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Protein

Glutathione peroxidase 3

Gene

GPX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei731

GO - Molecular functioni

  • glutathione peroxidase activity Source: UniProtKB
  • selenium binding Source: UniProtKB
  • transcription factor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase

Enzyme and pathway databases

BioCyciMetaCyc:HS08224-MONOMER
BRENDAi1.11.1.9 2681
ReactomeiR-HSA-3299685 Detoxification of Reactive Oxygen Species

Protein family/group databases

PeroxiBasei3602 HsGPx03

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione peroxidase 3 (EC:1.11.1.9)
Short name:
GPx-3
Short name:
GSHPx-3
Alternative name(s):
Extracellular glutathione peroxidase
Plasma glutathione peroxidase
Short name:
GPx-P
Short name:
GSHPx-P
Gene namesi
Name:GPX3
Synonyms:GPXP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000211445.11
HGNCiHGNC:4555 GPX3
MIMi138321 gene
neXtProtiNX_P22352

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2878
OpenTargetsiENSG00000211445
PharmGKBiPA28951

Chemistry databases

DrugBankiDB00143 Glutathione

Polymorphism and mutation databases

BioMutaiGPX3
DMDMi172046796

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001306221 – 226Glutathione peroxidase 3Add BLAST206

Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

EPDiP22352
MaxQBiP22352
PaxDbiP22352
PeptideAtlasiP22352
PRIDEiP22352
ProteomicsDBi53984

2D gel databases

REPRODUCTION-2DPAGEiIPI00026199
SWISS-2DPAGEiP22352

PTM databases

iPTMnetiP22352
PhosphoSitePlusiP22352

Expressioni

Tissue specificityi

Secreted in plasma.

Gene expression databases

BgeeiENSG00000211445 Expressed in 236 organ(s), highest expression level in thyroid gland
CleanExiHS_GPX3
ExpressionAtlasiP22352 baseline and differential
GenevisibleiP22352 HS

Organism-specific databases

HPAiCAB069456

Interactioni

Subunit structurei

Homotetramer.

Binary interactionsi

WithEntry#Exp.IntActNotes
UBQLN1Q9UMX0-23EBI-2832946,EBI-10173939

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109136, 3 interactors
IntActiP22352, 7 interactors
STRINGi9606.ENSP00000373477

Structurei

Secondary structure

1226
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP22352
SMRiP22352
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22352

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1651 Eukaryota
COG0386 LUCA
GeneTreeiENSGT00760000119230
HOGENOMiHOG000277055
HOVERGENiHBG004333
InParanoidiP22352
KOiK00432
OMAiIMRWHHR
OrthoDBiEOG091G10LN
PhylomeDBiP22352
TreeFamiTF105318

Family and domain databases

CDDicd00340 GSH_Peroxidase, 1 hit
InterProiView protein in InterPro
IPR000889 Glutathione_peroxidase
IPR029759 GPX_AS
IPR029760 GPX_CS
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR11592 PTHR11592, 1 hit
PfamiView protein in Pfam
PF00255 GSHPx, 1 hit
PIRSFiPIRSF000303 Glutathion_perox, 1 hit
PRINTSiPR01011 GLUTPROXDASE
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00460 GLUTATHIONE_PEROXID_1, 1 hit
PS00763 GLUTATHIONE_PEROXID_2, 1 hit
PS51355 GLUTATHIONE_PEROXID_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

P22352-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARLLQASCL LSLLLAGFVS QSRGQEKSKM DCHGGISGTI YEYGALTIDG
60 70 80 90 100
EEYIPFKQYA GKYVLFVNVA SYUGLTGQYI ELNALQEELA PFGLVILGFP
110 120 130 140 150
CNQFGKQEPG ENSEILPTLK YVRPGGGFVP NFQLFEKGDV NGEKEQKFYT
160 170 180 190 200
FLKNSCPPTS ELLGTSDRLF WEPMKVHDIR WNFEKFLVGP DGIPIMRWHH
210 220
RTTVSNVKMD ILSYMRRQAA LGVKRK
Length:226
Mass (Da):25,552
Last modified:February 26, 2008 - v2
Checksum:iA839E87A5CDB51A9
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RG32E5RG32_HUMAN
Glutathione peroxidase
GPX3
138Annotation score:
A0A087X1J7A0A087X1J7_HUMAN
Glutathione peroxidase
GPX3
225Annotation score:
H0YC19H0YC19_HUMAN
Glutathione peroxidase
GPX3
174Annotation score:
Q6NXQ3Q6NXQ3_HUMAN
GPX3 protein
GPX3
72Annotation score:
H0YBE4H0YBE4_HUMAN
Glutathione peroxidase 3
GPX3
79Annotation score:
A0A182DWH9A0A182DWH9_HUMAN
Glutathione peroxidase 3
GPX3
100Annotation score:
A0A182DWI0A0A182DWI0_HUMAN
Glutathione peroxidase 3
GPX3
63Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020943128F → L1 PublicationCorresponds to variant dbSNP:rs8177445Ensembl.1

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei73Selenocysteine1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00632 mRNA Translation: BAA00525.1
X58295 mRNA Translation: CAA41228.2
D16360 Genomic DNA Translation: BAA03862.1
D16361 Genomic DNA Translation: BAA03863.2
D16362 Genomic DNA Translation: BAA03864.1
AF217787 mRNA Translation: AAF43005.1
AY310878 Genomic DNA Translation: AAP50261.1
AC008641 Genomic DNA No translation available.
BC013601 mRNA Translation: AAH13601.1
BC035841 mRNA Translation: AAH35841.1
BC050378 mRNA Translation: AAH50378.2
CCDSiCCDS43389.1
PIRiI53822 JQ0476
RefSeqiNP_001316719.1, NM_001329790.1
NP_002075.2, NM_002084.4
UniGeneiHs.386793

Genome annotation databases

EnsembliENST00000388825; ENSP00000373477; ENSG00000211445
GeneIDi2878
KEGGihsa:2878
UCSCiuc021yga.2 human

Keywords - Coding sequence diversityi

Polymorphism, Selenocysteine

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Wikipedia

Glutathione peroxidase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00632 mRNA Translation: BAA00525.1
X58295 mRNA Translation: CAA41228.2
D16360 Genomic DNA Translation: BAA03862.1
D16361 Genomic DNA Translation: BAA03863.2
D16362 Genomic DNA Translation: BAA03864.1
AF217787 mRNA Translation: AAF43005.1
AY310878 Genomic DNA Translation: AAP50261.1
AC008641 Genomic DNA No translation available.
BC013601 mRNA Translation: AAH13601.1
BC035841 mRNA Translation: AAH35841.1
BC050378 mRNA Translation: AAH50378.2
CCDSiCCDS43389.1
PIRiI53822 JQ0476
RefSeqiNP_001316719.1, NM_001329790.1
NP_002075.2, NM_002084.4
UniGeneiHs.386793

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2R37X-ray1.85A/B25-223[»]
ProteinModelPortaliP22352
SMRiP22352
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109136, 3 interactors
IntActiP22352, 7 interactors
STRINGi9606.ENSP00000373477

Chemistry databases

DrugBankiDB00143 Glutathione

Protein family/group databases

PeroxiBasei3602 HsGPx03

PTM databases

iPTMnetiP22352
PhosphoSitePlusiP22352

Polymorphism and mutation databases

BioMutaiGPX3
DMDMi172046796

2D gel databases

REPRODUCTION-2DPAGEiIPI00026199
SWISS-2DPAGEiP22352

Proteomic databases

EPDiP22352
MaxQBiP22352
PaxDbiP22352
PeptideAtlasiP22352
PRIDEiP22352
ProteomicsDBi53984

Protocols and materials databases

DNASUi2878
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000388825; ENSP00000373477; ENSG00000211445
GeneIDi2878
KEGGihsa:2878
UCSCiuc021yga.2 human

Organism-specific databases

CTDi2878
DisGeNETi2878
EuPathDBiHostDB:ENSG00000211445.11
GeneCardsiGPX3
H-InvDBiHIX0024803
HGNCiHGNC:4555 GPX3
HPAiCAB069456
MIMi138321 gene
neXtProtiNX_P22352
OpenTargetsiENSG00000211445
PharmGKBiPA28951
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1651 Eukaryota
COG0386 LUCA
GeneTreeiENSGT00760000119230
HOGENOMiHOG000277055
HOVERGENiHBG004333
InParanoidiP22352
KOiK00432
OMAiIMRWHHR
OrthoDBiEOG091G10LN
PhylomeDBiP22352
TreeFamiTF105318

Enzyme and pathway databases

BioCyciMetaCyc:HS08224-MONOMER
BRENDAi1.11.1.9 2681
ReactomeiR-HSA-3299685 Detoxification of Reactive Oxygen Species

Miscellaneous databases

ChiTaRSiGPX3 human
EvolutionaryTraceiP22352
GeneWikiiGPX3
GenomeRNAii2878
PROiPR:P22352
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000211445 Expressed in 236 organ(s), highest expression level in thyroid gland
CleanExiHS_GPX3
ExpressionAtlasiP22352 baseline and differential
GenevisibleiP22352 HS

Family and domain databases

CDDicd00340 GSH_Peroxidase, 1 hit
InterProiView protein in InterPro
IPR000889 Glutathione_peroxidase
IPR029759 GPX_AS
IPR029760 GPX_CS
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR11592 PTHR11592, 1 hit
PfamiView protein in Pfam
PF00255 GSHPx, 1 hit
PIRSFiPIRSF000303 Glutathion_perox, 1 hit
PRINTSiPR01011 GLUTPROXDASE
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00460 GLUTATHIONE_PEROXID_1, 1 hit
PS00763 GLUTATHIONE_PEROXID_2, 1 hit
PS51355 GLUTATHIONE_PEROXID_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPX3_HUMAN
AccessioniPrimary (citable) accession number: P22352
Secondary accession number(s): O43787
, Q86W78, Q9NZ74, Q9UEL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: February 26, 2008
Last modified: September 12, 2018
This is version 186 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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