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Protein

Cyclin-O

Gene

CCNO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking.2 Publications

Caution

Was originally thought to have uracil-DNA glycosylase (UDG) activity and wrongly named UNG2 and UDG2 (PubMed:2001396). It was later shown that it is a member of the cyclin family (PubMed:8419333). UNG2 corresponds to the isoform 2 of UNG gene.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: GO_Central
  • protein kinase binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Cilium biogenesis/degradation

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.2.2.27 2681

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P22674

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cyclin-O
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCNO
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000152669.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18576 CCNO

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607752 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P22674

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ciliary dyskinesia, primary, 29 (CILD29)2 Publications
The disease is caused by mutations affecting the gene represented in this entry. Marked reduction of cilia in multiciliate cells due to defective mother centriole generation and placement. Remaining cilia correctly express axonemal motor proteins, are motile and do not show beating defects. Defects are probably caused by a strong reduction in the number of multiple motile cilia covering the cell surface in respiratory epithelial cells (PubMed:24747639).1 Publication
Disease descriptionA disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. CILD29 patients do not exhibit situs inversus, a congenital abnormality in which visceral organs are opposite to their normal positions (situs solitus) due to lateral transposition.
See also OMIM:615872
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_077581213L → P in CILD29; decreases formation of basal bodies in multiciliated cells. 1 PublicationCorresponds to variant dbSNP:rs775051461EnsemblClinVar.1
Natural variantiVAR_071197239H → R in CILD29. 1 PublicationCorresponds to variant dbSNP:rs797045150EnsemblClinVar.1

Keywords - Diseasei

Ciliopathy, Disease mutation, Primary ciliary dyskinesia

Organism-specific databases

DisGeNET

More...
DisGeNETi
10309

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
CCNO

MalaCards human disease database

More...
MalaCardsi
CCNO
MIMi615872 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000152669

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
244 Primary ciliary dyskinesia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38350

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCNO

Domain mapping of disease mutations (DMDM)

More...
DMDMi
118572733

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001761751 – 350Cyclin-OAdd BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei81PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
P22674

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P22674

PeptideAtlas

More...
PeptideAtlasi
P22674

PRoteomics IDEntifications database

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PRIDEi
P22674

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54013
54014 [P22674-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P22674

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P22674

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present in respiratory cells (at protein level).1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Maximum levels during G1 phase. Levels decrease through S and G2 phases.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000152669 Expressed in 114 organ(s), highest expression level in oocyte

CleanEx database of gene expression profiles

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CleanExi
HS_CCNO

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P22674 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA050090

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115595, 7 interactors

Database of interacting proteins

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DIPi
DIP-24234N

Protein interaction database and analysis system

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IntActi
P22674, 6 interactors

Molecular INTeraction database

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MINTi
P22674

STRING: functional protein association networks

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STRINGi
9606.ENSP00000282572

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P22674

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P22674

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cyclin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0653 Eukaryota
COG5024 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155998

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000060283

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG062171

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P22674

KEGG Orthology (KO)

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KOi
K10861

Identification of Orthologs from Complete Genome Data

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OMAi
LDLQTFR

Database of Orthologous Groups

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OrthoDBi
EOG091G0J8R

Database for complete collections of gene phylogenies

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PhylomeDBi
P22674

TreeFam database of animal gene trees

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TreeFami
TF332057

Family and domain databases

Conserved Domains Database

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CDDi
cd00043 CYCLIN, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR028864 Ccno
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N

The PANTHER Classification System

More...
PANTHERi
PTHR10177 PTHR10177, 1 hit
PTHR10177:SF14 PTHR10177:SF14, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF001771 Cyclin_A_B_D_E, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47954 SSF47954, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P22674-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVTPCPTSPS SPAARAGRRD NDQNLRAPVK KSRRPRLRRK QPLHPLNPCP
60 70 80 90 100
LPGDSGICDL FESPSSGSDG AESPSAARGG SPLPGPAQPV AQLDLQTFRD
110 120 130 140 150
YGQSCYAFRK AQESHFHPRE ALARQPQVTA ESRCKLLSWL IPVHRQFGLS
160 170 180 190 200
FESLCLTVNT LDRFLTTTPV AADCFQLLGV TSLLIACKQV EVHPPRVKQL
210 220 230 240 250
LALCCGAFSR QQLCNLECIV LHKLHFTLGA PTISFFLEHF THARVEAGQA
260 270 280 290 300
EASEALEAQA LARGVAELSL ADYAFTSYSP SLLAICCLAL ADRMLRVSRP
310 320 330 340 350
VDLRLGDHPE AALEDCMGKL QLLVAINSTS LTHMLPVQIC EKCSLPPSSK
Length:350
Mass (Da):38,096
Last modified:November 28, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAF1C1D1C34334BED
GO
Isoform 2 (identifier: P22674-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     129-131: TAE → RCW
     132-350: Missing.

Show »
Length:131
Mass (Da):14,297
Checksum:i75705330B7735297
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB05817 differs from that shown. Sequencing errors.Curated
The sequence CAA36728 differs from that shown. Sequencing errors.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti246E → G in BAB15351 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029081161L → M. Corresponds to variant dbSNP:rs13169396Ensembl.1
Natural variantiVAR_077581213L → P in CILD29; decreases formation of basal bodies in multiciliated cells. 1 PublicationCorresponds to variant dbSNP:rs775051461EnsemblClinVar.1
Natural variantiVAR_071197239H → R in CILD29. 1 PublicationCorresponds to variant dbSNP:rs797045150EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_021655129 – 131TAE → RCW in isoform 2. 2 Publications3
Alternative sequenceiVSP_021656132 – 350Missing in isoform 2. 2 PublicationsAdd BLAST219

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X52486 mRNA Translation: CAA36728.1 Sequence problems.
M87499 Genomic DNA Translation: AAB05817.1 Sequence problems.
AK026075 mRNA Translation: BAB15351.1
AK290030 mRNA Translation: BAF82719.1
AC026704 Genomic DNA No translation available.
CH471123 Genomic DNA Translation: EAW54913.1
BC004877 mRNA Translation: AAH04877.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS34157.1 [P22674-1]

Protein sequence database of the Protein Information Resource

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PIRi
S14266

NCBI Reference Sequences

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RefSeqi
NP_066970.3, NM_021147.4 [P22674-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.3041

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000282572; ENSP00000282572; ENSG00000152669 [P22674-1]
ENST00000501463; ENSP00000422485; ENSG00000152669 [P22674-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10309

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10309

UCSC genome browser

More...
UCSCi
uc003jpv.4 human [P22674-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52486 mRNA Translation: CAA36728.1 Sequence problems.
M87499 Genomic DNA Translation: AAB05817.1 Sequence problems.
AK026075 mRNA Translation: BAB15351.1
AK290030 mRNA Translation: BAF82719.1
AC026704 Genomic DNA No translation available.
CH471123 Genomic DNA Translation: EAW54913.1
BC004877 mRNA Translation: AAH04877.1
CCDSiCCDS34157.1 [P22674-1]
PIRiS14266
RefSeqiNP_066970.3, NM_021147.4 [P22674-1]
UniGeneiHs.3041

3D structure databases

ProteinModelPortaliP22674
SMRiP22674
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115595, 7 interactors
DIPiDIP-24234N
IntActiP22674, 6 interactors
MINTiP22674
STRINGi9606.ENSP00000282572

PTM databases

iPTMnetiP22674
PhosphoSitePlusiP22674

Polymorphism and mutation databases

BioMutaiCCNO
DMDMi118572733

Proteomic databases

MaxQBiP22674
PaxDbiP22674
PeptideAtlasiP22674
PRIDEiP22674
ProteomicsDBi54013
54014 [P22674-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10309
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282572; ENSP00000282572; ENSG00000152669 [P22674-1]
ENST00000501463; ENSP00000422485; ENSG00000152669 [P22674-2]
GeneIDi10309
KEGGihsa:10309
UCSCiuc003jpv.4 human [P22674-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10309
DisGeNETi10309
EuPathDBiHostDB:ENSG00000152669.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCNO
GeneReviewsiCCNO

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0022318
HIX0200729
HGNCiHGNC:18576 CCNO
HPAiHPA050090
MalaCardsiCCNO
MIMi607752 gene
615872 phenotype
neXtProtiNX_P22674
OpenTargetsiENSG00000152669
Orphaneti244 Primary ciliary dyskinesia
PharmGKBiPA38350

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0653 Eukaryota
COG5024 LUCA
GeneTreeiENSGT00940000155998
HOGENOMiHOG000060283
HOVERGENiHBG062171
InParanoidiP22674
KOiK10861
OMAiLDLQTFR
OrthoDBiEOG091G0J8R
PhylomeDBiP22674
TreeFamiTF332057

Enzyme and pathway databases

BRENDAi3.2.2.27 2681
SignaLinkiP22674

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Cyclin_O

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10309

Protein Ontology

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PROi
PR:P22674

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
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Gene expression databases

BgeeiENSG00000152669 Expressed in 114 organ(s), highest expression level in oocyte
CleanExiHS_CCNO
GenevisibleiP22674 HS

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR028864 Ccno
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PANTHERiPTHR10177 PTHR10177, 1 hit
PTHR10177:SF14 PTHR10177:SF14, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
PIRSFiPIRSF001771 Cyclin_A_B_D_E, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCNO_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22674
Secondary accession number(s): A8K1W5
, Q0P6J2, Q9H6B0, Q9UMD5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: November 28, 2006
Last modified: December 5, 2018
This is version 162 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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