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Protein

Duffy receptor alpha form

Gene
N/A
Organism
Plasmodium knowlesi
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the human erythrocytes Duffy blood group determinant.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Duffy receptor alpha form
Alternative name(s):
Erythrocyte-binding protein
OrganismiPlasmodium knowlesi
Taxonomic identifieri5850 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Plasmodium)

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 1007ExtracellularSequence analysisAdd BLAST986
Transmembranei1008 – 1029HelicalSequence analysisAdd BLAST22
Topological domaini1030 – 1073CytoplasmicSequence analysisAdd BLAST44

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Keywords - Diseasei

Malaria

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002461822 – 1073Duffy receptor alpha formAdd BLAST1052

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi179N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi202N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi214 ↔ 2431 Publication
Disulfide bondi227 ↔ 2341 Publication
Glycosylationi252N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi297 ↔ 3741 Publication
Glycosylationi348N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi412 ↔ 4291 Publication
Disulfide bondi424 ↔ 5041 Publication
Disulfide bondi433 ↔ 5021 Publication
Glycosylationi679N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi746N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi779N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi788N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP22545

Structurei

Secondary structure

11073
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP22545
SMRiP22545
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22545

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410K5CB Eukaryota
ENOG4110H8V LUCA

Family and domain databases

InterProiView protein in InterPro
IPR004258 DBL
IPR008602 Duffy-antigen_binding
IPR021015 Duffy-antigen_binding_C
IPR021032 Duffy-antigen_binding_N
IPR021620 EBA-175_C
PfamiView protein in Pfam
PF12361 DBP, 1 hit
PF05424 Duffy_binding, 1 hit
PF12377 DuffyBP_N, 1 hit
PF11556 EBA-175_VI, 1 hit
PF03011 PFEMP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22545-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGKKKRPLF FLLVLLLSHK ANNVLFERMN GILLLECENE YVKNENGYKL
60 70 80 90 100
ATGHHYMDND QIEQWLQGTD RSRRVKIEEN VKYKYNVEEL NTKYEQMKAP
110 120 130 140 150
RINRILKEST YEAQNVADNN YIDDKANGEH KTDNKTNKGE GARNMVMLDY
160 170 180 190 200
DISGSGQPDG IIDNVVELGT EDEGNFLENS SKGGDHPYRM NRKERMSNGV
210 220 230 240 250
INQTFLQNNV MDKCNDKRKR GERDWDCPAE KDICISVRRY QLCMKGLTNL
260 270 280 290 300
VNNTRTHSHN DITFLKLNLK RKLMYDAAVE GDLLLKKNNY QYNKEFCKDI
310 320 330 340 350
RWGLGDFGDI IMGTNMEGIG YSQVVENNLR QVFGTDEKAK QDRKQWWNES
360 370 380 390 400
KEHIWRAMMF SIRSRLKEKF VWICKKDVTL KVEPQIYRWI REWGRDYMSK
410 420 430 440 450
LPKEQGKLNE KCASKLYYNN MAICMLPLCH DACKSYDQWI TRKKKQWDVL
460 470 480 490 500
STKFSSVKKT QKIGTENIAT AYDILKQELN GFKEATFENE INKRDNLYNH
510 520 530 540 550
LCPCVVEEAR KNTQENVKNV GSGVESKAAS SNPITEAVKS SSGEGKVQED
560 570 580 590 600
SAHKSVNKGE GKSSTNEADP GSQSGAPASR SVDEKAGVPA LSAGQGHDKV
610 620 630 640 650
PPAEAAATES AVLHSADKTP NTVTEENKEG TQMDGAAGGD GKAPGPTVSS
660 670 680 690 700
DVPSVGGKDS GPSTSASHAL AGENGEVHNG TDTEPKEDGE KADPQKDIEV
710 720 730 740 750
KGKQDTDDRS QGSLGPHTDE RATLGETHME KDTETAGGST LTPEQNVSVA
760 770 780 790 800
SDNGNVPGSG NKQNEGATAL SGAESLKSNE SVHKTIDNTT HGLENKNGGN
810 820 830 840 850
EKDFQKHDFM NNDMLNDQAS SDHTSSDQTS SDHTSSDQTS SDHTSSDHTS
860 870 880 890 900
SDQTSSDQTS SDQTIDTEGH HRDNVRNPEI KSSEDMSKGD FMRNSNSNEL
910 920 930 940 950
YSHNNLNNRK LNRDQYEHRD VKATREKIIL MSEVNKCNNR ASVKYCNTIE
960 970 980 990 1000
DRMLSSTCSR ERRKNLCCSI SDFCLNYFEL YSYEFYNCMK KEFEDPSYEC
1010 1020 1030 1040 1050
FTKGSSTGIV YFATGGAFLI ILLLFASWNA ASNDYEEEAT FDEFVEYSDD
1060 1070
IHRTPLMPND IEHMQQFTPL DYS
Length:1,073
Mass (Da):120,683
Last modified:October 1, 1996 - v2
Checksum:i3965FC9F46B71808
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90466 Genomic DNA Translation: AAA29602.1
M68517 mRNA Translation: AAA29590.1
M68518 Genomic DNA Translation: AAA29591.1
PIRiA35970

Similar proteinsi

Entry informationi

Entry nameiPVDA_PLAKN
AccessioniPrimary (citable) accession number: P22545
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 75 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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