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Protein

Small proline-rich protein 2E

Gene

SPRR2E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.

GO - Molecular functioni

  • structural constituent of epidermis Source: CAFA
  • structural molecule activity Source: UniProtKB

GO - Biological processi

  • cornification Source: Reactome
  • epidermis development Source: UniProtKB
  • keratinocyte differentiation Source: GO_Central
  • peptide cross-linking Source: CAFA

Keywordsi

Biological processKeratinization

Enzyme and pathway databases

ReactomeiR-HSA-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Small proline-rich protein 2E
Short name:
SPR-2E
Alternative name(s):
Small proline-rich protein II
Short name:
SPR-II
Gene namesi
Name:SPRR2E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000203785.8
HGNCiHGNC:11265 SPRR2E
MIMi617588 gene
neXtProtiNX_P22531

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000203785
PharmGKBiPA36094

Polymorphism and mutation databases

BioMutaiSPRR2E

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001500111 – 72Small proline-rich protein 2EAdd BLAST72

Proteomic databases

MaxQBiP22531
PaxDbiP22531
PeptideAtlasiP22531
PRIDEiP22531
ProteomicsDBi53998

PTM databases

iPTMnetiP22531
PhosphoSitePlusiP22531

Expressioni

Inductioni

During squamous differentiation of epidermal keratinocytes.

Gene expression databases

BgeeiENSG00000203785
CleanExiHS_SPRR2E

Interactioni

Protein-protein interaction databases

BioGridi112582, 8 interactors
IntActiP22531, 10 interactors
STRINGi9606.ENSP00000357739

Structurei

3D structure databases

DisProtiDP00130
ProteinModelPortaliP22531
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati21 – 2919
Repeati30 – 3829
Repeati39 – 4739

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 473 X 9 AA tandem repeats of P-K-C-P-[EQ]-P-C-P-PAdd BLAST27

Sequence similaritiesi

Belongs to the cornifin (SPRR) family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410KCBD Eukaryota
ENOG4110P50 LUCA
GeneTreeiENSGT00920000149436
OMAiQQEQCKQ

Family and domain databases

InterProiView protein in InterPro
IPR026075 SPRR/LCE
IPR029142 SPRR2
PANTHERiPTHR23263 PTHR23263, 1 hit
PfamiView protein in Pfam
PF14820 SPRR2, 1 hit

Sequencei

Sequence statusi: Complete.

P22531-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYQQQQCKQ PCQPPPVCPT PKCPEPCPPP KCPEPCPPPK CPQPCPPQQC
60 70
QQKCPPVTPS PPCQPKCPPK SK
Length:72
Mass (Da):7,855
Last modified:March 15, 2004 - v2
Checksum:i87B4420A98A3D448
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45C → S in AAA36639 (PubMed:3133554).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20030 mRNA Translation: AAA36639.1
AF333955 Genomic DNA Translation: AAK70942.1
AL139417 Genomic DNA No translation available.
CCDSiCCDS30866.1
PIRiB27725
RefSeqiNP_001019380.2, NM_001024209.3
UniGeneiHs.568518

Genome annotation databases

EnsembliENST00000368750; ENSP00000357739; ENSG00000203785
ENST00000368751; ENSP00000357740; ENSG00000203785
GeneIDi6704
KEGGihsa:6704
UCSCiuc001fbh.3 human

Similar proteinsi

Entry informationi

Entry nameiSPR2E_HUMAN
AccessioniPrimary (citable) accession number: P22531
Secondary accession number(s): Q5T9T4, Q96RM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: March 15, 2004
Last modified: June 20, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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