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Entry version 110 (10 Feb 2021)
Sequence version 1 (01 Aug 1991)
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Protein

Dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1

Gene
N/A
Organism
Cyprinus carpio (Common carp)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei309Calcium ion selectivity and permeabilityBy similarity1
Sitei628Calcium ion selectivity and permeabilityBy similarity1
Sitei1030Calcium ion selectivity and permeabilityBy similarity1
Sitei1344Calcium ion selectivity and permeabilityBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi1431 – 1442PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCyprinus carpio (Common carp)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7962 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCyprininaeCyprinus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 70CytoplasmicSequence analysisAdd BLAST70
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei71 – 86Helical; Name=S1 of repeat IAdd BLAST16
Topological domaini87 – 107ExtracellularSequence analysisAdd BLAST21
Transmembranei108 – 127Helical; Name=S2 of repeat IAdd BLAST20
Topological domaini128 – 139CytoplasmicSequence analysisAdd BLAST12
Transmembranei140 – 155Helical; Name=S3 of repeat IAdd BLAST16
Topological domaini156 – 176ExtracellularSequence analysisAdd BLAST21
Transmembranei177 – 195Helical; Name=S4 of repeat IAdd BLAST19
Topological domaini196 – 214CytoplasmicSequence analysisAdd BLAST19
Transmembranei215 – 234Helical; Name=S5 of repeat IAdd BLAST20
Topological domaini235 – 326ExtracellularSequence analysisAdd BLAST92
Transmembranei327 – 351Helical; Name=S6 of repeat IAdd BLAST25
Topological domaini352 – 447CytoplasmicSequence analysisAdd BLAST96
Transmembranei448 – 466Helical; Name=S1 of repeat IIAdd BLAST19
Topological domaini467 – 481ExtracellularSequence analysisAdd BLAST15
Transmembranei482 – 501Helical; Name=S2 of repeat IIAdd BLAST20
Topological domaini502 – 509CytoplasmicSequence analysis8
Transmembranei510 – 528Helical; Name=S3 of repeat IIAdd BLAST19
Topological domaini529 – 538ExtracellularSequence analysis10
Transmembranei539 – 557Helical; Name=S4 of repeat IIAdd BLAST19
Topological domaini558 – 576CytoplasmicSequence analysisAdd BLAST19
Transmembranei577 – 596Helical; Name=S5 of repeat IIAdd BLAST20
Topological domaini597 – 651ExtracellularSequence analysisAdd BLAST55
Transmembranei652 – 675Helical; Name=S6 of repeat IIAdd BLAST24
Topological domaini676 – 815CytoplasmicSequence analysisAdd BLAST140
Transmembranei816 – 834Helical; Name=S1 of repeat IIIAdd BLAST19
Topological domaini835 – 850ExtracellularSequence analysisAdd BLAST16
Transmembranei851 – 870Helical; Name=S2 of repeat IIIAdd BLAST20
Topological domaini871 – 882CytoplasmicSequence analysisAdd BLAST12
Transmembranei883 – 901Helical; Name=S3 of repeat IIIAdd BLAST19
Topological domaini902 – 908ExtracellularSequence analysis7
Transmembranei909 – 927Helical; Name=S4 of repeat IIIAdd BLAST19
Topological domaini928 – 946CytoplasmicSequence analysisAdd BLAST19
Transmembranei947 – 966Helical; Name=S5 of repeat IIIAdd BLAST20
Topological domaini967 – 1056ExtracellularSequence analysisAdd BLAST90
Transmembranei1057 – 1081Helical; Name=S6 of repeat IIIAdd BLAST25
Topological domaini1082 – 1134CytoplasmicSequence analysisAdd BLAST53
Transmembranei1135 – 1153Helical; Name=S1 of repeat IVAdd BLAST19
Topological domaini1154 – 1168ExtracellularSequence analysisAdd BLAST15
Transmembranei1169 – 1188Helical; Name=S2 of repeat IVAdd BLAST20
Topological domaini1189 – 1196CytoplasmicSequence analysis8
Transmembranei1197 – 1215Helical; Name=S3 of repeat IVAdd BLAST19
Topological domaini1216 – 1252ExtracellularSequence analysisAdd BLAST37
Transmembranei1253 – 1271Helical; Name=S4 of repeat IVAdd BLAST19
Topological domaini1272 – 1290CytoplasmicSequence analysisAdd BLAST19
Transmembranei1291 – 1310Helical; Name=S5 of repeat IVAdd BLAST20
Topological domaini1311 – 1377ExtracellularSequence analysisAdd BLAST67
Transmembranei1378 – 1402Helical; Name=S6 of repeat IVAdd BLAST25
Topological domaini1403 – 1852CytoplasmicSequence analysisAdd BLAST450

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000539481 – 1852Dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1Add BLAST1852

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi274N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi470N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1157N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

May be non-phosphorylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P22316

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Skeletal muscle.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Multisubunit complex consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. An additional gamma subunit is present only in skeletal muscle L-type channel (By similarity).

By similarity

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati57 – 354IAdd BLAST298
Repeati433 – 679IIAdd BLAST247
Repeati802 – 1084IIIAdd BLAST283
Repeati1121 – 1405IVAdd BLAST285
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1418 – 1453EF-handPROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni374 – 391Binding to the beta subunitBy similarityAdd BLAST18
Regioni1004 – 1093Dihydropyridine bindingBy similarityAdd BLAST90
Regioni1358 – 1424Dihydropyridine bindingBy similarityAdd BLAST67
Regioni1370 – 1413Phenylalkylamine bindingBy similarityAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4 – 12Poly-Gly9
Compositional biasi400 – 403Poly-Leu4
Compositional biasi577 – 583Poly-Leu7
Compositional biasi1062 – 1068Poly-Ile7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031688, CAC1F_C
IPR002048, EF_hand_dom
IPR031649, GPHH_dom
IPR005821, Ion_trans_dom
IPR014873, VDCC_a1su_IQ
IPR005450, VDCC_L_a1ssu
IPR005446, VDCC_L_a1su
IPR002077, VDCCAlpha1
IPR027359, Volt_channel_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08763, Ca_chan_IQ, 1 hit
PF16885, CAC1F_C, 1 hit
PF16905, GPHH, 1 hit
PF00520, Ion_trans, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00167, CACHANNEL
PR01630, LVDCCALPHA1
PR01634, LVDCCALPHA1S

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01062, Ca_chan_IQ, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222, EF_HAND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P22316-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESGSGGGGG GGVAALASFI MNEEELKRKQ REKLKKLQAT GGNPRPPRSL
60 70 80 90 100
FFFTLKNPFR KTCINIVEWK PFEIIILLTI FANCVALAVF LPMPEEDTNN
110 120 130 140 150
TNLTLESLEY IFLVIFTLEC FLKIVAYGLL FHEGAYLRNC WNILDFVIVF
160 170 180 190 200
MGLFTLVVDT INTIAGVPTE KGGGFDMKAL RAFRVLRPLR LVSGVPSLQV
210 220 230 240 250
VMSSILKSML PLFHIALLVF FMVHIYAIMG LELFKCKMHK TCYYQGTNII
260 270 280 290 300
AVREGNEKPS PCAQAGHGRR CTINGTECRA GWPGPNFGIT HFDNSCFAML
310 320 330 340 350
TVFQCITTES WTDVLYWIND AMGNDWPWIY FLTLILVGSF FILNLVLGAL
360 370 380 390 400
SGEFTKEREE SRSRGEYQKL RERQQMDEDL EGYMEWITHA EVMDGDSEAL
410 420 430 440 450
LLLRKDTDSE SDSLYQMLDQ QVIYFYRLAR RWNVVLRRKC HVWVKSKFFN
460 470 480 490 500
WWVLLVVLLN TLVIAMEHHN QTEGLTSFQD TANVILLACF TIEMVMKMYA
510 520 530 540 550
FGPRAYFMSI FNRFDCFVVT IGILEIILVV SNIMTPLGIS VMRCIRLLRL
560 570 580 590 600
FKLTRYWTSL NNLVASLLNS VKSIASLLLL LFLFIVIFAL LGMQVFGGKF
610 620 630 640 650
NFPDRVIQRS NFDNFPQALI SVFQVLTGEE WDSIMYNGIM AHGGPQSPGI
660 670 680 690 700
LVSIYFIILY VCGNFVLLNV FLAIAVDNLA EAESLTAAQK EKAEEKARRK
710 720 730 740 750
LMRTLPEKSE EEKALMAKRL MESRSKAEGM PTTAKLKIDE FESNVNEVKD
760 770 780 790 800
PFPPADFPGD HEEVEPEIPI SPRPRPMADL QLKETVVPIA EASSFFIFGP
810 820 830 840 850
QHKFRKLCHR IVNHTTFTNI ILLFILLSSI SLAAEDPIDP RSFRNKVLAY
860 870 880 890 900
ADIVFTTVFT IEIVLKMTVY GAFLHTGSFC RNSFNILDLI VVGVSLLSMG
910 920 930 940 950
MESSTISVVK ILRVLRVLRP LRAINRAKGL KHVVQCMFVA IKTIGNIVLV
960 970 980 990 1000
TMLLDFMFAC IGVQLFKGKL YYCTDPLQKT AEECQGTFLK HVPNSLHDIE
1010 1020 1030 1040 1050
VHQRMWVNSD FNFDNVLNGM LALFTISTFE GWPEILYKAI DSNAVDTGPL
1060 1070 1080 1090 1100
YNNRVGISIF FIIYIIIIAF FMMNIFVGFV IVTFQKQGEQ EYKDCELDKN
1110 1120 1130 1140 1150
QRQCVQYALK ARPLKCYIPK NPHQYRVWYF VTSCYFEYLM FFLIMLNTLC
1160 1170 1180 1190 1200
LGIQHCNQSD HITKLSDTLN LIFTVLFTGE MIVKLIAFKA KGYFGDPWNV
1210 1220 1230 1240 1250
FDFIIVVGSI VDVVLSEVDA ALEARGGLWC LHGCAEVNPM QAIAEAENVR
1260 1270 1280 1290 1300
VSITFFRLFR VLRLIKLLNR SEGIRNLLWT FIKSFQALPH VGLLIVMLFF
1310 1320 1330 1340 1350
IYAVIGMQMF GKVALVDGTE INRNNNFQTF PQAVLLLFRV ATGEQWPKVI
1360 1370 1380 1390 1400
LASMYGKLCD AKSDYGPGEE YTCGSSIAVF YFLSFYILCA FLIINLFVAI
1410 1420 1430 1440 1450
IMDNVDYLTR DWSILGPHHL DEFKKIWAEY DPEATGRIKH LDVVTLLRRI
1460 1470 1480 1490 1500
QPPLGFGKFC PHRSACKRLI SMNMPLNSDG TVTFNATLFA LVRTALKIKT
1510 1520 1530 1540 1550
EGNFEQANEE LRAIIKSIWK RTSMKLLDQV IPPIGEDEVT VGKFYATFLI
1560 1570 1580 1590 1600
QEHFRKFMQR QEEYYGYRPT KKNADEIKAG LRSIEEEAAP ELHRAISGDL
1610 1620 1630 1640 1650
IAEDDMERAL EAGEEGIYRR TGGLFGLHTD PFSSEPSSPL STQMTSQRPL
1660 1670 1680 1690 1700
QFVETRLEDI ESPPDSVFLP NTEFFPDNMP TTTNTNNNAN FVEDMSSRFT
1710 1720 1730 1740 1750
FENESLSAAA TRNYSYEDIR GSSSYVGGAS SVDDRRLSDF TVRTNITQFP
1760 1770 1780 1790 1800
YNPSYGPSKN QTATEASPAT DKLIQQALRD GGLDSLAEDP KFVSVTRKEL
1810 1820 1830 1840 1850
AEAINIGMED MEGMAQGIVN RQSGKVTKRK RRPIPVPPGT KSTKPKENTS

AV
Length:1,852
Mass (Da):210,098
Last modified:August 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7D5FAE83501D6CDB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M62554 mRNA Translation: AAA49205.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A37860

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62554 mRNA Translation: AAA49205.1
PIRiA37860

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiP22316

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR031688, CAC1F_C
IPR002048, EF_hand_dom
IPR031649, GPHH_dom
IPR005821, Ion_trans_dom
IPR014873, VDCC_a1su_IQ
IPR005450, VDCC_L_a1ssu
IPR005446, VDCC_L_a1su
IPR002077, VDCCAlpha1
IPR027359, Volt_channel_dom_sf
PfamiView protein in Pfam
PF08763, Ca_chan_IQ, 1 hit
PF16885, CAC1F_C, 1 hit
PF16905, GPHH, 1 hit
PF00520, Ion_trans, 4 hits
PRINTSiPR00167, CACHANNEL
PR01630, LVDCCALPHA1
PR01634, LVDCCALPHA1S
SMARTiView protein in SMART
SM01062, Ca_chan_IQ, 1 hit
PROSITEiView protein in PROSITE
PS50222, EF_HAND_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAC1S_CYPCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22316
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: February 10, 2021
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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