UniProtKB - P22353 (RM08_YEAST)

BLAST

>sp|P22353|RM08_YEAST 54S ribosomal protein L8, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=MRPL8 PE=1 SV=4
MTVGIARKLSRDKAHRDALLKNLACQLFQHESIVSTHAKCKEASRVAERIITWTKRAITT
SNSVAQAELKSQIQSQLFLAGDNRKLMKRLFSEIAPRYLERPGGYTRVLRLEPRANDSAP
QSVLELVDSPVMSESHTVNRGNLKMWLLVKSVINDDANQLPHNPLTLQNLHKVAKFKAEA
QLHGEIMLIKQVLLKEMSLPYDEALENERTQALLKEVYSSSLPKKTKKPSSYVMVPRP

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History
Entry version 165 (07 Nov 2018)
Sequence version 4 (23 Jan 2007)
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Protein

54S ribosomal protein L8, mitochondrial

Gene

MRPL8

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.2 Publications

Miscellaneous

Although this protein has evidently no mitochondrial targeting pre-sequence, it is efficiently transported into mitochondria.

Present with 3000 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functionⁱ

structural constituent of ribosome
Source: SGD
Inferred from direct assayⁱ
- 12392552

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mitochondrial translation
Source: SGD
Inferred by curatorⁱ
- 12392552

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ribonucleoprotein, Ribosomal protein

Molecular function

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-31525-MONOMER

BioCycⁱ

YEAST:G3O-31525-MONOMER

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 54S ribosomal protein L8, mitochondrial Alternative name(s): Mitochondrial large ribosomal subunit protein bL17m1 Publication YmL8
Gene namesⁱ	Name:MRPL8 Ordered Locus Names:YJL063C ORF Names:HRD238, J1125
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome X

Organism-specific databases

Saccharomyces Genome Database More...SGDⁱ	S000003599 MRPL8

SGDⁱ

S000003599 MRPL8

Keywords - Cellular componentⁱ

Mitochondrion

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000175550	2 – 238	54S ribosomal protein L8, mitochondrialAdd BLAST		237

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P22353
PaxDbⁱ	P22353
PRIDEⁱ	P22353

Interactionⁱ

Subunit structureⁱ

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.2 Publications

Protein-protein interaction databases

BioGridⁱ	33690, 105 interactors
ComplexPortalⁱ	CPX-1602 54S mitochondrial large ribosomal subunit
Database of interacting proteins More...DIPⁱ	DIP-5672N
IntActⁱ	P22353, 8 interactors
Molecular INTeraction database More...MINTⁱ	P22353
STRINGⁱ	4932.YJL063C

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P22353
SMRⁱ	P22353
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the bacterial ribosomal protein bL17 family.Curated

Phylogenomic databases

HOGENOMⁱ	HOG000141790
InParanoidⁱ	P22353
OMAⁱ	RFMMTAK
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C4R3Y

Family and domain databases

Gene3Dⁱ	3.90.1030.10, 1 hit
InterProⁱ	View protein in InterPro IPR000456 Ribosomal_L17 IPR036373 Ribosomal_L17_sf
PANTHERⁱ	PTHR14413 PTHR14413, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01196 Ribosomal_L17, 1 hit
SUPFAMⁱ	SSF64263 SSF64263, 1 hit
TIGRFAMsⁱ	TIGR00059 L17, 1 hit
PROSITEⁱ	View protein in PROSITE PS01167 RIBOSOMAL_L17, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P22353-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTVGIARKLS RDKAHRDALL KNLACQLFQH ESIVSTHAKC KEASRVAERI 
        60         70         80         90        100
ITWTKRAITT SNSVAQAELK SQIQSQLFLA GDNRKLMKRL FSEIAPRYLE 
       110        120        130        140        150
RPGGYTRVLR LEPRANDSAP QSVLELVDSP VMSESHTVNR GNLKMWLLVK 
       160        170        180        190        200
SVINDDANQL PHNPLTLQNL HKVAKFKAEA QLHGEIMLIK QVLLKEMSLP 
       210        220        230 
YDEALENERT QALLKEVYSS SLPKKTKKPS SYVMVPRP

Length:238

Mass (Da):26,945

Last modified:January 23, 2007 - v4

Checksum:ⁱA130EFD95E8719BA

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	2	T → G AA sequence (PubMed:2183197).Curated		1
Sequence conflictⁱ	82	D → G in CAA37834 (PubMed:2183197).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X53841 Genomic DNA Translation: CAA37834.1 Z34288 Genomic DNA Translation: CAA84060.1 Z49338 Genomic DNA Translation: CAA89354.1 AY558249 Genomic DNA Translation: AAS56575.1 BK006943 Genomic DNA Translation: DAA08734.1
PIRⁱ	S50809
NCBI Reference Sequences More...RefSeqⁱ	NP_012472.1, NM_001181496.1

Genome annotation databases

EnsemblFungiⁱ	YJL063C; YJL063C; YJL063C
GeneIDⁱ	853382
KEGGⁱ	sce:YJL063C

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P22353	K7_Mrpl8p		YEASK		238	UniRef100_P22353
Mrpl8p		YEASC		238
Mrpl8p		YEASA		152
UPI0000358932		YEASX		237

Protein	Similar proteins		Species	Score	Length	Source
P22353	K7_Mrpl8p		YEASK		238	UniRef90_P22353
Mrpl8p		YEASC		238
Mrpl8p		YEASA		152
Mrpl8p		YEASB		238
Mitochondrial 60S ribosomal protein L8		YEAS1		238
+11

Protein	Similar proteins		Species	Score	Length	Source
P22353	K7_Mrpl8p		YEASK		238	UniRef50_P22353
Mrpl8p		YEASC		238
Mrpl8p		YEASA		152
Mrpl8p		YEASB		238
YmL8		YEAS7		238
+26

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X53841 Genomic DNA Translation: CAA37834.1 Z34288 Genomic DNA Translation: CAA84060.1 Z49338 Genomic DNA Translation: CAA89354.1 AY558249 Genomic DNA Translation: AAS56575.1 BK006943 Genomic DNA Translation: DAA08734.1
PIRⁱ	S50809
RefSeqⁱ	NP_012472.1, NM_001181496.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3J6B	electron microscopy	3.20	L	1-238	[»]
	5MRC	electron microscopy	3.25	L	2-238	[»]
	5MRE	electron microscopy	3.75	L	2-238	[»]
	5MRF	electron microscopy	4.97	L	2-238	[»]
ProteinModelPortalⁱ	P22353
SMRⁱ	P22353
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	33690, 105 interactors
ComplexPortalⁱ	CPX-1602 54S mitochondrial large ribosomal subunit
DIPⁱ	DIP-5672N
IntActⁱ	P22353, 8 interactors
MINTⁱ	P22353
STRINGⁱ	4932.YJL063C

Proteomic databases

MaxQBⁱ	P22353
PaxDbⁱ	P22353
PRIDEⁱ	P22353

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YJL063C; YJL063C; YJL063C
GeneIDⁱ	853382
KEGGⁱ	sce:YJL063C

Organism-specific databases

SGDⁱ	S000003599 MRPL8

Phylogenomic databases

HOGENOMⁱ	HOG000141790
InParanoidⁱ	P22353
OMAⁱ	RFMMTAK
OrthoDBⁱ	EOG092C4R3Y

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-31525-MONOMER

BioCycⁱ

YEAST:G3O-31525-MONOMER

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P22353

PROⁱ

PR:P22353

Family and domain databases

Gene3Dⁱ	3.90.1030.10, 1 hit
InterProⁱ	View protein in InterPro IPR000456 Ribosomal_L17 IPR036373 Ribosomal_L17_sf
PANTHERⁱ	PTHR14413 PTHR14413, 1 hit
Pfamⁱ	View protein in Pfam PF01196 Ribosomal_L17, 1 hit
SUPFAMⁱ	SSF64263 SSF64263, 1 hit
TIGRFAMsⁱ	TIGR00059 L17, 1 hit
PROSITEⁱ	View protein in PROSITE PS01167 RIBOSOMAL_L17, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RM08_YEAST
Accessionⁱ	P22353Primary (citable) accession number: P22353 Secondary accession number(s): D6VWB8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 165 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Ribosomal proteins
Ribosomal proteins families and list of entries
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
Yeast chromosome X
Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

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UniProtKB - P22353 (RM08_YEAST)

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54S ribosomal protein L8, mitochondrial

MRPL8

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ