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Protein

Endothelin-1

Gene

Edn1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

GO - Molecular functioni

  • cytokine activity Source: Ensembl
  • endothelin A receptor binding Source: RGD
  • endothelin B receptor binding Source: RGD
  • hormone activity Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionVasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiR-RNO-375276 Peptide ligand-binding receptors
R-RNO-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-1
Short name:
ET-1
Alternative name(s):
Preproendothelin-1
Short name:
PPET1
Cleaved into the following chain:
Gene namesi
Name:Edn1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi2532 Edn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
PropeptideiPRO_000000807226 – 501 PublicationAdd BLAST25
PeptideiPRO_000043639953 – 91Big endothelin-11 PublicationAdd BLAST39
PeptideiPRO_000000807353 – 73Endothelin-1Add BLAST21
PropeptideiPRO_000000807474 – 202Add BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 67By similarity
Disulfide bondi55 ↔ 63By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei73 – 74Cleavage; by KELBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP22388
PRIDEiP22388

Expressioni

Gene expression databases

BgeeiENSRNOG00000014361 Expressed in 9 organ(s), highest expression level in lung
GenevisibleiP22388 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019361

Structurei

Secondary structure

1202
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SMRiP22388
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22388

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 124Endothelin-likeAdd BLAST15

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWVG Eukaryota
ENOG4111WED LUCA
GeneTreeiENSGT00530000063310
HOGENOMiHOG000231110
HOVERGENiHBG051441
InParanoidiP22388
KOiK16366
OMAiWVNTPEH
OrthoDBiEOG091G0LEL
PhylomeDBiP22388
TreeFamiTF333184

Family and domain databases

InterProiView protein in InterPro
IPR020475 Endothelin
IPR019764 Endothelin_toxin_CS
IPR001928 Endothln-like_toxin
PfamiView protein in Pfam
PF00322 Endothelin, 1 hit
PRINTSiPR00365 ENDOTHELIN
SMARTiView protein in SMART
SM00272 END, 2 hits
PROSITEiView protein in PROSITE
PS00270 ENDOTHELIN, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22388-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDYFPVIFSL LFVAFQGAPE TAVLGAELSP RAEKEVQSPP PSTSWRPRRS
60 70 80 90 100
KRCSCSSLMD KECVYFCHLD IIWVNTPERV VPYGLGSPSR SKRSLKDLLP
110 120 130 140 150
TKTTDQGNRC QCAHQKDKKC WNFCQADKEL RAQSTMQKGV KDFKKGKPCP
160 170 180 190 200
KLGKKCIYQQ LVEGRKLRRL EAISNSIKTS FRVAKLKAEL YRDQKLIHNR

AH
Length:202
Mass (Da):23,135
Last modified:November 1, 1991 - v2
Checksum:i701886BAFD09AC4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64711 mRNA Translation: AAA41129.1
PIRiJN0125
RefSeqiNP_036680.1, NM_012548.2
XP_017455942.1, XM_017600453.1
UniGeneiRn.10918

Genome annotation databases

EnsembliENSRNOT00000019361; ENSRNOP00000019361; ENSRNOG00000014361
GeneIDi24323
KEGGirno:24323
UCSCiRGD:2532 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64711 mRNA Translation: AAA41129.1
PIRiJN0125
RefSeqiNP_036680.1, NM_012548.2
XP_017455942.1, XM_017600453.1
UniGeneiRn.10918

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CMHNMR-A60-73[»]
6CMHNMR-A53-73[»]
SMRiP22388
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019361

Proteomic databases

PaxDbiP22388
PRIDEiP22388

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019361; ENSRNOP00000019361; ENSRNOG00000014361
GeneIDi24323
KEGGirno:24323
UCSCiRGD:2532 rat

Organism-specific databases

CTDi1906
RGDi2532 Edn1

Phylogenomic databases

eggNOGiENOG410IWVG Eukaryota
ENOG4111WED LUCA
GeneTreeiENSGT00530000063310
HOGENOMiHOG000231110
HOVERGENiHBG051441
InParanoidiP22388
KOiK16366
OMAiWVNTPEH
OrthoDBiEOG091G0LEL
PhylomeDBiP22388
TreeFamiTF333184

Enzyme and pathway databases

ReactomeiR-RNO-375276 Peptide ligand-binding receptors
R-RNO-416476 G alpha (q) signalling events

Miscellaneous databases

EvolutionaryTraceiP22388
PROiPR:P22388

Gene expression databases

BgeeiENSRNOG00000014361 Expressed in 9 organ(s), highest expression level in lung
GenevisibleiP22388 RN

Family and domain databases

InterProiView protein in InterPro
IPR020475 Endothelin
IPR019764 Endothelin_toxin_CS
IPR001928 Endothln-like_toxin
PfamiView protein in Pfam
PF00322 Endothelin, 1 hit
PRINTSiPR00365 ENDOTHELIN
SMARTiView protein in SMART
SM00272 END, 2 hits
PROSITEiView protein in PROSITE
PS00270 ENDOTHELIN, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiEDN1_RAT
AccessioniPrimary (citable) accession number: P22388
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: November 1, 1991
Last modified: September 12, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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