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UniProtKB - P22326 (SYY1_BACSU)
Protein
Tyrosine--tRNA ligase 1
Gene
tyrS1
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
UniRule annotationCatalytic activityi
- EC:6.1.1.1UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 35 | TyrosineUniRule annotation | 1 | |
Binding sitei | 170 | TyrosineUniRule annotation | 1 | |
Binding sitei | 174 | TyrosineUniRule annotation | 1 | |
Binding sitei | 235 | ATPUniRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- RNA binding Source: UniProtKB-KW
- tyrosine-tRNA ligase activity Source: GO_Central
GO - Biological processi
- tRNA aminoacylation Source: GO_Central
- tyrosyl-tRNA aminoacylation Source: UniProtKB-UniRule
Keywordsi
Molecular function | Aminoacyl-tRNA synthetase, Ligase, RNA-binding |
Biological process | Protein biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | BSUB:BSU29670-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Tyrosine--tRNA ligase 1UniRule annotation (EC:6.1.1.1UniRule annotation)Alternative name(s): Tyrosyl-tRNA synthetase 1UniRule annotation Short name: TyrRS 1UniRule annotation |
Gene namesi | Name:tyrS1UniRule annotation Ordered Locus Names:BSU29670 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
Cytosol
- cytosol Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000055643 | 1 – 422 | Tyrosine--tRNA ligase 1Add BLAST | 422 |
Proteomic databases
jPOSTi | P22326 |
PaxDbi | P22326 |
Expressioni
Developmental stagei
Expressed during vegetative growth.
Interactioni
Subunit structurei
Homodimer.
Protein-protein interaction databases
STRINGi | 224308.BSU29670 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 355 – 421 | S4 RNA-bindingUniRule annotationAdd BLAST | 67 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 40 – 49 | 'HIGH' region | 10 | |
Motifi | 232 – 236 | 'KMSKS' region | 5 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0162, Bacteria |
InParanoidi | P22326 |
OMAi | VNYMMAK |
PhylomeDBi | P22326 |
Family and domain databases
CDDi | cd00165, S4, 1 hit |
Gene3Di | 3.10.290.10, 1 hit 3.40.50.620, 1 hit |
HAMAPi | MF_02006, Tyr_tRNA_synth_type1, 1 hit |
InterProi | View protein in InterPro IPR001412, aa-tRNA-synth_I_CS IPR002305, aa-tRNA-synth_Ic IPR014729, Rossmann-like_a/b/a_fold IPR002942, S4_RNA-bd IPR036986, S4_RNA-bd_sf IPR002307, Tyr-tRNA-ligase IPR024088, Tyr-tRNA-ligase_bac-type IPR024107, Tyr-tRNA-ligase_bac_1 |
PANTHERi | PTHR11766, PTHR11766, 1 hit |
Pfami | View protein in Pfam PF01479, S4, 1 hit PF00579, tRNA-synt_1b, 1 hit |
PRINTSi | PR01040, TRNASYNTHTYR |
SMARTi | View protein in SMART SM00363, S4, 1 hit |
TIGRFAMsi | TIGR00234, tyrS, 1 hit |
PROSITEi | View protein in PROSITE PS00178, AA_TRNA_LIGASE_I, 1 hit PS50889, S4, 1 hit |
i Sequence
Sequence statusi: Complete.
P22326-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTNLLEDLSF RGLIQQMTDE EGLNKQLNEE KIRLYSGFDP TADSLHIGHL
60 70 80 90 100
LPILTLRRFQ LAGHHPIALV GGATGLIGDP SGKKAERTLN TADIVSEWSQ
110 120 130 140 150
KIKNQLSRFL DFEAAENPAV IANNFDWIGK MNVIDFLRDV GKNFGINYML
160 170 180 190 200
AKDTVSSRIE SGISYTEFSY MILQSYDFLN LYRDKNCKLQ IGGSDQWGNI
210 220 230 240 250
TAGLELIRKS EEEGAKAFGL TIPLVTKADG TKFGKTEGGA IWLDKEKTSP
260 270 280 290 300
YEFYQFWINT DDRDVVKYLK YFTFLSKEEI EAYAEKTETA PEKREAQKRL
310 320 330 340 350
AEEVTSLVHG REALEQAINI SQALFSGNIK ELSAQDVKVG FKDVPSMEVD
360 370 380 390 400
STQELSLVDV LVQSKLSPSK RQAREDIQNG AVYINGERQT EINYTLSGED
410 420
RIENQFTVLR RGKKKYFLVT YK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M77668 Genomic DNA Translation: AAA22878.1 M59358 Genomic DNA Translation: AAA22718.1 AF008220 Genomic DNA Translation: AAC00303.1 AL009126 Genomic DNA Translation: CAB14945.1 L17309 Genomic DNA Translation: AAA68288.1 |
PIRi | A42648 |
RefSeqi | NP_390845.1, NC_000964.3 WP_003229300.1, NZ_JNCM01000036.1 |
Genome annotation databases
EnsemblBacteriai | CAB14945; CAB14945; BSU_29670 |
GeneIDi | 938185 |
KEGGi | bsu:BSU29670 |
PATRICi | fig|224308.179.peg.3225 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M77668 Genomic DNA Translation: AAA22878.1 M59358 Genomic DNA Translation: AAA22718.1 AF008220 Genomic DNA Translation: AAC00303.1 AL009126 Genomic DNA Translation: CAB14945.1 L17309 Genomic DNA Translation: AAA68288.1 |
PIRi | A42648 |
RefSeqi | NP_390845.1, NC_000964.3 WP_003229300.1, NZ_JNCM01000036.1 |
3D structure databases
SMRi | P22326 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 224308.BSU29670 |
Proteomic databases
jPOSTi | P22326 |
PaxDbi | P22326 |
Genome annotation databases
EnsemblBacteriai | CAB14945; CAB14945; BSU_29670 |
GeneIDi | 938185 |
KEGGi | bsu:BSU29670 |
PATRICi | fig|224308.179.peg.3225 |
Phylogenomic databases
eggNOGi | COG0162, Bacteria |
InParanoidi | P22326 |
OMAi | VNYMMAK |
PhylomeDBi | P22326 |
Enzyme and pathway databases
BioCyci | BSUB:BSU29670-MONOMER |
Family and domain databases
CDDi | cd00165, S4, 1 hit |
Gene3Di | 3.10.290.10, 1 hit 3.40.50.620, 1 hit |
HAMAPi | MF_02006, Tyr_tRNA_synth_type1, 1 hit |
InterProi | View protein in InterPro IPR001412, aa-tRNA-synth_I_CS IPR002305, aa-tRNA-synth_Ic IPR014729, Rossmann-like_a/b/a_fold IPR002942, S4_RNA-bd IPR036986, S4_RNA-bd_sf IPR002307, Tyr-tRNA-ligase IPR024088, Tyr-tRNA-ligase_bac-type IPR024107, Tyr-tRNA-ligase_bac_1 |
PANTHERi | PTHR11766, PTHR11766, 1 hit |
Pfami | View protein in Pfam PF01479, S4, 1 hit PF00579, tRNA-synt_1b, 1 hit |
PRINTSi | PR01040, TRNASYNTHTYR |
SMARTi | View protein in SMART SM00363, S4, 1 hit |
TIGRFAMsi | TIGR00234, tyrS, 1 hit |
PROSITEi | View protein in PROSITE PS00178, AA_TRNA_LIGASE_I, 1 hit PS50889, S4, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SYY1_BACSU | |
Accessioni | P22326Primary (citable) accession number: P22326 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1991 |
Last sequence update: | August 1, 1992 | |
Last modified: | April 7, 2021 | |
This is version 143 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Aminoacyl-tRNA synthetases
List of aminoacyl-tRNA synthetase entries - SIMILARITY comments
Index of protein domains and families