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UniProtKB - P22658 (HOXF_RHOOP)
Protein
NAD-reducing hydrogenase HoxS subunit alpha
Gene
hoxF
Organism
Rhodococcus opacus (Nocardia opaca)
Status
Functioni
Subunits alpha and gamma of HoxS constitute an NADH--oxidoreductase.
Catalytic activityi
- EC:1.12.1.2
Cofactori
Protein has several cofactor binding sites:- FMNCuratedNote: Binds 1 FMN.Curated
- [4Fe-4S] clusterCuratedNote: Binds 1 [4Fe-4S] cluster.Curated
GO - Molecular functioni
- 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
- hydrogen dehydrogenase activity Source: UniProtKB-EC
- metal ion binding Source: UniProtKB-KW
Keywordsi
Molecular function | Oxidoreductase |
Ligand | 4Fe-4S, Flavoprotein, FMN, Iron, Iron-sulfur, Metal-binding, NAD |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:hoxF |
Encoded oni | Plasmid |
Organismi | Rhodococcus opacus (Nocardia opaca) |
Taxonomic identifieri | 37919 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Nocardiaceae › Rhodococcus |
Subcellular locationi
Cytoplasm and Cytosol
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000118565 | 1 – ›37 | NAD-reducing hydrogenase HoxS subunit alphaAdd BLAST | ›37 |
Interactioni
Subunit structurei
Tetramer of an alpha and a gamma subunits (flavin-containing dimer), and a delta and a nickel-containing beta subunits (hydrogenase dimer).
Family & Domainsi
Sequence similaritiesi
Belongs to the complex I 51 kDa subunit family.Curated
Family and domain databases
Gene3Di | 1.10.10.1590, 1 hit |
InterProi | View protein in InterPro IPR041921, NuoE_N |
i Sequence
Sequence statusi: Fragment.
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 37 | 1 |
Similar proteinsi
Cross-referencesi
3D structure databases
AlphaFoldDBi | P22658 |
SMRi | P22658 |
ModBasei | Search... |
Family and domain databases
Gene3Di | 1.10.10.1590, 1 hit |
InterProi | View protein in InterPro IPR041921, NuoE_N |
MobiDBi | Search... |
Entry informationi
Entry namei | HOXF_RHOOP | |
Accessioni | P22658Primary (citable) accession number: P22658 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1991 |
Last sequence update: | August 1, 1991 | |
Last modified: | May 25, 2022 | |
This is version 74 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, PlasmidDocuments
- SIMILARITY comments
Index of protein domains and families