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Protein

Galanin peptides

Gene

GAL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • galanin receptor activity Source: UniProtKB
  • neuropeptide hormone activity Source: UniProtKB
  • type 1 galanin receptor binding Source: UniProtKB
  • type 2 galanin receptor binding Source: UniProtKB
  • type 3 galanin receptor binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHormone, Neuropeptide

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P22466

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Galanin peptides
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GAL
Synonyms:GAL1, GALN, GLNN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000069482.6

Human Gene Nomenclature Database

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HGNCi
HGNC:4114 GAL

Online Mendelian Inheritance in Man (OMIM)

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MIMi
137035 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P22466

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Epilepsy, familial temporal lobe, 8 (ETL8)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA focal form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe. Seizures are usually accompanied by sensory symptoms, most often auditory in nature.
See also OMIM:616461
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07467139A → E in ETL8; decreased affinity for GALR2; but no effect on affinity for GALR1 and GALR3; decreased activity in GALR2-mediated signaling; dominant-negative that inhibits GALR1-mediated signaling. 1 PublicationCorresponds to variant dbSNP:rs1057517661Ensembl.1

Keywords - Diseasei

Disease mutation, Epilepsy

Organism-specific databases

DisGeNET

More...
DisGeNETi
51083

MalaCards human disease database

More...
MalaCardsi
GAL
MIMi616461 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000069482

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28529

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GAL

Domain mapping of disease mutations (DMDM)

More...
DMDMi
2506449

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000001044820 – 30Add BLAST11
<p>This subsection of the ‘PTM / Processing’ section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000001044933 – 62GalaninAdd BLAST30
PeptideiPRO_000001045065 – 123Galanin message-associated peptideAdd BLAST59

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei116PhosphoserineCombined sources1
Modified residuei117PhosphoserineCombined sources1 Publication1

Keywords - PTMi

Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P22466

MaxQB - The MaxQuant DataBase

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MaxQBi
P22466

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P22466

PeptideAtlas

More...
PeptideAtlasi
P22466

PRoteomics IDEntifications database

More...
PRIDEi
P22466

ProteomicsDB human proteome resource

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ProteomicsDBi
53995

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P22466

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P22466

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000069482 Expressed in 106 organ(s), highest expression level in adenohypophysis

CleanEx database of gene expression profiles

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CleanExi
HS_GAL

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P22466 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA049864

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
119273, 12 interactors

Protein interaction database and analysis system

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IntActi
P22466, 7 interactors

Molecular INTeraction database

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MINTi
P22466

STRING: functional protein association networks

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STRINGi
9606.ENSP00000265643

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P22466

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P22466

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P22466

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the galanin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IZPR Eukaryota
ENOG410YNUP LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000009663

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112690

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG005799

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P22466

KEGG Orthology (KO)

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KOi
K05244

Identification of Orthologs from Complete Genome Data

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OMAi
WSPAKEK

Database of Orthologous Groups

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OrthoDBi
EOG091G109K

Database for complete collections of gene phylogenies

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PhylomeDBi
P22466

TreeFam database of animal gene trees

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TreeFami
TF335850

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR008174 Galanin
IPR008175 Galanin_pre
IPR013068 GMAP

The PANTHER Classification System

More...
PANTHERi
PTHR16839 PTHR16839, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01296 Galanin, 1 hit
PF06540 GMAP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00273 GALANIN

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD005962 Galanin, 1 hit
PD012185 GMAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00071 Galanin, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00861 GALANIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P22466-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARGSALLLA SLLLAAALSA SAGLWSPAKE KRGWTLNSAG YLLGPHAVGN
60 70 80 90 100
HRSFSDKNGL TSKRELRPED DMKPGSFDRS IPENNIMRTI IEFLSFLHLK
110 120
EAGALDRLLD LPAAASSEDI ERS
Length:123
Mass (Da):13,302
Last modified:November 1, 1997 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i48D2170AF1248E6D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04912116A → V. Corresponds to variant dbSNP:rs34725707EnsemblClinVar.1
Natural variantiVAR_07467139A → E in ETL8; decreased affinity for GALR2; but no effect on affinity for GALR1 and GALR3; decreased activity in GALR2-mediated signaling; dominant-negative that inhibits GALR1-mediated signaling. 1 PublicationCorresponds to variant dbSNP:rs1057517661Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L11144 Genomic DNA Translation: AAA18248.1
M77140 mRNA Translation: AAA60178.1
BC030241 mRNA Translation: AAH30241.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8183.1

Protein sequence database of the Protein Information Resource

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PIRi
A49353 RHHUN

NCBI Reference Sequences

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RefSeqi
NP_057057.2, NM_015973.4

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.278959

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000265643; ENSP00000265643; ENSG00000069482

Database of genes from NCBI RefSeq genomes

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GeneIDi
51083

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51083

UCSC genome browser

More...
UCSCi
uc001oob.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11144 Genomic DNA Translation: AAA18248.1
M77140 mRNA Translation: AAA60178.1
BC030241 mRNA Translation: AAH30241.1
CCDSiCCDS8183.1
PIRiA49353 RHHUN
RefSeqiNP_057057.2, NM_015973.4
UniGeneiHs.278959

3D structure databases

ProteinModelPortaliP22466
SMRiP22466
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119273, 12 interactors
IntActiP22466, 7 interactors
MINTiP22466
STRINGi9606.ENSP00000265643

Chemistry databases

BindingDBiP22466

PTM databases

iPTMnetiP22466
PhosphoSitePlusiP22466

Polymorphism and mutation databases

BioMutaiGAL
DMDMi2506449

Proteomic databases

EPDiP22466
MaxQBiP22466
PaxDbiP22466
PeptideAtlasiP22466
PRIDEiP22466
ProteomicsDBi53995

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
51083
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265643; ENSP00000265643; ENSG00000069482
GeneIDi51083
KEGGihsa:51083
UCSCiuc001oob.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51083
DisGeNETi51083
EuPathDBiHostDB:ENSG00000069482.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GAL
HGNCiHGNC:4114 GAL
HPAiHPA049864
MalaCardsiGAL
MIMi137035 gene
616461 phenotype
neXtProtiNX_P22466
OpenTargetsiENSG00000069482
PharmGKBiPA28529

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IZPR Eukaryota
ENOG410YNUP LUCA
GeneTreeiENSGT00390000009663
HOGENOMiHOG000112690
HOVERGENiHBG005799
InParanoidiP22466
KOiK05244
OMAiWSPAKEK
OrthoDBiEOG091G109K
PhylomeDBiP22466
TreeFamiTF335850

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
SIGNORiP22466

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GAL human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Galanin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51083

Protein Ontology

More...
PROi
PR:P22466

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000069482 Expressed in 106 organ(s), highest expression level in adenohypophysis
CleanExiHS_GAL
GenevisibleiP22466 HS

Family and domain databases

InterProiView protein in InterPro
IPR008174 Galanin
IPR008175 Galanin_pre
IPR013068 GMAP
PANTHERiPTHR16839 PTHR16839, 1 hit
PfamiView protein in Pfam
PF01296 Galanin, 1 hit
PF06540 GMAP, 1 hit
PRINTSiPR00273 GALANIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005962 Galanin, 1 hit
PD012185 GMAP, 1 hit
SMARTiView protein in SMART
SM00071 Galanin, 1 hit
PROSITEiView protein in PROSITE
PS00861 GALANIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGALA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22466
Secondary accession number(s): Q14413
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 168 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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