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Protein

Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

Gene

ENPP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

By generating PPi, plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. PPi inhibits mineralization by binding to nascent hydroxyapatite (HA) crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity and function.3 Publications

Caution

It is uncertain whether Met-1 or Met-53 is the initiator.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.1 Publication EC:3.1.4.1

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

At low concentrations of ATP, a phosphorylated intermediate is formed which inhibits further hydrolysis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi218Zinc 1; catalyticBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei256AMP-threonine intermediateBy similarity1
Metal bindingi256Zinc 1; catalyticBy similarity1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei277SubstrateBy similarity1
Binding sitei295SubstrateBy similarity1
Binding sitei340SubstrateBy similarity1
Metal bindingi376Zinc 2; catalyticBy similarity1
Metal bindingi380Zinc 2; via tele nitrogen; catalyticBy similarity1
Metal bindingi423Zinc 1; catalyticBy similarity1
Metal bindingi424Zinc 1; via tele nitrogen; catalyticBy similarity1
Metal bindingi535Zinc 2; via tele nitrogen; catalyticBy similarity1
Metal bindingi800CalciumBy similarity1
Metal bindingi802CalciumBy similarity1
Metal bindingi804CalciumBy similarity1
Metal bindingi806Calcium; via carbonyl oxygenBy similarity1
Metal bindingi808CalciumBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei915Essential for catalytic activityBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processBiomineralization
LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
3.6.1.9 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-196843 Vitamin B2 (riboflavin) metabolism
R-HSA-199220 Vitamin B5 (pantothenate) metabolism

SABIO-RK: Biochemical Reaction Kinetics Database

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SABIO-RKi
P22413

SIGNOR Signaling Network Open Resource

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SIGNORi
P22413

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
Short name:
E-NPP 1
Alternative name(s):
Membrane component chromosome 6 surface marker 1
Phosphodiesterase I/nucleotide pyrophosphatase 1
Plasma-cell membrane glycoprotein PC-1
Including the following 2 domains:
Alkaline phosphodiesterase I (EC:3.1.4.11 Publication)
Nucleotide pyrophosphatase (EC:3.6.1.91 Publication)
Short name:
NPPase
Alternative name(s):
Nucleotide diphosphataseCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ENPP1
Synonyms:M6S1, NPPS, PC1, PDNP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000197594.11

Human Gene Nomenclature Database

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HGNCi
HGNC:3356 ENPP1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
173335 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P22413

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 76CytoplasmicSequence analysisAdd BLAST76
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei77 – 97Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini98 – 925ExtracellularSequence analysisAdd BLAST828

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ossification of the posterior longitudinal ligament of the spine (OPLL)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA calcification of the posterior longitudinal ligament of the spinal column, usually at the level of the cervical spine. Patients with OPLL frequently present with a severe myelopathy that can lead to tetraparesis.
See also OMIM:602475
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01414191L → P in OPLL. 1 Publication1
Natural variantiVAR_014143287S → F in OPLL. 1 PublicationCorresponds to variant dbSNP:rs190947144Ensembl.1
Arterial calcification of infancy, generalized, 1 (GACI1)7 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA severe autosomal recessive disorder characterized by calcification of the internal elastic lamina of muscular arteries and stenosis due to myointimal proliferation. The disorder is often fatal within the first 6 months of life because of myocardial ischemia resulting in refractory heart failure.
See also OMIM:208000
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_077256126C → R in GACI1. 1 Publication1
Natural variantiVAR_077259195C → R in GACI1; loss of nucleotide phosphodiesterase activity; loss of localization to plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs763457176Ensembl.1
Natural variantiVAR_077260195C → S in GACI1; loss of nucleotide phosphodiesterase activity; loss of localization to plasma membrane. 1 Publication1
Natural variantiVAR_077261216S → Y in GACI1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs760786509Ensembl.1
Natural variantiVAR_077262218D → V in GACI1. 1 PublicationCorresponds to variant dbSNP:rs1231182870Ensembl.1
Natural variantiVAR_077264242G → E in GACI1; unknown pathological significance. 1 Publication1
Natural variantiVAR_067910250P → L in GACI1; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs754659608Ensembl.1
Natural variantiVAR_067911252Missing in GACI1. 1 Publication1
Natural variantiVAR_077265276D → N in GACI1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs143771474Ensembl.1
Natural variantiVAR_077266301Y → C in GACI1; loss of nucleotide phosphodiesterase activity; loss of localization to plasma membrane. 1 Publication1
Natural variantiVAR_067912305P → T in GACI1; loss of nucleotide phosphodiesterase activity; no effect on localization to plasma membrane. 3 PublicationsCorresponds to variant dbSNP:rs374270497EnsemblClinVar.1
Natural variantiVAR_037433342G → V in GACI1. 3 PublicationsCorresponds to variant dbSNP:rs121918025EnsemblClinVar.1
Natural variantiVAR_077267349R → K in GACI1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs764735802Ensembl.1
Natural variantiVAR_037434371Y → F in GACI1; unknown pathological significance. 3 PublicationsCorresponds to variant dbSNP:rs121918026EnsemblClinVar.1
Natural variantiVAR_077268456R → Q in GACI1. 1 PublicationCorresponds to variant dbSNP:rs765071179Ensembl.1
Natural variantiVAR_077269471Y → C in GACI1; decreased nucleotide phosphodiesterase activity; no effect on localization to plasma membrane. 2 PublicationsCorresponds to variant dbSNP:rs148462924Ensembl.1
Natural variantiVAR_077270481R → W in GACI1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs373044722EnsemblClinVar.1
Natural variantiVAR_077271500H → P in GACI1. 1 Publication1
Natural variantiVAR_077272504S → R in GACI1; decreased nucleotide phosphodiesterase activity; no effect on localization to plasma membrane. 2 Publications1
Natural variantiVAR_077273513Y → C in GACI1; loss of nucleotide phosphodiesterase activity; no effect on localization to plasma membrane. 2 PublicationsCorresponds to variant dbSNP:rs1243920034Ensembl.1
Natural variantiVAR_067913538D → H in GACI1; loss of nucleotide phosphodiesterase activity; no effect on localization to plasma membrane. 2 PublicationsCorresponds to variant dbSNP:rs387906673EnsemblClinVar.1
Natural variantiVAR_077274570Y → C in GACI1. 1 PublicationCorresponds to variant dbSNP:rs140248167Ensembl.1
Natural variantiVAR_018514579L → F in GACI1; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs121918024EnsemblClinVar.1
Natural variantiVAR_067914586G → R in GACI1; loss of nucleotide phosphodiesterase activity; loss of localization to plasma membrane. 2 PublicationsCorresponds to variant dbSNP:rs777367269EnsemblClinVar.1
Natural variantiVAR_077276659Y → C in GACI1; decreased nucleotide phosphodiesterase activity; no effect on localization to plasma membrane. 2 PublicationsCorresponds to variant dbSNP:rs143393727Ensembl.1
Natural variantiVAR_077278726C → R in GACI1. 1 Publication1
Natural variantiVAR_077279777H → R in GACI1; decreased nucleotide phosphodiesterase activity; no effect on localization to plasma membrane. 2 PublicationsCorresponds to variant dbSNP:rs147346173EnsemblClinVar.1
Natural variantiVAR_077280792N → S in ARHR2 and GACI1. 2 PublicationsCorresponds to variant dbSNP:rs370184526Ensembl.1
Natural variantiVAR_077281804D → H in GACI1. 1 Publication1
Natural variantiVAR_077283888R → W in GACI1; loss of nucleotide phosphodiesterase activity; loss of localization to plasma membrane. 2 PublicationsCorresponds to variant dbSNP:rs184483616Ensembl.1
Diabetes mellitus, non-insulin-dependent (NIDDM)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
See also OMIM:125853
Hypophosphatemic rickets, autosomal recessive, 2 (ARHR2)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA hereditary form of hypophosphatemic rickets, a disorder of proximal renal tubule function that causes phosphate loss, hypophosphatemia and skeletal deformities, including rickets and osteomalacia unresponsive to vitamin D. Symptoms are bone pain, fractures and growth abnormalities.
See also OMIM:613312
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07725592G → D in ARHR2. 1 Publication1
Natural variantiVAR_077263219G → R in ARHR2; unknown pathological significance. 1 Publication1
Natural variantiVAR_063719266G → V in ARHR2. 1 PublicationCorresponds to variant dbSNP:rs121908248EnsemblClinVar.1
Natural variantiVAR_077280792N → S in ARHR2 and GACI1. 2 PublicationsCorresponds to variant dbSNP:rs370184526Ensembl.1
Natural variantiVAR_063720901Y → S in ARHR2; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs121908249EnsemblClinVar.1
Cole disease (COLED)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare autosomal dominant genodermatosis characterized by punctate keratoderma associated with irregularly shaped hypopigmented macules, which are typically found over the arms and legs but not the trunk or acral regions. Skin biopsies of palmoplantar lesions show hyperorthokeratosis, hypergranulosis, and acanthosis. Hypopigmented areas of skin, however, reveal a reduction in melanin content in keratinocytes but not in melanocytes, as well as hyperkeratosis and a normal number of melanocytes. Ultrastructurally, melanocytes show a disproportionately large number of melanosomes in the cytoplasm and dendrites, whereas keratinocytes show a paucity of these organelles, suggestive of impaired melanosome transfer. Some patients also exhibit calcinosis cutis or calcific tendinopathy.
See also OMIM:615522
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_077257133C → R in COLED. 1 Publication1
Natural variantiVAR_070782149C → S in COLED. 1 PublicationCorresponds to variant dbSNP:rs397518477EnsemblClinVar.1
Natural variantiVAR_070783164C → S in COLED. 1 PublicationCorresponds to variant dbSNP:rs397518476EnsemblClinVar.1
Natural variantiVAR_077258177C → S in COLED. 1 Publication1
Natural variantiVAR_070784177C → Y in COLED. 1 PublicationCorresponds to variant dbSNP:rs397518475EnsemblClinVar.1

Keywords - Diseasei

Diabetes mellitus, Disease mutation, Obesity

Organism-specific databases

DisGeNET

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DisGeNETi
5167

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
ENPP1

MalaCards human disease database

More...
MalaCardsi
ENPP1
MIMi125853 phenotype
208000 phenotype
602475 phenotype
613312 phenotype
615522 phenotype

Open Targets

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OpenTargetsi
ENSG00000197594

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
289176 Autosomal recessive hypophosphatemic rickets
51608 Generalized arterial calcification of infancy
324561 Hypopigmentation-punctate palmoplantar keratoderma syndrome
758 Pseudoxanthoma elasticum

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA27791

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL5925

Drug and drug target database

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DrugBanki
DB01143 Amifostine
DB00811 Ribavirin

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
ENPP1

Domain mapping of disease mutations (DMDM)

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DMDMi
23503088

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001885641 – 925Ectonucleotide pyrophosphatase/phosphodiesterase family member 1Add BLAST925

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi108 ↔ 122PROSITE-ProRule annotation
Disulfide bondi112 ↔ 140PROSITE-ProRule annotation
Disulfide bondi120 ↔ 133PROSITE-ProRule annotation
Disulfide bondi126 ↔ 132PROSITE-ProRule annotation
Disulfide bondi149 ↔ 166PROSITE-ProRule annotation
Disulfide bondi154 ↔ 184PROSITE-ProRule annotation
Disulfide bondi164 ↔ 177PROSITE-ProRule annotation
Disulfide bondi170 ↔ 176PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi179N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi195 ↔ 241PROSITE-ProRule annotation
Disulfide bondi203 ↔ 415PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei256PhosphothreonineBy similarity1
Glycosylationi285N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi341N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi431 ↔ 530PROSITE-ProRule annotation
Glycosylationi477N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi480 ↔ 868PROSITE-ProRule annotation
Glycosylationi585N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi614 ↔ 672PROSITE-ProRule annotation
Disulfide bondi626 ↔ 726PROSITE-ProRule annotation
Disulfide bondi628 ↔ 711PROSITE-ProRule annotation
Glycosylationi643N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi700N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi731N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi748N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi838 ↔ 848PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated as part of the catalytic cycle of phosphodiesterase/pyrophosphatase activity.
N-glycosylated.3 Publications
A secreted form is produced through cleavage at Lys-103 by intracellular processing.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei102 – 103CleavageBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P22413

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P22413

MaxQB - The MaxQuant DataBase

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MaxQBi
P22413

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P22413

PeptideAtlas

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PeptideAtlasi
P22413

PRoteomics IDEntifications database

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PRIDEi
P22413

ProteomicsDB human proteome resource

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ProteomicsDBi
53988

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1196

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P22413

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P22413

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in plasma cells and also in a number of non-lymphoid tissues, including the distal convoluted tubule of the kidney, chondrocytes and epididymis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000197594 Expressed in 192 organ(s), highest expression level in tibia

CleanEx database of gene expression profiles

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CleanExi
HS_ENPP1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P22413 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P22413 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB032904
HPA062066

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The secreted form is monomeric (By similarity). Homodimer. Interacts with INSR.By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
INSRP062132EBI-3197846,EBI-475899

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111193, 15 interactors

Protein interaction database and analysis system

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IntActi
P22413, 5 interactors

Molecular INTeraction database

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MINTi
P22413

STRING: functional protein association networks

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STRINGi
9606.ENSP00000354238

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P22413

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1925
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YS0NMR-A147-189[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P22413

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P22413

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P22413

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini104 – 144SMB 1PROSITE-ProRule annotationAdd BLAST41
Domaini145 – 189SMB 2PROSITE-ProRule annotationAdd BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni191 – 591PhosphodiesteraseAdd BLAST401
Regioni597 – 647LinkerBy similarityAdd BLAST51
Regioni654 – 925NucleaseAdd BLAST272

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi45 – 52Di-leucine motif8

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The di-leucine motif is required for basolateral targeting in epithelial cells, and for targeting to matrix vesicles derived from mineralizing cells.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2645 Eukaryota
COG1524 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156034

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000037439

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG051484

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P22413

KEGG Orthology (KO)

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KOi
K01513

Identification of Orthologs from Complete Genome Data

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OMAi
RCDVACV

Database of Orthologous Groups

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OrthoDBi
1030907at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P22413

TreeFam database of animal gene trees

More...
TreeFami
TF330032

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.720.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR001604 DNA/RNA_non-sp_Endonuclease
IPR020821 Extracellular_endonuc_su_A
IPR002591 Phosphodiest/P_Trfase
IPR036024 Somatomedin_B-like_dom_sf
IPR020436 Somatomedin_B_chordata
IPR001212 Somatomedin_B_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01223 Endonuclease_NS, 1 hit
PF01663 Phosphodiest, 1 hit
PF01033 Somatomedin_B, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00022 SOMATOMEDINB

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00892 Endonuclease_NS, 1 hit
SM00477 NUC, 1 hit
SM00201 SO, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53649 SSF53649, 1 hit
SSF90188 SSF90188, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00524 SMB_1, 2 hits
PS50958 SMB_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P22413-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERDGCAGGG SRGGEGGRAP REGPAGNGRD RGRSHAAEAP GDPQAAASLL
60 70 80 90 100
APMDVGEEPL EKAARARTAK DPNTYKVLSL VLSVCVLTTI LGCIFGLKPS
110 120 130 140 150
CAKEVKSCKG RCFERTFGNC RCDAACVELG NCCLDYQETC IEPEHIWTCN
160 170 180 190 200
KFRCGEKRLT RSLCACSDDC KDKGDCCINY SSVCQGEKSW VEEPCESINE
210 220 230 240 250
PQCPAGFETP PTLLFSLDGF RAEYLHTWGG LLPVISKLKK CGTYTKNMRP
260 270 280 290 300
VYPTKTFPNH YSIVTGLYPE SHGIIDNKMY DPKMNASFSL KSKEKFNPEW
310 320 330 340 350
YKGEPIWVTA KYQGLKSGTF FWPGSDVEIN GIFPDIYKMY NGSVPFEERI
360 370 380 390 400
LAVLQWLQLP KDERPHFYTL YLEEPDSSGH SYGPVSSEVI KALQRVDGMV
410 420 430 440 450
GMLMDGLKEL NLHRCLNLIL ISDHGMEQGS CKKYIYLNKY LGDVKNIKVI
460 470 480 490 500
YGPAARLRPS DVPDKYYSFN YEGIARNLSC REPNQHFKPY LKHFLPKRLH
510 520 530 540 550
FAKSDRIEPL TFYLDPQWQL ALNPSERKYC GSGFHGSDNV FSNMQALFVG
560 570 580 590 600
YGPGFKHGIE ADTFENIEVY NLMCDLLNLT PAPNNGTHGS LNHLLKNPVY
610 620 630 640 650
TPKHPKEVHP LVQCPFTRNP RDNLGCSCNP SILPIEDFQT QFNLTVAEEK
660 670 680 690 700
IIKHETLPYG RPRVLQKENT ICLLSQHQFM SGYSQDILMP LWTSYTVDRN
710 720 730 740 750
DSFSTEDFSN CLYQDFRIPL SPVHKCSFYK NNTKVSYGFL SPPQLNKNSS
760 770 780 790 800
GIYSEALLTT NIVPMYQSFQ VIWRYFHDTL LRKYAEERNG VNVVSGPVFD
810 820 830 840 850
FDYDGRCDSL ENLRQKRRVI RNQEILIPTH FFIVLTSCKD TSQTPLHCEN
860 870 880 890 900
LDTLAFILPH RTDNSESCVH GKHDSSWVEE LLMLHRARIT DVEHITGLSF
910 920
YQQRKEPVSD ILKLKTHLPT FSQED
Length:925
Mass (Da):104,924
Last modified:September 19, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0ECAA063801CAFEB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PE72E9PE72_HUMAN
Ectonucleotide pyrophosphatase/phos...
ENPP1
378Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IU14A0A3B3IU14_HUMAN
Ectonucleotide pyrophosphatase/phos...
ENPP1
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ISN7A0A3B3ISN7_HUMAN
Ectonucleotide pyrophosphatase/phos...
ENPP1
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IST7A0A3B3IST7_HUMAN
Ectonucleotide pyrophosphatase/phos...
ENPP1
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA63237 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH59375 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA02054 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01414191L → P in OPLL. 1 Publication1
Natural variantiVAR_07725592G → D in ARHR2. 1 Publication1
Natural variantiVAR_077256126C → R in GACI1. 1 Publication1
Natural variantiVAR_077257133C → R in COLED. 1 Publication1
Natural variantiVAR_070782149C → S in COLED. 1 PublicationCorresponds to variant dbSNP:rs397518477EnsemblClinVar.1
Natural variantiVAR_070783164C → S in COLED. 1 PublicationCorresponds to variant dbSNP:rs397518476EnsemblClinVar.1
Natural variantiVAR_008873173K → Q Polymorphism; associated with NIDDM; decreased nucleotide phosphodiesterase activity; no effect on localization to plasma membrane. 5 PublicationsCorresponds to variant dbSNP:rs1044498EnsemblClinVar.1
Natural variantiVAR_077258177C → S in COLED. 1 Publication1
Natural variantiVAR_070784177C → Y in COLED. 1 PublicationCorresponds to variant dbSNP:rs397518475EnsemblClinVar.1
Natural variantiVAR_037432179N → S. Corresponds to variant dbSNP:rs2273411Ensembl.1
Natural variantiVAR_077259195C → R in GACI1; loss of nucleotide phosphodiesterase activity; loss of localization to plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs763457176Ensembl.1
Natural variantiVAR_077260195C → S in GACI1; loss of nucleotide phosphodiesterase activity; loss of localization to plasma membrane. 1 Publication1
Natural variantiVAR_077261216S → Y in GACI1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs760786509Ensembl.1
Natural variantiVAR_077262218D → V in GACI1. 1 PublicationCorresponds to variant dbSNP:rs1231182870Ensembl.1
Natural variantiVAR_077263219G → R in ARHR2; unknown pathological significance. 1 Publication1
Natural variantiVAR_077264242G → E in GACI1; unknown pathological significance. 1 Publication1
Natural variantiVAR_067910250P → L in GACI1; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs754659608Ensembl.1
Natural variantiVAR_067911252Missing in GACI1. 1 Publication1
Natural variantiVAR_063719266G → V in ARHR2. 1 PublicationCorresponds to variant dbSNP:rs121908248EnsemblClinVar.1
Natural variantiVAR_014142268Y → H1 PublicationCorresponds to variant dbSNP:rs17847050EnsemblClinVar.1
Natural variantiVAR_077265276D → N in GACI1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs143771474Ensembl.1
Natural variantiVAR_014143287S → F in OPLL. 1 PublicationCorresponds to variant dbSNP:rs190947144Ensembl.1
Natural variantiVAR_077266301Y → C in GACI1; loss of nucleotide phosphodiesterase activity; loss of localization to plasma membrane. 1 Publication1
Natural variantiVAR_067912305P → T in GACI1; loss of nucleotide phosphodiesterase activity; no effect on localization to plasma membrane. 3 PublicationsCorresponds to variant dbSNP:rs374270497EnsemblClinVar.1
Natural variantiVAR_037433342G → V in GACI1. 3 PublicationsCorresponds to variant dbSNP:rs121918025EnsemblClinVar.1
Natural variantiVAR_077267349R → K in GACI1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs764735802Ensembl.1
Natural variantiVAR_037434371Y → F in GACI1; unknown pathological significance. 3 PublicationsCorresponds to variant dbSNP:rs121918026EnsemblClinVar.1
Natural variantiVAR_077268456R → Q in GACI1. 1 PublicationCorresponds to variant dbSNP:rs765071179Ensembl.1
Natural variantiVAR_077269471Y → C in GACI1; decreased nucleotide phosphodiesterase activity; no effect on localization to plasma membrane. 2 PublicationsCorresponds to variant dbSNP:rs148462924Ensembl.1
Natural variantiVAR_077270481R → W in GACI1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs373044722EnsemblClinVar.1
Natural variantiVAR_077271500H → P in GACI1. 1 Publication1
Natural variantiVAR_077272504S → R in GACI1; decreased nucleotide phosphodiesterase activity; no effect on localization to plasma membrane. 2 Publications1
Natural variantiVAR_077273513Y → C in GACI1; loss of nucleotide phosphodiesterase activity; no effect on localization to plasma membrane. 2 PublicationsCorresponds to variant dbSNP:rs1243920034Ensembl.1
Natural variantiVAR_067913538D → H in GACI1; loss of nucleotide phosphodiesterase activity; no effect on localization to plasma membrane. 2 PublicationsCorresponds to variant dbSNP:rs387906673EnsemblClinVar.1
Natural variantiVAR_077274570Y → C in GACI1. 1 PublicationCorresponds to variant dbSNP:rs140248167Ensembl.1
Natural variantiVAR_018514579L → F in GACI1; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs121918024EnsemblClinVar.1
Natural variantiVAR_067914586G → R in GACI1; loss of nucleotide phosphodiesterase activity; loss of localization to plasma membrane. 2 PublicationsCorresponds to variant dbSNP:rs777367269EnsemblClinVar.1
Natural variantiVAR_077275611L → V1 PublicationCorresponds to variant dbSNP:rs79079368EnsemblClinVar.1
Natural variantiVAR_077276659Y → C in GACI1; decreased nucleotide phosphodiesterase activity; no effect on localization to plasma membrane. 2 PublicationsCorresponds to variant dbSNP:rs143393727Ensembl.1
Natural variantiVAR_077277668E → K Polymorphism; no effect on nucleotide phosphodiesterase activity; no effect on localization to plasma membrane. 2 PublicationsCorresponds to variant dbSNP:rs115371819EnsemblClinVar.1
Natural variantiVAR_077278726C → R in GACI1. 1 Publication1
Natural variantiVAR_018515774R → C Polymorphism; decreased nucleotide phosphodiesterase activity; no effect on localization to plasma membrane. 4 PublicationsCorresponds to variant dbSNP:rs28933977EnsemblClinVar.1
Natural variantiVAR_077279777H → R in GACI1; decreased nucleotide phosphodiesterase activity; no effect on localization to plasma membrane. 2 PublicationsCorresponds to variant dbSNP:rs147346173EnsemblClinVar.1
Natural variantiVAR_014144779T → P1 PublicationCorresponds to variant dbSNP:rs1805138EnsemblClinVar.1
Natural variantiVAR_077280792N → S in ARHR2 and GACI1. 2 PublicationsCorresponds to variant dbSNP:rs370184526Ensembl.1
Natural variantiVAR_077281804D → H in GACI1. 1 Publication1
Natural variantiVAR_077282821R → H Polymorphism; decreased nucleotide phosphodiesterase activity; no effect on localization to plasma membrane. 2 PublicationsCorresponds to variant dbSNP:rs367759638Ensembl.1
Natural variantiVAR_037435886R → T. Corresponds to variant dbSNP:rs8192683EnsemblClinVar.1
Natural variantiVAR_077283888R → W in GACI1; loss of nucleotide phosphodiesterase activity; loss of localization to plasma membrane. 2 PublicationsCorresponds to variant dbSNP:rs184483616Ensembl.1
Natural variantiVAR_063720901Y → S in ARHR2; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs121908249EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M57736 mRNA Translation: AAA63237.1 Different initiation.
D12485 mRNA Translation: BAA02054.1 Different initiation.
AF110304
, AF110280, AF110281, AF110283, AF110284, AF110285, AF110286, AF110287, AF110288, AF110289, AF110290, AF110291, AF110292, AF110293, AF110294, AF110295, AF110296, AF110297, AF110298, AF110299, AF110300, AF110301, AF110302, AF110303 Genomic DNA Translation: AAF36094.1
AJ242020
, AJ242021, AJ242022, AJ242023, AJ242024, AJ242025, AJ242026, AJ242027, AJ242028, AJ242029, AJ242030, AJ242031, AJ242032, AJ242033, AJ242034, AJ242035, AJ242036, AJ242037, AJ242038, AJ242039, AJ242040, AJ242041, AJ242042, AJ242043, AJ242044 Genomic DNA Translation: CAC39442.1
AL117378 Genomic DNA No translation available.
AL139805 Genomic DNA No translation available.
BC059375 mRNA Translation: AAH59375.2 Different initiation.
AF067177 Genomic DNA Translation: AAD38420.1
AF067178 Genomic DNA Translation: AAD38421.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5150.2

Protein sequence database of the Protein Information Resource

More...
PIRi
A39216

NCBI Reference Sequences

More...
RefSeqi
NP_006199.2, NM_006208.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.527295

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000360971; ENSP00000354238; ENSG00000197594
ENST00000647893; ENSP00000498074; ENSG00000197594

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5167

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5167

UCSC genome browser

More...
UCSCi
uc011ecf.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57736 mRNA Translation: AAA63237.1 Different initiation.
D12485 mRNA Translation: BAA02054.1 Different initiation.
AF110304
, AF110280, AF110281, AF110283, AF110284, AF110285, AF110286, AF110287, AF110288, AF110289, AF110290, AF110291, AF110292, AF110293, AF110294, AF110295, AF110296, AF110297, AF110298, AF110299, AF110300, AF110301, AF110302, AF110303 Genomic DNA Translation: AAF36094.1
AJ242020
, AJ242021, AJ242022, AJ242023, AJ242024, AJ242025, AJ242026, AJ242027, AJ242028, AJ242029, AJ242030, AJ242031, AJ242032, AJ242033, AJ242034, AJ242035, AJ242036, AJ242037, AJ242038, AJ242039, AJ242040, AJ242041, AJ242042, AJ242043, AJ242044 Genomic DNA Translation: CAC39442.1
AL117378 Genomic DNA No translation available.
AL139805 Genomic DNA No translation available.
BC059375 mRNA Translation: AAH59375.2 Different initiation.
AF067177 Genomic DNA Translation: AAD38420.1
AF067178 Genomic DNA Translation: AAD38421.1
CCDSiCCDS5150.2
PIRiA39216
RefSeqiNP_006199.2, NM_006208.2
UniGeneiHs.527295

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YS0NMR-A147-189[»]
ProteinModelPortaliP22413
SMRiP22413
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111193, 15 interactors
IntActiP22413, 5 interactors
MINTiP22413
STRINGi9606.ENSP00000354238

Chemistry databases

BindingDBiP22413
ChEMBLiCHEMBL5925
DrugBankiDB01143 Amifostine
DB00811 Ribavirin

PTM databases

GlyConnecti1196
iPTMnetiP22413
PhosphoSitePlusiP22413

Polymorphism and mutation databases

BioMutaiENPP1
DMDMi23503088

Proteomic databases

EPDiP22413
jPOSTiP22413
MaxQBiP22413
PaxDbiP22413
PeptideAtlasiP22413
PRIDEiP22413
ProteomicsDBi53988

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360971; ENSP00000354238; ENSG00000197594
ENST00000647893; ENSP00000498074; ENSG00000197594
GeneIDi5167
KEGGihsa:5167
UCSCiuc011ecf.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5167
DisGeNETi5167
EuPathDBiHostDB:ENSG00000197594.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ENPP1
GeneReviewsiENPP1
HGNCiHGNC:3356 ENPP1
HPAiCAB032904
HPA062066
MalaCardsiENPP1
MIMi125853 phenotype
173335 gene
208000 phenotype
602475 phenotype
613312 phenotype
615522 phenotype
neXtProtiNX_P22413
OpenTargetsiENSG00000197594
Orphaneti289176 Autosomal recessive hypophosphatemic rickets
51608 Generalized arterial calcification of infancy
324561 Hypopigmentation-punctate palmoplantar keratoderma syndrome
758 Pseudoxanthoma elasticum
PharmGKBiPA27791

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2645 Eukaryota
COG1524 LUCA
GeneTreeiENSGT00940000156034
HOGENOMiHOG000037439
HOVERGENiHBG051484
InParanoidiP22413
KOiK01513
OMAiRCDVACV
OrthoDBi1030907at2759
PhylomeDBiP22413
TreeFamiTF330032

Enzyme and pathway databases

BRENDAi3.6.1.9 2681
ReactomeiR-HSA-196843 Vitamin B2 (riboflavin) metabolism
R-HSA-199220 Vitamin B5 (pantothenate) metabolism
SABIO-RKiP22413
SIGNORiP22413

Miscellaneous databases

EvolutionaryTraceiP22413

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Ectonucleotide_pyrophosphatase/phosphodiesterase_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5167

Protein Ontology

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PROi
PR:P22413

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000197594 Expressed in 192 organ(s), highest expression level in tibia
CleanExiHS_ENPP1
ExpressionAtlasiP22413 baseline and differential
GenevisibleiP22413 HS

Family and domain databases

Gene3Di3.40.720.10, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR001604 DNA/RNA_non-sp_Endonuclease
IPR020821 Extracellular_endonuc_su_A
IPR002591 Phosphodiest/P_Trfase
IPR036024 Somatomedin_B-like_dom_sf
IPR020436 Somatomedin_B_chordata
IPR001212 Somatomedin_B_dom
PfamiView protein in Pfam
PF01223 Endonuclease_NS, 1 hit
PF01663 Phosphodiest, 1 hit
PF01033 Somatomedin_B, 2 hits
PRINTSiPR00022 SOMATOMEDINB
SMARTiView protein in SMART
SM00892 Endonuclease_NS, 1 hit
SM00477 NUC, 1 hit
SM00201 SO, 2 hits
SUPFAMiSSF53649 SSF53649, 1 hit
SSF90188 SSF90188, 2 hits
PROSITEiView protein in PROSITE
PS00524 SMB_1, 2 hits
PS50958 SMB_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiENPP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22413
Secondary accession number(s): Q5T9R6
, Q9NPZ3, Q9P1P6, Q9UP61, Q9Y6K3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: September 19, 2002
Last modified: January 16, 2019
This is version 203 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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