CCL1

Functionⁱ

Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8.1 Publication

GO - Molecular functionⁱ

CCR chemokine receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemokine activity
Source: CAFA
Inferred from direct assayⁱ
- 1557400

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

antimicrobial humoral immune response mediated by antimicrobial peptide
Source: UniProtKB
Inferred from direct assayⁱ
- 12949249
cellular calcium ion homeostasis
Source: ProtInc
Traceable author statementⁱ
- 9417093
cellular response to interferon-gamma
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cellular response to interleukin-1
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cellular response to tumor necrosis factor
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemokine-mediated signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemotaxis
Source: ProtInc
Traceable author statementⁱ
- 9417093
eosinophil chemotaxis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
inflammatory response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
killing of cells of other organism
Source: UniProtKB
Inferred from direct assayⁱ
- 12949249
lymphocyte chemotaxis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
monocyte chemotaxis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neutrophil chemotaxis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of cytosolic calcium ion concentration
Source: CAFA
Inferred from direct assayⁱ
- 1557400
positive regulation of ERK1 and ERK2 cascade
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of GTPase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of inflammatory response
Source: BHF-UCL
Inferred from direct assayⁱ
- 28972028
positive regulation of interleukin-17 secretion
Source: BHF-UCL
Inferred from direct assayⁱ
- 28972028
positive regulation of monocyte chemotaxis
Source: CAFA
Inferred from direct assayⁱ
- 1557400
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 9417093
viral process
Source: ProtInc
Traceable author statementⁱ
- 9417093

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine
Biological process	Chemotaxis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-380108 Chemokine receptors bind chemokines R-HSA-418594 G alpha (i) signalling events
SIGNORⁱ	P22362

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: C-C motif chemokine 1 Alternative name(s): Small-inducible cytokine A1 T lymphocyte-secreted protein I-309
Gene namesⁱ	Name:CCL1 Synonyms:SCYA1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000108702.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10609 CCL1
MIMⁱ	182281 gene
neXtProtⁱ	NX_P22362

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6346
Open Targets More...OpenTargetsⁱ	ENSG00000108702
PharmGKBⁱ	PA35542

Polymorphism and mutation databases

DMDMⁱ	123950

DMDMⁱ

123950

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 23	2 PublicationsAdd BLAST		23
ChainⁱPRO_0000005141	24 – 96	C-C motif chemokine 1Add BLAST		73

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	33 ↔ 57
Disulfide bondⁱ	34 ↔ 73
Disulfide bondⁱ	49 ↔ 91
Glycosylationⁱ	52	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P22362
PeptideAtlas More...PeptideAtlasⁱ	P22362
PRIDEⁱ	P22362
ProteomicsDBⁱ	53985

Expressionⁱ

Inductionⁱ

By phorbol myristate acetate (PMA).

Gene expression databases

Bgeeⁱ	ENSG00000108702 Expressed in 20 organ(s), highest expression level in upper lobe of left lung
CleanExⁱ	HS_CCL1
Genevisibleⁱ	P22362 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA049861

HPAⁱ

HPA049861

Interactionⁱ

Subunit structureⁱ

Monomer.

GO - Molecular functionⁱ

CCR chemokine receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemokine activity
Source: CAFA
Inferred from direct assayⁱ
- 1557400

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

Database of interacting proteins More...DIPⁱ	DIP-5835N
IntActⁱ	P22362, 1 interactor
STRINGⁱ	9606.ENSP00000225842

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	28 – 30	Combined sources	3
Beta strandⁱ	31 – 33	Combined sources	3
Helixⁱ	44 – 46	Combined sources	3
Beta strandⁱ	47 – 52	Combined sources	6
Helixⁱ	55 – 57	Combined sources	3
Beta strandⁱ	61 – 67	Combined sources	7
Beta strandⁱ	71 – 75	Combined sources	5
Helixⁱ	79 – 86	Combined sources	8

Show more details

3D structure databases

Database of protein disorder More...DisProtⁱ	DP00644
ProteinModelPortalⁱ	P22362
SMRⁱ	P22362
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P22362

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the intercrine beta (chemokine CC) family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J85U Eukaryota ENOG4111AVY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000064270
HOGENOMⁱ	HOG000036686
HOVERGENⁱ	HBG098128
InParanoidⁱ	P22362
KEGG Orthology (KO) More...KOⁱ	K05514
OMAⁱ	MQIITTA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G15E8
PhylomeDBⁱ	P22362
TreeFamⁱ	TF334888

Family and domain databases

InterProⁱ	View protein in InterPro IPR039809 Chemokine_b/g/d IPR000827 Chemokine_CC_CS IPR001811 Chemokine_IL8-like_dom IPR036048 Interleukin_8-like_sf
PANTHERⁱ	PTHR12015 PTHR12015, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00048 IL8, 1 hit
SMARTⁱ	View protein in SMART SM00199 SCY, 1 hit
SUPFAMⁱ	SSF54117 SSF54117, 1 hit
PROSITEⁱ	View protein in PROSITE PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P22362-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQIITTALVC LLLAGMWPED VDSKSMQVPF SRCCFSFAEQ EIPLRAILCY 
        60         70         80         90 
RNTSSICSNE GLIFKLKRGK EACALDTVGW VQRHRKMLRH CPSKRK

Length:96

Mass (Da):10,992

Last modified:August 1, 1991 - v1

Checksum:ⁱ7E67F1F82892F3C7

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M57502 mRNA Translation: AAA61196.1 M57506 Genomic DNA Translation: AAA52705.1 AK312183 mRNA Translation: BAG35116.1 CH471147 Genomic DNA Translation: EAW80204.1 BC105073 mRNA Translation: AAI05074.1 BC105075 mRNA Translation: AAI05076.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11282.1
PIRⁱ	A37236
NCBI Reference Sequences More...RefSeqⁱ	NP_002972.1, NM_002981.2
UniGeneⁱ	Hs.72918

Genome annotation databases

Ensemblⁱ	ENST00000225842; ENSP00000225842; ENSG00000108702
GeneIDⁱ	6346
KEGGⁱ	hsa:6346
UCSC genome browser More...UCSCⁱ	uc002hid.3 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P22362	I-309 (Fragment)		HUMAN		29	UniRef100_P22362
UPI00000476FA		HUMAN		74

Protein	Similar proteins		Species	Score	Length	Source
P22362	I-309 (Fragment)		HUMAN		29	UniRef90_P22362
C-C motif chemokine		PANTR		96
C-C motif chemokine		PONAB		96
C-C motif chemokine		PANPA		96
C-C motif chemokine		NOMLE		96
+2

Protein	Similar proteins		Species	Score	Length	Source
P22362	C-C motif chemokine 1		MOUSE		92	UniRef50_P22362
I-309 (Fragment)		HUMAN		29
C-C motif chemokine		PONAB		96
C-C motif chemokine		PANTR		96
C-C motif chemokine		GORGO		96
+83

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

CCL1 entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M57502 mRNA Translation: AAA61196.1 M57506 Genomic DNA Translation: AAA52705.1 AK312183 mRNA Translation: BAG35116.1 CH471147 Genomic DNA Translation: EAW80204.1 BC105073 mRNA Translation: AAI05074.1 BC105075 mRNA Translation: AAI05076.1
CCDSⁱ	CCDS11282.1
PIRⁱ	A37236
RefSeqⁱ	NP_002972.1, NM_002981.2
UniGeneⁱ	Hs.72918

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1EL0	NMR	-	A	23-96	[»]
	4OIJ	X-ray	2.00	A/B	23-96	[»]
	4OIK	X-ray	2.10	A/B	23-96	[»]
DisProtⁱ	DP00644
ProteinModelPortalⁱ	P22362
SMRⁱ	P22362
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

DIPⁱ	DIP-5835N
IntActⁱ	P22362, 1 interactor
STRINGⁱ	9606.ENSP00000225842

Polymorphism and mutation databases

DMDMⁱ	123950

DMDMⁱ

123950

Proteomic databases

PaxDbⁱ	P22362
PeptideAtlasⁱ	P22362
PRIDEⁱ	P22362
ProteomicsDBⁱ	53985

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6346
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000225842; ENSP00000225842; ENSG00000108702
GeneIDⁱ	6346
KEGGⁱ	hsa:6346
UCSCⁱ	uc002hid.3 human

Organism-specific databases

CTDⁱ	6346
DisGeNETⁱ	6346
EuPathDBⁱ	HostDB:ENSG00000108702.3
GeneCardsⁱ	CCL1
HGNCⁱ	HGNC:10609 CCL1
HPAⁱ	HPA049861
MIMⁱ	182281 gene
neXtProtⁱ	NX_P22362
OpenTargetsⁱ	ENSG00000108702
PharmGKBⁱ	PA35542
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J85U Eukaryota ENOG4111AVY LUCA
GeneTreeⁱ	ENSGT00530000064270
HOGENOMⁱ	HOG000036686
HOVERGENⁱ	HBG098128
InParanoidⁱ	P22362
KOⁱ	K05514
OMAⁱ	MQIITTA
OrthoDBⁱ	EOG091G15E8
PhylomeDBⁱ	P22362
TreeFamⁱ	TF334888

Enzyme and pathway databases

Reactomeⁱ	R-HSA-380108 Chemokine receptors bind chemokines R-HSA-418594 G alpha (i) signalling events
SIGNORⁱ	P22362

Miscellaneous databases

EvolutionaryTraceⁱ	P22362
GenomeRNAiⁱ	6346
Protein Ontology More...PROⁱ	PR:P22362
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000108702 Expressed in 20 organ(s), highest expression level in upper lobe of left lung
CleanExⁱ	HS_CCL1
Genevisibleⁱ	P22362 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR039809 Chemokine_b/g/d IPR000827 Chemokine_CC_CS IPR001811 Chemokine_IL8-like_dom IPR036048 Interleukin_8-like_sf
PANTHERⁱ	PTHR12015 PTHR12015, 1 hit
Pfamⁱ	View protein in Pfam PF00048 IL8, 1 hit
SMARTⁱ	View protein in SMART SM00199 SCY, 1 hit
SUPFAMⁱ	SSF54117 SSF54117, 1 hit
PROSITEⁱ	View protein in PROSITE PS00472 SMALL_CYTOKINES_CC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CCL1_HUMAN
Accessionⁱ	P22362Primary (citable) accession number: P22362 Secondary accession number(s): B2R5G9, Q2M309
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
	Last sequence update:	August 1, 1991
	Last modified:	November 7, 2018
	This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P22362 (CCL1_HUMAN)

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C-C motif chemokine 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ