Upstream stimulatory factor 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• bHLH transcription factor binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms."
    Viollet B., Lefrancois-Martinez A.-M., Henrion A., Kahn A., Raymondjean M., Martinez A.
    J. Biol. Chem. 271:1405-1415(1996) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.1

    "The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer."
    Gregor P.D., Sawadogo M., Roeder R.G.
    Genes Dev. 4:1730-1740(1990) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 1-25.
• double-stranded DNA binding Source: Ensembl
• enzyme binding Source: BHF-UCLInferred from physical interactionⁱ
  • "A role of DNA-PK for the metabolic gene regulation in response to insulin."
    Wong R.H., Chang I., Hudak C.S., Hyun S., Kwan H.Y., Sul H.S.
    Cell 136:1056-1072(2009) [PubMed] [Europe PMC] [Abstract]
• histone deacetylase binding Source: BHF-UCLInferred from physical interactionⁱ
  • "A role of DNA-PK for the metabolic gene regulation in response to insulin."
    Wong R.H., Chang I., Hudak C.S., Hyun S., Kwan H.Y., Sul H.S.
    Cell 136:1056-1072(2009) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: IntActInferred from physical interactionⁱ
  • "A proteome-scale map of the human interactome network."
    Rolland T., Tasan M., Charloteaux B., Pevzner S.J., Zhong Q., Sahni N., Yi S., Lemmens I., Fontanillo C., Mosca R., Kamburov A., Ghiassian S.D., Yang X., Ghamsari L., Balcha D., Begg B.E., Braun P., Brehme M.

    , Broly M.P., Carvunis A.R., Convery-Zupan D., Corominas R., Coulombe-Huntington J., Dann E., Dreze M., Dricot A., Fan C., Franzosa E., Gebreab F., Gutierrez B.J., Hardy M.F., Jin M., Kang S., Kiros R., Lin G.N., Luck K., MacWilliams A., Menche J., Murray R.R., Palagi A., Poulin M.M., Rambout X., Rasla J., Reichert P., Romero V., Ruyssinck E., Sahalie J.M., Scholz A., Shah A.A., Sharma A., Shen Y., Spirohn K., Tam S., Tejeda A.O., Trigg S.A., Twizere J.C., Vega K., Walsh J., Cusick M.E., Xia Y., Barabasi A.L., Iakoucheva L.M., Aloy P., De Las Rivas J., Tavernier J., Calderwood M.A., Hill D.E., Hao T., Roth F.P., Vidal M.
    Cell 159:1212-1226(2014) [PubMed] [Europe PMC] [Abstract]
• protein-containing complex binding Source: ParkinsonsUK-UCLInferred from physical interactionⁱ
  • "Setd1a and NURF mediate chromatin dynamics and gene regulation during erythroid lineage commitment and differentiation."
    Li Y., Schulz V.P., Deng C., Li G., Shen Y., Tusi B.K., Ma G., Stees J., Qiu Y., Steiner L.A., Zhou L., Zhao K., Bungert J., Gallagher P.G., Huang S.
    Nucleic Acids Res. 44:7173-7188(2016) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: BHF-UCLInferred from physical interactionⁱ
  • "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms."
    Viollet B., Lefrancois-Martinez A.-M., Henrion A., Kahn A., Raymondjean M., Martinez A.
    J. Biol. Chem. 271:1405-1415(1996) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: BHF-UCLInferred from physical interactionⁱ
  • "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms."
    Viollet B., Lefrancois-Martinez A.-M., Henrion A., Kahn A., Raymondjean M., Martinez A.
    J. Biol. Chem. 271:1405-1415(1996) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: BHF-UCLInferred from physical interactionⁱ
  • "A role of DNA-PK for the metabolic gene regulation in response to insulin."
    Wong R.H., Chang I., Hudak C.S., Hyun S., Kwan H.Y., Sul H.S.
    Cell 136:1056-1072(2009) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: BHF-UCLInferred from direct assayⁱ
  • Ref.1

    "The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer."
    Gregor P.D., Sawadogo M., Roeder R.G.
    Genes Dev. 4:1730-1740(1990) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 1-25.
  • "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms."
    Viollet B., Lefrancois-Martinez A.-M., Henrion A., Kahn A., Raymondjean M., Martinez A.
    J. Biol. Chem. 271:1405-1415(1996) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• carbon catabolite regulation of transcription Source: BHF-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "A role of DNA-PK for the metabolic gene regulation in response to insulin."
    Wong R.H., Chang I., Hudak C.S., Hyun S., Kwan H.Y., Sul H.S.
    Cell 136:1056-1072(2009) [PubMed] [Europe PMC] [Abstract]
• cellular response to insulin stimulus Source: BHF-UCLInferred from direct assayⁱ
  • "A role of DNA-PK for the metabolic gene regulation in response to insulin."
    Wong R.H., Chang I., Hudak C.S., Hyun S., Kwan H.Y., Sul H.S.
    Cell 136:1056-1072(2009) [PubMed] [Europe PMC] [Abstract]
• glucose homeostasis Source: BHF-UCLTraceable author statementⁱ
  • "USF1 on trial."
    Shoulders C.C.
    Nat. Genet. 36:322-323(2004) [PubMed] [Europe PMC] [Abstract]
• glucose metabolic process Source: Ensembl
• late viral transcription Source: BHF-UCLInferred from direct assayⁱ
  • Ref.1

    "The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer."
    Gregor P.D., Sawadogo M., Roeder R.G.
    Genes Dev. 4:1730-1740(1990) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 1-25.
• lipid homeostasis Source: BHF-UCL
• negative regulation of fibrinolysis Source: BHF-UCL <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence<br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • "Binding of upstream stimulatory factor 1 to the E-box regulates the 4G/5G polymorphism-dependent plasminogen activator inhibitor 1 expression in mast cells."
    Ma Z., Jhun B., Jung S.Y., Oh C.K.
    J. Allergy Clin. Immunol. 121:1006-1012.e2(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Binding of upstream stimulatory factor 1 to the E-box regulates the 4G/5G polymorphism-dependent plasminogen activator inhibitor 1 expression in mast cells."
    Ma Z., Jhun B., Jung S.Y., Oh C.K.
    J. Allergy Clin. Immunol. 121:1006-1012.e2(2008) [PubMed] [Europe PMC] [Abstract]
  • "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms."
    Viollet B., Lefrancois-Martinez A.-M., Henrion A., Kahn A., Raymondjean M., Martinez A.
    J. Biol. Chem. 271:1405-1415(1996) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription from RNA polymerase II promoter by glucose Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Upstream stimulatory factor proteins are major components of the glucose response complex of the L-type pyruvate kinase gene promoter."
    Lefrancois-Martinez A.M., Martinez A., Antoine B., Raymondjean M., Kahn A.
    J. Biol. Chem. 270:2640-2643(1995) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: BHF-UCLTraceable author statementⁱ
  • Ref.1

    "The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer."
    Gregor P.D., Sawadogo M., Roeder R.G.
    Genes Dev. 4:1730-1740(1990) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 1-25.
• regulation of transcription from RNA polymerase II promoter by glucose Source: BHF-UCLInferred by curatorⁱ
  • "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms."
    Viollet B., Lefrancois-Martinez A.-M., Henrion A., Kahn A., Raymondjean M., Martinez A.
    J. Biol. Chem. 271:1405-1415(1996) [PubMed] [Europe PMC] [Abstract]
• response to hypoxia Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "USF1 and USF2 mediate inhibition of human trophoblast differentiation and CYP19 gene expression by Mash-2 and hypoxia."
    Jiang B., Mendelson C.R.
    Mol. Cell. Biol. 23:6117-6128(2003) [PubMed] [Europe PMC] [Abstract]
• response to UV Source: BHF-UCL
• transcription by RNA polymerase II Source: BHF-UCLInferred from direct assayⁱ
  • Ref.1

    "The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer."
    Gregor P.D., Sawadogo M., Roeder R.G.
    Genes Dev. 4:1730-1740(1990) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 1-25.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Organism-specific databases

Miscellaneous databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• bHLH transcription factor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms."
    Viollet B., Lefrancois-Martinez A.-M., Henrion A., Kahn A., Raymondjean M., Martinez A.
    J. Biol. Chem. 271:1405-1415(1996) [PubMed] [Europe PMC] [Abstract]
• enzyme binding Source: BHF-UCLInferred from physical interactionⁱ
  • "A role of DNA-PK for the metabolic gene regulation in response to insulin."
    Wong R.H., Chang I., Hudak C.S., Hyun S., Kwan H.Y., Sul H.S.
    Cell 136:1056-1072(2009) [PubMed] [Europe PMC] [Abstract]
• histone deacetylase binding Source: BHF-UCLInferred from physical interactionⁱ
  • "A role of DNA-PK for the metabolic gene regulation in response to insulin."
    Wong R.H., Chang I., Hudak C.S., Hyun S., Kwan H.Y., Sul H.S.
    Cell 136:1056-1072(2009) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: IntActInferred from physical interactionⁱ
  • "A proteome-scale map of the human interactome network."
    Rolland T., Tasan M., Charloteaux B., Pevzner S.J., Zhong Q., Sahni N., Yi S., Lemmens I., Fontanillo C., Mosca R., Kamburov A., Ghiassian S.D., Yang X., Ghamsari L., Balcha D., Begg B.E., Braun P., Brehme M.

    , Broly M.P., Carvunis A.R., Convery-Zupan D., Corominas R., Coulombe-Huntington J., Dann E., Dreze M., Dricot A., Fan C., Franzosa E., Gebreab F., Gutierrez B.J., Hardy M.F., Jin M., Kang S., Kiros R., Lin G.N., Luck K., MacWilliams A., Menche J., Murray R.R., Palagi A., Poulin M.M., Rambout X., Rasla J., Reichert P., Romero V., Ruyssinck E., Sahalie J.M., Scholz A., Shah A.A., Sharma A., Shen Y., Spirohn K., Tam S., Tejeda A.O., Trigg S.A., Twizere J.C., Vega K., Walsh J., Cusick M.E., Xia Y., Barabasi A.L., Iakoucheva L.M., Aloy P., De Las Rivas J., Tavernier J., Calderwood M.A., Hill D.E., Hao T., Roth F.P., Vidal M.
    Cell 159:1212-1226(2014) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: BHF-UCLInferred from physical interactionⁱ
  • "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms."
    Viollet B., Lefrancois-Martinez A.-M., Henrion A., Kahn A., Raymondjean M., Martinez A.
    J. Biol. Chem. 271:1405-1415(1996) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: BHF-UCLInferred from physical interactionⁱ
  • "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms."
    Viollet B., Lefrancois-Martinez A.-M., Henrion A., Kahn A., Raymondjean M., Martinez A.
    J. Biol. Chem. 271:1405-1415(1996) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: BHF-UCLInferred from physical interactionⁱ
  • "A role of DNA-PK for the metabolic gene regulation in response to insulin."
    Wong R.H., Chang I., Hudak C.S., Hyun S., Kwan H.Y., Sul H.S.
    Cell 136:1056-1072(2009) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MKGQQKTAET EEGTVQIQEG AVATGEDPTS VAIASIQSAA TFPDPNVKYV 
        60         70         80         90        100
FRTENGGQVM YRVIQVSEGQ LDGQTEGTGA ISGYPATQSM TQAVIQGAFT 
       110        120        130        140        150
SDDAVDTEGT AAETHYTYFP STAVGDGAGG TTSGSTAAVV TTQGSEALLG 
       160        170        180        190        200
QATPPGTGQF FVMMSPQEVL QGGSQRSIAP RTHPYSPKSE APRTTRDEKR 
       210        220        230        240        250
RAQHNEVERR RRDKINNWIV QLSKIIPDCS MESTKSGQSK GGILSKACDY 
       260        270        280        290        300
IQELRQSNHR LSEELQGLDQ LQLDNDVLRQ QVEDLKNKNL LLRAQLRHHG 
       310
LEVVIKNDSN                                             

        10         20         30         40         50
MYRVIQVSEG QLDGQTEGTG AISGYPATQS MTQAVIQGAF TSDDAVDTEG 
        60         70         80         90        100
TAAETHYTYF PSTAVGDGAG GTTSGSTAAV VTTQGSEALL GQATPPGTGQ 
       110        120        130        140        150
FFVMMSPQEV LQGGSQRSIA PRTHPYSPKS EAPRTTRDEK RRAQHNEVER 
       160        170        180        190        200
RRRDKINNWI VQLSKIIPDC SMESTKSGQS KGGILSKACD YIQELRQSNH 
       210        220        230        240        250
RLSEELQGLD QLQLDNDVLR QQVEDLKNKN LLLRAQLRHH GLEVVIKNDS 

N                                                      

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 1
   Human chromosome 1: entries, gene names and cross-references to MIM
2. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
3. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references