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Protein

Glutamate racemase

Gene

murI

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Provides the (R)-glutamate required for cell wall biosynthesis.UniRule annotation1 Publication2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

The low basal catalytic activity in increased 1000-fold in the presence of UDP-MurNAc-Ala, the product of the preceding enzyme in the peptidoglycan biosynthesis.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation1 Publication2 Publications
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei92Proton donor/acceptorUniRule annotationBy similarity1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei104UDP-MurNAc-L-AlaCombined sources1 Publication1
Active sitei204Proton donor/acceptorUniRule annotationBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • glutamate racemase activity Source: EcoCyc

GO - Biological processi

  • cell wall organization Source: UniProtKB-KW
  • peptidoglycan biosynthetic process Source: EcoCyc
  • regulation of cell shape Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:GLUTRACE-MONOMER
MetaCyc:GLUTRACE-MONOMER

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P22634

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00219

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutamate racemase1 PublicationUniRule annotation (EC:5.1.1.3UniRule annotation2 Publications)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:murI2 PublicationsUniRule annotation
Synonyms:dga, glr, yijA
Ordered Locus Names:b3967, JW5550
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

Escherichia coli strain K12 genome database

More...
EcoGenei
EG11204 murI

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000954701 – 285Glutamate racemaseAdd BLAST285

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P22634

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P22634

PRoteomics IDEntifications database

More...
PRIDEi
P22634

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
tufAP0CE472EBI-554903,EBI-301077

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4259606, 251 interactors

Database of interacting proteins

More...
DIPi
DIP-10283N

Protein interaction database and analysis system

More...
IntActi
P22634, 14 interactors

STRING: functional protein association networks

More...
STRINGi
316385.ECDH10B_4156

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1285
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JFNX-ray1.90A1-285[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P22634

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P22634

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P22634

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni28 – 29Substrate bindingUniRule annotationCombined sources1 Publication2
Regioni60 – 61Substrate bindingUniRule annotationCombined sources1 Publication2
Regioni93 – 94Substrate bindingUniRule annotationCombined sources1 Publication2
Regioni113 – 119UDP-MurNAc-Ala bindingCombined sources1 Publication7
Regioni205 – 206Substrate bindingUniRule annotationCombined sources1 Publication2

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the aspartate/glutamate racemases family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105F03 Bacteria
COG0796 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000262397

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P22634

KEGG Orthology (KO)

More...
KOi
K01776

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P22634

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_00258 Glu_racemase, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015942 Asp/Glu/hydantoin_racemase
IPR001920 Asp/Glu_race
IPR018187 Asp/Glu_racemase_AS_1
IPR033134 Asp/Glu_racemase_AS_2
IPR004391 Glu_race

The PANTHER Classification System

More...
PANTHERi
PTHR21198:SF2 PTHR21198:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01177 Asp_Glu_race, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53681 SSF53681, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00067 glut_race, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00923 ASP_GLU_RACEMASE_1, 1 hit
PS00924 ASP_GLU_RACEMASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P22634-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATKLQDGNT PCLAATPSEP RPTVLVFDSG VGGLSVYDEI RHLLPDLHYI
60 70 80 90 100
YAFDNVAFPY GEKSEAFIVE RVVAIVTAVQ ERYPLALAVV ACNTASTVSL
110 120 130 140 150
PALREKFDFP VVGVVPAIKP AARLTANGIV GLLATRGTVK RSYTHELIAR
160 170 180 190 200
FANECQIEML GSAEMVELAE AKLHGEDVSL DALKRILRPW LRMKEPPDTV
210 220 230 240 250
VLGCTHFPLL QEELLQVLPE GTRLVDSGAA IARRTAWLLE HEAPDAKSAD
260 270 280
ANIAFCMAMT PGAEQLLPVL QRYGFETLEK LAVLG
Length:285
Mass (Da):31,002
Last modified:February 1, 1995 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEC87281B577B8E93
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA23677 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAC43073 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAA23637 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAA23638 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
V00348 Genomic DNA Translation: CAA23638.1 Different initiation.
V00347 Genomic DNA Translation: CAA23637.1 Different initiation.
L14556 Genomic DNA Translation: AAA23677.1 Different initiation.
U00006 Genomic DNA Translation: AAC43073.1 Different initiation.
U00096 Genomic DNA Translation: AAC76949.2
AP009048 Genomic DNA Translation: BAE77344.1

Protein sequence database of the Protein Information Resource

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PIRi
I41187

NCBI Reference Sequences

More...
RefSeqi
NP_418402.2, NC_000913.3
WP_000201820.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC76949; AAC76949; b3967
BAE77344; BAE77344; BAE77344

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
948467

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW5550
eco:b3967

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.2737

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00348 Genomic DNA Translation: CAA23638.1 Different initiation.
V00347 Genomic DNA Translation: CAA23637.1 Different initiation.
L14556 Genomic DNA Translation: AAA23677.1 Different initiation.
U00006 Genomic DNA Translation: AAC43073.1 Different initiation.
U00096 Genomic DNA Translation: AAC76949.2
AP009048 Genomic DNA Translation: BAE77344.1
PIRiI41187
RefSeqiNP_418402.2, NC_000913.3
WP_000201820.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JFNX-ray1.90A1-285[»]
ProteinModelPortaliP22634
SMRiP22634
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259606, 251 interactors
DIPiDIP-10283N
IntActiP22634, 14 interactors
STRINGi316385.ECDH10B_4156

Proteomic databases

jPOSTiP22634
PaxDbiP22634
PRIDEiP22634

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76949; AAC76949; b3967
BAE77344; BAE77344; BAE77344
GeneIDi948467
KEGGiecj:JW5550
eco:b3967
PATRICifig|1411691.4.peg.2737

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB1189
EcoGeneiEG11204 murI

Phylogenomic databases

eggNOGiENOG4105F03 Bacteria
COG0796 LUCA
HOGENOMiHOG000262397
InParanoidiP22634
KOiK01776
PhylomeDBiP22634

Enzyme and pathway databases

UniPathwayi
UPA00219

BioCyciEcoCyc:GLUTRACE-MONOMER
MetaCyc:GLUTRACE-MONOMER
SABIO-RKiP22634

Miscellaneous databases

EvolutionaryTraceiP22634

Protein Ontology

More...
PROi
PR:P22634

Family and domain databases

HAMAPiMF_00258 Glu_racemase, 1 hit
InterProiView protein in InterPro
IPR015942 Asp/Glu/hydantoin_racemase
IPR001920 Asp/Glu_race
IPR018187 Asp/Glu_racemase_AS_1
IPR033134 Asp/Glu_racemase_AS_2
IPR004391 Glu_race
PANTHERiPTHR21198:SF2 PTHR21198:SF2, 1 hit
PfamiView protein in Pfam
PF01177 Asp_Glu_race, 1 hit
SUPFAMiSSF53681 SSF53681, 2 hits
TIGRFAMsiTIGR00067 glut_race, 1 hit
PROSITEiView protein in PROSITE
PS00923 ASP_GLU_RACEMASE_1, 1 hit
PS00924 ASP_GLU_RACEMASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMURI_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22634
Secondary accession number(s): P78133, Q2M8R2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: February 1, 1995
Last modified: January 16, 2019
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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