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Entry version 109 (08 May 2019)
Sequence version 2 (01 Oct 1996)
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Protein

Endoglucanase A

Gene

celA

Organism
Caldicellulosiruptor saccharolyticus (Caldocellum saccharolyticum)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The N-terminal domain of CelA codes for an endoglucanase activity on carboxymethylcellulose. The C-terminal domain probably acts synergistically to hydrolyze crystalline cellulose.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans. EC:3.2.1.4

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei80NucleophilePROSITE-ProRule annotation1
Active sitei396PROSITE-ProRule annotation1
Active sitei434PROSITE-ProRule annotation1
Active sitei443PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
CBM3 Carbohydrate-Binding Module Family 3
GH48 Glycoside Hydrolase Family 48
GH9 Glycoside Hydrolase Family 9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endoglucanase A (EC:3.2.1.4)
Alternative name(s):
Cellulase A
Endo-1,4-beta-glucanase A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:celA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaldicellulosiruptor saccharolyticus (Caldocellum saccharolyticum)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44001 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000794424 – 1742Endoglucanase AAdd BLAST1719

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The linker region (also termed "hinge") may be a potential site for proteolysis.

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P22534

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini477 – 637CBM3 1PROSITE-ProRule annotationAdd BLAST161
Domaini703 – 856CBM3 2PROSITE-ProRule annotationAdd BLAST154
Domaini906 – 1059CBM3 3PROSITE-ProRule annotationAdd BLAST154

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni24 – 476Catalytic 1Add BLAST453
Regioni638 – 702Linker ("hinge") (Pro-Thr box)Add BLAST65
Regioni857 – 905Linker ("hinge") (Pro-Thr box)Add BLAST49
Regioni1060 – 1112Linker ("hinge") (Pro-Thr box)Add BLAST53
Regioni1113 – 1742Catalytic 2Add BLAST630

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the C-terminal section; belongs to the glycosyl hydrolase 48 (cellulase L) family.Curated
In the N-terminal section; belongs to the glycosyl hydrolase 9 (cellulase E) family.PROSITE-ProRule annotationCurated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105CYP Bacteria
COG2730 LUCA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.50.10.10, 2 hits
2.170.160.10, 1 hit
2.60.40.710, 3 hits
4.10.870.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR008965 CBM2/CBM3_carb-bd_dom_sf
IPR001956 CBM3
IPR036966 CBM3_sf
IPR023309 Endo-1-4-beta-glucanase_dom2
IPR027390 Endoglucanase_F_dom3
IPR000556 Glyco_hydro_48F
IPR001701 Glyco_hydro_9
IPR033126 Glyco_hydro_9_Asp/Glu_AS
IPR018221 Glyco_hydro_9_His_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00942 CBM_3, 3 hits
PF02011 Glyco_hydro_48, 1 hit
PF00759 Glyco_hydro_9, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00844 GLHYDRLASE48

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01067 CBM_3, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48208 SSF48208, 2 hits
SSF49384 SSF49384, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51172 CBM3, 3 hits
PS60032 GH9_1, 1 hit
PS00592 GH9_2, 1 hit
PS00698 GH9_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P22534-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVVTFLFILG VVYGVKPWQE ARAGSFNYGE ALQKAIMFYE FQMSGKLPNW
60 70 80 90 100
VRNNWRGDSA LKDGQDNGLD LTGGWFDAGD HVKFNLPMSY TGTMLSWAAY
110 120 130 140 150
EYKDAFVKSG QLEHILNQIE WVNDYFVKCH PSKYVYYYQV GDGGKDHAWW
160 170 180 190 200
GPAEVMQMER PSFKVTQSSP GSAVVAETAA SLAAASIVLK DRNPTKAATY
210 220 230 240 250
LQHAKDLYEF AEVTKSDSGY TAANGYYNSW SGFYDELSWA AVWLYLATND
260 270 280 290 300
STYLTKAESY VQNWPKISGS NIIDYKWAHC WDDVHNGAAL LLAKITDKDT
310 320 330 340 350
YKQIIESHLD YWTTGYNGER IKYTPKGLAW LDQWGSLRYA TTTAFLAFVY
360 370 380 390 400
SDWSGCPTGK KETYRKFGES QIDYALGSTG RSFVVGFGTN PPKRPHHRTA
410 420 430 440 450
HSSWADSQSI PSYHRHTLYG ALVGGPGSDD SYTDDISNYV NNEVACDYNA
460 470 480 490 500
GFVGALAKMY LLYGGNPIPD FKAIETPTND EFFVEAGINA SGTNFIEIKA
510 520 530 540 550
IVNNQSGWPA RATNKLKFRY FVDLSELIKA GYSPNQLTLS TNYNQGAKVS
560 570 580 590 600
GPYVWDSSRN IYYILVDFTG TLIYPGGQDK YKKEVQFRIA APQNVQWDNS
610 620 630 640 650
NDYSFQDIKG VSSGSVVKTK YIPLYDEDIK VWGEEPGTSG VSPTPTASVT
660 670 680 690 700
PTPTPTPTAT PTPTPTPTVT PTPTVTATPT PTPTPTSTPT VTPTPTPVST
710 720 730 740 750
PATSGQIKVL YANKETNSTT NTIRPWLKVV NSGSSSIDLS RVTIRYWYTV
760 770 780 790 800
DGERAQSAIS DWAQIGASNV TFKFVKLSSS VSGADYYLEI GFKSGAGQLQ
810 820 830 840 850
PGKDTGEIQI RFNKDDWSNY NQGNDWSWIQ SMTSYGENEK VTAYIDGVLV
860 870 880 890 900
WGQEPSGTTP APTSTPTVTV TPTPTPTPTV TPTPTVTATP TPTPTPTSTP
910 920 930 940 950
VSTPATGGQI KVLYANKETN STTNTIRPWL KVVNSGSSSI DLSRVTIRYW
960 970 980 990 1000
YTVDGERAQS AISDWAQIGA SNVTFKFVKL SSSVSGADYY LEIGFKSGAG
1010 1020 1030 1040 1050
QLQPGKDTGE IQIRFNKDDW SNYNQGNDWS WIQSMTSYGE NEKVTAYIDG
1060 1070 1080 1090 1100
VLVWGQEPSG ATPAPTVTPT PTVTPTPTPA PTPTATPTPT PTPTVTPTPT
1110 1120 1130 1140 1150
VAPTPTPSST PSGLGKYGQR FMWLWNKIHD PASGYFNQDG IPYHSVETLI
1160 1170 1180 1190 1200
CEAPDYGHLT TSEAFSYYVW LEAVYGKLTG DWSKFKTAWD TLEKYMIPSA
1210 1220 1230 1240 1250
EDQPMRSYDP NKPATYAGEW ETPDKYPSPL EFNVPVGKDP LHNELVSTYG
1260 1270 1280 1290 1300
STLMYGMHWL MDVDNWYGYG KRGDGVSRAS FINTFQRGPE ESVWETVPHP
1310 1320 1330 1340 1350
SWEEFKWGGP NGFLDLFIKD QNYSKQWRYT NAPDADARAI QATYWAKVWA
1360 1370 1380 1390 1400
KEQGKFNEIS SYVGKAAKMG DYLRYAMFDK YFKPLGCQDK NAAGGTGYDS
1410 1420 1430 1440 1450
AHYLLSWYYA WGGALDGAWS WKIGCSHAHF GYQNPMAAWA LANDSDMKPK
1460 1470 1480 1490 1500
SPNGASDWAK SLKRQIEFYR WLQSAEGAIA GGATNSWNGR YEKYPAGTAT
1510 1520 1530 1540 1550
FYGMAYEPNP VYRDPGSNTW FGFQAWSMQR VAEYYYVTGD KDAGTLLEKW
1560 1570 1580 1590 1600
VSWIKSVVKL NSDGTFAIPS TLDWSGQPDT WNGTYTGNPN LHVKVVDYGT
1610 1620 1630 1640 1650
DLGITASLAN ALLYYSAGTK KYGVFDEEAK NLAKELLDRM WKLYRDEKGL
1660 1670 1680 1690 1700
SAPEKRADYK RFFEQEVYIP AGWTGKMPNG DVIKSGVKFI DIRSKYKQDP
1710 1720 1730 1740
DWPKLEAAYK SGQVPEFRYH RFWAQCDIAI VNATYEILFG NQ
Length:1,742
Mass (Da):193,697
Last modified:October 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3F0699A2123EED07
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1545T → A in AAA72860 (PubMed:2039230).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L32742 Genomic DNA Translation: AAA91086.1
M36063 Genomic DNA Translation: AAA72860.1
L01257 Unassigned DNA No translation available.

Protein sequence database of the Protein Information Resource

More...
PIRi
T17120

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L32742 Genomic DNA Translation: AAA91086.1
M36063 Genomic DNA Translation: AAA72860.1
L01257 Unassigned DNA No translation available.
PIRiT17120

3D structure databases

SMRiP22534
ModBaseiSearch...

Protein family/group databases

CAZyiCBM3 Carbohydrate-Binding Module Family 3
GH48 Glycoside Hydrolase Family 48
GH9 Glycoside Hydrolase Family 9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105CYP Bacteria
COG2730 LUCA

Family and domain databases

Gene3Di1.50.10.10, 2 hits
2.170.160.10, 1 hit
2.60.40.710, 3 hits
4.10.870.10, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR008965 CBM2/CBM3_carb-bd_dom_sf
IPR001956 CBM3
IPR036966 CBM3_sf
IPR023309 Endo-1-4-beta-glucanase_dom2
IPR027390 Endoglucanase_F_dom3
IPR000556 Glyco_hydro_48F
IPR001701 Glyco_hydro_9
IPR033126 Glyco_hydro_9_Asp/Glu_AS
IPR018221 Glyco_hydro_9_His_AS
PfamiView protein in Pfam
PF00942 CBM_3, 3 hits
PF02011 Glyco_hydro_48, 1 hit
PF00759 Glyco_hydro_9, 1 hit
PRINTSiPR00844 GLHYDRLASE48
SMARTiView protein in SMART
SM01067 CBM_3, 3 hits
SUPFAMiSSF48208 SSF48208, 2 hits
SSF49384 SSF49384, 3 hits
PROSITEiView protein in PROSITE
PS51172 CBM3, 3 hits
PS60032 GH9_1, 1 hit
PS00592 GH9_2, 1 hit
PS00698 GH9_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGUNA_CALSA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22534
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: October 1, 1996
Last modified: May 8, 2019
This is version 109 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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