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Protein

54S ribosomal protein L8, mitochondrial

Gene

MRPL8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.2 Publications

Miscellaneous

Although this protein has evidently no mitochondrial targeting pre-sequence, it is efficiently transported into mitochondria.
Present with 3000 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • mitochondrial genome maintenance Source: GO_Central
  • mitochondrial translation Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-31525-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
54S ribosomal protein L8, mitochondrial
Alternative name(s):
Mitochondrial large ribosomal subunit protein bL17m1 Publication
YmL8
Gene namesi
Name:MRPL8
Ordered Locus Names:YJL063C
ORF Names:HRD238, J1125
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL063C
SGDiS000003599 MRPL8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001755502 – 23854S ribosomal protein L8, mitochondrialAdd BLAST237

Proteomic databases

MaxQBiP22353
PaxDbiP22353
PRIDEiP22353

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.2 Publications

Protein-protein interaction databases

BioGridi33690, 105 interactors
ComplexPortaliCPX-1602 54S mitochondrial large ribosomal subunit
DIPiDIP-5672N
IntActiP22353, 17 interactors
MINTiP22353
STRINGi4932.YJL063C

Structurei

3D structure databases

ProteinModelPortaliP22353
SMRiP22353
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000141790
InParanoidiP22353
OMAiSTHAKCK
OrthoDBiEOG092C4R3Y

Family and domain databases

Gene3Di3.90.1030.10, 1 hit
InterProiView protein in InterPro
IPR000456 Ribosomal_L17
IPR036373 Ribosomal_L17_sf
PANTHERiPTHR14413 PTHR14413, 1 hit
PfamiView protein in Pfam
PF01196 Ribosomal_L17, 1 hit
SUPFAMiSSF64263 SSF64263, 1 hit
TIGRFAMsiTIGR00059 L17, 1 hit
PROSITEiView protein in PROSITE
PS01167 RIBOSOMAL_L17, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22353-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVGIARKLS RDKAHRDALL KNLACQLFQH ESIVSTHAKC KEASRVAERI
60 70 80 90 100
ITWTKRAITT SNSVAQAELK SQIQSQLFLA GDNRKLMKRL FSEIAPRYLE
110 120 130 140 150
RPGGYTRVLR LEPRANDSAP QSVLELVDSP VMSESHTVNR GNLKMWLLVK
160 170 180 190 200
SVINDDANQL PHNPLTLQNL HKVAKFKAEA QLHGEIMLIK QVLLKEMSLP
210 220 230
YDEALENERT QALLKEVYSS SLPKKTKKPS SYVMVPRP
Length:238
Mass (Da):26,945
Last modified:January 23, 2007 - v4
Checksum:iA130EFD95E8719BA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2T → G AA sequence (PubMed:2183197).Curated1
Sequence conflicti82D → G in CAA37834 (PubMed:2183197).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53841 Genomic DNA Translation: CAA37834.1
Z34288 Genomic DNA Translation: CAA84060.1
Z49338 Genomic DNA Translation: CAA89354.1
AY558249 Genomic DNA Translation: AAS56575.1
BK006943 Genomic DNA Translation: DAA08734.1
PIRiS50809
RefSeqiNP_012472.1, NM_001181496.1

Genome annotation databases

EnsemblFungiiYJL063C; YJL063C; YJL063C
GeneIDi853382
KEGGisce:YJL063C

Similar proteinsi

Entry informationi

Entry nameiRM08_YEAST
AccessioniPrimary (citable) accession number: P22353
Secondary accession number(s): D6VWB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 163 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

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