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Protein

Fibroblast growth factor receptor 4

Gene

FGFR4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.14 Publications

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation4 Publications

Activity regulationi

Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to dimerization and activation by autophosphorylation on tyrosine residues.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei503ATPPROSITE-ProRule annotation1
Active sitei612Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi473 – 481ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Receptor, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1 2681
ReactomeiR-HSA-109704 PI3K Cascade
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1307965 betaKlotho-mediated ligand binding
R-HSA-1839128 FGFR4 mutant receptor activation
R-HSA-190322 FGFR4 ligand binding and activation
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5654228 Phospholipase C-mediated cascade, FGFR4
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-5654720 PI-3K cascade:FGFR4
R-HSA-5654733 Negative regulation of FGFR4 signaling
R-HSA-5655291 Signaling by FGFR4 in disease
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
SIGNORiP22455

Protein family/group databases

TCDBi8.A.23.1.9 the basigin (basigin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptor 4 (EC:2.7.10.1)
Short name:
FGFR-4
Alternative name(s):
CD_antigen: CD334
Gene namesi
Name:FGFR4
Synonyms:JTK2, TKF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000160867.14
HGNCiHGNC:3691 FGFR4
MIMi134935 gene
neXtProtiNX_P22455

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 369ExtracellularSequence analysisAdd BLAST348
Transmembranei370 – 390HelicalSequence analysisAdd BLAST21
Topological domaini391 – 802CytoplasmicSequence analysisAdd BLAST412

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endoplasmic reticulum, Endosome, Membrane, Secreted

Pathology & Biotechi

Involvement in diseasei

Prostate cancer (PC)4 Publications
The gene represented in this entry is involved in disease pathogenesis. FGFR4 variant Arg-388 has been associated with prostate cancer as well as cancers of the breast, colon, head and neck, larynx, lung, skin. Arg-388 predisposes cancer patients for accelerated disease progression and is associated with poor prognosis.10 Publications
Disease descriptionA malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
See also OMIM:176807
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014797388G → R in PC; also found in other types of cancer; associated with increased disease susceptibility, accelerated cancer progression and poor prognosis; results in prolonged FGFR4 activity; causes increased cell motility and tumor cell invasion possibly due to increased stability of the protease MMP14; increased interaction with STAT3; results in STAT3 phosphorylation and signaling activation. 8 PublicationsCorresponds to variant dbSNP:rs351855EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi503K → R: Loss of kinase activity. 2 Publications1
Mutagenesisi754Y → F: Loss of interaction with PLCG1. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi2264
MalaCardsiFGFR4
MIMi176807 phenotype
OpenTargetsiENSG00000160867
PharmGKBiPA28130

Chemistry databases

ChEMBLiCHEMBL3973
DrugBankiDB09078 Lenvatinib
DB00039 Palifermin
DB08901 Ponatinib
GuidetoPHARMACOLOGYi1811

Polymorphism and mutation databases

BioMutaiFGFR4
DMDMi13432140

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000001678722 – 802Fibroblast growth factor receptor 4Add BLAST781

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi57 ↔ 101PROSITE-ProRule annotation
Glycosylationi112N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi172 ↔ 224PROSITE-ProRule annotation
Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi271 ↔ 333PROSITE-ProRule annotation
Glycosylationi290N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi311N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi322N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei573PhosphoserineCombined sources1
Modified residuei642Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei643Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei754Phosphotyrosine; by autocatalysis1 Publication1

Post-translational modificationi

N-glycosylated. Full maturation of the glycan chains in the Golgi is essential for high affinity interaction with FGF19.
Ubiquitinated. Subject to proteasomal degradation when not fully glycosylated.1 Publication
Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer.3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP22455
MaxQBiP22455
PaxDbiP22455
PeptideAtlasiP22455
PRIDEiP22455
ProteomicsDBi53990
53991 [P22455-2]

PTM databases

iPTMnetiP22455
PhosphoSitePlusiP22455

Expressioni

Tissue specificityi

Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines.1 Publication

Gene expression databases

BgeeiENSG00000160867 Expressed in 119 organ(s), highest expression level in right lobe of liver
CleanExiHS_FGFR4
ExpressionAtlasiP22455 baseline and differential
GenevisibleiP22455 HS

Organism-specific databases

HPAiCAB005196
HPA027273
HPA027369
HPA028251

Interactioni

Subunit structurei

Monomer. Homodimer after ligand binding. Interacts with FGF1, FGF2, FGF4, FGF6, FGF8, FGF9, FGF16, FGF17, FGF18, FGF19, FGF21 and FGF23 (in vitro). Binding affinity for FGF family members is enhanced by interactions between FGFs and heparan sulfate proteoglycans. Interacts with KLB; this strongly increases the affinity for FGF19 and FGF23. Affinity for FGF19 is strongly increased by KLB and sulfated glycosaminoglycans. KLB and KL both interact with the core-glycosylated FGFR4 in the endoplasmic reticulum and promote its degradation, so that only FGFR4 with fully mature N-glycans is expressed at the cell surface. Identified in a complex with NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with MMP14 and HIP1 (PubMed:11433297, PubMed:16597617, PubMed:17623664, PubMed:18670643, PubMed:20683963, PubMed:20798051, PubMed:21653700, PubMed:7518429, PubMed:8663044). Interacts with STAT3 (PubMed:26675719).10 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MMP14P502816EBI-6256193,EBI-992788

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108555, 38 interactors
CORUMiP22455
DIPiDIP-5149N
IntActiP22455, 25 interactors
MINTiP22455
STRINGi9606.ENSP00000292408

Chemistry databases

BindingDBiP22455

Structurei

Secondary structure

1802
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP22455
SMRiP22455
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 118Ig-like C2-type 1Add BLAST97
Domaini152 – 240Ig-like C2-type 2Add BLAST89
Domaini249 – 349Ig-like C2-type 3Add BLAST101
Domaini467 – 755Protein kinasePROSITE-ProRule annotationAdd BLAST289

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118923
HOGENOMiHOG000263410
HOVERGENiHBG000345
InParanoidiP22455
KOiK05095
OMAiTHPQRME
OrthoDBiEOG091G0CQZ
PhylomeDBiP22455
TreeFamiTF316307

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR016248 FGF_rcpt_fam
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PIRSFiPIRSF000628 FGFR, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P22455-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRLLLALLGV LLSVPGPPVL SLEASEEVEL EPCLAPSLEQ QEQELTVALG
60 70 80 90 100
QPVRLCCGRA ERGGHWYKEG SRLAPAGRVR GWRGRLEIAS FLPEDAGRYL
110 120 130 140 150
CLARGSMIVL QNLTLITGDS LTSSNDDEDP KSHRDPSNRH SYPQQAPYWT
160 170 180 190 200
HPQRMEKKLH AVPAGNTVKF RCPAAGNPTP TIRWLKDGQA FHGENRIGGI
210 220 230 240 250
RLRHQHWSLV MESVVPSDRG TYTCLVENAV GSIRYNYLLD VLERSPHRPI
260 270 280 290 300
LQAGLPANTT AVVGSDVELL CKVYSDAQPH IQWLKHIVIN GSSFGADGFP
310 320 330 340 350
YVQVLKTADI NSSEVEVLYL RNVSAEDAGE YTCLAGNSIG LSYQSAWLTV
360 370 380 390 400
LPEEDPTWTA AAPEARYTDI ILYASGSLAL AVLLLLAGLY RGQALHGRHP
410 420 430 440 450
RPPATVQKLS RFPLARQFSL ESGSSGKSSS SLVRGVRLSS SGPALLAGLV
460 470 480 490 500
SLDLPLDPLW EFPRDRLVLG KPLGEGCFGQ VVRAEAFGMD PARPDQASTV
510 520 530 540 550
AVKMLKDNAS DKDLADLVSE MEVMKLIGRH KNIINLLGVC TQEGPLYVIV
560 570 580 590 600
ECAAKGNLRE FLRARRPPGP DLSPDGPRSS EGPLSFPVLV SCAYQVARGM
610 620 630 640 650
QYLESRKCIH RDLAARNVLV TEDNVMKIAD FGLARGVHHI DYYKKTSNGR
660 670 680 690 700
LPVKWMAPEA LFDRVYTHQS DVWSFGILLW EIFTLGGSPY PGIPVEELFS
710 720 730 740 750
LLREGHRMDR PPHCPPELYG LMRECWHAAP SQRPTFKQLV EALDKVLLAV
760 770 780 790 800
SEEYLDLRLT FGPYSPSGGD ASSTCSSSDS VFSHDPLPLG SSSFPFGSGV

QT
Length:802
Mass (Da):87,954
Last modified:April 27, 2001 - v2
Checksum:iB22B259831BB889F
GO
Isoform 2 (identifier: P22455-2) [UniParc]FASTAAdd to basket
Also known as: Soluble-form

The sequence of this isoform differs from the canonical sequence as follows:
     353-416: EEDPTWTAAA...QKLSRFPLAR → GTGRIPHLTCDSLTPAGRTKSPTL

Show »
Length:762
Mass (Da):83,452
Checksum:iBECABBA4E04A35BC
GO
Isoform 3 (identifier: P22455-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-210: Missing.

Note: Lacks a signal peptide. Constitutively phosphorylated.
Show »
Length:592
Mass (Da):64,640
Checksum:i26B7B22E4DAF8A87
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KPQ0J3KPQ0_HUMAN
Fibroblast growth factor receptor
FGFR4
734Annotation score:
H0Y9P2H0Y9P2_HUMAN
Fibroblast growth factor receptor 4
FGFR4
280Annotation score:
E7EWF4E7EWF4_HUMAN
Fibroblast growth factor receptor 4
FGFR4
201Annotation score:
D6RG06D6RG06_HUMAN
Fibroblast growth factor receptor 4
FGFR4
114Annotation score:
D6R9V0D6R9V0_HUMAN
Fibroblast growth factor receptor 4
FGFR4
108Annotation score:
D6RJD4D6RJD4_HUMAN
Fibroblast growth factor receptor 4
FGFR4
87Annotation score:
B5A964B5A964_HUMAN
Fibroblast growth factor receptor 4
FGFR4
72Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti121L → S in AAF27432 (PubMed:10631118).Curated1
Sequence conflicti194E → G in AAF27432 (PubMed:10631118).Curated1
Sequence conflicti297D → V in CAA40490 (PubMed:1709094).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02918510V → I3 PublicationsCorresponds to variant dbSNP:rs1966265Ensembl.1
Natural variantiVAR_042211136P → L6 PublicationsCorresponds to variant dbSNP:rs376618Ensembl.1
Natural variantiVAR_042212179T → A1 PublicationCorresponds to variant dbSNP:rs55675160Ensembl.1
Natural variantiVAR_014797388G → R in PC; also found in other types of cancer; associated with increased disease susceptibility, accelerated cancer progression and poor prognosis; results in prolonged FGFR4 activity; causes increased cell motility and tumor cell invasion possibly due to increased stability of the protease MMP14; increased interaction with STAT3; results in STAT3 phosphorylation and signaling activation. 8 PublicationsCorresponds to variant dbSNP:rs351855EnsemblClinVar.1
Natural variantiVAR_046102426G → S1 PublicationCorresponds to variant dbSNP:rs55879131Ensembl.1
Natural variantiVAR_042213516D → N1 PublicationCorresponds to variant dbSNP:rs34158682Ensembl.1
Natural variantiVAR_049720529R → Q. Corresponds to variant dbSNP:rs34284947Ensembl.1
Natural variantiVAR_046103550V → M in breast pleomorphic lobular sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs774571806Ensembl.1
Natural variantiVAR_046104712P → T in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_046105772S → N in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0535421 – 210Missing in isoform 3. 1 PublicationAdd BLAST210
Alternative sequenceiVSP_035108353 – 416EEDPT…FPLAR → GTGRIPHLTCDSLTPAGRTK SPTL in isoform 2. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57205 mRNA Translation: CAA40490.1
L03840 mRNA Translation: AAB59389.1
AF202063 mRNA Translation: AAF27432.1
Y13901 Genomic DNA Translation: CAA74200.1
AF359246 mRNA Translation: AAK51435.1
JN007471 mRNA Translation: AEO19712.1
JN007472 mRNA Translation: AEO19713.1
JN007473 mRNA Translation: AEO19714.1
JN007474 mRNA Translation: AEO19715.1
JN007475 mRNA Translation: AEO19716.1
JN007476 mRNA Translation: AEO19717.1
JN007477 mRNA Translation: AEO19718.1
JN007478 mRNA Translation: AEO19719.1
JN007479 mRNA Translation: AEO19720.1
JN007480 mRNA Translation: AEO19721.1
JN007481 mRNA Translation: AEO19722.1
JN007482 mRNA Translation: AEO19723.1
AF487555 Genomic DNA Translation: AAM13666.1
EF571596 Genomic DNA Translation: ABQ01235.1
AC027314 Genomic DNA No translation available.
CH471195 Genomic DNA Translation: EAW85036.1
BC011847 mRNA Translation: AAH11847.1
M59373 mRNA Translation: AAA63208.1
CCDSiCCDS4410.1 [P22455-1]
CCDS4411.1 [P22455-2]
PIRiS15345 TVHUF4
RefSeqiNP_001278909.1, NM_001291980.1
NP_002002.3, NM_002011.4 [P22455-1]
NP_075252.2, NM_022963.3 [P22455-2]
NP_998812.1, NM_213647.2 [P22455-1]
XP_005265895.1, XM_005265838.3
UniGeneiHs.165950

Genome annotation databases

EnsembliENST00000292408; ENSP00000292408; ENSG00000160867 [P22455-1]
ENST00000393637; ENSP00000377254; ENSG00000160867 [P22455-2]
ENST00000502906; ENSP00000424960; ENSG00000160867 [P22455-1]
GeneIDi2264
KEGGihsa:2264
UCSCiuc003mfl.4 human [P22455-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57205 mRNA Translation: CAA40490.1
L03840 mRNA Translation: AAB59389.1
AF202063 mRNA Translation: AAF27432.1
Y13901 Genomic DNA Translation: CAA74200.1
AF359246 mRNA Translation: AAK51435.1
JN007471 mRNA Translation: AEO19712.1
JN007472 mRNA Translation: AEO19713.1
JN007473 mRNA Translation: AEO19714.1
JN007474 mRNA Translation: AEO19715.1
JN007475 mRNA Translation: AEO19716.1
JN007476 mRNA Translation: AEO19717.1
JN007477 mRNA Translation: AEO19718.1
JN007478 mRNA Translation: AEO19719.1
JN007479 mRNA Translation: AEO19720.1
JN007480 mRNA Translation: AEO19721.1
JN007481 mRNA Translation: AEO19722.1
JN007482 mRNA Translation: AEO19723.1
AF487555 Genomic DNA Translation: AAM13666.1
EF571596 Genomic DNA Translation: ABQ01235.1
AC027314 Genomic DNA No translation available.
CH471195 Genomic DNA Translation: EAW85036.1
BC011847 mRNA Translation: AAH11847.1
M59373 mRNA Translation: AAA63208.1
CCDSiCCDS4410.1 [P22455-1]
CCDS4411.1 [P22455-2]
PIRiS15345 TVHUF4
RefSeqiNP_001278909.1, NM_001291980.1
NP_002002.3, NM_002011.4 [P22455-1]
NP_075252.2, NM_022963.3 [P22455-2]
NP_998812.1, NM_213647.2 [P22455-1]
XP_005265895.1, XM_005265838.3
UniGeneiHs.165950

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QCTmodel-B/E36-353[»]
4QQ5X-ray2.20A445-753[»]
4QQCX-ray2.40A445-753[»]
4QQJX-ray1.68A445-753[»]
4QQTX-ray1.50A445-753[»]
4QRCX-ray1.90A445-753[»]
4R6VX-ray2.35A445-753[»]
4TYEX-ray2.80A447-753[»]
4TYGX-ray2.40A447-753[»]
4TYIX-ray3.40A447-753[»]
4TYJX-ray2.45A447-753[»]
4UXQX-ray1.85A447-753[»]
4XCUX-ray1.71A449-751[»]
5JKGX-ray2.35A445-753[»]
5NUDX-ray2.50A/B449-753[»]
5NWZX-ray2.37A/B449-753[»]
5XFJX-ray3.25A445-753[»]
ProteinModelPortaliP22455
SMRiP22455
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108555, 38 interactors
CORUMiP22455
DIPiDIP-5149N
IntActiP22455, 25 interactors
MINTiP22455
STRINGi9606.ENSP00000292408

Chemistry databases

BindingDBiP22455
ChEMBLiCHEMBL3973
DrugBankiDB09078 Lenvatinib
DB00039 Palifermin
DB08901 Ponatinib
GuidetoPHARMACOLOGYi1811

Protein family/group databases

TCDBi8.A.23.1.9 the basigin (basigin) family

PTM databases

iPTMnetiP22455
PhosphoSitePlusiP22455

Polymorphism and mutation databases

BioMutaiFGFR4
DMDMi13432140

Proteomic databases

EPDiP22455
MaxQBiP22455
PaxDbiP22455
PeptideAtlasiP22455
PRIDEiP22455
ProteomicsDBi53990
53991 [P22455-2]

Protocols and materials databases

DNASUi2264
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292408; ENSP00000292408; ENSG00000160867 [P22455-1]
ENST00000393637; ENSP00000377254; ENSG00000160867 [P22455-2]
ENST00000502906; ENSP00000424960; ENSG00000160867 [P22455-1]
GeneIDi2264
KEGGihsa:2264
UCSCiuc003mfl.4 human [P22455-1]

Organism-specific databases

CTDi2264
DisGeNETi2264
EuPathDBiHostDB:ENSG00000160867.14
GeneCardsiFGFR4
HGNCiHGNC:3691 FGFR4
HPAiCAB005196
HPA027273
HPA027369
HPA028251
MalaCardsiFGFR4
MIMi134935 gene
176807 phenotype
neXtProtiNX_P22455
OpenTargetsiENSG00000160867
PharmGKBiPA28130
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118923
HOGENOMiHOG000263410
HOVERGENiHBG000345
InParanoidiP22455
KOiK05095
OMAiTHPQRME
OrthoDBiEOG091G0CQZ
PhylomeDBiP22455
TreeFamiTF316307

Enzyme and pathway databases

BRENDAi2.7.10.1 2681
ReactomeiR-HSA-109704 PI3K Cascade
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1307965 betaKlotho-mediated ligand binding
R-HSA-1839128 FGFR4 mutant receptor activation
R-HSA-190322 FGFR4 ligand binding and activation
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5654228 Phospholipase C-mediated cascade, FGFR4
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-5654720 PI-3K cascade:FGFR4
R-HSA-5654733 Negative regulation of FGFR4 signaling
R-HSA-5655291 Signaling by FGFR4 in disease
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
SIGNORiP22455

Miscellaneous databases

ChiTaRSiFGFR4 human
GeneWikiiFibroblast_growth_factor_receptor_4
GenomeRNAii2264
PROiPR:P22455
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160867 Expressed in 119 organ(s), highest expression level in right lobe of liver
CleanExiHS_FGFR4
ExpressionAtlasiP22455 baseline and differential
GenevisibleiP22455 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR016248 FGF_rcpt_fam
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PIRSFiPIRSF000628 FGFR, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFGFR4_HUMAN
AccessioniPrimary (citable) accession number: P22455
Secondary accession number(s): G3JVM2
, G3JVM5, G3JVM7, G3JVM9, O43785, Q14309, Q71TW8, Q8TDA0, Q96KE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: April 27, 2001
Last modified: October 10, 2018
This is version 206 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  5. SIMILARITY comments
    Index of protein domains and families
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  8. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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