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UniProtKB - P22367 (MSAS_PENPA)
Protein
6-methylsalicylic acid synthase
Gene
N/A
Organism
Penicillium patulum (Penicillium griseofulvum)
Status
Functioni
This multifunctional enzyme is a polyketide synthase. It catalyzes a total of 11 steps by seven different component enzymes, in the biosynthesis of the antibiotic patulin.
Catalytic activityi
- EC:2.3.1.165
: patulin biosynthesis Pathwayi
This protein is involved in the pathway patulin biosynthesis, which is part of Mycotoxin biosynthesis.View all proteins of this organism that are known to be involved in the pathway patulin biosynthesis and in Mycotoxin biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 204 | For beta-ketoacyl synthase activityPROSITE-ProRule annotation | 1 | |
Active sitei | 653 | For malonyltransferase activityPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 1419 – 1424 | NADPSequence analysis | 6 |
GO - Molecular functioni
- 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: InterPro
- 6-methylsalicylic acid synthase activity Source: UniProtKB-EC
- phosphopantetheine binding Source: InterPro
GO - Biological processi
- antibiotic biosynthetic process Source: UniProtKB-KW
- fatty acid biosynthetic process Source: InterPro
Keywordsi
Molecular function | Multifunctional enzyme, Transferase |
Biological process | Antibiotic biosynthesis |
Ligand | NADP |
Enzyme and pathway databases
BRENDAi | 2.3.1.165, 4632 |
UniPathwayi | UPA00918 |
Names & Taxonomyi
Protein namesi | |
Organismi | Penicillium patulum (Penicillium griseofulvum) |
Taxonomic identifieri | 5078 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Penicillium |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000180292 | 1 – 1774 | 6-methylsalicylic acid synthaseAdd BLAST | 1774 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1732 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 |
Keywords - PTMi
Phosphopantetheine, PhosphoproteinExpressioni
Inductioni
In the late logarithmic growth phase.
Interactioni
Subunit structurei
Homomultimer.
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1698 – 1772 | CarrierPROSITE-ProRule annotationAdd BLAST | 75 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 21 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 186 – 238 | AcyltransferaseAdd BLAST | 53 | |
Regioni | 642 – 676 | Acetyl/malonyl transferasesAdd BLAST | 35 | |
Regioni | 1403 – 1450 | 2-oxoacyl reductaseAdd BLAST | 48 |
Phylogenomic databases
OMAi | HRRFWRT |
Family and domain databases
Gene3Di | 1.10.1200.10, 1 hit 3.10.129.110, 1 hit 3.40.366.10, 1 hit 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR001227, Ac_transferase_dom_sf IPR036736, ACP-like_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR016036, Malonyl_transacylase_ACP-bd IPR036291, NAD(P)-bd_dom_sf IPR032821, PKS_assoc IPR020841, PKS_Beta-ketoAc_synthase_dom IPR020807, PKS_dehydratase IPR042104, PKS_dehydratase_sf IPR013968, PKS_KR IPR020806, PKS_PP-bd IPR009081, PP-bd_ACP IPR006162, Ppantetheine_attach_site IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit PF16197, KAsynt_C_assoc, 1 hit PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit PF08659, KR, 1 hit PF00550, PP-binding, 1 hit PF14765, PS-DH, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit SM00826, PKS_DH, 1 hit SM00825, PKS_KS, 1 hit SM00823, PKS_PP, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit SSF51735, SSF51735, 2 hits SSF52151, SSF52151, 1 hit SSF53901, SSF53901, 1 hit SSF55048, SSF55048, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit PS50075, CARRIER, 1 hit PS00012, PHOSPHOPANTETHEINE, 1 hit |
i Sequence
Sequence statusi: Complete.
P22367-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHSAATSTYP SGKTSPAPVG TPGTEYSEYE FSNDVAVVGM ACRVAGGNHN
60 70 80 90 100
PELLWQSLLS QKSAMGEIPP MRWEPYYRRD ARNEKFLKNT TSRGYFLDRL
110 120 130 140 150
EDFDCQFFGI SPKEAEQMDP QQRVSLEVAS EALEDAGIPA KSLSGSDTAV
160 170 180 190 200
FWGVNSDDYS KLVLEDLPNV EAWMGIGTAY CGVPNRISYH LNLMGPSTAV
210 220 230 240 250
DAACASSLVA IHHGVQAIRL GESKVAIVGG VNALCGPGLT RVLDKAGAIS
260 270 280 290 300
SDGSCKSFDD DAHGYARGEG AGALVLKSLH RALLDHDNVL AVIKGSAVCQ
310 320 330 340 350
DGKTNGIMAP NSVAQQLAAN NALSAANIDP HTVRYVEAHA TSTPLGDPTE
360 370 380 390 400
ISAIASVYGA DRPADDPCYI GSIKPNIGHL EAGAGVMGFI KAVLAIQKGV
410 420 430 440 450
LPPQANLTKL NSRIDWKTAG VKVVQEATPW PESDPIRRAG VCSYGYGGTV
460 470 480 490 500
SHAVIEEFSP ILQPDPLGNG AVSGPGLLLL SGPQEKRLAL QAKTLRDWMT
510 520 530 540 550
AEGKDHNLSD ILTTLATRRD HHDYRAALVV DDYRDAEQVL QSLANGVDHT
560 570 580 590 600
FTTQSRVLGS DISKDVVWVF SGHGAQWPDM GKQLIHNPVF FAAIQPLDEL
610 620 630 640 650
IQAEIGLSPI ELLRTGDFES SDRVQILTYV MQIGLSALLQ SNGITPQAVI
660 670 680 690 700
GHSVGEIAAS VVAGALSPAE GALIVTRRAL LYRQVMGKGG MILVNLPSAE
710 720 730 740 750
TEEILGSRSD LVVAIDSSPS SCVVAGDKEL VAETAEALKA RGVKTFTVKS
760 770 780 790 800
DIAFHSPTLN GLVDPLRDVL AETLSPVSPN VKLYSTALAD PRGQDLRDVE
810 820 830 840 850
YWAGNMVNRV RLTSAVKAAV EDGYRLFLEV STHPVVSHSI NETLMDAGME
860 870 880 890 900
DFAVIPTLLR KKPTEKHILH SIAQLHCRGA EVNWAAQMPG RWATGVPTTT
910 920 930 940 950
WMHKPIWRKI ETAPLHTGLT HDVEKHTLLG QRIPVPGTDT YVYTTRLDND
960 970 980 990 1000
TKPFPGSHPL HGTEIVPAAG LINTFLKGTG GQMLQNVVLR VPVAINAPRS
1010 1020 1030 1040 1050
VQVVVQQDQV KVVSRLIPSE PSQLDDDASW VTHTTAYWDR KVAGSEDRID
1060 1070 1080 1090 1100
FAAVKSRLVT KLADNFSIDY LDKVGVSAMG FPWAVTEHYR NDKEMLARVD
1110 1120 1130 1140 1150
VNPAISGDAP LPWDSSSWAP VLDAATSVGS TIFPTPALRM PAQIERVEVF
1160 1170 1180 1190 1200
TSQDPPKISW LYVQEASDSV PTSHVSVVSE AGEVLAKFTA MRFSEIEGTP
1210 1220 1230 1240 1250
GVSGSMESLV HQIAWPPATP AEEPLSIETV ILVSPDATTR ALYAASLPTR
1260 1270 1280 1290 1300
VNSFQFSSTQ EFFSNASSLP LEKGTVVTYI PGEVASLAEV PAASESFTWN
1310 1320 1330 1340 1350
LLELIKFTVN GSLPIKVFTL TANIGEGQTP TALAQSPLYG LARVIASEHP
1360 1370 1380 1390 1400
DLGTLIDVEE PVIPLSTMRY IQGADIIRIN DGIARTSRFR SLPRNKLLPA
1410 1420 1430 1440 1450
SEGPRLLPRP EGTYLITGGL GVLGLEVADF LVEKGARRLL LISRRALPPR
1460 1470 1480 1490 1500
RTWDQVSEDL QPTIAKIRLL ESRGASVHVL PLDITKPDAV EQLTTALDRL
1510 1520 1530 1540 1550
SLPSVQGVVH AAGVLDNELV MQTTRDAFNR VLAPKIAGAL ALHEVFPPKS
1560 1570 1580 1590 1600
VDFFVMFSSC GNLVGFTGQA SYGSGNAFLD TLATHRARLG DAAVSFQWTS
1610 1620 1630 1640 1650
WRGLGMGAST DFINAELESK GITDVTRDEA FAAWQHLAKY DMDHGVVLRS
1660 1670 1680 1690 1700
RAFEDGEPIP VSILNDIAVR RVGTVSNTSP AAAGSSDAVP TSGPELKAYL
1710 1720 1730 1740 1750
DEKIRGCVAK VLQMTAEDVD SKAALADLGV DSVMTVTLRR QLQLTLKIAV
1760 1770
PPTLTWSHPT VSHLAVWFAE KLAK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X55776 Genomic DNA Translation: CAA39295.1 |
PIRi | S13178 |
Genome annotation databases
KEGGi | ag:CAA39295 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X55776 Genomic DNA Translation: CAA39295.1 |
PIRi | S13178 |
3D structure databases
AlphaFoldDBi | P22367 |
SMRi | P22367 |
ModBasei | Search... |
Genome annotation databases
KEGGi | ag:CAA39295 |
Phylogenomic databases
OMAi | HRRFWRT |
Enzyme and pathway databases
UniPathwayi | UPA00918 |
BRENDAi | 2.3.1.165, 4632 |
Family and domain databases
Gene3Di | 1.10.1200.10, 1 hit 3.10.129.110, 1 hit 3.40.366.10, 1 hit 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR001227, Ac_transferase_dom_sf IPR036736, ACP-like_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR016036, Malonyl_transacylase_ACP-bd IPR036291, NAD(P)-bd_dom_sf IPR032821, PKS_assoc IPR020841, PKS_Beta-ketoAc_synthase_dom IPR020807, PKS_dehydratase IPR042104, PKS_dehydratase_sf IPR013968, PKS_KR IPR020806, PKS_PP-bd IPR009081, PP-bd_ACP IPR006162, Ppantetheine_attach_site IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit PF16197, KAsynt_C_assoc, 1 hit PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit PF08659, KR, 1 hit PF00550, PP-binding, 1 hit PF14765, PS-DH, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit SM00826, PKS_DH, 1 hit SM00825, PKS_KS, 1 hit SM00823, PKS_PP, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit SSF51735, SSF51735, 2 hits SSF52151, SSF52151, 1 hit SSF53901, SSF53901, 1 hit SSF55048, SSF55048, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit PS50075, CARRIER, 1 hit PS00012, PHOSPHOPANTETHEINE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MSAS_PENPA | |
Accessioni | P22367Primary (citable) accession number: P22367 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1991 |
Last sequence update: | August 1, 1991 | |
Last modified: | May 25, 2022 | |
This is version 118 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways