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Protein

Calretinin

Gene

CALB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Calretinin is a calcium-binding protein which is abundant in auditory neurons.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi29 – 401CuratedAdd BLAST12
Calcium bindingi76 – 872; possibly ancestralCuratedAdd BLAST12
Calcium bindingi120 – 1313CuratedAdd BLAST12
Calcium bindingi164 – 1754CuratedAdd BLAST12
Calcium bindingi208 – 2195CuratedAdd BLAST12
Calcium bindingi251 – 2626; possibly ancestralCuratedAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Protein family/group databases

TCDBi8.A.82.1.2 the calmodulin calcium binding protein (calmodulin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Calretinin
Short name:
CR
Alternative name(s):
29 kDa calbindin
Gene namesi
Name:CALB2
Synonyms:CAB29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000172137.18
HGNCiHGNC:1435 CALB2
MIMi114051 gene
neXtProtiNX_P22676

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi794
OpenTargetsiENSG00000172137
PharmGKBiPA26027

Polymorphism and mutation databases

BioMutaiCALB2
DMDMi109940061

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000734791 – 271CalretininAdd BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei214PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP22676
MaxQBiP22676
PaxDbiP22676
PeptideAtlasiP22676
PRIDEiP22676
ProteomicsDBi54015

2D gel databases

REPRODUCTION-2DPAGEiIPI00027264

PTM databases

iPTMnetiP22676
PhosphoSitePlusiP22676

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiENSG00000172137 Expressed in 163 organ(s), highest expression level in hypothalamus
CleanExiHS_CALB2
ExpressionAtlasiP22676 baseline and differential
GenevisibleiP22676 HS

Organism-specific databases

HPAiCAB000106
HPA007305
HPA007306

Interactioni

Protein-protein interaction databases

BioGridi107245, 4 interactors
STRINGi9606.ENSP00000307508

Structurei

3D structure databases

ProteinModelPortaliP22676
SMRiP22676
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 51EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini63 – 98EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini107 – 142EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini151 – 186EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Domaini195 – 230EF-hand 5PROSITE-ProRule annotationAdd BLAST36
Domaini235 – 270EF-hand 6PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the calbindin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00390000013118
HOGENOMiHOG000231866
HOVERGENiHBG000855
InParanoidiP22676
OMAiFLDIWKH
OrthoDBiEOG091G0GNH
PhylomeDBiP22676
TreeFamiTF325083

Family and domain databases

CDDicd16177 EFh_HEF_CR, 1 hit
InterProiView protein in InterPro
IPR029646 CALB2
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PANTHERiPTHR19972:SF4 PTHR19972:SF4, 1 hit
PfamiView protein in Pfam
PF13405 EF-hand_6, 1 hit
PF13499 EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 5 hits
SUPFAMiSSF47473 SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 5 hits
PS50222 EF_HAND_2, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

P22676-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGPQQQPPY LHLAELTASQ FLEIWKHFDA DGNGYIEGKE LENFFQELEK
60 70 80 90 100
ARKGSGMMSK SDNFGEKMKE FMQKYDKNSD GKIEMAELAQ ILPTEENFLL
110 120 130 140 150
CFRQHVGSSA EFMEAWRKYD TDRSGYIEAN ELKGFLSDLL KKANRPYDEP
160 170 180 190 200
KLQEYTQTIL RMFDLNGDGK LGLSEMSRLL PVQENFLLKF QGMKLTSEEF
210 220 230 240 250
NAIFTFYDKD RSGYIDEHEL DALLKDLYEK NKKEMNIQQL TNYRKSVMSL
260 270
AEAGKLYRKD LEIVLCSEPP M
Length:271
Mass (Da):31,540
Last modified:June 27, 2006 - v2
Checksum:i98116AD706079DB9
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NER6A6NER6_HUMAN
Calbindin 2, 29kDa (Calretinin), is...
CALB2 hCG_2011413
192Annotation score:
H3BN14H3BN14_HUMAN
Calretinin
CALB2
235Annotation score:
H3BMN5H3BMN5_HUMAN
Calretinin
CALB2
158Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti110A → T in AAH15484 (PubMed:15489334).Curated1
Sequence conflicti235M → I in CAA39991 (PubMed:2001709).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56667 mRNA Translation: CAA39991.1
X56668 Genomic DNA Translation: CAA39992.1
AK291096 mRNA Translation: BAF83785.1
AK222495 mRNA Translation: BAD96215.1
AK222648 mRNA Translation: BAD96368.1
BC015484 mRNA Translation: AAH15484.1
CCDSiCCDS10899.1
PIRiS14109 A60253
RefSeqiNP_001731.2, NM_001740.4
NP_009019.1, NM_007088.3
UniGeneiHs.106857

Genome annotation databases

EnsembliENST00000302628; ENSP00000307508; ENSG00000172137
ENST00000635371; ENSP00000488916; ENSG00000282830
GeneIDi794
KEGGihsa:794
UCSCiuc002faa.6 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Calbindin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56667 mRNA Translation: CAA39991.1
X56668 Genomic DNA Translation: CAA39992.1
AK291096 mRNA Translation: BAF83785.1
AK222495 mRNA Translation: BAD96215.1
AK222648 mRNA Translation: BAD96368.1
BC015484 mRNA Translation: AAH15484.1
CCDSiCCDS10899.1
PIRiS14109 A60253
RefSeqiNP_001731.2, NM_001740.4
NP_009019.1, NM_007088.3
UniGeneiHs.106857

3D structure databases

ProteinModelPortaliP22676
SMRiP22676
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107245, 4 interactors
STRINGi9606.ENSP00000307508

Protein family/group databases

TCDBi8.A.82.1.2 the calmodulin calcium binding protein (calmodulin) family

PTM databases

iPTMnetiP22676
PhosphoSitePlusiP22676

Polymorphism and mutation databases

BioMutaiCALB2
DMDMi109940061

2D gel databases

REPRODUCTION-2DPAGEiIPI00027264

Proteomic databases

EPDiP22676
MaxQBiP22676
PaxDbiP22676
PeptideAtlasiP22676
PRIDEiP22676
ProteomicsDBi54015

Protocols and materials databases

DNASUi794
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302628; ENSP00000307508; ENSG00000172137
ENST00000635371; ENSP00000488916; ENSG00000282830
GeneIDi794
KEGGihsa:794
UCSCiuc002faa.6 human

Organism-specific databases

CTDi794
DisGeNETi794
EuPathDBiHostDB:ENSG00000172137.18
GeneCardsiCALB2
HGNCiHGNC:1435 CALB2
HPAiCAB000106
HPA007305
HPA007306
MIMi114051 gene
neXtProtiNX_P22676
OpenTargetsiENSG00000172137
PharmGKBiPA26027
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00390000013118
HOGENOMiHOG000231866
HOVERGENiHBG000855
InParanoidiP22676
OMAiFLDIWKH
OrthoDBiEOG091G0GNH
PhylomeDBiP22676
TreeFamiTF325083

Miscellaneous databases

GeneWikiiCalretinin
GenomeRNAii794
PROiPR:P22676
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172137 Expressed in 163 organ(s), highest expression level in hypothalamus
CleanExiHS_CALB2
ExpressionAtlasiP22676 baseline and differential
GenevisibleiP22676 HS

Family and domain databases

CDDicd16177 EFh_HEF_CR, 1 hit
InterProiView protein in InterPro
IPR029646 CALB2
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PANTHERiPTHR19972:SF4 PTHR19972:SF4, 1 hit
PfamiView protein in Pfam
PF13405 EF-hand_6, 1 hit
PF13499 EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 5 hits
SUPFAMiSSF47473 SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 5 hits
PS50222 EF_HAND_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCALB2_HUMAN
AccessioniPrimary (citable) accession number: P22676
Secondary accession number(s): A8K4Y1, Q53HD2, Q96BK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: June 27, 2006
Last modified: September 12, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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