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Protein

Potassium voltage-gated channel subfamily A member 5

Gene

KCNA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12130714). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:12130714). Homotetrameric channels display rapid activation and slow inactivation (PubMed:8505626, PubMed:12130714). May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation (PubMed:11524461).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1296072 Voltage gated Potassium channels

Protein family/group databases

Transport Classification Database

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TCDBi
1.A.1.2.4 the voltage-gated ion channel (vic) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily A member 5
Alternative name(s):
HPCN1
Voltage-gated potassium channel HK2
Voltage-gated potassium channel subunit Kv1.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNA5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000130037.4

Human Gene Nomenclature Database

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HGNCi
HGNC:6224 KCNA5

Online Mendelian Inheritance in Man (OMIM)

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MIMi
176267 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P22460

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 247CytoplasmicBy similarityAdd BLAST247
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei248 – 269Helical; Name=Segment S1By similarityAdd BLAST22
Topological domaini270 – 323ExtracellularBy similarityAdd BLAST54
Transmembranei324 – 345Helical; Name=Segment S2By similarityAdd BLAST22
Topological domaini346 – 356CytoplasmicBy similarityAdd BLAST11
Transmembranei357 – 377Helical; Name=Segment S3By similarityAdd BLAST21
Topological domaini378 – 395ExtracellularBy similarityAdd BLAST18
Transmembranei396 – 416Helical; Voltage-sensor; Name=Segment S4By similarityAdd BLAST21
Topological domaini417 – 431CytoplasmicBy similarityAdd BLAST15
Transmembranei432 – 453Helical; Name=Segment S5By similarityAdd BLAST22
Topological domaini454 – 467ExtracellularBy similarityAdd BLAST14
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei468 – 479Helical; Name=Pore helixBy similarityAdd BLAST12
Intramembranei480 – 487By similarity8
Topological domaini488 – 494ExtracellularBy similarity7
Transmembranei495 – 523Helical; Name=Segment S6By similarityAdd BLAST29
Topological domaini524 – 613CytoplasmicBy similarityAdd BLAST90

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Atrial fibrillation, familial, 7 (ATFB7)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.
See also OMIM:612240

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi15T → A: Loss of DLG1 effect on channel current. 1 Publication1
Mutagenesisi220I → N: Reduces sumoylation; when associated with N-535. 1 Publication1
Mutagenesisi221K → R: Abolishes sumoylation; when associated with R-536. 1 Publication1
Mutagenesisi535L → N: Reduces sumoylation; when associated with N-220. 1 Publication1
Mutagenesisi536K → R: Abolishes sumoylation; when associated with R-221. 1 Publication1

Keywords - Diseasei

Atrial fibrillation

Organism-specific databases

DisGeNET

More...
DisGeNETi
3741

MalaCards human disease database

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MalaCardsi
KCNA5
MIMi612240 phenotype

Open Targets

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OpenTargetsi
ENSG00000130037

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
334 Familial atrial fibrillation

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA208

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL4306

Drug and drug target database

More...
DrugBanki
DB06637 Dalfampridine

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
542

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KCNA5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
146345443

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000539851 – 613Potassium voltage-gated channel subfamily A member 5Add BLAST613

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki221Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi346S-palmitoyl cysteineSequence analysis1
Cross-linki536Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei557Phosphoserine; by PKASequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated on Lys-221, and Lys-536, preferentially with SUMO3. Sumoylation regulates the voltage sensitivity of the channel.1 Publication

Keywords - PTMi

Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P22460

PeptideAtlas

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PeptideAtlasi
P22460

PRoteomics IDEntifications database

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PRIDEi
P22460

ProteomicsDB human proteome resource

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ProteomicsDBi
53993
53994 [P22460-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P22460

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P22460

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P22460

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Pancreatic islets and insulinoma.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000130037 Expressed in 133 organ(s), highest expression level in cardiac muscle of right atrium

CleanEx database of gene expression profiles

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CleanExi
HS_KCNA5

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P22460 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB022562
HPA021516

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer and heterotetramer of potassium channel proteins. Interacts with DLG1, which enhances channel currents. Forms a ternary complex with DLG1 and CAV3 (By similarity). Interacts with KCNAB1 (PubMed:12130714). Interacts with UBE2I (PubMed:17261810).By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109943, 58 interactors

Database of interacting proteins

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DIPi
DIP-42010N

Protein interaction database and analysis system

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IntActi
P22460, 10 interactors

Molecular INTeraction database

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MINTi
P22460

STRING: functional protein association networks

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STRINGi
9606.ENSP00000252321

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P22460

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P22460

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P22460

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati61 – 711Add BLAST11
Repeati72 – 822Add BLAST11

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni61 – 822 X 11 AA tandem repeat of D-[SP]-G-V-R-P-L-P-P-L-PAdd BLAST22
Regioni418 – 431S4-S5 linkerBy similarityAdd BLAST14

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi480 – 485Selectivity filterBy similarity6
Motifi611 – 613PDZ-bindingBy similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi94 – 99Poly-Glu6
Compositional biasi382 – 387Poly-Gly6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The amino terminus may be important in determining the rate of inactivation of the channel while the C-terminal PDZ-binding motif may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1545 Eukaryota
COG1226 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161860

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231015

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052230

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P22460

KEGG Orthology (KO)

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KOi
K04878

Identification of Orthologs from Complete Genome Data

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OMAi
GGELQCP

Database of Orthologous Groups

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OrthoDBi
EOG091G10NU

Database for complete collections of gene phylogenies

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PhylomeDBi
P22460

TreeFam database of animal gene trees

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TreeFami
TF313103

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.120.350, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003972 K_chnl_volt-dep_Kv1
IPR004052 K_chnl_volt-dep_Kv1.5
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR11537 PTHR11537, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00169 KCHANNEL
PR01512 KV15CHANNEL
PR01491 KVCHANNEL
PR01496 SHAKERCHANEL

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00225 BTB, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54695 SSF54695, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P22460-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEIALVPLEN GGAMTVRGGD EARAGCGQAT GGELQCPPTA GLSDGPKEPA
60 70 80 90 100
PKGRGAQRDA DSGVRPLPPL PDPGVRPLPP LPEELPRPRR PPPEDEEEEG
110 120 130 140 150
DPGLGTVEDQ ALGTASLHHQ RVHINISGLR FETQLGTLAQ FPNTLLGDPA
160 170 180 190 200
KRLRYFDPLR NEYFFDRNRP SFDGILYYYQ SGGRLRRPVN VSLDVFADEI
210 220 230 240 250
RFYQLGDEAM ERFREDEGFI KEEEKPLPRN EFQRQVWLIF EYPESSGSAR
260 270 280 290 300
AIAIVSVLVI LISIITFCLE TLPEFRDERE LLRHPPAPHQ PPAPAPGANG
310 320 330 340 350
SGVMAPPSGP TVAPLLPRTL ADPFFIVETT CVIWFTFELL VRFFACPSKA
360 370 380 390 400
GFSRNIMNII DVVAIFPYFI TLGTELAEQQ PGGGGGGQNG QQAMSLAILR
410 420 430 440 450
VIRLVRVFRI FKLSRHSKGL QILGKTLQAS MRELGLLIFF LFIGVILFSS
460 470 480 490 500
AVYFAEADNQ GTHFSSIPDA FWWAVVTMTT VGYGDMRPIT VGGKIVGSLC
510 520 530 540 550
AIAGVLTIAL PVPVIVSNFN YFYHRETDHE EPAVLKEEQG TQSQGPGLDR
560 570 580 590 600
GVQRKVSGSR GSFCKAGGTL ENADSARRGS CPLEKCNVKA KSNVDLRRSL
610
YALCLDTSRE TDL
Length:613
Mass (Da):67,228
Last modified:May 1, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA5B02B27F8396E3D
GO
Isoform 2 (identifier: P22460-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-209: Missing.

Show »
Length:404
Mass (Da):44,427
Checksum:i75826108B430EAC1
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA60146 differs from that shown. Reason: Frameshift at position 579.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti55Missing in AAA61276 (PubMed:2001794).Curated1
Sequence conflicti138L → Q in AAA36422 (PubMed:1986382).Curated1
Sequence conflicti154R → P in AAA61276 (PubMed:2001794).Curated1
Sequence conflicti154R → P in AAA36422 (PubMed:1986382).Curated1
Sequence conflicti187 – 188RP → G in AAA61276 (PubMed:2001794).Curated2
Sequence conflicti214R → G in AAA36422 (PubMed:1986382).Curated1
Sequence conflicti228P → V in AAA36422 (PubMed:1986382).Curated1
Sequence conflicti282L → V in AAA60146 (PubMed:1349297).Curated1
Sequence conflicti307P → A in AAA61276 (PubMed:2001794).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07960242L → H Found in a patient with pulmonary arterial hypertension; unknown pathological significance. 1 Publication1
Natural variantiVAR_07960385L → M1 Publication1
Natural variantiVAR_079604114T → P Found in a patient with pulmonary arterial hypertension; unknown pathological significance. 1 Publication1
Natural variantiVAR_079605170P → R Found in a patient with pulmonary arterial hypertension; unknown pathological significance. 1 Publication1
Natural variantiVAR_079606184R → P Found in a patient with pulmonary arterial hypertension; unknown pathological significance. 1 Publication1
Natural variantiVAR_053856228P → S. Corresponds to variant dbSNP:rs1056464Ensembl.1
Natural variantiVAR_035770300G → S in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs148708451EnsemblClinVar.1
Natural variantiVAR_054786578R → K. Corresponds to variant dbSNP:rs12720445EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0371101 – 209Missing in isoform 2. CuratedAdd BLAST209

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M60451 mRNA Translation: AAA61276.1
M55513 mRNA Translation: AAA36422.1
M83254 mRNA Translation: AAA60146.1 Frameshift.
BC096357 mRNA Translation: AAH96357.1
BC096358 mRNA Translation: AAH96358.3
BC099665 mRNA Translation: AAH99665.3
BC099666 mRNA Translation: AAH99666.3

The Consensus CDS (CCDS) project

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CCDSi
CCDS8536.1 [P22460-1]

Protein sequence database of the Protein Information Resource

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PIRi
A56031

NCBI Reference Sequences

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RefSeqi
NP_002225.2, NM_002234.3 [P22460-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.150208
Hs.741439

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000252321; ENSP00000252321; ENSG00000130037 [P22460-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
3741

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3741

UCSC genome browser

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UCSCi
uc001qni.5 human [P22460-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60451 mRNA Translation: AAA61276.1
M55513 mRNA Translation: AAA36422.1
M83254 mRNA Translation: AAA60146.1 Frameshift.
BC096357 mRNA Translation: AAH96357.1
BC096358 mRNA Translation: AAH96358.3
BC099665 mRNA Translation: AAH99665.3
BC099666 mRNA Translation: AAH99666.3
CCDSiCCDS8536.1 [P22460-1]
PIRiA56031
RefSeqiNP_002225.2, NM_002234.3 [P22460-1]
UniGeneiHs.150208
Hs.741439

3D structure databases

ProteinModelPortaliP22460
SMRiP22460
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109943, 58 interactors
DIPiDIP-42010N
IntActiP22460, 10 interactors
MINTiP22460
STRINGi9606.ENSP00000252321

Chemistry databases

BindingDBiP22460
ChEMBLiCHEMBL4306
DrugBankiDB06637 Dalfampridine
GuidetoPHARMACOLOGYi542

Protein family/group databases

TCDBi1.A.1.2.4 the voltage-gated ion channel (vic) superfamily

PTM databases

iPTMnetiP22460
PhosphoSitePlusiP22460
SwissPalmiP22460

Polymorphism and mutation databases

BioMutaiKCNA5
DMDMi146345443

Proteomic databases

PaxDbiP22460
PeptideAtlasiP22460
PRIDEiP22460
ProteomicsDBi53993
53994 [P22460-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252321; ENSP00000252321; ENSG00000130037 [P22460-1]
GeneIDi3741
KEGGihsa:3741
UCSCiuc001qni.5 human [P22460-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3741
DisGeNETi3741
EuPathDBiHostDB:ENSG00000130037.4

GeneCards: human genes, protein and diseases

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GeneCardsi
KCNA5
HGNCiHGNC:6224 KCNA5
HPAiCAB022562
HPA021516
MalaCardsiKCNA5
MIMi176267 gene
612240 phenotype
neXtProtiNX_P22460
OpenTargetsiENSG00000130037
Orphaneti334 Familial atrial fibrillation
PharmGKBiPA208

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1545 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00940000161860
HOGENOMiHOG000231015
HOVERGENiHBG052230
InParanoidiP22460
KOiK04878
OMAiGGELQCP
OrthoDBiEOG091G10NU
PhylomeDBiP22460
TreeFamiTF313103

Enzyme and pathway databases

ReactomeiR-HSA-1296072 Voltage gated Potassium channels

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
KCNA5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3741

Protein Ontology

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PROi
PR:P22460

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000130037 Expressed in 133 organ(s), highest expression level in cardiac muscle of right atrium
CleanExiHS_KCNA5
GenevisibleiP22460 HS

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003972 K_chnl_volt-dep_Kv1
IPR004052 K_chnl_volt-dep_Kv1.5
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01512 KV15CHANNEL
PR01491 KVCHANNEL
PR01496 SHAKERCHANEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCNA5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22460
Secondary accession number(s): Q4KKT8
, Q4VAJ1, Q4VAJ2, Q9UDA4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: May 1, 2007
Last modified: December 5, 2018
This is version 185 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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