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Protein

Cornifin-B

Gene

SPRR1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross-linkage.

GO - Molecular functioni

  • protein binding, bridging Source: UniProtKB
  • structural molecule activity Source: UniProtKB

GO - Biological processi

  • cornification Source: Reactome
  • epidermis development Source: ProtInc
  • keratinocyte differentiation Source: UniProtKB
  • peptide cross-linking Source: UniProtKB

Keywordsi

Biological processKeratinization

Enzyme and pathway databases

ReactomeiR-HSA-6809371 Formation of the cornified envelope
SIGNORiP22528

Names & Taxonomyi

Protein namesi
Recommended name:
Cornifin-B
Alternative name(s):
14.9 kDa pancornulin
Small proline-rich protein IB
Short name:
SPR-IB
Gene namesi
Name:SPRR1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000169469.8
HGNCiHGNC:11260 SPRR1B
MIMi182266 gene
neXtProtiNX_P22528

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi6699
OpenTargetsiENSG00000169469
PharmGKBiPA36089

Polymorphism and mutation databases

BioMutaiSPRR1B
DMDMi84028265

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001499961 – 89Cornifin-BAdd BLAST89

Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

EPDiP22528
MaxQBiP22528
PaxDbiP22528
PeptideAtlasiP22528
PRIDEiP22528
ProteomicsDBi53997

2D gel databases

UCD-2DPAGEiP22528

PTM databases

iPTMnetiP22528
PhosphoSitePlusiP22528

Expressioni

Tissue specificityi

Suprabasal layers of squamous-differentiated tissues such as epidermis, esophagus, tongue and trachea.

Developmental stagei

Expressed during differentiation of squamous cells.

Inductioni

By carcinogenic agents and by UV light. During squamous differentiation of epidermal keratinocytes.

Gene expression databases

BgeeiENSG00000169469 Expressed in 111 organ(s), highest expression level in ectocervix
CleanExiHS_SPRR1B
GenevisibleiP22528 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112577, 3 interactors
IntActiP22528, 8 interactors
STRINGi9606.ENSP00000306461

Structurei

3D structure databases

ProteinModelPortaliP22528
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati3 – 141Add BLAST12
Repeati18 – 292Add BLAST12
Repeati31 – 3818
Repeati39 – 4628
Repeati47 – 5438
Repeati55 – 6248
Repeati63 – 7058
Repeati71 – 7868

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni3 – 292 X 12 AA approximate repeatsAdd BLAST27
Regioni31 – 786 X 8 AA approximate tandem repeatsAdd BLAST48

Sequence similaritiesi

Belongs to the cornifin (SPRR) family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JH2M Eukaryota
ENOG410XUVY LUCA
GeneTreeiENSGT00730000111065
HOGENOMiHOG000059526
HOVERGENiHBG079213
InParanoidiP22528
OMAiEPCPSIV
OrthoDBiEOG091G15WJ
PhylomeDBiP22528
TreeFamiTF338205

Family and domain databases

InterProiView protein in InterPro
IPR003302 Cornifin
IPR026075 SPRR/LCE
PANTHERiPTHR23263 PTHR23263, 1 hit
PTHR23263:SF108 PTHR23263:SF108, 1 hit

Sequencei

Sequence statusi: Complete.

P22528-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSQQQKQPC TPPPQLQQQQ VKQPCQPPPQ EPCIPKTKEP CHPKVPEPCH
60 70 80
PKVPEPCQPK VPEPCHPKVP EPCPSIVTPA PAQQKTKQK
Length:89
Mass (Da):9,888
Last modified:December 20, 2005 - v2
Checksum:i8B10DF32103496D3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02109911T → I5 PublicationsCorresponds to variant dbSNP:rs3795382Ensembl.1
Natural variantiVAR_00216423Q → H1 Publication1
Natural variantiVAR_00216561V → L1 PublicationCorresponds to variant dbSNP:rs768218193Ensembl.1
Natural variantiVAR_00216680A → P1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19888 mRNA Translation: AAA36636.1
M21300 mRNA Translation: AAA36637.1
M21301 mRNA Translation: AAA36638.1
M84757 Genomic DNA Translation: AAA36643.1
AK312191 mRNA Translation: BAG35124.1
AY787223 Genomic DNA Translation: AAV40826.1
AL356867 Genomic DNA No translation available.
BC056240 mRNA Translation: AAH56240.1
CCDSiCCDS30863.1
PIRiA46709
RefSeqiNP_003116.2, NM_003125.2
UniGeneiHs.1076

Genome annotation databases

EnsembliENST00000307098; ENSP00000306461; ENSG00000169469
GeneIDi6699
KEGGihsa:6699
UCSCiuc001fba.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19888 mRNA Translation: AAA36636.1
M21300 mRNA Translation: AAA36637.1
M21301 mRNA Translation: AAA36638.1
M84757 Genomic DNA Translation: AAA36643.1
AK312191 mRNA Translation: BAG35124.1
AY787223 Genomic DNA Translation: AAV40826.1
AL356867 Genomic DNA No translation available.
BC056240 mRNA Translation: AAH56240.1
CCDSiCCDS30863.1
PIRiA46709
RefSeqiNP_003116.2, NM_003125.2
UniGeneiHs.1076

3D structure databases

ProteinModelPortaliP22528
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112577, 3 interactors
IntActiP22528, 8 interactors
STRINGi9606.ENSP00000306461

PTM databases

iPTMnetiP22528
PhosphoSitePlusiP22528

Polymorphism and mutation databases

BioMutaiSPRR1B
DMDMi84028265

2D gel databases

UCD-2DPAGEiP22528

Proteomic databases

EPDiP22528
MaxQBiP22528
PaxDbiP22528
PeptideAtlasiP22528
PRIDEiP22528
ProteomicsDBi53997

Protocols and materials databases

DNASUi6699
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307098; ENSP00000306461; ENSG00000169469
GeneIDi6699
KEGGihsa:6699
UCSCiuc001fba.4 human

Organism-specific databases

CTDi6699
DisGeNETi6699
EuPathDBiHostDB:ENSG00000169469.8
GeneCardsiSPRR1B
H-InvDBiHIX0023650
HGNCiHGNC:11260 SPRR1B
MIMi182266 gene
neXtProtiNX_P22528
OpenTargetsiENSG00000169469
PharmGKBiPA36089
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JH2M Eukaryota
ENOG410XUVY LUCA
GeneTreeiENSGT00730000111065
HOGENOMiHOG000059526
HOVERGENiHBG079213
InParanoidiP22528
OMAiEPCPSIV
OrthoDBiEOG091G15WJ
PhylomeDBiP22528
TreeFamiTF338205

Enzyme and pathway databases

ReactomeiR-HSA-6809371 Formation of the cornified envelope
SIGNORiP22528

Miscellaneous databases

ChiTaRSiSPRR1B human
GeneWikiiSPRR1B
GenomeRNAii6699
PROiPR:P22528
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169469 Expressed in 111 organ(s), highest expression level in ectocervix
CleanExiHS_SPRR1B
GenevisibleiP22528 HS

Family and domain databases

InterProiView protein in InterPro
IPR003302 Cornifin
IPR026075 SPRR/LCE
PANTHERiPTHR23263 PTHR23263, 1 hit
PTHR23263:SF108 PTHR23263:SF108, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPR1B_HUMAN
AccessioniPrimary (citable) accession number: P22528
Secondary accession number(s): B2R5H7
, P22529, P22530, Q5T524
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: December 20, 2005
Last modified: November 7, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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