Retinoic acid receptor beta

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription factor activity Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 8152920
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • 21873635
• drug binding Source: MGI
• nuclear receptor transcription coactivator activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• protein-containing complex binding Source: MGI
• retinoic acid receptor activity Source: MGI
• retinoid X receptor binding Source: MGI
• RNA polymerase II regulatory region sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • 1655807
• sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • 7823919
• signaling receptor activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• steroid hormone receptor activity Source: InterPro
• transcription factor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• transcription regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• bone development Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 7607067
• bone morphogenesis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• cell differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• cellular response to retinoic acid Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• embryonic digestive tract development Source: MGI
• embryonic eye morphogenesis Source: MGIInferred from genetic interactionⁱ
  • 16207763
• embryonic hindlimb morphogenesis Source: MGIInferred from genetic interactionⁱ
  • 10075839
• epithelium development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• gland development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• glandular epithelial cell development Source: MGIInferred from genetic interactionⁱ
  • 7607067
• growth plate cartilage development Source: MGIInferred from genetic interactionⁱ
  • 19389355
• hormone-mediated signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• liver development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• multicellular organism development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• multicellular organism growth Source: MGIInferred from genetic interactionⁱ
  • 19389355
• negative regulation of apoptotic process Source: MGIInferred from genetic interactionⁱ
  • 9659935
  • 8681798
• negative regulation of cartilage development Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 10684250
• negative regulation of cell proliferation Source: MGIInferred from genetic interactionⁱ
  • 10075839
• negative regulation of chondrocyte differentiation Source: MGIInferred from mutant phenotypeⁱ
  • 10684250
• negative regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • 8152920
• neurogenesis Source: MGIInferred from mutant phenotypeⁱ
  • 18443282
• outflow tract septum morphogenesis Source: MGIInferred from genetic interactionⁱ
  • 9659935
• positive regulation of apoptotic process Source: MGIInferred from genetic interactionⁱ
  • 16207763
• positive regulation of cell proliferation Source: MGIInferred from genetic interactionⁱ
  • 8681798
• positive regulation of neuron differentiation Source: MGI
• positive regulation of programmed cell death Source: MGIInferred from genetic interactionⁱ
  • 10075839
• positive regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • 1313565
• regulation of myelination Source: MGI
• response to lipid Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• response to retinoic acid Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• retina development in camera-type eye Source: MGIInferred from genetic interactionⁱ
  • 8681798
• retinal pigment epithelium development Source: MGIInferred from genetic interactionⁱ
  • 8681798
• retinoic acid receptor signaling pathway Source: MGI
• striatum development Source: MGIInferred from mutant phenotypeⁱ
  • 18443282
• ureteric bud development Source: MGIInferred from mutant phenotypeⁱ
  • 12195422
• ventricular cardiac muscle cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • 9428411

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• retinoid X receptor binding Source: MGI
• transcription factor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MSTSSHACPV PAVRGHMTHY PAAPYPLLFP PVIRGLSLPP LHGLHGHPPP 
        60         70         80         90        100
SGCSTPSPAS VGQACQRTTG GSQFAASTKW TPSLNAAIET QSTSSEELVP 
       110        120        130        140        150
SPPSPLPPPR VYKPCFVCQD KSSGYHYGVS ACEGCKGFFR RSIQKNMIYT 
       160        170        180        190        200
CHRDKNCVIN KVTRNRCQYC RLQKCFEVGM SKESVRNDRN KKKKEPSKQE 
       210        220        230        240        250
CTESYEMTAE LDDLTEKIRK AHQETFPSLC QLGKYTTNSS ADHRVRLDLG 
       260        270        280        290        300
LWDKFSELAT KCIIKIVEFA KRLPGFTGLT IADQITLLKA ACLDILILRI 
       310        320        330        340        350
CTRYTPEQDT MTFSDGLTLN RTQMHNAGFG PLTDLVFTFA NQLLPLEMDD 
       360        370        380        390        400
TETGLLSAIC LICGDRQDLE EPTKVDKLQE PLLEALKIYI RKRRPSKPHM 
       410        420        430        440        450
FPKILMKITD LRSISAKGAE RVITLKMEIP GSMPPLIQEM LENSEGHEPL 
       460        470        480 
TPSSSGNIAE HSPSVSPSSV ENSGVSQSPL LQ                    

        10         20         30         40         50
MSTSSHACPV PAVRGHMTHY PAAPYPLLFP PVIRGLSLPP LHGLHGHPPP 
        60         70         80         90        100
SGCSTPSPAT IETQSTSSEE LVPSPPSPLP PPRVYKPCFV CQDKSSGYHY 
       110        120        130        140        150
GVSACEGCKG FFRRSIQKNM IYTCHRDKNC VINKVTRNRC QYCRLQKCFE 
       160        170        180        190        200
VGMSKESVRN DRNKKKKEPS KQECTESYEM TAELDDLTEK IRKAHQETFP 
       210        220        230        240        250
SLCQLGKYTT NSSADHRVRL DLGLWDKFSE LATKCIIKIV EFAKRLPGFT 
       260        270        280        290        300
GLTIADQITL LKAACLDILI LRICTRYTPE QDTMTFSDGL TLNRTQMHNA 
       310        320        330        340        350
GFGPLTDLVF TFANQLLPLE MDDTETGLLS AICLICGDRQ DLEEPTKVDK 
       360        370        380        390        400
LQEPLLEALK IYIRKRRPSK PHMFPKILMK ITDLRSISAK GAERVITLKM 
       410        420        430        440        450
EIPGSMPPLI QEMLENSEGH EPLTPSSSGN IAEHSPSVSP SSVENSGVSQ 

SPLLQ                                                  

        10         20         30         40         50
MFDCMDVLSV SPGQILDFYT ASPSSCMLQE KALKACLSGF TQAEWQHRHT 
        60         70         80         90        100
AQSIETQSTS SEELVPSPPS PLPPPRVYKP CFVCQDKSSG YHYGVSACEG 
       110        120        130        140        150
CKGFFRRSIQ KNMIYTCHRD KNCVINKVTR NRCQYCRLQK CFEVGMSKES 
       160        170        180        190        200
VRNDRNKKKK EPSKQECTES YEMTAELDDL TEKIRKAHQE TFPSLCQLGK 
       210        220        230        240        250
YTTNSSADHR VRLDLGLWDK FSELATKCII KIVEFAKRLP GFTGLTIADQ 
       260        270        280        290        300
ITLLKAACLD ILILRICTRY TPEQDTMTFS DGLTLNRTQM HNAGFGPLTD 
       310        320        330        340        350
LVFTFANQLL PLEMDDTETG LLSAICLICG DRQDLEEPTK VDKLQEPLLE 
       360        370        380        390        400
ALKIYIRKRR PSKPHMFPKI LMKITDLRSI SAKGAERVIT LKMEIPGSMP 
       410        420        430        440 
PLIQEMLENS EGHEPLTPSS SGNIAEHSPS VSPSSVENSG VSQSPLLQ   

        10         20         30         40         50
MENAIETQST SSEELVPSPP SPLPPPRVYK PCFVCQDKSS GYHYGVSACE 
        60         70         80         90        100
GCKGFFRRSI QKNMIYTCHR DKNCVINKVT RNRCQYCRLQ KCFEVGMSKE 
       110        120        130        140        150
SVRNDRNKKK KEPSKQECTE SYEMTAELDD LTEKIRKAHQ ETFPSLCQLG 
       160        170        180        190        200
KYTTNSSADH RVRLDLGLWD KFSELATKCI IKIVEFAKRL PGFTGLTIAD 
       210        220        230        240        250
QITLLKAACL DILILRICTR YTPEQDTMTF SDGLTLNRTQ MHNAGFGPLT 
       260        270        280        290        300
DLVFTFANQL LPLEMDDTET GLLSAICLIC GDRQDLEEPT KVDKLQEPLL 
       310        320        330        340        350
EALKIYIRKR RPSKPHMFPK ILMKITDLRS ISAKGAERVI TLKMEIPGSM 
       360        370        380        390 
PPLIQEMLEN SEGHEPLTPS SSGNIAEHSP SVSPSSVENS GVSQSPLLQ  

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
3. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references