Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Streptavidin

Gene
N/A
Organism
Streptomyces avidinii
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei67Biotin1
Binding sitei78Biotin1
Binding sitei116Biotin1
Binding sitei132Biotin1
Binding sitei144Biotin1

Keywordsi

LigandBiotin

Enzyme and pathway databases

SABIO-RKiP22629

Names & Taxonomyi

Protein namesi
Recommended name:
Streptavidin
OrganismiStreptomyces avidinii
Taxonomic identifieri1895 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075026
DrugBankiDB08181 2-((3'-METHYL-4'-HYDROXYPHENYL)AZO)BENZOIC ACID
DB08216 2-((3'-TERTBUTYL-4'-HYDROXYPHENYL)AZO)BENZOIC ACID
DB08252 2-((4'-HYDROXYNAPHTHYL)-AZO)BENZOIC ACID
DB07880 2-((4'-HYDROXYPHENYL)-AZO)BENZOIC ACID
DB03353 2-Iminobiotin
DB03549 Biotinyl P-Nitroaniline
DB01942 Formic Acid
DB03533 Glycoluril
DB04464 N-Formylmethionine

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000000272925 – 183StreptavidinAdd BLAST159

Proteomic databases

PRIDEiP22629

Interactioni

Subunit structurei

Homotetramer.

Chemistry databases

BindingDBiP22629

Structurei

Secondary structure

1183
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP22629
SMRiP22629
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22629

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 159Avidin-likePROSITE-ProRule annotationAdd BLAST123

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi83 – 85Cell attachment site; atypical3

Sequence similaritiesi

Belongs to the avidin/streptavidin family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.40.128.30, 1 hit
InterProiView protein in InterPro
IPR005469 Avidin
IPR017889 Avidin-like_CS
IPR036896 Avidin-like_sf
IPR005468 Avidin/str
PfamiView protein in Pfam
PF01382 Avidin, 1 hit
PRINTSiPR00709 AVIDIN
SUPFAMiSSF50876 SSF50876, 1 hit
PROSITEiView protein in PROSITE
PS00577 AVIDIN_1, 1 hit
PS51326 AVIDIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22629-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKIVVAAIA VSLTTVSITA SASADPSKDS KAQVSAAEAG ITGTWYNQLG
60 70 80 90 100
STFIVTAGAD GALTGTYESA VGNAESRYVL TGRYDSAPAT DGSGTALGWT
110 120 130 140 150
VAWKNNYRNA HSATTWSGQY VGGAEARINT QWLLTSGTTE ANAWKSTLVG
160 170 180
HDTFTKVKPS AASIDAAKKA GVNNGNPLDA VQQ
Length:183
Mass (Da):18,834
Last modified:August 1, 1991 - v1
Checksum:i4652D8AE018468F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03591 Genomic DNA Translation: CAA27265.1
PIRiA23513

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03591 Genomic DNA Translation: CAA27265.1
PIRiA23513

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DF8X-ray1.51A/B37-163[»]
1HQQX-ray1.70A/B/C/D36-163[»]
1HXLX-ray1.80A/B36-163[»]
1HXZX-ray1.80A/B36-163[»]
1HY2X-ray2.00A/B/C/D36-163[»]
1I9HX-ray2.40A/B25-163[»]
1KFFX-ray1.90A/B/C/D38-163[»]
1KL3X-ray1.70A/B/C/D38-163[»]
1KL4X-ray1.70A/B/C/D38-163[»]
1KL5X-ray1.80A/B/C/D38-163[»]
1LCVX-ray2.30A/B39-159[»]
1LCWX-ray2.20A/B39-159[»]
1LCZX-ray1.95A/B25-159[»]
1LUQX-ray0.96A/B37-163[»]
1MEPX-ray1.65A/B/C/D37-163[»]
1MK5X-ray1.40A/B37-163[»]
1MM9X-ray1.66A37-163[»]
1MOYX-ray1.55A37-163[»]
1N43X-ray1.89A/B/C/D37-163[»]
1N4JX-ray2.18A37-163[»]
1N7YX-ray1.96A/B/C/D37-163[»]
1N9MX-ray1.60A/B/C/D37-163[»]
1N9YX-ray1.53A/B/C/D37-163[»]
1NBXX-ray1.70A/B/C/D37-163[»]
1NC9X-ray1.80A/B/C/D37-163[»]
1NDJX-ray1.81A/B/C/D37-163[»]
1NQMX-ray1.70A/B/C/D24-159[»]
1PTSX-ray2.00A/B37-157[»]
1RSTX-ray1.70B38-163[»]
1RSUX-ray1.70B38-163[»]
1RXHX-ray2.90A/B37-163[»]
1RXJX-ray1.14A/B/C/D39-159[»]
1RXKX-ray1.70A/B38-159[»]
1SLDX-ray2.50B25-159[»]
1SLEX-ray2.00B/D25-159[»]
1SLFX-ray1.76B/D25-159[»]
1SLGX-ray1.76B/D25-159[»]
1SREX-ray1.78A/B37-157[»]
1SRFX-ray2.00A/B37-157[»]
1SRGX-ray1.80A/B37-157[»]
1SRHX-ray2.20A/B37-157[»]
1SRIX-ray1.65A/B37-157[»]
1SRJX-ray1.80A/B37-157[»]
1STPX-ray2.60A25-183[»]
1STRX-ray1.80B/D37-159[»]
1STSX-ray1.95B/D37-159[»]
1SWAX-ray1.90A/B/C/D37-163[»]
1SWBX-ray1.85A/B/C/D37-163[»]
1SWCX-ray1.80A/B/C/D37-163[»]
1SWDX-ray1.90A/B/C/D37-163[»]
1SWEX-ray2.06A/B/C/D37-163[»]
1SWFX-ray2.00A/B/C/D75-163[»]
1SWGX-ray1.80A/B/C/D75-178[»]
1SWHX-ray1.70A/B/C/D37-163[»]
1SWJX-ray2.00A/B/C/D37-163[»]
1SWKX-ray2.00A/B/C/D37-163[»]
1SWLX-ray1.80A/B/C/D37-163[»]
1SWNX-ray2.20A/B/C/D37-163[»]
1SWOX-ray1.95A/B/C/D37-163[»]
1SWPX-ray2.00A/B/C/D37-163[»]
1SWQX-ray1.90A/B/C/D37-163[»]
1SWRX-ray1.90A/B/C/D37-163[»]
1SWSX-ray2.00A/B/C/D37-163[»]
1SWTX-ray2.00A/B37-163[»]
1SWUX-ray1.14A/B/C/D37-163[»]
1VWAX-ray1.85B/D37-159[»]
1VWBX-ray1.82B37-159[»]
1VWCX-ray1.86B37-159[»]
1VWDX-ray1.87B37-159[»]
1VWEX-ray1.50B37-159[»]
1VWFX-ray1.92B37-159[»]
1VWGX-ray1.46B37-159[»]
1VWHX-ray1.48B37-159[»]
1VWIX-ray1.50B/D37-159[»]
1VWJX-ray1.45B/D37-159[»]
1VWKX-ray1.45B/D37-159[»]
1VWLX-ray1.45B/D37-159[»]
1VWMX-ray1.60B37-159[»]
1VWNX-ray1.85B37-159[»]
1VWOX-ray1.65B37-159[»]
1VWPX-ray1.75B37-159[»]
1VWQX-ray1.70B37-159[»]
1VWRX-ray1.50B37-159[»]
2BC3X-ray1.54A/B38-183[»]
2F01X-ray0.85A/B37-163[»]
2G5LX-ray1.15A/B37-163[»]
2GH7X-ray1.00A/B37-163[»]
2IZAX-ray1.46A37-157[»]
2IZBX-ray1.20A37-158[»]
2IZCX-ray1.40B/D37-159[»]
2IZDX-ray1.60B/D37-159[»]
2IZEX-ray1.57B/D37-159[»]
2IZFX-ray1.58B/D37-159[»]
2IZGX-ray1.36B/D37-159[»]
2IZHX-ray1.36B/D37-159[»]
2IZIX-ray1.50A37-159[»]
2IZJX-ray1.30A37-159[»]
2IZKX-ray1.30A37-159[»]
2IZLX-ray1.48B/D37-159[»]
2QCBX-ray1.65A38-183[»]
2RTAX-ray1.39A25-159[»]
2RTBX-ray1.50B/D25-159[»]
2RTCX-ray1.50B/D25-159[»]
2RTDX-ray1.65B/D25-159[»]
2RTEX-ray1.50B/D25-159[»]
2RTFX-ray1.47B/D25-159[»]
2RTGX-ray1.39B/D25-159[»]
2RTHX-ray1.56B/D25-159[»]
2RTIX-ray1.40B/D25-159[»]
2RTJX-ray1.40A25-159[»]
2RTKX-ray1.82A25-159[»]
2RTLX-ray1.41A25-159[»]
2RTMX-ray1.30A25-159[»]
2RTNX-ray1.80B/D25-159[»]
2RTOX-ray1.58B/D25-159[»]
2RTPX-ray1.50B/D25-159[»]
2RTQX-ray1.39B/D25-159[»]
2RTRX-ray1.62B/D25-159[»]
2WPUX-ray1.92A38-183[»]
2Y3EX-ray1.45A/B37-163[»]
2Y3FX-ray1.49A37-163[»]
3MG5X-ray1.30A/B/C/D37-163[»]
3PK2X-ray1.90A38-183[»]
3RDMX-ray1.60A37-164[»]
3RDOX-ray1.40A37-164[»]
3RDQX-ray1.60A37-164[»]
3RDSX-ray1.50A37-164[»]
3RDUX-ray1.50A37-164[»]
3RDXX-ray2.10A/B37-164[»]
3RE5X-ray1.95A37-164[»]
3RE6X-ray1.82A37-164[»]
3RY1X-ray1.03A/B/C/D37-163[»]
3RY2X-ray0.95A/B37-163[»]
3T6FX-ray1.22A/B37-163[»]
3T6LX-ray1.30A37-163[»]
3WYPX-ray1.30A/B/C/D37-163[»]
3WYQX-ray1.00A/B37-163[»]
3WZNX-ray1.30A/B37-163[»]
3WZOX-ray1.50A/B/C/D37-163[»]
3WZPX-ray1.20A/B/C/D37-163[»]
3WZQX-ray1.70A/B/C/D37-163[»]
3X00X-ray1.30A/B/C/D37-163[»]
4BX5X-ray1.43A/C37-72[»]
B/D37-163[»]
4BX6X-ray1.60A/B/C/D37-163[»]
4BX7X-ray2.26A/B37-163[»]
4CPEX-ray1.06A/B37-163[»]
4CPFX-ray1.14A/B37-163[»]
4CPHX-ray1.64A/B/C/D37-163[»]
4CPIX-ray1.54A/B/C/D37-163[»]
4DNEX-ray1.88A/B1-183[»]
4EKVX-ray2.00A25-183[»]
4GD9X-ray1.50A/B/C/D37-163[»]
4GDAX-ray1.00A/B37-163[»]
4GJSX-ray1.85A/B38-183[»]
4GJVX-ray2.40A38-183[»]
4IRWX-ray1.40A36-163[»]
4JO6X-ray1.75A/B/C/D25-183[»]
4OKAX-ray2.50A38-183[»]
4Y59X-ray1.22A/B/C/D39-159[»]
4Y5DX-ray1.20A/B/C/D39-160[»]
4YVBX-ray1.35A/B/C/D40-159[»]
5B5FX-ray1.20A/B/C/D40-159[»]
5B5GX-ray1.50A/B/C/D40-159[»]
5CSEX-ray1.79A/B38-158[»]
5F2BX-ray1.70A38-183[»]
5JD2X-ray1.90A/B/C/D40-159[»]
5K67X-ray1.70A38-183[»]
5K68X-ray1.40A38-183[»]
5L3YX-ray1.70A38-183[»]
5N7XX-ray1.12A/B/E/F/H/K/M/O1-183[»]
5N89X-ray1.27A/B/D/F/H/K/M/O1-183[»]
5N8BX-ray1.03A/B/D/G1-183[»]
5N8EX-ray1.10A/B/C/D1-183[»]
5N8JX-ray1.05A/B/C/D1-183[»]
5N8TX-ray1.61A1-183[»]
5N8WX-ray1.10A/B1-183[»]
5N99X-ray1.50A/B/D/G/I/K/M/O/Q/S/U/Y1-183[»]
5TO2X-ray1.65A/B/C39-163[»]
D39-162[»]
5VCQX-ray2.05A/B/C/D1-183[»]
5VKXX-ray1.37A38-183[»]
5VL5X-ray1.46A38-183[»]
5VL8X-ray1.70A38-183[»]
5WBAX-ray1.50A38-183[»]
5WBBX-ray1.50A38-183[»]
5WBCX-ray1.72A38-183[»]
5WBDX-ray1.50A38-183[»]
6ANXX-ray1.62A38-183[»]
6AUCX-ray1.46A38-183[»]
6AUEX-ray1.36A38-183[»]
6AUHX-ray1.60A38-183[»]
6AULX-ray1.36A38-183[»]
6AUOX-ray1.70A38-183[»]
6AVKX-ray1.40A/B37-159[»]
6ESSX-ray1.91A38-183[»]
6ESUX-ray1.78A38-183[»]
6FH8X-ray1.64A38-183[»]
ProteinModelPortaliP22629
SMRiP22629
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiP22629
ChEMBLiCHEMBL1075026
DrugBankiDB08181 2-((3'-METHYL-4'-HYDROXYPHENYL)AZO)BENZOIC ACID
DB08216 2-((3'-TERTBUTYL-4'-HYDROXYPHENYL)AZO)BENZOIC ACID
DB08252 2-((4'-HYDROXYNAPHTHYL)-AZO)BENZOIC ACID
DB07880 2-((4'-HYDROXYPHENYL)-AZO)BENZOIC ACID
DB03353 2-Iminobiotin
DB03549 Biotinyl P-Nitroaniline
DB01942 Formic Acid
DB03533 Glycoluril
DB04464 N-Formylmethionine

Proteomic databases

PRIDEiP22629

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

SABIO-RKiP22629

Miscellaneous databases

EvolutionaryTraceiP22629

Family and domain databases

Gene3Di2.40.128.30, 1 hit
InterProiView protein in InterPro
IPR005469 Avidin
IPR017889 Avidin-like_CS
IPR036896 Avidin-like_sf
IPR005468 Avidin/str
PfamiView protein in Pfam
PF01382 Avidin, 1 hit
PRINTSiPR00709 AVIDIN
SUPFAMiSSF50876 SSF50876, 1 hit
PROSITEiView protein in PROSITE
PS00577 AVIDIN_1, 1 hit
PS51326 AVIDIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSAV_STRAV
AccessioniPrimary (citable) accession number: P22629
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: October 10, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again