UniProtKB - P22362 (CCL1_HUMAN)
Protein
C-C motif chemokine 1
Gene
CCL1
Organism
Homo sapiens (Human)
Status
Functioni
Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8.1 Publication
GO - Molecular functioni
- CCR chemokine receptor binding Source: GO_Central
- chemokine activity Source: CAFA
GO - Biological processi
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
- cellular calcium ion homeostasis Source: ProtInc
- cellular response to interferon-gamma Source: GO_Central
- cellular response to interleukin-1 Source: GO_Central
- cellular response to tumor necrosis factor Source: GO_Central
- chemokine-mediated signaling pathway Source: GO_Central
- chemotaxis Source: ProtInc
- eosinophil chemotaxis Source: GO_Central
- G protein-coupled receptor signaling pathway Source: GO_Central
- inflammatory response Source: GO_Central
- killing of cells of other organism Source: UniProtKB
- lymphocyte chemotaxis Source: GO_Central
- monocyte chemotaxis Source: GO_Central
- neutrophil chemotaxis Source: GO_Central
- positive regulation of cytosolic calcium ion concentration Source: CAFA
- positive regulation of ERK1 and ERK2 cascade Source: GO_Central
- positive regulation of GTPase activity Source: GO_Central
- positive regulation of inflammatory response Source: BHF-UCL
- positive regulation of interleukin-17 production Source: BHF-UCL
- positive regulation of monocyte chemotaxis Source: CAFA
- signal transduction Source: ProtInc
- viral process Source: ProtInc
Keywordsi
Molecular function | Cytokine |
Biological process | Chemotaxis |
Enzyme and pathway databases
PathwayCommonsi | P22362 |
Reactomei | R-HSA-380108, Chemokine receptors bind chemokines R-HSA-418594, G alpha (i) signalling events |
SIGNORi | P22362 |
Names & Taxonomyi
Protein namesi | Recommended name: C-C motif chemokine 1Alternative name(s): Small-inducible cytokine A1 T lymphocyte-secreted protein I-309 |
Gene namesi | Name:CCL1 Synonyms:SCYA1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000108702.3 |
HGNCi | HGNC:10609, CCL1 |
MIMi | 182281, gene |
neXtProti | NX_P22362 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: CAFA
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 6346 |
OpenTargetsi | ENSG00000108702 |
PharmGKBi | PA35542 |
Miscellaneous databases
Pharosi | P22362, Tbio |
Polymorphism and mutation databases
BioMutai | CCL1 |
DMDMi | 123950 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | 2 PublicationsAdd BLAST | 23 | |
ChainiPRO_0000005141 | 24 – 96 | C-C motif chemokine 1Add BLAST | 73 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 33 ↔ 57 | |||
Disulfide bondi | 34 ↔ 73 | |||
Disulfide bondi | 49 ↔ 91 | |||
Glycosylationi | 52 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | P22362 |
PaxDbi | P22362 |
PeptideAtlasi | P22362 |
PRIDEi | P22362 |
ProteomicsDBi | 53985 |
PTM databases
GlyGeni | P22362, 1 site |
Expressioni
Inductioni
By phorbol myristate acetate (PMA).
Gene expression databases
Bgeei | ENSG00000108702, Expressed in testis and 44 other tissues |
Genevisiblei | P22362, HS |
Organism-specific databases
HPAi | ENSG00000108702, Tissue enhanced (intestine, lymphoid tissue, tongue) |
Interactioni
Subunit structurei
Monomer.
GO - Molecular functioni
- CCR chemokine receptor binding Source: GO_Central
- chemokine activity Source: CAFA
Protein-protein interaction databases
DIPi | DIP-5835N |
IntActi | P22362, 1 interactor |
STRINGi | 9606.ENSP00000225842 |
Miscellaneous databases
RNActi | P22362, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P22362 |
SMRi | P22362 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P22362 |
Family & Domainsi
Sequence similaritiesi
Belongs to the intercrine beta (chemokine CC) family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502SZRS, Eukaryota |
GeneTreei | ENSGT01000000214365 |
HOGENOMi | CLU_141716_5_0_1 |
InParanoidi | P22362 |
OMAi | MHVSSSN |
OrthoDBi | 1600839at2759 |
PhylomeDBi | P22362 |
TreeFami | TF334888 |
Family and domain databases
DisProti | DP00644 |
InterProi | View protein in InterPro IPR039809, Chemokine_b/g/d IPR000827, Chemokine_CC_CS IPR001811, Chemokine_IL8-like_dom IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR12015, PTHR12015, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00472, SMALL_CYTOKINES_CC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P22362-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQIITTALVC LLLAGMWPED VDSKSMQVPF SRCCFSFAEQ EIPLRAILCY
60 70 80 90
RNTSSICSNE GLIFKLKRGK EACALDTVGW VQRHRKMLRH CPSKRK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M57502 mRNA Translation: AAA61196.1 M57506 Genomic DNA Translation: AAA52705.1 AK312183 mRNA Translation: BAG35116.1 CH471147 Genomic DNA Translation: EAW80204.1 BC105073 mRNA Translation: AAI05074.1 BC105075 mRNA Translation: AAI05076.1 |
CCDSi | CCDS11282.1 |
PIRi | A37236 |
RefSeqi | NP_002972.1, NM_002981.2 |
Genome annotation databases
Ensembli | ENST00000225842; ENSP00000225842; ENSG00000108702 |
GeneIDi | 6346 |
KEGGi | hsa:6346 |
UCSCi | uc002hid.3, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia CCL1 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M57502 mRNA Translation: AAA61196.1 M57506 Genomic DNA Translation: AAA52705.1 AK312183 mRNA Translation: BAG35116.1 CH471147 Genomic DNA Translation: EAW80204.1 BC105073 mRNA Translation: AAI05074.1 BC105075 mRNA Translation: AAI05076.1 |
CCDSi | CCDS11282.1 |
PIRi | A37236 |
RefSeqi | NP_002972.1, NM_002981.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1EL0 | NMR | - | A | 23-96 | [»] | |
4OIJ | X-ray | 2.00 | A/B | 23-96 | [»] | |
4OIK | X-ray | 2.10 | A/B | 23-96 | [»] | |
BMRBi | P22362 | |||||
SMRi | P22362 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-5835N |
IntActi | P22362, 1 interactor |
STRINGi | 9606.ENSP00000225842 |
PTM databases
GlyGeni | P22362, 1 site |
Polymorphism and mutation databases
BioMutai | CCL1 |
DMDMi | 123950 |
Proteomic databases
MassIVEi | P22362 |
PaxDbi | P22362 |
PeptideAtlasi | P22362 |
PRIDEi | P22362 |
ProteomicsDBi | 53985 |
Protocols and materials databases
Antibodypediai | 15502, 316 antibodies |
DNASUi | 6346 |
Genome annotation databases
Ensembli | ENST00000225842; ENSP00000225842; ENSG00000108702 |
GeneIDi | 6346 |
KEGGi | hsa:6346 |
UCSCi | uc002hid.3, human |
Organism-specific databases
CTDi | 6346 |
DisGeNETi | 6346 |
EuPathDBi | HostDB:ENSG00000108702.3 |
GeneCardsi | CCL1 |
HGNCi | HGNC:10609, CCL1 |
HPAi | ENSG00000108702, Tissue enhanced (intestine, lymphoid tissue, tongue) |
MIMi | 182281, gene |
neXtProti | NX_P22362 |
OpenTargetsi | ENSG00000108702 |
PharmGKBi | PA35542 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SZRS, Eukaryota |
GeneTreei | ENSGT01000000214365 |
HOGENOMi | CLU_141716_5_0_1 |
InParanoidi | P22362 |
OMAi | MHVSSSN |
OrthoDBi | 1600839at2759 |
PhylomeDBi | P22362 |
TreeFami | TF334888 |
Enzyme and pathway databases
PathwayCommonsi | P22362 |
Reactomei | R-HSA-380108, Chemokine receptors bind chemokines R-HSA-418594, G alpha (i) signalling events |
SIGNORi | P22362 |
Miscellaneous databases
BioGRID-ORCSi | 6346, 4 hits in 836 CRISPR screens |
EvolutionaryTracei | P22362 |
GenomeRNAii | 6346 |
Pharosi | P22362, Tbio |
PROi | PR:P22362 |
RNActi | P22362, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000108702, Expressed in testis and 44 other tissues |
Genevisiblei | P22362, HS |
Family and domain databases
DisProti | DP00644 |
InterProi | View protein in InterPro IPR039809, Chemokine_b/g/d IPR000827, Chemokine_CC_CS IPR001811, Chemokine_IL8-like_dom IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR12015, PTHR12015, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00472, SMALL_CYTOKINES_CC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCL1_HUMAN | |
Accessioni | P22362Primary (citable) accession number: P22362 Secondary accession number(s): B2R5G9, Q2M309 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1991 |
Last sequence update: | August 1, 1991 | |
Last modified: | December 2, 2020 | |
This is version 183 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM