UniProtKB - P22670 (RFX1_HUMAN)
Protein
MHC class II regulatory factor RFX1
Gene
RFX1
Organism
Homo sapiens (Human)
Status
Functioni
Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 438 – 513 | RFX-type winged-helixPROSITE-ProRule annotationAdd BLAST | 76 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: GO_Central
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- immune response Source: ProtInc
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P22670 |
SignaLinki | P22670 |
SIGNORi | P22670 |
Names & Taxonomyi
Protein namesi | Recommended name: MHC class II regulatory factor RFX1Alternative name(s): Enhancer factor C Short name: EF-C Regulatory factor X 1 Short name: RFX Transcription factor RFX1 |
Gene namesi | Name:RFX1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9982, RFX1 |
MIMi | 600006, gene |
neXtProti | NX_P22670 |
VEuPathDBi | HostDB:ENSG00000132005.8 |
Subcellular locationi
Nucleus
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 5989 |
OpenTargetsi | ENSG00000132005 |
PharmGKBi | PA34352 |
Miscellaneous databases
Pharosi | P22670, Tbio |
Genetic variation databases
BioMutai | RFX1 |
DMDMi | 288558824 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000215286 | 1 – 979 | MHC class II regulatory factor RFX1Add BLAST | 979 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 60 | PhosphoserineCombined sources | 1 | |
Modified residuei | 978 | PhosphoserineCombined sources | 1 | |
Modified residuei | 979 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P22670 |
jPOSTi | P22670 |
MassIVEi | P22670 |
MaxQBi | P22670 |
PaxDbi | P22670 |
PeptideAtlasi | P22670 |
PRIDEi | P22670 |
ProteomicsDBi | 54012 |
PTM databases
iPTMneti | P22670 |
PhosphoSitePlusi | P22670 |
SwissPalmi | P22670 |
Expressioni
Gene expression databases
Bgeei | ENSG00000132005, Expressed in testis and 217 other tissues |
ExpressionAtlasi | P22670, baseline and differential |
Genevisiblei | P22670, HS |
Organism-specific databases
HPAi | ENSG00000132005, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
P22670
With | #Exp. | IntAct |
---|---|---|
FOXN2 [P32314] | 3 | EBI-716037,EBI-10706164 |
Protein-protein interaction databases
BioGRIDi | 111921, 33 interactors |
IntActi | P22670, 20 interactors |
MINTi | P22670 |
STRINGi | 9606.ENSP00000254325 |
Miscellaneous databases
RNActi | P22670, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P22670 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P22670 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 744 – 979 | Necessary for dimerizationAdd BLAST | 236 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 381 – 411 | Gly-richAdd BLAST | 31 | |
Compositional biasi | 920 – 936 | Asp/Glu-rich (acidic)Add BLAST | 17 |
Sequence similaritiesi
Belongs to the RFX family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG3712, Eukaryota |
GeneTreei | ENSGT00980000198514 |
HOGENOMi | CLU_010393_1_0_1 |
InParanoidi | P22670 |
OMAi | HITQEVQ |
OrthoDBi | 346630at2759 |
PhylomeDBi | P22670 |
TreeFami | TF321340 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR003150, DNA-bd_RFX IPR039779, RFX-like IPR007668, RFX1_trans_act IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR12619, PTHR12619, 1 hit |
Pfami | View protein in Pfam PF04589, RFX1_trans_act, 2 hits PF02257, RFX_DNA_binding, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS51526, RFX_DBD, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P22670-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATQAYTELQ AAPPPSQPPQ APPQAQPQPP PPPPPAAPQP PQPPTAAATP
60 70 80 90 100
QPQYVTELQS PQPQAQPPGG QKQYVTELPA VPAPSQPTGA PTPSPAPQQY
110 120 130 140 150
IVVTVSEGAM RASETVSEAS PGSTASQTGV PTQVVQQVQG TQQRLLVQTS
160 170 180 190 200
VQAKPGHVSP LQLTNIQVPQ QALPTQRLVV QSAAPGSKGG QVSLTVHGTQ
210 220 230 240 250
QVHSPPEQSP VQANSSSSKT AGAPTGTVPQ QLQVHGVQQS VPVTQERSVV
260 270 280 290 300
QATPQAPKPG PVQPLTVQGL QPVHVAQEVQ QLQQVPVPHV YSSQVQYVEG
310 320 330 340 350
GDASYTASAI RSSTYSYPET PLYTQTASTS YYEAAGTATQ VSTPATSQAV
360 370 380 390 400
ASSGSMPMYV SGSQVVASST STGAGASNSS GGGGSGGGGG GGGGGGGGGS
410 420 430 440 450
GSTGGGGSGA GTYVIQGGYM LGSASQSYSH TTRASPATVQ WLLDNYETAE
460 470 480 490 500
GVSLPRSTLY CHYLLHCQEQ KLEPVNAASF GKLIRSVFMG LRTRRLGTRG
510 520 530 540 550
NSKYHYYGLR IKASSPLLRL MEDQQHMAMR GQPFSQKQRL KPIQKMEGMT
560 570 580 590 600
NGVAVGQQPS TGLSDISAQV QQYQQFLDAS RSLPDFTELD LQGKVLPEGV
610 620 630 640 650
GPGDIKAFQV LYREHCEAIV DVMVNLQFTL VETLWKTFWR YNLSQPSEAP
660 670 680 690 700
PLAVHDEAEK RLPKAILVLL SKFEPVLQWT KHCDNVLYQG LVEILIPDVL
710 720 730 740 750
RPIPSALTQA IRNFAKSLES WLTHAMVNIP EEMLRVKVAA AGAFAQTLRR
760 770 780 790 800
YTSLNHLAQA ARAVLQNTAQ INQMLSDLNR VDFANVQEQA SWVCRCEDRV
810 820 830 840 850
VQRLEQDFKV TLQQQNSLEQ WAAWLDGVVS QVLKPYQGSA GFPKAAKLFL
860 870 880 890 900
LKWSFYSSMV IRDLTLRSAA SFGSFHLIRL LYDEYMYYLI EHRVAQAKGE
910 920 930 940 950
TPIAVMGEFA NLATSLNPLD PDKDEEEEEE EESEDELPQD ISLAAGGESP
960 970
ALGPETLEPP AKLARTDARG LFVQALPSS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketK7EIZ8 | K7EIZ8_HUMAN | MHC class II regulatory factor RFX1 | RFX1 | 158 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059781 | 370 | T → A2 PublicationsCorresponds to variant dbSNP:rs2305780Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X58964 mRNA Translation: CAA41730.1 AC020916 Genomic DNA No translation available. AC022098 Genomic DNA No translation available. BC049826 mRNA Translation: AAH49826.1 |
CCDSi | CCDS12301.1 |
PIRi | A35913 |
RefSeqi | NP_002909.4, NM_002918.4 |
Genome annotation databases
Ensembli | ENST00000254325; ENSP00000254325; ENSG00000132005 ENST00000672295; ENSP00000500760; ENSG00000288283 |
GeneIDi | 5989 |
KEGGi | hsa:5989 |
UCSCi | uc002mxv.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X58964 mRNA Translation: CAA41730.1 AC020916 Genomic DNA No translation available. AC022098 Genomic DNA No translation available. BC049826 mRNA Translation: AAH49826.1 |
CCDSi | CCDS12301.1 |
PIRi | A35913 |
RefSeqi | NP_002909.4, NM_002918.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1DP7 | X-ray | 1.50 | P | 438-513 | [»] | |
SMRi | P22670 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111921, 33 interactors |
IntActi | P22670, 20 interactors |
MINTi | P22670 |
STRINGi | 9606.ENSP00000254325 |
PTM databases
iPTMneti | P22670 |
PhosphoSitePlusi | P22670 |
SwissPalmi | P22670 |
Genetic variation databases
BioMutai | RFX1 |
DMDMi | 288558824 |
Proteomic databases
EPDi | P22670 |
jPOSTi | P22670 |
MassIVEi | P22670 |
MaxQBi | P22670 |
PaxDbi | P22670 |
PeptideAtlasi | P22670 |
PRIDEi | P22670 |
ProteomicsDBi | 54012 |
Protocols and materials databases
Antibodypediai | 26599, 168 antibodies |
Genome annotation databases
Ensembli | ENST00000254325; ENSP00000254325; ENSG00000132005 ENST00000672295; ENSP00000500760; ENSG00000288283 |
GeneIDi | 5989 |
KEGGi | hsa:5989 |
UCSCi | uc002mxv.4, human |
Organism-specific databases
CTDi | 5989 |
DisGeNETi | 5989 |
GeneCardsi | RFX1 |
HGNCi | HGNC:9982, RFX1 |
HPAi | ENSG00000132005, Low tissue specificity |
MIMi | 600006, gene |
neXtProti | NX_P22670 |
OpenTargetsi | ENSG00000132005 |
PharmGKBi | PA34352 |
VEuPathDBi | HostDB:ENSG00000132005.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3712, Eukaryota |
GeneTreei | ENSGT00980000198514 |
HOGENOMi | CLU_010393_1_0_1 |
InParanoidi | P22670 |
OMAi | HITQEVQ |
OrthoDBi | 346630at2759 |
PhylomeDBi | P22670 |
TreeFami | TF321340 |
Enzyme and pathway databases
PathwayCommonsi | P22670 |
SignaLinki | P22670 |
SIGNORi | P22670 |
Miscellaneous databases
BioGRID-ORCSi | 5989, 5 hits in 898 CRISPR screens |
ChiTaRSi | RFX1, human |
EvolutionaryTracei | P22670 |
GeneWikii | RFX1 |
GenomeRNAii | 5989 |
Pharosi | P22670, Tbio |
PROi | PR:P22670 |
RNActi | P22670, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000132005, Expressed in testis and 217 other tissues |
ExpressionAtlasi | P22670, baseline and differential |
Genevisiblei | P22670, HS |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR003150, DNA-bd_RFX IPR039779, RFX-like IPR007668, RFX1_trans_act IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR12619, PTHR12619, 1 hit |
Pfami | View protein in Pfam PF04589, RFX1_trans_act, 2 hits PF02257, RFX_DNA_binding, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS51526, RFX_DBD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RFX1_HUMAN | |
Accessioni | P22670Primary (citable) accession number: P22670 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1991 |
Last sequence update: | February 9, 2010 | |
Last modified: | February 10, 2021 | |
This is version 198 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families