UGT1A4

Functionⁱ

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity).By similarity

Miscellaneous

The gene is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.

Catalytic activityⁱ

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functionⁱ

enzyme binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 20610558
glucuronosyltransferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 22579593
protein heterodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 17179145
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 17179145

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

bilirubin conjugation Source: Reactome
cellular glucuronidation
Source: UniProtKB
Inferred from direct assayⁱ
- 22579593
flavonoid glucuronidation Source: GO_Central
heme catabolic process Source: Reactome
negative regulation of cellular glucuronidation
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 20610558
negative regulation of fatty acid metabolic process
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 20610558
negative regulation of glucuronosyltransferase activity
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 20610558
xenobiotic glucuronidation Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Glycosyltransferase, Transferase

Molecular function

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS11970-MONOMER
BRENDAⁱ	2.4.1.17 2681
Reactomeⁱ	R-HSA-156588 Glucuronidation R-HSA-189483 Heme degradation R-HSA-5579016 Defective UGT1A4 causes hyperbilirubinemia
SABIO-RKⁱ	P22310
SIGNORⁱ	P22310

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GT1 Glycosyltransferase Family 1

CAZyⁱ

GT1 Glycosyltransferase Family 1

Chemistry databases

SwissLipidsⁱ	SLP:000001872

SwissLipidsⁱ

SLP:000001872

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: UDP-glucuronosyltransferase 1-4 (EC:2.4.1.17) Short name: UDPGT 1-4 Short name: UGT1*4 Short name: UGT1-04 Short name: UGT1.4 Alternative name(s): Bilirubin-specific UDPGT isozyme 2 Short name: hUG-BR2 UDP-glucuronosyltransferase 1-D Short name: UGT-1D Short name: UGT1D UDP-glucuronosyltransferase 1A4
Gene namesⁱ	Name:UGT1A4 Synonyms:GNT1, UGT1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000244474.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12536 UGT1A4
MIMⁱ	191740 gene 606429 gene
neXtProtⁱ	NX_P22310

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	492 – 508	HelicalSequence analysisAdd BLAST		17

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Gilbert syndrome (GILBS)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionOccurs as a consequence of reduced bilirubin transferase activity and is often detected in young adults with vague non-specific complaints.

Crigler-Najjar syndrome 1 (CN1)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionPatients have severe hyperbilirubinemia and usually die of kernicterus (bilirubin accumulation in the basal ganglia and brainstem nuclei) within the first year of life. CN1 inheritance is autosomal recessive.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_007711	376	S → F in CN1. 1 PublicationCorresponds to variant dbSNP:rs72551353EnsemblClinVar.		1

Crigler-Najjar syndrome 2 (CN2)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionPatients have less severe hyperbilirubinemia and usually survive into adulthood without neurologic damage. Phenobarbital, which induces the partially deficient glucuronyl transferase, can diminish the jaundice. CN2 inheritance is autosomal dominant.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_009506	132	L → P in CN2. 1 PublicationCorresponds to variant dbSNP:rs72551337Ensembl.	1
Natural variantⁱVAR_007710	332	Q → R in CN2. 1 PublicationCorresponds to variant dbSNP:rs72551348EnsemblClinVar.	1
Natural variantⁱVAR_009507	487	Y → D in CN2. 1 PublicationCorresponds to variant dbSNP:rs34993780EnsemblClinVar.	1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	54657
MalaCards human disease database More...MalaCardsⁱ	UGT1A4
MIMⁱ	143500 phenotype 218800 phenotype 606785 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000244474
PharmGKBⁱ	PA37179

Chemistry databases

ChEMBLⁱ	CHEMBL3619
Drug and drug target database More...DrugBankⁱ	DB06216 Asenapine DB00363 Clozapine DB04953 Ezogabine DB00555 Lamotrigine DB00683 Midazolam DB00910 Paricalcitol DB00675 Tamoxifen DB00831 Trifluoperazine DB00197 Troglitazone DB00313 Valproic Acid

Polymorphism and mutation databases

BioMutaⁱ	UGT1A4
DMDMⁱ	136731

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 28	Sequence analysisAdd BLAST		28
ChainⁱPRO_0000036003	29 – 534	UDP-glucuronosyltransferase 1-4Add BLAST		506

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	119	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	142	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	296	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	348	N-linked (GlcNAc...) asparagine1 Publication	1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

EPDⁱ	P22310
PaxDbⁱ	P22310
PeptideAtlas More...PeptideAtlasⁱ	P22310
PRIDEⁱ	P22310
ProteomicsDBⁱ	53982

PTM databases

iPTMnetⁱ	P22310
PhosphoSitePlusⁱ	P22310

Expressionⁱ

Tissue specificityⁱ

Isoform 1 and isoform 2 are expressed in liver, kidney, colon and small intestine. Isoform 2 but not isoform 1 is expressed in esophagus. Not expressed in skin.2 Publications

Inductionⁱ

By phenobarbital.

Gene expression databases

Bgeeⁱ	ENSG00000244474 Expressed in 29 organ(s), highest expression level in right lobe of liver
Genevisibleⁱ	P22310 HS

Interactionⁱ

Subunit structureⁱ

Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10.1 Publication

GO - Molecular functionⁱ

enzyme binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 20610558
protein heterodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 17179145
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 17179145

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	120086, 3 interactors
IntActⁱ	P22310, 9 interactors
STRINGⁱ	9606.ENSP00000362508

Chemistry databases

BindingDBⁱ	P22310

BindingDBⁱ

P22310

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P22310
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1192 Eukaryota COG1819 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118949
HOGENOMⁱ	HOG000220832
HOVERGENⁱ	HBG004033
InParanoidⁱ	P22310
KEGG Orthology (KO) More...KOⁱ	K00699
OMAⁱ	DGVMGNI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06JC
PhylomeDBⁱ	P22310
TreeFamⁱ	TF315472

Family and domain databases

InterProⁱ	View protein in InterPro IPR002213 UDP_glucos_trans IPR035595 UDP_glycos_trans_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00201 UDPGT, 1 hit
PROSITEⁱ	View protein in PROSITE PS00375 UDPGT, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P22310-1) [UniParc]FASTA Add to basket

Also known as: i1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARGLQVPLP RLATGLLLLL SVQPWAESGK VLVVPTDGSP WLSMREALRE 
        60         70         80         90        100
LHARGHQAVV LTPEVNMHIK EEKFFTLTAY AVPWTQKEFD RVTLGYTQGF 
       110        120        130        140        150
FETEHLLKRY SRSMAIMNNV SLALHRCCVE LLHNEALIRH LNATSFDVVL 
       160        170        180        190        200
TDPVNLCGAV LAKYLSIPAV FFWRYIPCDL DFKGTQCPNP SSYIPKLLTT 
       210        220        230        240        250
NSDHMTFLQR VKNMLYPLAL SYICHTFSAP YASLASELFQ REVSVVDLVS 
       260        270        280        290        300
YASVWLFRGD FVMDYPRPIM PNMVFIGGIN CANGKPLSQE FEAYINASGE 
       310        320        330        340        350
HGIVVFSLGS MVSEIPEKKA MAIADALGKI PQTVLWRYTG TRPSNLANNT 
       360        370        380        390        400
ILVKWLPQND LLGHPMTRAF ITHAGSHGVY ESICNGVPMV MMPLFGDQMD 
       410        420        430        440        450
NAKRMETKGA GVTLNVLEMT SEDLENALKA VINDKSYKEN IMRLSSLHKD 
       460        470        480        490        500
RPVEPLDLAV FWVEFVMRHK GAPHLRPAAH DLTWYQYHSL DVIGFLLAVV 
       510        520        530 
LTVAFITFKC CAYGYRKCLG KKGRVKKAHK SKTH

Length:534

Mass (Da):60,025

Last modified:August 1, 1991 - v1

Checksum:ⁱAB745D46F57538BE

GO

Isoform 2 (identifier: P22310-2) [UniParc]FASTA Add to basket

Also known as: i2, UGT1A4s

The sequence of this isoform differs from the canonical sequence as follows:
436-534: SYKENIMRLS...VKKAHKSKTH → RKKQQSGRQM

« Hide

        10         20         30         40         50
MARGLQVPLP RLATGLLLLL SVQPWAESGK VLVVPTDGSP WLSMREALRE 
        60         70         80         90        100
LHARGHQAVV LTPEVNMHIK EEKFFTLTAY AVPWTQKEFD RVTLGYTQGF 
       110        120        130        140        150
FETEHLLKRY SRSMAIMNNV SLALHRCCVE LLHNEALIRH LNATSFDVVL 
       160        170        180        190        200
TDPVNLCGAV LAKYLSIPAV FFWRYIPCDL DFKGTQCPNP SSYIPKLLTT 
       210        220        230        240        250
NSDHMTFLQR VKNMLYPLAL SYICHTFSAP YASLASELFQ REVSVVDLVS 
       260        270        280        290        300
YASVWLFRGD FVMDYPRPIM PNMVFIGGIN CANGKPLSQE FEAYINASGE 
       310        320        330        340        350
HGIVVFSLGS MVSEIPEKKA MAIADALGKI PQTVLWRYTG TRPSNLANNT 
       360        370        380        390        400
ILVKWLPQND LLGHPMTRAF ITHAGSHGVY ESICNGVPMV MMPLFGDQMD 
       410        420        430        440 
NAKRMETKGA GVTLNVLEMT SEDLENALKA VINDKRKKQQ SGRQM

Show »

Length:445

Mass (Da):49,802

Checksum:ⁱBB72EF2CDE4C0482

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_059844	11	R → W. Corresponds to variant dbSNP:rs3892221Ensembl.	1
Natural variantⁱVAR_024684	24	P → T1 PublicationCorresponds to variant dbSNP:rs6755571Ensembl.	1
Natural variantⁱVAR_058584	48	L → V2 PublicationsCorresponds to variant dbSNP:rs2011425EnsemblClinVar.	1
Natural variantⁱVAR_061870	68	H → Y. Corresponds to variant dbSNP:rs45621441Ensembl.	1
Natural variantⁱVAR_009506	132	L → P in CN2. 1 PublicationCorresponds to variant dbSNP:rs72551337Ensembl.	1
Natural variantⁱVAR_052454	176	I → F. Corresponds to variant dbSNP:rs45540231Ensembl.	1
Natural variantⁱVAR_007710	332	Q → R in CN2. 1 PublicationCorresponds to variant dbSNP:rs72551348EnsemblClinVar.	1
Natural variantⁱVAR_007711	376	S → F in CN1. 1 PublicationCorresponds to variant dbSNP:rs72551353EnsemblClinVar.	1
Natural variantⁱVAR_009507	487	Y → D in CN2. 1 PublicationCorresponds to variant dbSNP:rs34993780EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_053960	436 – 534	SYKEN…KSKTH → RKKQQSGRQM in isoform 2. 2 PublicationsAdd BLAST		99

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M84128 Genomic DNA Translation: AAA61249.1 M84124, M84122, M84123 Genomic DNA Translation: AAA61247.1 Sequence problems. M57951 mRNA Translation: AAA63196.1 AF297093 Genomic DNA Translation: AAG30422.1 AY435139 mRNA Translation: AAR95640.1 AK313623 mRNA Translation: BAG36384.1 DQ364249 mRNA Translation: ABC96773.1 AC006985 Genomic DNA No translation available. AC114812 Genomic DNA No translation available. CH471063 Genomic DNA Translation: EAW71061.1 BC139784 mRNA Translation: AAI39785.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33405.1 [P22310-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_009051.1, NM_007120.2 [P22310-1]
UniGeneⁱ	Hs.554822

Genome annotation databases

Ensemblⁱ	ENST00000373409; ENSP00000362508; ENSG00000244474 [P22310-1] ENST00000450233; ENSP00000408608; ENSG00000244474 [P22310-2]
GeneIDⁱ	54657
KEGGⁱ	hsa:54657
UCSC genome browser More...UCSCⁱ	uc002vux.4 human [P22310-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P22310	UDP-glucuronosyltransferase (Fragment)		HUMAN		287	UniRef100_P22310
UDP-glucuronosyltransferase 1A4 (Fragment)		HUMAN		289
UDP-glucuronosyltransferase 1A4 (Fragment)		HUMAN		59

Protein	Similar proteins		Species	Score	Length	Source
P22310	UDP-glucuronosyltransferase 1-5		HUMAN		534	UniRef90_P22310
UDP-glucuronosyltransferase		MACMU		534
UDP-glucuronosyltransferase		COLAP		534
UDP-glucuronosyltransferase		PONAB		534
UDP-glucuronosyltransferase		PANTR		534
+48
P22310-2	UDP-glucuronosyltransferase		HUMAN		445	UniRef90_P22310-2
UPI00062A6492		NOMLE		445
UDP-glucuronosyltransferase 1A4 (Fragment)		HUMAN		59
Isoform 2 of UDP-glucuronosyltransferase 1-3		HUMAN		445
Isoform 2 of UDP-glucuronosyltransferase 1-5		HUMAN		445

Protein	Similar proteins		Species	Score	Length	Source
P22310	UDP-glucuronosyltransferase 1-5		HUMAN		534	UniRef50_P22310
UDP-glucuronosyltransferase		MANLE		534
UDP-glucuronosyltransferase		RHIRO		534
UDP-glucuronosyltransferase		GORGO		534
UDP-glucuronosyltransferase		PONAB		534
+50
P22310-2	UDP-glucuronosyltransferase 1-6		HUMAN		532	UniRef50_P22310-2
UDP-glucuronosyltransferase 1-8		RAT		530
UDP-glucuronosyltransferase 1-6		RABIT		531
UDP-glucuronosyltransferase 1-7C		MOUSE		531
UDP-glucuronosyltransferase		DIPOR		533
+158

Entry informationⁱ

Entry nameⁱ	UD14_HUMAN
Accessionⁱ	P22310Primary (citable) accession number: P22310 Secondary accession number(s): B2R937, B8K288, Q5DT00
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
	Last sequence update:	August 1, 1991
	Last modified:	September 12, 2018
	This is version 187 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P22310 (UD14_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

UDP-glucuronosyltransferase 1-4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ