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UniProtKB - P22599 (A1AT2_MOUSE)

Entry version 156 (16 Jan 2019)
Sequence version 2 (21 Jun 2005)
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Protein

Alpha-1-antitrypsin 1-2

Gene

Serpina1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin.2 Publications

Miscellaneous

Murine alpha-1-antitrypsin is represented by a cluster of up to 6 individual Serpina1-related genes. The precise complement of Serpina1-related genes present varies according to the strain of the animal.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei377 – 378Reactive bondBy similarity2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor
Biological processAcute phase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-114608 Platelet degranulation
R-MMU-204005 COPII-mediated vesicle transport
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-5694530 Cargo concentration in the ER
R-MMU-6798695 Neutrophil degranulation
R-MMU-8957275 Post-translational protein phosphorylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-1-antitrypsin 1-2
Short name:
AAT
Alternative name(s):
Alpha-1 protease inhibitor 2
Alpha-1-antiproteinase
Serine protease inhibitor 1-2
Serine protease inhibitor A1b
Short name:
Serpin A1b
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Serpina1b
Synonyms:Aat2, Dom2, Spi1-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:891970 Serpina1b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24By similarityAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003238925 – 413Alpha-1-antitrypsin 1-2Add BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi101N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi265N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P22599

MaxQB - The MaxQuant DataBase

More...MaxQBi		P22599

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P22599

PeptideAtlas

More...PeptideAtlasi		P22599

PRoteomics IDEntifications database

More...PRIDEi		P22599

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		799

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P22599

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P22599

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000071178 Expressed in 115 organ(s), highest expression level in left lobe of liver

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P22599 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P22599 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		203428, 1 interactor

Protein interaction database and analysis system

More...IntActi		P22599, 2 interactors

Molecular INTeraction database

More...MINTi		P22599

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000093101

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P22599

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P22599

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni368 – 387RCLAdd BLAST20

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable (By similarity). Variability within the reactive center loop (RCL) sequences of Serpina1-related genes may determine target protease specificity.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2392 Eukaryota
COG4826 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154493

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000238521

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG005957

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P22599

KEGG Orthology (KO)

More...KOi		K03984

Identification of Orthologs from Complete Genome Data

More...OMAi		REYDDFK

Database of Orthologous Groups

More...OrthoDBi		1124079at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P22599

TreeFam database of animal gene trees

More...TreeFami		TF343201

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf

The PANTHER Classification System

More...PANTHERi		PTHR11461 PTHR11461, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00079 Serpin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00093 SERPIN, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56574 SSF56574, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00284 SERPIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P22599-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPSISWGLL LLAGLCCMVP SFLAEDVQET DTSQKDQSPA SHEIATNLGD 
        60         70         80         90        100
FAISLYRELV HQSNTSNIFF SPVSIATAFA MLSLGSKGDT HTQILEGLQF 
       110        120        130        140        150
NLTQTSEADI HKSFQHLLQT LNRPDSELQL STGNGLFVNN DLKLVEKFLE 
       160        170        180        190        200
EAKNHYQAEV FSVNFAESEE AKKVINDFVE KGTQGKIVEA VKELDQDTVF 
       210        220        230        240        250
ALANYILFKG KWKKPFDPEN TEEAEFHVDK STTVKVPMMM LSGMLDVHHC 
       260        270        280        290        300
SILSSWVLLM DYAGNASAVF LLPEDGKMQH LEQTLNKELI SKILLNRRRR 
       310        320        330        340        350
LVQIHIPRLS ISGDYNLKTL MSPLGITRIF NNGADLSGIT EENAPLKLSK 
       360        370        380        390        400
AVHKAVLTID ETGTEAAAAT VFEAVPMSMP PILRFDHPFL FIIFEEHTQS 
       410 
PIFVGKVVDP THK
Length:413
Mass (Da):45,975
Last modified:June 21, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i92BD12B6D4768D7B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WSE0A0A087WSE0_MOUSE
Alpha-1-antitrypsin 1-2
Serpina1b
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18M → L (PubMed:2303252).Curated1
Sequence conflicti18M → L (PubMed:12408969).Curated1
Sequence conflicti18M → L in AAH22109 (PubMed:15489334).Curated1
Sequence conflicti18M → L in AAH25445 (PubMed:15489334).Curated1
Sequence conflicti18M → L in AAH49255 (PubMed:15489334).Curated1
Sequence conflicti203A → G in AAA37132 (PubMed:2303252).Curated1
Sequence conflicti240M → T (PubMed:2303252).Curated1
Sequence conflicti240M → T (PubMed:12408969).Curated1
Sequence conflicti240M → T in AAH22109 (PubMed:15489334).Curated1
Sequence conflicti240M → T in AAH25445 (PubMed:15489334).Curated1
Sequence conflicti240M → T in AAH49255 (PubMed:15489334).Curated1
Sequence conflicti252I → T (PubMed:2303252).Curated1
Sequence conflicti252I → T (PubMed:12408969).Curated1
Sequence conflicti252I → T in AAH22109 (PubMed:15489334).Curated1
Sequence conflicti252I → T in AAH25445 (PubMed:15489334).Curated1
Sequence conflicti252I → T in AAH49255 (PubMed:15489334).Curated1
Sequence conflicti263A → V in AAM47489 (PubMed:12408969).Curated1
Sequence conflicti263A → V in AAH22109 (PubMed:15489334).Curated1
Sequence conflicti263A → V in AAH25445 (PubMed:15489334).Curated1
Sequence conflicti263A → V in AAH49255 (PubMed:15489334).Curated1
Sequence conflicti286N → S in AAM47489 (PubMed:12408969).Curated1
Sequence conflicti286N → S in AAH22109 (PubMed:15489334).Curated1
Sequence conflicti286N → S in AAH25445 (PubMed:15489334).Curated1
Sequence conflicti286N → S in AAH49255 (PubMed:15489334).Curated1
Sequence conflicti298R → H in AAM47489 (PubMed:12408969).Curated1
Sequence conflicti298R → H in AAH22109 (PubMed:15489334).Curated1
Sequence conflicti298R → H in AAH25445 (PubMed:15489334).Curated1
Sequence conflicti298R → H in AAH49255 (PubMed:15489334).Curated1
Sequence conflicti314D → E in AAA37132 (PubMed:2303252).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M25529 mRNA Translation: AAA37132.1
AF481949 Genomic DNA Translation: AAM47489.1
BC022109 mRNA Translation: AAH22109.1
BC025445 mRNA Translation: AAH25445.1
BC049255 mRNA Translation: AAH49255.2
M75716 mRNA Translation: AAC28865.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS26138.1

Protein sequence database of the Protein Information Resource

More...PIRi		I49452
I49471

NCBI Reference Sequences

More...RefSeqi		NP_033270.3, NM_009244.4

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Mm.439692
Mm.439693
Mm.439695

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000095450; ENSMUSP00000093101; ENSMUSG00000071178
ENSMUST00000164454; ENSMUSP00000127266; ENSMUSG00000071178
ENSMUST00000186166; ENSMUSP00000139941; ENSMUSG00000071178

Database of genes from NCBI RefSeq genomes

More...GeneIDi		20701

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:20701

UCSC genome browser

More...UCSCi		uc007owe.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25529 mRNA Translation: AAA37132.1
AF481949 Genomic DNA Translation: AAM47489.1
BC022109 mRNA Translation: AAH22109.1
BC025445 mRNA Translation: AAH25445.1
BC049255 mRNA Translation: AAH49255.2
M75716 mRNA Translation: AAC28865.1
CCDSiCCDS26138.1
PIRiI49452
I49471
RefSeqiNP_033270.3, NM_009244.4
UniGeneiMm.439692
Mm.439693
Mm.439695

3D structure databases

ProteinModelPortaliP22599
SMRiP22599
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203428, 1 interactor
IntActiP22599, 2 interactors
MINTiP22599
STRINGi10090.ENSMUSP00000093101

PTM databases

GlyConnecti799
iPTMnetiP22599
PhosphoSitePlusiP22599

Proteomic databases

jPOSTiP22599
MaxQBiP22599
PaxDbiP22599
PeptideAtlasiP22599
PRIDEiP22599

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095450; ENSMUSP00000093101; ENSMUSG00000071178
ENSMUST00000164454; ENSMUSP00000127266; ENSMUSG00000071178
ENSMUST00000186166; ENSMUSP00000139941; ENSMUSG00000071178
GeneIDi20701
KEGGimmu:20701
UCSCiuc007owe.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		20701
MGIiMGI:891970 Serpina1b

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00940000154493
HOGENOMiHOG000238521
HOVERGENiHBG005957
InParanoidiP22599
KOiK03984
OMAiREYDDFK
OrthoDBi1124079at2759
PhylomeDBiP22599
TreeFamiTF343201

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-204005 COPII-mediated vesicle transport
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-5694530 Cargo concentration in the ER
R-MMU-6798695 Neutrophil degranulation
R-MMU-8957275 Post-translational protein phosphorylation

Miscellaneous databases

Protein Ontology

More...PROi		PR:P22599

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000071178 Expressed in 115 organ(s), highest expression level in left lobe of liver
ExpressionAtlasiP22599 baseline and differential
GenevisibleiP22599 MM

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA1AT2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22599
Secondary accession number(s): Q61283, Q80ZH5, Q8VC20
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: June 21, 2005
Last modified: January 16, 2019
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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