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Protein

NAD-reducing hydrogenase HoxS subunit gamma

Gene

hoxU

Organism
Rhodococcus opacus (Nocardia opaca)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunits alpha and gamma of HoxS constitute an NADH--oxidoreductase.

Catalytic activityi

H2 + NAD+ = H+ + NADH.

Cofactori

[4Fe-4S] clusterCuratedNote: Binds 3 [4Fe-4S] clusters per subunit.Curated

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Ligand2Fe-2S, 4Fe-4S, Flavoprotein, FMN, Iron, Iron-sulfur, Metal-binding, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
NAD-reducing hydrogenase HoxS subunit gamma (EC:1.12.1.2)
Gene namesi
Name:hoxU
Encoded oniPlasmid0 Publication
OrganismiRhodococcus opacus (Nocardia opaca)
Taxonomic identifieri37919 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001185391 – ›33NAD-reducing hydrogenase HoxS subunit gammaAdd BLAST›33

Interactioni

Subunit structurei

Tetramer of an alpha and a gamma subunits (flavin-containing dimer), and a delta and a nickel-containing beta subunits (hydrogenase dimer).

Structurei

3D structure databases

ProteinModelPortaliP22659
SMRiP22659
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – ›332Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST›33

Sequence similaritiesi

Belongs to the complex I 75 kDa subunit family.Curated

Family and domain databases

InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
SUPFAMiSSF54292 SSF54292, 1 hit

Sequencei

Sequence statusi: Fragment.

P22659-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30 
SIEIEIDGVT VTTEESRTLV DVAAEAGVYI PTL
Length:33
Mass (Da):3,492
Last modified:August 1, 1991 - v1
Checksum:i62AF6E43F64E719D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei331

Similar proteinsi

Cross-referencesi

3D structure databases

ProteinModelPortaliP22659
SMRiP22659
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
SUPFAMiSSF54292 SSF54292, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHOXU_RHOOP
AccessioniPrimary (citable) accession number: P22659
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: February 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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