UniProtKB - P22605 (RARB_MOUSE)
Retinoic acid receptor beta
Rarb
Functioni
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (By similarity).
The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element (By similarity).
In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (PubMed:19389355).
By similarity1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 115 – 180 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 66 | |
Zinc fingeri | 115 – 135 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 151 – 175 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: MGI
- heterocyclic compound binding Source: MGI
- nuclear receptor activity Source: GO_Central
- protein-containing complex binding Source: MGI
- retinoid X receptor binding Source: MGI
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
- zinc ion binding Source: InterPro
GO - Biological processi
- bone development Source: MGI
- cell differentiation Source: GO_Central
- embryonic digestive tract development Source: MGI
- embryonic eye morphogenesis Source: MGI
- embryonic hindlimb morphogenesis Source: MGI
- glandular epithelial cell development Source: MGI
- growth plate cartilage development Source: MGI
- hormone-mediated signaling pathway Source: GO_Central
- multicellular organism growth Source: MGI
- negative regulation of cartilage development Source: MGI
- negative regulation of cell population proliferation Source: MGI
- negative regulation of chondrocyte differentiation Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- neural precursor cell proliferation Source: MGI
- neurogenesis Source: MGI
- positive regulation of apoptotic process Source: MGI
- positive regulation of programmed cell death Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of myelination Source: MGI
- retinoic acid receptor signaling pathway Source: GO_Central
- striatum development Source: MGI
- ureteric bud development Source: MGI
- ventricular cardiac muscle cell differentiation Source: MGI
Keywordsi
Molecular function | DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-383280, Nuclear Receptor transcription pathway R-MMU-5362517, Signaling by Retinoic Acid |
Names & Taxonomyi
Protein namesi | Recommended name: Retinoic acid receptor betaShort name: RAR-beta Alternative name(s): Nuclear receptor subfamily 1 group B member 2 |
Gene namesi | Name:Rarb Synonyms:Nr1b2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97857, Rarb |
VEuPathDBi | HostDB:ENSMUSG00000017491 |
Subcellular locationi
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Disruption phenotypei
Chemistry databases
ChEMBLi | CHEMBL3266 |
DrugCentrali | P22605 |
GuidetoPHARMACOLOGYi | 591 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053468 | 1 – 482 | Retinoic acid receptor betaAdd BLAST | 482 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 104 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P22605 |
PRIDEi | P22605 |
ProteomicsDBi | 255096 [P22605-1] 255097 [P22605-2] 255098 [P22605-3] 255099 [P22605-4] |
PTM databases
iPTMneti | P22605 |
PhosphoSitePlusi | P22605 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000017491, Expressed in caudate-putamen and 303 other tissues |
ExpressionAtlasi | P22605, baseline and differential |
Genevisiblei | P22605, MM |
Interactioni
Subunit structurei
Homodimer (By similarity). Heterodimer; with a RXR molecule (By similarity). Binds DNA preferentially as a RAR/RXR heterodimer (By similarity). Heterodimerizes (via NR LBD) with RXRA (By similarity).
Interacts weakly with NCOR2 (By similarity).
By similarityBinary interactionsi
P22605
With | #Exp. | IntAct |
---|---|---|
Ing4 [Q8C0D7] | 3 | EBI-2903247,EBI-645598 |
GO - Molecular functioni
- retinoid X receptor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 230063, 3 interactors |
IntActi | P22605, 4 interactors |
MINTi | P22605 |
STRINGi | 10090.ENSMUSP00000067694 |
Chemistry databases
BindingDBi | P22605 |
Miscellaneous databases
RNActi | P22605, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P22605 |
SMRi | P22605 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P22605 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 210 – 444 | NR LBDPROSITE-ProRule annotationAdd BLAST | 235 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 114 | ModulatingAdd BLAST | 114 | |
Regioni | 181 – 209 | HingeAdd BLAST | 29 | |
Regioni | 443 – 482 | DisorderedSequence analysisAdd BLAST | 40 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 447 – 482 | Polar residuesSequence analysisAdd BLAST | 36 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 115 – 135 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 151 – 175 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000156196 |
HOGENOMi | CLU_007368_18_2_1 |
InParanoidi | P22605 |
OMAi | PFHATRN |
PhylomeDBi | P22605 |
TreeFami | TF328382 |
Family and domain databases
DisProti | DP02633 |
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003078, Retinoic_acid_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01292, RETNOICACIDR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSTSSHACPV PAVRGHMTHY PAAPYPLLFP PVIRGLSLPP LHGLHGHPPP
60 70 80 90 100
SGCSTPSPAS VGQACQRTTG GSQFAASTKW TPSLNAAIET QSTSSEELVP
110 120 130 140 150
SPPSPLPPPR VYKPCFVCQD KSSGYHYGVS ACEGCKGFFR RSIQKNMIYT
160 170 180 190 200
CHRDKNCVIN KVTRNRCQYC RLQKCFEVGM SKESVRNDRN KKKKEPSKQE
210 220 230 240 250
CTESYEMTAE LDDLTEKIRK AHQETFPSLC QLGKYTTNSS ADHRVRLDLG
260 270 280 290 300
LWDKFSELAT KCIIKIVEFA KRLPGFTGLT IADQITLLKA ACLDILILRI
310 320 330 340 350
CTRYTPEQDT MTFSDGLTLN RTQMHNAGFG PLTDLVFTFA NQLLPLEMDD
360 370 380 390 400
TETGLLSAIC LICGDRQDLE EPTKVDKLQE PLLEALKIYI RKRRPSKPHM
410 420 430 440 450
FPKILMKITD LRSISAKGAE RVITLKMEIP GSMPPLIQEM LENSEGHEPL
460 470 480
TPSSSGNIAE HSPSVSPSSV ENSGVSQSPL LQ
The sequence of this isoform differs from the canonical sequence as follows:
60-60: S → T
61-87: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-87: MSTSSHACPV...TKWTPSLNAA → MFDCMDVLSV...EWQHRHTAQS
The sequence of this isoform differs from the canonical sequence as follows:
1-83: Missing.
84-86: LNA → MEN
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A286YCH1 | A0A286YCH1_MOUSE | Retinoic acid receptor beta | Rarb | 402 | Annotation score: | ||
A0A286YCX1 | A0A286YCX1_MOUSE | Retinoic acid receptor beta | Rarb | 164 | Annotation score: | ||
A0A286YDP5 | A0A286YDP5_MOUSE | Retinoic acid receptor beta | Rarb | 139 | Annotation score: | ||
A0A286YE15 | A0A286YE15_MOUSE | Retinoic acid receptor beta | Rarb | 74 | Annotation score: | ||
A0A286YCR2 | A0A286YCR2_MOUSE | Retinoic acid receptor beta | Rarb | 61 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003636 | 1 – 87 | MSTSS…SLNAA → MFDCMDVLSVSPGQILDFYT ASPSSCMLQEKALKACLSGF TQAEWQHRHTAQS in isoform Beta-2. 4 PublicationsAdd BLAST | 87 | |
Alternative sequenceiVSP_003637 | 1 – 83 | Missing in isoform Beta-4. 1 PublicationAdd BLAST | 83 | |
Alternative sequenceiVSP_003639 | 60 | S → T in isoform Beta-1. 1 Publication | 1 | |
Alternative sequenceiVSP_003640 | 61 – 87 | Missing in isoform Beta-1. 1 PublicationAdd BLAST | 27 | |
Alternative sequenceiVSP_003638 | 84 – 86 | LNA → MEN in isoform Beta-4. 1 Publication | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X56574 mRNA Translation: CAA39921.1 X56569 mRNA Translation: CAA39918.1 X56573 mRNA Translation: CAA39920.1 S56660 mRNA Translation: AAB25784.2 S92180 mRNA No translation available. |
CCDSi | CCDS26834.1 [P22605-3] |
PIRi | S05051 |
RefSeqi | NP_001276689.1, NM_001289760.1 [P22605-1] NP_001276690.1, NM_001289761.1 [P22605-2] NP_001276691.1, NM_001289762.1 [P22605-4] NP_035373.1, NM_011243.2 [P22605-3] |
Genome annotation databases
Ensembli | ENSMUST00000063750; ENSMUSP00000067694; ENSMUSG00000017491 [P22605-3] |
GeneIDi | 218772 |
KEGGi | mmu:218772 |
UCSCi | uc007shh.2, mouse [P22605-4] uc007shi.2, mouse [P22605-2] uc007shj.2, mouse [P22605-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X56574 mRNA Translation: CAA39921.1 X56569 mRNA Translation: CAA39918.1 X56573 mRNA Translation: CAA39920.1 S56660 mRNA Translation: AAB25784.2 S92180 mRNA No translation available. |
CCDSi | CCDS26834.1 [P22605-3] |
PIRi | S05051 |
RefSeqi | NP_001276689.1, NM_001289760.1 [P22605-1] NP_001276690.1, NM_001289761.1 [P22605-2] NP_001276691.1, NM_001289762.1 [P22605-4] NP_035373.1, NM_011243.2 [P22605-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1XDK | X-ray | 2.90 | B/F | 180-482 | [»] | |
AlphaFoldDBi | P22605 | |||||
SMRi | P22605 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 230063, 3 interactors |
IntActi | P22605, 4 interactors |
MINTi | P22605 |
STRINGi | 10090.ENSMUSP00000067694 |
Chemistry databases
BindingDBi | P22605 |
ChEMBLi | CHEMBL3266 |
DrugCentrali | P22605 |
GuidetoPHARMACOLOGYi | 591 |
PTM databases
iPTMneti | P22605 |
PhosphoSitePlusi | P22605 |
Proteomic databases
PaxDbi | P22605 |
PRIDEi | P22605 |
ProteomicsDBi | 255096 [P22605-1] 255097 [P22605-2] 255098 [P22605-3] 255099 [P22605-4] |
Protocols and materials databases
Antibodypediai | 934, 528 antibodies from 44 providers |
DNASUi | 218772 |
Genome annotation databases
Ensembli | ENSMUST00000063750; ENSMUSP00000067694; ENSMUSG00000017491 [P22605-3] |
GeneIDi | 218772 |
KEGGi | mmu:218772 |
UCSCi | uc007shh.2, mouse [P22605-4] uc007shi.2, mouse [P22605-2] uc007shj.2, mouse [P22605-1] |
Organism-specific databases
CTDi | 5915 |
MGIi | MGI:97857, Rarb |
VEuPathDBi | HostDB:ENSMUSG00000017491 |
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000156196 |
HOGENOMi | CLU_007368_18_2_1 |
InParanoidi | P22605 |
OMAi | PFHATRN |
PhylomeDBi | P22605 |
TreeFami | TF328382 |
Enzyme and pathway databases
Reactomei | R-MMU-383280, Nuclear Receptor transcription pathway R-MMU-5362517, Signaling by Retinoic Acid |
Miscellaneous databases
BioGRID-ORCSi | 218772, 3 hits in 76 CRISPR screens |
ChiTaRSi | Rarb, mouse |
EvolutionaryTracei | P22605 |
PROi | PR:P22605 |
RNActi | P22605, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000017491, Expressed in caudate-putamen and 303 other tissues |
ExpressionAtlasi | P22605, baseline and differential |
Genevisiblei | P22605, MM |
Family and domain databases
DisProti | DP02633 |
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003078, Retinoic_acid_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01292, RETNOICACIDR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RARB_MOUSE | |
Accessioni | P22605Primary (citable) accession number: P22605 Secondary accession number(s): P11417, P22604 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1991 |
Last sequence update: | August 1, 1991 | |
Last modified: | May 25, 2022 | |
This is version 202 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families