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Protein

Nucleoside diphosphate kinase B

Gene

NME2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC (PubMed:15249197). Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752, PubMed:19435876). Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III1 region of the MYC gene promoter. Does not bind to duplex NHE III1 (PubMed:19435876). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not (PubMed:25679041). Exhibits histidine protein kinase activity (PubMed:20946858).By similarity5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei12ATPCombined sources1 Publication1
Binding sitei60ATPCombined sources1 Publication1
Binding sitei88ATPCombined sources1 Publication1
Binding sitei94ATPCombined sources1 Publication1
Binding sitei105ATPCombined sources1 Publication1
Binding sitei115ATPCombined sources1 Publication1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei118Pros-phosphohistidine intermediate1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • DNA binding Source: UniProtKB
  • DNA-binding transcription factor activity Source: UniProtKB
  • enzyme binding Source: Ensembl
  • fatty acid binding Source: Ensembl
  • GDP binding Source: UniProtKB
  • G-quadruplex DNA binding Source: UniProtKB
  • intermediate filament binding Source: Ensembl
  • metal ion binding Source: UniProtKB-KW
  • nucleoside diphosphate kinase activity Source: UniProtKB
  • protein histidine kinase activity Source: UniProtKB-EC
  • protein serine/threonine kinase activity Source: Ensembl

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Kinase, Transferase
Biological processNucleotide metabolism, Transcription, Transcription regulation
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS04463-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-499943 Interconversion of nucleotide di- and triphosphates
R-HSA-6798695 Neutrophil degranulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P22392

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P22392

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleoside diphosphate kinase B (EC:2.7.4.62 Publications)
Short name:
NDK B
Short name:
NDP kinase B
Alternative name(s):
C-myc purine-binding transcription factor PUF
Histidine protein kinase NDKB (EC:2.7.13.31 Publication)
nm23-H2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NME2
Synonyms:NM23B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000011052.21

Human Gene Nomenclature Database

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HGNCi
HGNC:7850 NME2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
156491 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P22392

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi88R → A: Decreased single-stranded DNA-binding and nucleotide-binding activity. No effect on 3D-structure. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
4831
654364

Open Targets

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OpenTargetsi
ENSG00000011052
ENSG00000243678

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162398077

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2160

Drug and drug target database

More...
DrugBanki
DB00718 Adefovir Dipivoxil
DB04315 Guanosine-5'-Diphosphate
DB00709 Lamivudine
DB00300 Tenofovir

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NME2

Domain mapping of disease mutations (DMDM)

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DMDMi
127983

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001371171 – 152Nucleoside diphosphate kinase BAdd BLAST152

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P22392

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P22392

PeptideAtlas

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PeptideAtlasi
P22392

PRoteomics IDEntifications database

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PRIDEi
P22392

ProteomicsDB human proteome resource

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ProteomicsDBi
53986
53987 [P22392-2]

Consortium for Top Down Proteomics

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TopDownProteomicsi
P22392-1 [P22392-1]
P22392-2 [P22392-2]

2D gel databases

DOSAC-COBS 2D-PAGE database

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DOSAC-COBS-2DPAGEi
P22392

USC-OGP 2-DE database

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OGPi
P22392

University College Dublin 2-DE Proteome Database

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UCD-2DPAGEi
P22392

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P22392

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P22392

SwissPalm database of S-palmitoylation events

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SwissPalmi
P22392

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 and isoform 3 are ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000011052 Expressed in 91 organ(s), highest expression level in putamen

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P22392 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P22392 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA041113

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6) (PubMed:1851158). Interacts with CAPN8 (By similarity). Interacts with AKAP13 (PubMed:15249197). Interacts ITGB1BP1 (via C-terminal domain region) (PubMed:11919189).By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110895, 93 interactors
576341, 47 interactors

Database of interacting proteins

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DIPi
DIP-50179N

Protein interaction database and analysis system

More...
IntActi
P22392, 27 interactors

Molecular INTeraction database

More...
MINTi
P22392

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000376886

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1152
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P22392

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P22392

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P22392

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 66Interaction with AKAP131 PublicationAdd BLAST66

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NDK family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0888 Eukaryota
COG0105 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161569
ENSGT00940000163317

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000224564

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000423

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P22392

KEGG Orthology (KO)

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KOi
K00940

Database for complete collections of gene phylogenies

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PhylomeDBi
P22392

TreeFam database of animal gene trees

More...
TreeFami
TF106373

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.70.141, 1 hit

HAMAP database of protein families

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HAMAPi
MF_00451 NDP_kinase, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR034907 NDK-like_dom
IPR036850 NDK-like_dom_sf
IPR001564 Nucleoside_diP_kinase
IPR023005 Nucleoside_diP_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00334 NDK, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01243 NUCDPKINASE

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00562 NDK, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54919 SSF54919, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00469 NDP_KINASES, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P22392-1) [UniParc]FASTAAdd to basket
Also known as: NM23-H2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MANLERTFIA IKPDGVQRGL VGEIIKRFEQ KGFRLVAMKF LRASEEHLKQ
60 70 80 90 100
HYIDLKDRPF FPGLVKYMNS GPVVAMVWEG LNVVKTGRVM LGETNPADSK
110 120 130 140 150
PGTIRGDFCI QVGRNIIHGS DSVKSAEKEI SLWFKPEELV DYKSCAHDWV

YE
Length:152
Mass (Da):17,298
Last modified:August 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1A5C3F84D7AD272C
GO
Isoform 3 (identifier: P22392-2) [UniParc]FASTAAdd to basket
Also known as: NM23-LV

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MANCERTFIA...DFCIQVGRTM

Note: Based on a naturally occurring readthrough transcript which produces an NME1-NME2 fusion protein.By similarity
Show »
Length:267
Mass (Da):30,137
Checksum:i3AB02272AF24AAC3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q32Q12Q32Q12_HUMAN
Nucleoside diphosphate kinase
NME1-NME2 hCG_2001850
292Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6XY72F6XY72_HUMAN
HCG2001850, isoform CRA_c
NME2 hCG_2001850
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KPD9J3KPD9_HUMAN
NME1-NME2 readthrough
NME1-NME2
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0367081M → MANCERTFIAIKPDGVQRGL VGEIIKRFEQKGFRLVGLKF MQASEDLLKEHYVDLKDRPF FAGLVKYMHSGPVVAMVWEG LNVVKTGRVMLGETNPADSK PGTIRGDFCIQVGRTM in isoform 3. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X58965 mRNA Translation: CAB37870.1
M36981 mRNA Translation: AAA36369.1
L16785 mRNA Translation: AAA60228.1
DQ109675 mRNA Translation: AAZ82097.1
AC005839 Genomic DNA No translation available.
BC002476 mRNA Translation: AAH02476.1
BC133029 mRNA Translation: AAI33030.1
BC133031 mRNA Translation: AAI33032.1
U29200 Genomic DNA Translation: AAA86745.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11580.1 [P22392-1]

Protein sequence database of the Protein Information Resource

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PIRi
A49798

NCBI Reference Sequences

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RefSeqi
NP_001018146.1, NM_001018136.2 [P22392-2]
NP_001018147.1, NM_001018137.2 [P22392-1]
NP_001018148.1, NM_001018138.1 [P22392-1]
NP_001018149.1, NM_001018139.2 [P22392-1]
NP_002503.1, NM_002512.3 [P22392-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.463456

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000393190; ENSP00000376886; ENSG00000243678 [P22392-1]
ENST00000503064; ENSP00000426901; ENSG00000243678 [P22392-1]
ENST00000512737; ENSP00000421064; ENSG00000243678 [P22392-1]
ENST00000513177; ENSP00000425581; ENSG00000243678 [P22392-1]
ENST00000514264; ENSP00000426976; ENSG00000243678 [P22392-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
4831
654364

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4831
hsa:654364

UCSC genome browser

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UCSCi
uc002itj.4 human [P22392-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58965 mRNA Translation: CAB37870.1
M36981 mRNA Translation: AAA36369.1
L16785 mRNA Translation: AAA60228.1
DQ109675 mRNA Translation: AAZ82097.1
AC005839 Genomic DNA No translation available.
BC002476 mRNA Translation: AAH02476.1
BC133029 mRNA Translation: AAI33030.1
BC133031 mRNA Translation: AAI33032.1
U29200 Genomic DNA Translation: AAA86745.1
CCDSiCCDS11580.1 [P22392-1]
PIRiA49798
RefSeqiNP_001018146.1, NM_001018136.2 [P22392-2]
NP_001018147.1, NM_001018137.2 [P22392-1]
NP_001018148.1, NM_001018138.1 [P22392-1]
NP_001018149.1, NM_001018139.2 [P22392-1]
NP_002503.1, NM_002512.3 [P22392-1]
UniGeneiHs.463456

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NSKX-ray2.80L/N/O/R/T/U1-152[»]
1NUEX-ray2.00A/B/C/D/E/F2-152[»]
3BBBX-ray1.30A/B/C/D/E/F2-152[»]
3BBCX-ray1.70A/B/C/D/E/F2-152[»]
3BBFX-ray1.70A/B/C/D/E/F2-152[»]
ProteinModelPortaliP22392
SMRiP22392
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110895, 93 interactors
576341, 47 interactors
DIPiDIP-50179N
IntActiP22392, 27 interactors
MINTiP22392
STRINGi9606.ENSP00000376886

Chemistry databases

ChEMBLiCHEMBL2160
DrugBankiDB00718 Adefovir Dipivoxil
DB04315 Guanosine-5'-Diphosphate
DB00709 Lamivudine
DB00300 Tenofovir

PTM databases

iPTMnetiP22392
PhosphoSitePlusiP22392
SwissPalmiP22392

Polymorphism and mutation databases

BioMutaiNME2
DMDMi127983

2D gel databases

DOSAC-COBS-2DPAGEiP22392
OGPiP22392
UCD-2DPAGEiP22392

Proteomic databases

EPDiP22392
PaxDbiP22392
PeptideAtlasiP22392
PRIDEiP22392
ProteomicsDBi53986
53987 [P22392-2]
TopDownProteomicsiP22392-1 [P22392-1]
P22392-2 [P22392-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
4831
654364
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393190; ENSP00000376886; ENSG00000243678 [P22392-1]
ENST00000503064; ENSP00000426901; ENSG00000243678 [P22392-1]
ENST00000512737; ENSP00000421064; ENSG00000243678 [P22392-1]
ENST00000513177; ENSP00000425581; ENSG00000243678 [P22392-1]
ENST00000514264; ENSP00000426976; ENSG00000243678 [P22392-1]
GeneIDi4831
654364
KEGGihsa:4831
hsa:654364
UCSCiuc002itj.4 human [P22392-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4831
654364
DisGeNETi4831
654364
EuPathDBiHostDB:ENSG00000011052.21

GeneCards: human genes, protein and diseases

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GeneCardsi
NME2
HGNCiHGNC:7850 NME2
HPAiHPA041113
MIMi156491 gene
neXtProtiNX_P22392
OpenTargetsiENSG00000011052
ENSG00000243678
PharmGKBiPA162398077

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0888 Eukaryota
COG0105 LUCA
GeneTreeiENSGT00940000161569
ENSGT00940000163317
HOGENOMiHOG000224564
HOVERGENiHBG000423
InParanoidiP22392
KOiK00940
PhylomeDBiP22392
TreeFamiTF106373

Enzyme and pathway databases

BioCyciMetaCyc:HS04463-MONOMER
ReactomeiR-HSA-499943 Interconversion of nucleotide di- and triphosphates
R-HSA-6798695 Neutrophil degranulation
SignaLinkiP22392
SIGNORiP22392

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NME2 human
EvolutionaryTraceiP22392

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NME1-NME2
NME2

Protein Ontology

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PROi
PR:P22392

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000011052 Expressed in 91 organ(s), highest expression level in putamen
ExpressionAtlasiP22392 baseline and differential
GenevisibleiP22392 HS

Family and domain databases

Gene3Di3.30.70.141, 1 hit
HAMAPiMF_00451 NDP_kinase, 1 hit
InterProiView protein in InterPro
IPR034907 NDK-like_dom
IPR036850 NDK-like_dom_sf
IPR001564 Nucleoside_diP_kinase
IPR023005 Nucleoside_diP_kinase_AS
PfamiView protein in Pfam
PF00334 NDK, 1 hit
PRINTSiPR01243 NUCDPKINASE
SMARTiView protein in SMART
SM00562 NDK, 1 hit
SUPFAMiSSF54919 SSF54919, 1 hit
PROSITEiView protein in PROSITE
PS00469 NDP_KINASES, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNDKB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22392
Secondary accession number(s): A8MWA3, Q1WM23, Q6LCT6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: December 5, 2018
This is version 221 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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