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Protein

Histone H1t

Gene

HIST1H1T

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes (PubMed:26757249). Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination (PubMed:26757249). Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration (Probable).Curated1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei56Important for nucleosome binding propertiesBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • multicellular organism development Source: UniProtKB-KW
  • nucleosome assembly Source: InterPro
  • spermatogenesis Source: ProtInc

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H1t
Alternative name(s):
Testicular H1 histone
Gene namesi
Name:HIST1H1T
Synonyms:H1FT, H1T
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000187475.5
HGNCiHGNC:4720 HIST1H1T
MIMi142712 gene
neXtProtiNX_P22492

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3010
OpenTargetsiENSG00000187475
PharmGKBiPA29098

Polymorphism and mutation databases

BioMutaiHIST1H1T
DMDMi34395930

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCurated
ChainiPRO_00001959102 – 207Histone H1tAdd BLAST206

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineBy similarity1
Modified residuei58CitrullineBy similarity1
Modified residuei143PhosphoserineBy similarity1
Modified residuei159PhosphothreonineBy similarity1
Modified residuei166PhosphoserineBy similarity1
Modified residuei181PhosphoserineBy similarity1
Modified residuei190PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated in early spermatids.By similarity
Citrullination at Arg-58 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.By similarity

Keywords - PTMi

Citrullination, Phosphoprotein

Proteomic databases

EPDiP22492
MaxQBiP22492
PaxDbiP22492
PeptideAtlasiP22492
PRIDEiP22492
ProteomicsDBi53996

PTM databases

iPTMnetiP22492
PhosphoSitePlusiP22492
SwissPalmiP22492

Expressioni

Tissue specificityi

Testis-specific.2 Publications

Developmental stagei

This histone is a testis-specific H1 variant that appears during meiosis in spermatogenesis.1 Publication

Gene expression databases

BgeeiENSG00000187475
CleanExiHS_HIST1H1T
GenevisibleiP22492 HS

Organism-specific databases

HPAiHPA065718
HPA068266

Interactioni

Protein-protein interaction databases

BioGridi109265, 114 interactors
IntActiP22492, 17 interactors
MINTiP22492
STRINGi9606.ENSP00000341214

Structurei

3D structure databases

ProteinModelPortaliP22492
SMRiP22492
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 113H15PROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Belongs to the histone H1/H5 family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4012 Eukaryota
ENOG4112541 LUCA
GeneTreeiENSGT00670000097781
HOGENOMiHOG000251627
HOVERGENiHBG009035
InParanoidiP22492
KOiK11275
OMAiQERVGMS
OrthoDBiEOG091G0XGD
PhylomeDBiP22492
TreeFamiTF313664

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005818 Histone_H1/H5_H15
IPR005819 Histone_H5
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00538 Linker_histone, 1 hit
PRINTSiPR00624 HISTONEH5
SMARTiView protein in SMART
SM00526 H15, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS51504 H15, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22492-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETVPAASA SAGVAAMEKL PTKKRGRKPA GLISASRKVP NLSVSKLITE
60 70 80 90 100
ALSVSQERVG MSLVALKKAL AAAGYDVEKN NSRIKLSLKS LVNKGILVQT
110 120 130 140 150
RGTGASGSFK LSKKVIPKST RSKAKKSVSA KTKKLVLSRD SKSPKTAKTN
160 170 180 190 200
KRAKKPRATT PKTVRSGRKA KGAKGKQQQK SPVKARASKS KLTQHHEVNV

RKATSKK
Length:207
Mass (Da):22,019
Last modified:January 23, 2007 - v4
Checksum:i9CF27B275DA29B48
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04931014V → L1 PublicationCorresponds to variant dbSNP:rs198844Ensembl.1
Natural variantiVAR_04931152L → F. Corresponds to variant dbSNP:rs2051542Ensembl.1
Natural variantiVAR_049312178Q → K1 PublicationCorresponds to variant dbSNP:rs198845Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60094 Genomic DNA Translation: AAA35944.1
M97755 Genomic DNA Translation: AAA19936.1
AF531301 Genomic DNA Translation: AAN06701.1
BC069517 mRNA Translation: AAH69517.2
CCDSiCCDS34349.1
PIRiJH0550
RefSeqiNP_005314.2, NM_005323.3
UniGeneiHs.533293

Genome annotation databases

EnsembliENST00000338379; ENSP00000341214; ENSG00000187475
GeneIDi3010
KEGGihsa:3010
UCSCiuc003ngj.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiH1T_HUMAN
AccessioniPrimary (citable) accession number: P22492
Secondary accession number(s): Q6ISI1, Q8IUE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 155 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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