UniProtKB - P22314 (UBA1_HUMAN)
Protein
Ubiquitin-like modifier-activating enzyme 1
Gene
UBA1
Organism
Homo sapiens (Human)
Status
Functioni
Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1606621, PubMed:1447181). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334).3 Publications
Miscellaneous
There are two active sites within the E1 molecule, allowing it to accommodate two ubiquitin moieties at a time, with a new ubiquitin forming an adenylate intermediate as the previous one is transferred to the thiol site.By similarity
Catalytic activityi
- ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.1 Publication EC:6.2.1.45
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.2 PublicationsView all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 478 | ATP; via amide nitrogenBy similarity | 1 | |
Binding sitei | 504 | ATPBy similarity | 1 | |
Binding sitei | 515 | ATPBy similarity | 1 | |
Binding sitei | 528 | ATPBy similarity | 1 | |
Active sitei | 632 | Glycyl thioester intermediatePROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 576 – 577 | ATPBy similarity | 2 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- RNA binding Source: UniProtKB
- ubiquitin activating enzyme activity Source: MGI
GO - Biological processi
- cellular response to DNA damage stimulus Source: UniProtKB
- protein modification by small protein conjugation Source: GO_Central
- protein ubiquitination Source: GO_Central
- ubiquitin-dependent protein catabolic process Source: GO_Central
Keywordsi
Molecular function | Ligase |
Biological process | Ubl conjugation pathway |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | MetaCyc:HS05465-MONOMER |
BRENDAi | 2.3.2.B5, 2681 6.2.1.B9, 2681 |
PathwayCommonsi | P22314 |
Reactomei | R-HSA-8866652, Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SIGNORi | P22314 |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: Ubiquitin-like modifier-activating enzyme 1 (EC:6.2.1.451 Publication)Alternative name(s): Protein A1S9 Ubiquitin-activating enzyme E1 |
Gene namesi | Name:UBA1 Synonyms:A1S9T, UBE1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000130985.16 |
HGNCi | HGNC:12469, UBA1 |
MIMi | 314370, gene |
neXtProti | NX_P22314 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Mitochondrion
- Mitochondrion 1 Publication
Other locations
- Cytoplasm 1 Publication
Nucleus
- Nucleus 2 Publications
Other locations
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Mitochondrion
- mitochondrion Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Mitochondrion, NucleusPathology & Biotechi
Involvement in diseasei
Spinal muscular atrophy X-linked 2 (SMAX2)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA lethal infantile form of spinal muscular atrophy, a neuromuscular disorder characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. Clinical features include hypotonia, areflexia, and multiple congenital contractures.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_043501 | 539 | M → I in SMAX2. 1 PublicationCorresponds to variant dbSNP:rs80356545EnsemblClinVar. | 1 | |
Natural variantiVAR_043502 | 547 | S → G in SMAX2. 1 PublicationCorresponds to variant dbSNP:rs80356546EnsemblClinVar. | 1 | |
Natural variantiVAR_071121 | 557 | E → V in SMAX2. 1 Publication | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 4 | S → A: Reduces phosphorylation. 1 Publication | 1 | |
Mutagenesisi | 8 – 11 | KKRR → AAAA: Loss of nuclear localization and a 90-95% decrease in the phosphorylation. 1 Publication | 4 |
Keywords - Diseasei
Disease mutation, NeurodegenerationOrganism-specific databases
DisGeNETi | 7317 |
GeneReviewsi | UBA1 |
MalaCardsi | UBA1 |
MIMi | 301830, phenotype |
OpenTargetsi | ENSG00000130985 |
Orphaneti | 1145, Infantile-onset X-linked spinal muscular atrophy |
PharmGKBi | PA37119 |
Miscellaneous databases
Pharosi | P22314, Tbio |
Chemistry databases
ChEMBLi | CHEMBL5924 |
DrugBanki | DB04119, Hexatantalum Dodecabromide DB04216, Quercetin |
Polymorphism and mutation databases
BioMutai | UBA1 |
DMDMi | 24418865 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | ||||
ChainiPRO_0000194934 | 2 – 1058 | Ubiquitin-like modifier-activating enzyme 1Add BLAST | 1057 | ||
Isoform 2 (identifier: P22314-2) | |||||
Initiator methioninei | RemovedCombined sources |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | ||
Modified residuei | 4 | Phosphoserine1 Publication | 1 | ||
Modified residuei | 13 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 21 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 24 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 46 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 55 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 528 | N6-succinyllysineBy similarity | 1 | ||
Modified residuei | 671 | N6-acetyllysineCombined sources | 1 | ||
Modified residuei | 800 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 810 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 816 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 820 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 835 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 980 | N6-acetyllysineCombined sources | 1 | ||
Isoform 2 (identifier: P22314-2) | |||||
Modified residuei | 2 | N-acetylalanineCombined sources | 1 |
Post-translational modificationi
ISGylated.1 Publication
Keywords - PTMi
Acetylation, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-136 CPTAC-137 |
EPDi | P22314 |
jPOSTi | P22314 |
MassIVEi | P22314 |
MaxQBi | P22314 |
PaxDbi | P22314 |
PeptideAtlasi | P22314 |
PRIDEi | P22314 |
ProteomicsDBi | 53983 [P22314-1] |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00645078 |
PTM databases
iPTMneti | P22314 |
MetOSitei | P22314 |
PhosphoSitePlusi | P22314 |
SwissPalmi | P22314 |
Expressioni
Tissue specificityi
Detected in erythrocytes (at protein level). Ubiquitous.1 Publication
Gene expression databases
Bgeei | ENSG00000130985, Expressed in pituitary gland and 256 other tissues |
ExpressionAtlasi | P22314, baseline and differential |
Genevisiblei | P22314, HS |
Organism-specific databases
HPAi | ENSG00000130985, Low tissue specificity |
Interactioni
Subunit structurei
Monomer (By similarity).
Interacts with GAN (via BTB domain).
By similarity1 PublicationBinary interactionsi
Hide detailsP22314
With | #Exp. | IntAct |
---|---|---|
GAN [Q9H2C0] | 5 | EBI-709688,EBI-764342 |
UBE2I [P63279] | 2 | EBI-709688,EBI-80168 |
Q76353 from Human immunodeficiency virus 1. | 2 | EBI-709688,EBI-6248077 |
Protein-protein interaction databases
BioGRIDi | 113165, 208 interactors |
DIPi | DIP-33686N |
IntActi | P22314, 152 interactors |
MINTi | P22314 |
STRINGi | 9606.ENSP00000338413 |
Chemistry databases
BindingDBi | P22314 |
Miscellaneous databases
RNActi | P22314, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P22314 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 63 – 199 | 1-1Add BLAST | 137 | |
Repeati | 459 – 611 | 1-2Add BLAST | 153 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 63 – 611 | 2 approximate repeatsAdd BLAST | 549 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 5 – 11 | Nuclear localization signal | 7 |
Domaini
The first 11 amino acids are essential for phosphorylation and exclusive nuclear localization.
Sequence similaritiesi
Belongs to the ubiquitin-activating E1 family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG2012, Eukaryota |
GeneTreei | ENSGT00940000158975 |
HOGENOMi | CLU_002556_0_0_1 |
InParanoidi | P22314 |
OMAi | CIVWARL |
OrthoDBi | 91748at2759 |
PhylomeDBi | P22314 |
TreeFami | TF300586 |
Family and domain databases
Gene3Di | 1.10.10.2660, 1 hit 2.40.30.180, 1 hit 3.10.290.60, 1 hit 3.50.50.80, 1 hit |
InterProi | View protein in InterPro IPR032420, E1_4HB IPR032418, E1_FCCH IPR042302, E1_FCCH_sf IPR000594, ThiF_NAD_FAD-bd IPR018965, Ub-activating_enz_E1_C IPR042449, Ub-E1_IAD_1 IPR038252, UBA_E1_C_sf IPR019572, UBA_E1_Cys IPR042063, Ubi_acti_E1_SCCH IPR035985, Ubiquitin-activating_enz IPR018075, UBQ-activ_enz_E1 IPR018074, UBQ-activ_enz_E1_CS IPR033127, UBQ-activ_enz_E1_Cys_AS IPR000011, UBQ/SUMO-activ_enz_E1-like |
Pfami | View protein in Pfam PF16191, E1_4HB, 1 hit PF16190, E1_FCCH, 1 hit PF09358, E1_UFD, 1 hit PF00899, ThiF, 2 hits PF10585, UBA_e1_thiolCys, 1 hit |
PRINTSi | PR01849, UBIQUITINACT |
SMARTi | View protein in SMART SM00985, UBA_e1_C, 1 hit |
SUPFAMi | SSF69572, SSF69572, 2 hits |
TIGRFAMsi | TIGR01408, Ube1, 1 hit |
PROSITEi | View protein in PROSITE PS00536, UBIQUITIN_ACTIVAT_1, 1 hit PS00865, UBIQUITIN_ACTIVAT_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative initiation. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P22314-1) [UniParc]FASTAAdd to basket
Also known as: E1a
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSSSPLSKKR RVSGPDPKPG SNCSPAQSVL SEVPSVPTNG MAKNGSEADI
60 70 80 90 100
DEGLYSRQLY VLGHEAMKRL QTSSVLVSGL RGLGVEIAKN IILGGVKAVT
110 120 130 140 150
LHDQGTAQWA DLSSQFYLRE EDIGKNRAEV SQPRLAELNS YVPVTAYTGP
160 170 180 190 200
LVEDFLSGFQ VVVLTNTPLE DQLRVGEFCH NRGIKLVVAD TRGLFGQLFC
210 220 230 240 250
DFGEEMILTD SNGEQPLSAM VSMVTKDNPG VVTCLDEARH GFESGDFVSF
260 270 280 290 300
SEVQGMVELN GNQPMEIKVL GPYTFSICDT SNFSDYIRGG IVSQVKVPKK
310 320 330 340 350
ISFKSLVASL AEPDFVVTDF AKFSRPAQLH IGFQALHQFC AQHGRPPRPR
360 370 380 390 400
NEEDAAELVA LAQAVNARAL PAVQQNNLDE DLIRKLAYVA AGDLAPINAF
410 420 430 440 450
IGGLAAQEVM KACSGKFMPI MQWLYFDALE CLPEDKEVLT EDKCLQRQNR
460 470 480 490 500
YDGQVAVFGS DLQEKLGKQK YFLVGAGAIG CELLKNFAMI GLGCGEGGEI
510 520 530 540 550
IVTDMDTIEK SNLNRQFLFR PWDVTKLKSD TAAAAVRQMN PHIRVTSHQN
560 570 580 590 600
RVGPDTERIY DDDFFQNLDG VANALDNVDA RMYMDRRCVY YRKPLLESGT
610 620 630 640 650
LGTKGNVQVV IPFLTESYSS SQDPPEKSIP ICTLKNFPNA IEHTLQWARD
660 670 680 690 700
EFEGLFKQPA ENVNQYLTDP KFVERTLRLA GTQPLEVLEA VQRSLVLQRP
710 720 730 740 750
QTWADCVTWA CHHWHTQYSN NIRQLLHNFP PDQLTSSGAP FWSGPKRCPH
760 770 780 790 800
PLTFDVNNPL HLDYVMAAAN LFAQTYGLTG SQDRAAVATF LQSVQVPEFT
810 820 830 840 850
PKSGVKIHVS DQELQSANAS VDDSRLEELK ATLPSPDKLP GFKMYPIDFE
860 870 880 890 900
KDDDSNFHMD FIVAASNLRA ENYDIPSADR HKSKLIAGKI IPAIATTTAA
910 920 930 940 950
VVGLVCLELY KVVQGHRQLD SYKNGFLNLA LPFFGFSEPL AAPRHQYYNQ
960 970 980 990 1000
EWTLWDRFEV QGLQPNGEEM TLKQFLDYFK TEHKLEITML SQGVSMLYSF
1010 1020 1030 1040 1050
FMPAAKLKER LDQPMTEIVS RVSKRKLGRH VRALVLELCC NDESGEDVEV
PYVRYTIR
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5JRR6 | Q5JRR6_HUMAN | Ubiquitin-like modifier-activating ... | UBA1 | 506 | Annotation score: | ||
Q5JRR9 | Q5JRR9_HUMAN | Ubiquitin-like modifier-activating ... | UBA1 | 270 | Annotation score: | ||
Q5JRS0 | Q5JRS0_HUMAN | Ubiquitin-like modifier-activating ... | UBA1 | 284 | Annotation score: | ||
Q5JRS3 | Q5JRS3_HUMAN | Ubiquitin-like modifier-activating ... | UBA1 | 195 | Annotation score: | ||
Q5JRS1 | Q5JRS1_HUMAN | Ubiquitin-like modifier-activating ... | UBA1 | 173 | Annotation score: | ||
Q5JRS2 | Q5JRS2_HUMAN | Ubiquitin-like modifier-activating ... | UBA1 | 234 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 190 | D → G in CAA40296 (PubMed:1606621).Curated | 1 | |
Sequence conflicti | 434 | E → Q in CAA40296 (PubMed:1606621).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_043500 | 447 | R → H. Corresponds to variant dbSNP:rs2070169EnsemblClinVar. | 1 | |
Natural variantiVAR_043501 | 539 | M → I in SMAX2. 1 PublicationCorresponds to variant dbSNP:rs80356545EnsemblClinVar. | 1 | |
Natural variantiVAR_043502 | 547 | S → G in SMAX2. 1 PublicationCorresponds to variant dbSNP:rs80356546EnsemblClinVar. | 1 | |
Natural variantiVAR_071121 | 557 | E → V in SMAX2. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055913 | 1 – 40 | Missing in isoform 2. CuratedAdd BLAST | 40 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X56976 mRNA Translation: CAA40296.1 M58028 mRNA Translation: AAA61246.1 AL513366 Genomic DNA No translation available. CH471164 Genomic DNA Translation: EAW59290.1 BC013041 mRNA Translation: AAH13041.1 X52897 mRNA Translation: CAA37078.1 |
CCDSi | CCDS14275.1 [P22314-1] |
PIRi | A38564 |
RefSeqi | NP_003325.2, NM_003334.3 [P22314-1] NP_695012.1, NM_153280.2 [P22314-1] XP_016885269.1, XM_017029780.1 [P22314-1] XP_016885270.1, XM_017029781.1 [P22314-1] |
Genome annotation databases
Ensembli | ENST00000335972; ENSP00000338413; ENSG00000130985 [P22314-1] ENST00000377351; ENSP00000366568; ENSG00000130985 [P22314-1] |
GeneIDi | 7317 |
KEGGi | hsa:7317 |
UCSCi | uc004dhj.5, human [P22314-1] |
Keywords - Coding sequence diversityi
Alternative initiation, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X56976 mRNA Translation: CAA40296.1 M58028 mRNA Translation: AAA61246.1 AL513366 Genomic DNA No translation available. CH471164 Genomic DNA Translation: EAW59290.1 BC013041 mRNA Translation: AAH13041.1 X52897 mRNA Translation: CAA37078.1 |
CCDSi | CCDS14275.1 [P22314-1] |
PIRi | A38564 |
RefSeqi | NP_003325.2, NM_003334.3 [P22314-1] NP_695012.1, NM_153280.2 [P22314-1] XP_016885269.1, XM_017029780.1 [P22314-1] XP_016885270.1, XM_017029781.1 [P22314-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4P22 | X-ray | 2.75 | A/B | 1-439 | [»] | |
6DC6 | X-ray | 3.14 | A/C | 49-1058 | [»] | |
SMRi | P22314 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113165, 208 interactors |
DIPi | DIP-33686N |
IntActi | P22314, 152 interactors |
MINTi | P22314 |
STRINGi | 9606.ENSP00000338413 |
Chemistry databases
BindingDBi | P22314 |
ChEMBLi | CHEMBL5924 |
DrugBanki | DB04119, Hexatantalum Dodecabromide DB04216, Quercetin |
PTM databases
iPTMneti | P22314 |
MetOSitei | P22314 |
PhosphoSitePlusi | P22314 |
SwissPalmi | P22314 |
Polymorphism and mutation databases
BioMutai | UBA1 |
DMDMi | 24418865 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00645078 |
Proteomic databases
CPTACi | CPTAC-136 CPTAC-137 |
EPDi | P22314 |
jPOSTi | P22314 |
MassIVEi | P22314 |
MaxQBi | P22314 |
PaxDbi | P22314 |
PeptideAtlasi | P22314 |
PRIDEi | P22314 |
ProteomicsDBi | 53983 [P22314-1] |
Protocols and materials databases
Antibodypediai | 345, 385 antibodies |
CPTCi | P22314, 3 antibodies |
DNASUi | 7317 |
Genome annotation databases
Ensembli | ENST00000335972; ENSP00000338413; ENSG00000130985 [P22314-1] ENST00000377351; ENSP00000366568; ENSG00000130985 [P22314-1] |
GeneIDi | 7317 |
KEGGi | hsa:7317 |
UCSCi | uc004dhj.5, human [P22314-1] |
Organism-specific databases
CTDi | 7317 |
DisGeNETi | 7317 |
EuPathDBi | HostDB:ENSG00000130985.16 |
GeneCardsi | UBA1 |
GeneReviewsi | UBA1 |
HGNCi | HGNC:12469, UBA1 |
HPAi | ENSG00000130985, Low tissue specificity |
MalaCardsi | UBA1 |
MIMi | 301830, phenotype 314370, gene |
neXtProti | NX_P22314 |
OpenTargetsi | ENSG00000130985 |
Orphaneti | 1145, Infantile-onset X-linked spinal muscular atrophy |
PharmGKBi | PA37119 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2012, Eukaryota |
GeneTreei | ENSGT00940000158975 |
HOGENOMi | CLU_002556_0_0_1 |
InParanoidi | P22314 |
OMAi | CIVWARL |
OrthoDBi | 91748at2759 |
PhylomeDBi | P22314 |
TreeFami | TF300586 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
BioCyci | MetaCyc:HS05465-MONOMER |
BRENDAi | 2.3.2.B5, 2681 6.2.1.B9, 2681 |
PathwayCommonsi | P22314 |
Reactomei | R-HSA-8866652, Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SIGNORi | P22314 |
Miscellaneous databases
BioGRID-ORCSi | 7317, 373 hits in 469 CRISPR screens |
ChiTaRSi | UBA1, human |
GeneWikii | UBA1 |
GenomeRNAii | 7317 |
Pharosi | P22314, Tbio |
PROi | PR:P22314 |
RNActi | P22314, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000130985, Expressed in pituitary gland and 256 other tissues |
ExpressionAtlasi | P22314, baseline and differential |
Genevisiblei | P22314, HS |
Family and domain databases
Gene3Di | 1.10.10.2660, 1 hit 2.40.30.180, 1 hit 3.10.290.60, 1 hit 3.50.50.80, 1 hit |
InterProi | View protein in InterPro IPR032420, E1_4HB IPR032418, E1_FCCH IPR042302, E1_FCCH_sf IPR000594, ThiF_NAD_FAD-bd IPR018965, Ub-activating_enz_E1_C IPR042449, Ub-E1_IAD_1 IPR038252, UBA_E1_C_sf IPR019572, UBA_E1_Cys IPR042063, Ubi_acti_E1_SCCH IPR035985, Ubiquitin-activating_enz IPR018075, UBQ-activ_enz_E1 IPR018074, UBQ-activ_enz_E1_CS IPR033127, UBQ-activ_enz_E1_Cys_AS IPR000011, UBQ/SUMO-activ_enz_E1-like |
Pfami | View protein in Pfam PF16191, E1_4HB, 1 hit PF16190, E1_FCCH, 1 hit PF09358, E1_UFD, 1 hit PF00899, ThiF, 2 hits PF10585, UBA_e1_thiolCys, 1 hit |
PRINTSi | PR01849, UBIQUITINACT |
SMARTi | View protein in SMART SM00985, UBA_e1_C, 1 hit |
SUPFAMi | SSF69572, SSF69572, 2 hits |
TIGRFAMsi | TIGR01408, Ube1, 1 hit |
PROSITEi | View protein in PROSITE PS00536, UBIQUITIN_ACTIVAT_1, 1 hit PS00865, UBIQUITIN_ACTIVAT_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UBA1_HUMAN | |
Accessioni | P22314Primary (citable) accession number: P22314 Secondary accession number(s): Q5JRR8, Q96E13 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1991 |
Last sequence update: | October 25, 2002 | |
Last modified: | December 2, 2020 | |
This is version 228 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations