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Protein

C-C motif chemokine 1

Gene

CCL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8.1 Publication

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: CAFA

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
SIGNORiP22362

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 1
Alternative name(s):
Small-inducible cytokine A1
T lymphocyte-secreted protein I-309
Gene namesi
Name:CCL1
Synonyms:SCYA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108702.3
HGNCiHGNC:10609 CCL1
MIMi182281 gene
neXtProtiNX_P22362

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6346
OpenTargetsiENSG00000108702
PharmGKBiPA35542

Polymorphism and mutation databases

DMDMi123950

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 232 PublicationsAdd BLAST23
ChainiPRO_000000514124 – 96C-C motif chemokine 1Add BLAST73

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 57
Disulfide bondi34 ↔ 73
Disulfide bondi49 ↔ 91
Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP22362
PeptideAtlasiP22362
PRIDEiP22362
ProteomicsDBi53985

Expressioni

Inductioni

By phorbol myristate acetate (PMA).

Gene expression databases

BgeeiENSG00000108702 Expressed in 20 organ(s), highest expression level in upper lobe of left lung
CleanExiHS_CCL1
GenevisibleiP22362 HS

Organism-specific databases

HPAiHPA049861

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-5835N
IntActiP22362, 1 interactor
STRINGi9606.ENSP00000225842

Structurei

Secondary structure

196
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00644
ProteinModelPortaliP22362
SMRiP22362
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22362

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J85U Eukaryota
ENOG4111AVY LUCA
GeneTreeiENSGT00530000064270
HOGENOMiHOG000036686
HOVERGENiHBG098128
InParanoidiP22362
KOiK05514
OMAiMQIITTA
OrthoDBiEOG091G15E8
PhylomeDBiP22362
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22362-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQIITTALVC LLLAGMWPED VDSKSMQVPF SRCCFSFAEQ EIPLRAILCY
60 70 80 90
RNTSSICSNE GLIFKLKRGK EACALDTVGW VQRHRKMLRH CPSKRK
Length:96
Mass (Da):10,992
Last modified:August 1, 1991 - v1
Checksum:i7E67F1F82892F3C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57502 mRNA Translation: AAA61196.1
M57506 Genomic DNA Translation: AAA52705.1
AK312183 mRNA Translation: BAG35116.1
CH471147 Genomic DNA Translation: EAW80204.1
BC105073 mRNA Translation: AAI05074.1
BC105075 mRNA Translation: AAI05076.1
CCDSiCCDS11282.1
PIRiA37236
RefSeqiNP_002972.1, NM_002981.2
UniGeneiHs.72918

Genome annotation databases

EnsembliENST00000225842; ENSP00000225842; ENSG00000108702
GeneIDi6346
KEGGihsa:6346
UCSCiuc002hid.3 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

CCL1 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57502 mRNA Translation: AAA61196.1
M57506 Genomic DNA Translation: AAA52705.1
AK312183 mRNA Translation: BAG35116.1
CH471147 Genomic DNA Translation: EAW80204.1
BC105073 mRNA Translation: AAI05074.1
BC105075 mRNA Translation: AAI05076.1
CCDSiCCDS11282.1
PIRiA37236
RefSeqiNP_002972.1, NM_002981.2
UniGeneiHs.72918

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EL0NMR-A23-96[»]
4OIJX-ray2.00A/B23-96[»]
4OIKX-ray2.10A/B23-96[»]
DisProtiDP00644
ProteinModelPortaliP22362
SMRiP22362
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-5835N
IntActiP22362, 1 interactor
STRINGi9606.ENSP00000225842

Polymorphism and mutation databases

DMDMi123950

Proteomic databases

PaxDbiP22362
PeptideAtlasiP22362
PRIDEiP22362
ProteomicsDBi53985

Protocols and materials databases

DNASUi6346
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225842; ENSP00000225842; ENSG00000108702
GeneIDi6346
KEGGihsa:6346
UCSCiuc002hid.3 human

Organism-specific databases

CTDi6346
DisGeNETi6346
EuPathDBiHostDB:ENSG00000108702.3
GeneCardsiCCL1
HGNCiHGNC:10609 CCL1
HPAiHPA049861
MIMi182281 gene
neXtProtiNX_P22362
OpenTargetsiENSG00000108702
PharmGKBiPA35542
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J85U Eukaryota
ENOG4111AVY LUCA
GeneTreeiENSGT00530000064270
HOGENOMiHOG000036686
HOVERGENiHBG098128
InParanoidiP22362
KOiK05514
OMAiMQIITTA
OrthoDBiEOG091G15E8
PhylomeDBiP22362
TreeFamiTF334888

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
SIGNORiP22362

Miscellaneous databases

EvolutionaryTraceiP22362
GenomeRNAii6346
PROiPR:P22362
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108702 Expressed in 20 organ(s), highest expression level in upper lobe of left lung
CleanExiHS_CCL1
GenevisibleiP22362 HS

Family and domain databases

InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCL1_HUMAN
AccessioniPrimary (citable) accession number: P22362
Secondary accession number(s): B2R5G9, Q2M309
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: November 7, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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