMiSSF48264 SSF48264, 1 hit
    PROSITEiView protein in PROSITE
    PS00086 CYTOCHROME_P450, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCP7A1_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22680
    Secondary accession number(s): P78454, Q3MIL8, Q7KZ19
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: June 1, 1994
    Last modified: February 13, 2019
    This is version 180 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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