USF1

Functionⁱ

Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.

GO - Molecular functionⁱ

bHLH transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 8576131
double-stranded DNA binding Source: Ensembl
enzyme binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19303849
histone deacetylase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19303849
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 25416956
protein heterodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 8576131
protein homodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 8576131
protein kinase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19303849
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
sequence-specific DNA binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 2249772
- 8576131
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 2249772

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

carbon catabolite regulation of transcription
Source: BHF-UCL
Traceable author statementⁱ
- 19303849
cellular response to insulin stimulus
Source: BHF-UCL
Inferred from direct assayⁱ
- 19303849
glucose homeostasis
Source: BHF-UCL
Traceable author statementⁱ
- 15054483
glucose metabolic process Source: Ensembl
late viral transcription
Source: BHF-UCL
Inferred from direct assayⁱ
- 2249772
lipid homeostasis Source: BHF-UCL
negative regulation of fibrinolysis
Source: BHF-UCL
Inferred by curatorⁱ
- 18234320
positive regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18234320
- 8576131
positive regulation of transcription from RNA polymerase II promoter by glucose
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 7852331
regulation of transcription by RNA polymerase II
Source: BHF-UCL
Traceable author statementⁱ
- 2249772
regulation of transcription from RNA polymerase II promoter by glucose
Source: BHF-UCL
Inferred by curatorⁱ
- 8576131
response to hypoxia
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12917334
response to UV Source: BHF-UCL
transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 2249772

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-9018519 Estrogen-dependent gene expression
SignaLinkⁱ	P22415
SIGNORⁱ	P22415

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Upstream stimulatory factor 1 Alternative name(s): Class B basic helix-loop-helix protein 11 Short name: bHLHb11 Major late transcription factor 1
Gene namesⁱ	Name:USF1 Synonyms:BHLHB11, USF
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000158773.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12593 USF1
MIMⁱ	191523 gene
neXtProtⁱ	NX_P22415

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Hyperlipidemia combined 1 (HYPLIP1)1 Publication

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionA disorder characterized by a variable pattern of elevated levels of serum total cholesterol, triglycerides or both. It is observed in a percentage of individuals with premature coronary heart disease.

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7391
MalaCards human disease database More...MalaCardsⁱ	USF1
MIMⁱ	144250 phenotype 602491 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000158773
PharmGKBⁱ	PA37223

Polymorphism and mutation databases

DMDMⁱ	137170

DMDMⁱ

137170

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127496	1 – 310	Upstream stimulatory factor 1Add BLAST		310

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	306	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDⁱ	P22415
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P22415
PaxDbⁱ	P22415
PeptideAtlas More...PeptideAtlasⁱ	P22415
PRIDEⁱ	P22415
ProteomicsDBⁱ	53989

PTM databases

iPTMnetⁱ	P22415
PhosphoSitePlusⁱ	P22415

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000158773 Expressed in 104 organ(s), highest expression level in small intestine Peyer's patch
CleanExⁱ	HS_USF1
ExpressionAtlasⁱ	P22415 baseline and differential
Genevisibleⁱ	P22415 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB001480 HPA036233 HPA036535

HPAⁱ

CAB001480
HPA036233
HPA036535

Interactionⁱ

Subunit structureⁱ

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer (USF1/USF2). Interacts with varicella-zoster virus IE62 protein.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
itself		3	EBI-1054489,EBI-1054489
FOS	Q6FG41	3	EBI-1054489,EBI-10198738
FOSL1	P15407	5	EBI-1054489,EBI-744510
KAT2B	Q92831	5	EBI-1054489,EBI-477430
TRAF2	Q12933	3	EBI-1054489,EBI-355744

GO - Molecular functionⁱ

bHLH transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 8576131
enzyme binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19303849
histone deacetylase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19303849
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 25416956
protein heterodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 8576131
protein homodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 8576131
protein kinase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19303849

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	113237, 64 interactors
ComplexPortalⁱ	CPX-3079 USF1-USF2 upstream stimulatory factor complex CPX-3082 USF1 upstream stimulatory factor complex
CORUMⁱ	P22415
Database of interacting proteins More...DIPⁱ	DIP-654N
IntActⁱ	P22415, 37 interactors
Molecular INTeraction database More...MINTⁱ	P22415
STRINGⁱ	9606.ENSP00000356999

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	205 – 225	Combined sources	21
Beta strandⁱ	233 – 236	Combined sources	4
Turnⁱ	240 – 247	Combined sources	8
Helixⁱ	248 – 255	Combined sources	8
Turnⁱ	256 – 258	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P22415
SMRⁱ	P22415
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P22415

EvolutionaryTraceⁱ

P22415

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	199 – 254	bHLHPROSITE-ProRule annotationAdd BLAST		56

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	271 – 292	Leucine-zipperAdd BLAST		22

Phylogenomic databases

eggNOGⁱ	ENOG410INSE Eukaryota ENOG4110B3H LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004498
HOGENOMⁱ	HOG000294174
HOVERGENⁱ	HBG004346
InParanoidⁱ	P22415
KEGG Orthology (KO) More...KOⁱ	K09106
OMAⁱ	NQRTIAP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0RH5
PhylomeDBⁱ	P22415
TreeFamⁱ	TF323338

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P22415-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKGQQKTAET EEGTVQIQEG AVATGEDPTS VAIASIQSAA TFPDPNVKYV 
        60         70         80         90        100
FRTENGGQVM YRVIQVSEGQ LDGQTEGTGA ISGYPATQSM TQAVIQGAFT 
       110        120        130        140        150
SDDAVDTEGT AAETHYTYFP STAVGDGAGG TTSGSTAAVV TTQGSEALLG 
       160        170        180        190        200
QATPPGTGQF FVMMSPQEVL QGGSQRSIAP RTHPYSPKSE APRTTRDEKR 
       210        220        230        240        250
RAQHNEVERR RRDKINNWIV QLSKIIPDCS MESTKSGQSK GGILSKACDY 
       260        270        280        290        300
IQELRQSNHR LSEELQGLDQ LQLDNDVLRQ QVEDLKNKNL LLRAQLRHHG 
       310
LEVVIKNDSN

Length:310

Mass (Da):33,538

Last modified:August 1, 1991 - v1

Checksum:ⁱBFDA91519B4B80AE

GO

Isoform 2 (identifier: P22415-2) [UniParc]FASTA Add to basket

Also known as: usf1-bd

The sequence of this isoform differs from the canonical sequence as follows:
1-59: Missing.

« Hide

        10         20         30         40         50
MYRVIQVSEG QLDGQTEGTG AISGYPATQS MTQAVIQGAF TSDDAVDTEG 
        60         70         80         90        100
TAAETHYTYF PSTAVGDGAG GTTSGSTAAV VTTQGSEALL GQATPPGTGQ 
       110        120        130        140        150
FFVMMSPQEV LQGGSQRSIA PRTHPYSPKS EAPRTTRDEK RRAQHNEVER 
       160        170        180        190        200
RRRDKINNWI VQLSKIIPDC SMESTKSGQS KGGILSKACD YIQELRQSNH 
       210        220        230        240        250
RLSEELQGLD QLQLDNDVLR QQVEDLKNKN LLLRAQLRHH GLEVVIKNDS 

N

Show »

Length:251

Mass (Da):27,372

Checksum:ⁱAA50D545E179EFCB

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B1AQP1	B1AQP1_HUMAN	Upstream stimulatory factor 1 Upstream stimulatory factor 1 (Upstream transcription factor 1, isoform CRA_b)	USF1 hCG_20846	282	Annotation score:
E9PME6	E9PME6_HUMAN	Upstream stimulatory factor 1 Upstream stimulatory factor 1	USF1	217	Annotation score:
H0YD59	H0YD59_HUMAN	Upstream stimulatory factor 1 Upstream stimulatory factor 1	USF1	165	Annotation score:
E9PQA2	E9PQA2_HUMAN	Upstream stimulatory factor 1 Upstream stimulatory factor 1	USF1	105	Annotation score:
E9PJ52	E9PJ52_HUMAN	Upstream stimulatory factor 1 Upstream stimulatory factor 1 (Upstream transcription factor 1 isoform 2)	USF1	48	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_047740	1 – 59	Missing in isoform 2. 1 PublicationAdd BLAST		59

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X55666 mRNA Translation: CAA39201.1 AB017568 Genomic DNA Translation: BAA76541.1 AB098540 mRNA Translation: BAC78384.1 AK314876 mRNA Translation: BAG37391.1 AL832119 mRNA No translation available. AY593992 Genomic DNA Translation: AAS89301.1 AL591806 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW52675.1 BC035505 mRNA Translation: AAH35505.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1214.1 [P22415-1]
PIRⁱ	S13525
NCBI Reference Sequences More...RefSeqⁱ	NP_001263302.1, NM_001276373.1 [P22415-1] NP_009053.1, NM_007122.4 [P22415-1] NP_996888.1, NM_207005.2 [P22415-2]
UniGeneⁱ	Hs.414880

Genome annotation databases

Ensemblⁱ	ENST00000368020; ENSP00000356999; ENSG00000158773 [P22415-1] ENST00000368021; ENSP00000357000; ENSG00000158773 [P22415-1]
GeneIDⁱ	7391
KEGGⁱ	hsa:7391
UCSC genome browser More...UCSCⁱ	uc001fxi.5 human [P22415-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P22415	Upstream stimulatory factor 1		HUMAN		48	UniRef100_P22415
USF1 (Fragment)		CEREH		234
USF1 isoform 5		PONAB		48
USF1 isoform 5		PANTR		48
Upstream stimulatory factor 1		MOUSE		48
+19
P22415-2	Rho GTPase-activating protein 30		TUPCH		1370	UniRef100_L8YFR2
Upstream stimulatory factor 1 (Fragment)		NEOVI		98
USF1 isoform 10 (Fragment)		PONAB		106
USF1 isoform 10 (Fragment)		PANTR		106
Uncharacterized protein		MACMU		251
+1

Protein	Similar proteins		Species	Score	Length	Source
P22415	Upstream stimulatory factor 1		BOVIN		310	UniRef90_P22415
Upstream stimulatory factor 1		MOUSE		310
Upstream stimulatory factor 1		RABIT		310
Upstream stimulatory factor 1		HUMAN		48
USF1 (Fragment)		CEREH		234
+155
P22415-2	Rho GTPase-activating protein 30		TUPCH		1370	UniRef90_L8YFR2
Upstream stimulatory factor 1 (Fragment)		NEOVI		98
USF1 isoform 10 (Fragment)		PONAB		106
USF1 isoform 10 (Fragment)		PANTR		106
Uncharacterized protein		MACMU		251
+2

Protein	Similar proteins		Species	Score	Length	Source
P22415	Upstream stimulatory factor 1		MOUSE		310	UniRef50_P22415
Upstream stimulatory factor 1		BOVIN		310
Upstream stimulatory factor 1		RABIT		310
Upstream stimulatory factor 1		HUMAN		48
USF1 (Fragment)		CEREH		234
+303
P22415-2	Rho GTPase-activating protein 30		MOUSE		1101	UniRef50_Q640N3
Uncharacterized protein (Fragment)		Daphnia magna		121
ARHGAP30 isoform 4		PONAB		923
Uncharacterized protein		Cebus capucinus imitator		1104
Rho GTPase activating protein 30		CALJA		1103
+202

Cross-referencesⁱ

Web resourcesⁱ

SeattleSNPs

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X55666 mRNA Translation: CAA39201.1 AB017568 Genomic DNA Translation: BAA76541.1 AB098540 mRNA Translation: BAC78384.1 AK314876 mRNA Translation: BAG37391.1 AL832119 mRNA No translation available. AY593992 Genomic DNA Translation: AAS89301.1 AL591806 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW52675.1 BC035505 mRNA Translation: AAH35505.1
CCDSⁱ	CCDS1214.1 [P22415-1]
PIRⁱ	S13525
RefSeqⁱ	NP_001263302.1, NM_001276373.1 [P22415-1] NP_009053.1, NM_007122.4 [P22415-1] NP_996888.1, NM_207005.2 [P22415-2]
UniGeneⁱ	Hs.414880

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1AN4	X-ray	2.90	A/B	197-260	[»]
ProteinModelPortalⁱ	P22415
SMRⁱ	P22415
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113237, 64 interactors
ComplexPortalⁱ	CPX-3079 USF1-USF2 upstream stimulatory factor complex CPX-3082 USF1 upstream stimulatory factor complex
CORUMⁱ	P22415
DIPⁱ	DIP-654N
IntActⁱ	P22415, 37 interactors
MINTⁱ	P22415
STRINGⁱ	9606.ENSP00000356999

PTM databases

iPTMnetⁱ	P22415
PhosphoSitePlusⁱ	P22415

Polymorphism and mutation databases

DMDMⁱ	137170

DMDMⁱ

137170

Proteomic databases

EPDⁱ	P22415
MaxQBⁱ	P22415
PaxDbⁱ	P22415
PeptideAtlasⁱ	P22415
PRIDEⁱ	P22415
ProteomicsDBⁱ	53989

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7391
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000368020; ENSP00000356999; ENSG00000158773 [P22415-1] ENST00000368021; ENSP00000357000; ENSG00000158773 [P22415-1]
GeneIDⁱ	7391
KEGGⁱ	hsa:7391
UCSCⁱ	uc001fxi.5 human [P22415-1]

Organism-specific databases

CTDⁱ	7391
DisGeNETⁱ	7391
EuPathDBⁱ	HostDB:ENSG00000158773.14
GeneCardsⁱ	USF1
HGNCⁱ	HGNC:12593 USF1
HPAⁱ	CAB001480 HPA036233 HPA036535
MalaCardsⁱ	USF1
MIMⁱ	144250 phenotype 191523 gene 602491 phenotype
neXtProtⁱ	NX_P22415
OpenTargetsⁱ	ENSG00000158773
PharmGKBⁱ	PA37223
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410INSE Eukaryota ENOG4110B3H LUCA
GeneTreeⁱ	ENSGT00390000004498
HOGENOMⁱ	HOG000294174
HOVERGENⁱ	HBG004346
InParanoidⁱ	P22415
KOⁱ	K09106
OMAⁱ	NQRTIAP
OrthoDBⁱ	EOG091G0RH5
PhylomeDBⁱ	P22415
TreeFamⁱ	TF323338

Enzyme and pathway databases

Reactomeⁱ	R-HSA-9018519 Estrogen-dependent gene expression
SignaLinkⁱ	P22415
SIGNORⁱ	P22415

Miscellaneous databases

ChiTaRSⁱ	USF1 human
EvolutionaryTraceⁱ	P22415
GeneWikiⁱ	USF1
GenomeRNAiⁱ	7391
Protein Ontology More...PROⁱ	PR:P22415
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000158773 Expressed in 104 organ(s), highest expression level in small intestine Peyer's patch
CleanExⁱ	HS_USF1
ExpressionAtlasⁱ	P22415 baseline and differential
Genevisibleⁱ	P22415 HS

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	USF1_HUMAN
Accessionⁱ	P22415Primary (citable) accession number: P22415 Secondary accession number(s): B2RBZ4, Q5SY46, Q7Z5Y1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
	Last sequence update:	August 1, 1991
	Last modified:	September 12, 2018
	This is version 180 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P22415 (USF1_HUMAN)

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Upstream stimulatory factor 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ