UniProtKB - P22524 (MUKE_ECOLI)
Protein
Chromosome partition protein MukE
Gene
mukE
Organism
Escherichia coli (strain K12)
Status
Functioni
Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF.1 Publication
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- chromosome condensation Source: UniProtKB-KW
- chromosome segregation Source: UniProtKB-UniRule
- DNA replication Source: UniProtKB-UniRule
Keywordsi
Biological process | Cell cycle, Cell division, Chromosome partition, DNA condensation |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11252-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Chromosome partition protein MukEAlternative name(s): Protein KicA |
Gene namesi | Name:mukE Synonyms:kicA, ycbA Ordered Locus Names:b0923, JW0906 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- nucleoid Note: Restricted to the nucleoid region.
GO - Cellular componenti
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000206792 | 1 – 234 | Chromosome partition protein MukEAdd BLAST | 234 |
Proteomic databases
jPOSTi | P22524 |
PaxDbi | P22524 |
PRIDEi | P22524 |
Interactioni
Subunit structurei
Forms a hexameric complex with MukF, (MukF-(MukE)2)2, which forms a ternary complex with MukB. The complex formation is stimulated by calcium or magnesium.
1 PublicationBinary interactionsi
P22524
With | #Exp. | IntAct |
---|---|---|
mukF [P60293] | 6 | EBI-554672,EBI-554679 |
Protein-protein interaction databases
BioGRIDi | 4261869, 77 interactors 849924, 2 interactors |
ComplexPortali | CPX-1090, MukBEF condensin complex |
DIPi | DIP-10274N |
IntActi | P22524, 11 interactors |
MINTi | P22524 |
STRINGi | 511145.b0923 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P22524 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P22524 |
Family & Domainsi
Sequence similaritiesi
Belongs to the MukE family.Curated
Phylogenomic databases
eggNOGi | COG3095, Bacteria |
HOGENOMi | CLU_1146408_0_0_6 |
Family and domain databases
Gene3Di | 1.10.10.2250, 1 hit 1.10.10.2260, 1 hit |
HAMAPi | MF_01802, MukE, 1 hit |
InterProi | View protein in InterPro IPR042037, MukE_C IPR042038, MukE_N IPR007385, Scp_MukE |
Pfami | View protein in Pfam PF04288, MukE, 1 hit |
i Sequence
Sequence statusi: Complete.
P22524-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSTNIEQVM PVKLAQALAN PLFPALDSAL RSGRHIGLDE LDNHAFLMDF
60 70 80 90 100
QEYLEEFYAR YNVELIRAPE GFFYLRPRST TLIPRSVLSE LDMMVGKILC
110 120 130 140 150
YLYLSPERLA NEGIFTQQEL YDELLTLADE AKLLKLVNNR STGSDVDRQK
160 170 180 190 200
LQEKVRSSLN RLRRLGMVWF MGHDSSKFRI TESVFRFGAD VRAGDDPREA
210 220 230
QRRLIRDGEA MPIENHLQLN DETEENQPDS GEEE
Sequence cautioni
The sequence BAA05458 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA35669 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAA40775 differs from that shown. Reason: Frameshift.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D26440 Genomic DNA Translation: BAA05458.1 Different initiation. U00096 Genomic DNA Translation: AAC74009.2 AP009048 Genomic DNA Translation: BAA35669.2 Different initiation. X57550 Genomic DNA Translation: CAA40775.1 Frameshift. |
PIRi | B64832 |
RefSeqi | NP_415443.2, NC_000913.3 WP_001295347.1, NZ_STEB01000006.1 |
Genome annotation databases
EnsemblBacteriai | AAC74009; AAC74009; b0923 BAA35669; BAA35669; BAA35669 |
GeneIDi | 945550 |
KEGGi | ecj:JW0906 eco:b0923 |
PATRICi | fig|1411691.4.peg.1353 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D26440 Genomic DNA Translation: BAA05458.1 Different initiation. U00096 Genomic DNA Translation: AAC74009.2 AP009048 Genomic DNA Translation: BAA35669.2 Different initiation. X57550 Genomic DNA Translation: CAA40775.1 Frameshift. |
PIRi | B64832 |
RefSeqi | NP_415443.2, NC_000913.3 WP_001295347.1, NZ_STEB01000006.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3EUH | X-ray | 2.90 | C/D/E/F | 1-234 | [»] | |
3RPU | X-ray | 3.60 | D/E/G/H/Y/Z | 10-234 | [»] | |
SMRi | P22524 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4261869, 77 interactors 849924, 2 interactors |
ComplexPortali | CPX-1090, MukBEF condensin complex |
DIPi | DIP-10274N |
IntActi | P22524, 11 interactors |
MINTi | P22524 |
STRINGi | 511145.b0923 |
Proteomic databases
jPOSTi | P22524 |
PaxDbi | P22524 |
PRIDEi | P22524 |
Genome annotation databases
EnsemblBacteriai | AAC74009; AAC74009; b0923 BAA35669; BAA35669; BAA35669 |
GeneIDi | 945550 |
KEGGi | ecj:JW0906 eco:b0923 |
PATRICi | fig|1411691.4.peg.1353 |
Organism-specific databases
EchoBASEi | EB1232 |
Phylogenomic databases
eggNOGi | COG3095, Bacteria |
HOGENOMi | CLU_1146408_0_0_6 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11252-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P22524 |
PROi | PR:P22524 |
Family and domain databases
Gene3Di | 1.10.10.2250, 1 hit 1.10.10.2260, 1 hit |
HAMAPi | MF_01802, MukE, 1 hit |
InterProi | View protein in InterPro IPR042037, MukE_C IPR042038, MukE_N IPR007385, Scp_MukE |
Pfami | View protein in Pfam PF04288, MukE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MUKE_ECOLI | |
Accessioni | P22524Primary (citable) accession number: P22524 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1991 |
Last sequence update: | November 24, 2009 | |
Last modified: | February 10, 2021 | |
This is version 155 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families