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UniProtKB - P22310 (UD14_HUMAN)

Entry version 204 (10 Feb 2021)
Sequence version 1 (01 Aug 1991)
Previous versions | rss
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Protein

UDP-glucuronosyltransferase 1A4

Gene

UGT1A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18177842, PubMed:24641623). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18177842). Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3 essential for the regulation of calcium and phosphate homeostasis (PubMed:24641623). Also glucuronidates the biologically active form of vitamin D3, calcitriol, probably leading to its biliary transport and intestinal reabsorption (PubMed:18177842).2 Publications
Lacks UDP-glucuronosyltransferase (UGT) activity but acts as a negative regulator of isoform 1.2 Publications

Miscellaneous

UGT1A4 isoform is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Some kinetic parameters were assessed using commercial enzymes, which may represent a mix of both active and inactive protein forms, and therefore modify the kinetic values.2 Publications
  1. KM=6.39 µM for calcidiol (when assaying glucuronidation at position 25)1 Publication
  2. KM=2.16 µM for calcidiol (when assaying glucuronidation at position 3)1 Publication
  3. KM=4.19 µM for 5,6-trans-calcidiol (when assaying glucuronidation at position 25)1 Publication
  4. KM=7.3 µM for calcitriol (when assaying glucuronidation at position 25)1 Publication
  5. KM=10.6 µM for 17beta-estradiol/estradiol (when assaying glucuronidation at position 17)1 Publication
  6. KM=21.7 µM for 17alpha-estradiol/epiestradiol (when assaying glucuronidation at position 17)1 Publication
  1. Vmax=7.35 pmol/min/mg enzyme for the formation of calcidiol 25-O-(beta-D-glucuronate)1 Publication
  2. Vmax=0.93 pmol/min/mg enzyme for the formation of calcidiol 3-O-(beta-D-glucuronate)1 Publication
  3. Vmax=0.26 pmol/min/mg enzyme for the formation of 5,6-trans-calcidiol 25-O-(beta-D-glucuronate)1 Publication
  4. Vmax=33.7 pmol/min/mg enzyme for the formation of calcitriol 25-O-(beta-D-glucuronate)1 Publication
  5. Vmax=14 pmol/min/mg enzyme for the formation of 17beta-estradiol 17-O-(beta-D-glucuronate)1 Publication
  6. Vmax=41 pmol/min/mg enzyme for the formation of 17alpha-estradiol 17-O-(beta-D-glucuronate)1 Publication
  7. Vmax=5.5 pmol/min/mg enzyme for the formation of 16alpha,17beta-estriol 16-O-(beta-D-glucuronate)1 Publication
  8. Vmax=4.1 pmol/min/mg enzyme for the formation of 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate)1 Publication
  9. Vmax=1.9 pmol/min/mg enzyme for the formation of 17beta-estradiol 17-O-(beta-D-glucuronate)1 Publication
  10. Vmax=6.1 pmol/min/mg enzyme for the formation of 17alpha-estradiol 17-O-(beta-D-glucuronate)1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS11970-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.4.1.17, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P22310

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-156588, Glucuronidation
R-HSA-189483, Heme degradation
R-HSA-5579016, Defective UGT1A4 causes hyperbilirubinemia

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P22310

SIGNOR Signaling Network Open Resource

More...SIGNORi		P22310

Protein family/group databases

Carbohydrate-Active enZymes

More...CAZyi		GT1, Glycosyltransferase Family 1

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001872

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UDP-glucuronosyltransferase 1A41 Publication (EC:2.4.1.172 Publications)
Short name:
UGT1A4
Alternative name(s):
Bilirubin-specific UDPGT isozyme 2
Short name:
hUG-BR2
UDP-glucuronosyltransferase 1-4
Short name:
UDPGT 1-4
Short name:
UGT1*4
Short name:
UGT1-04
Short name:
UGT1.4
UDP-glucuronosyltransferase 1-D
Short name:
UGT-1D
Short name:
UGT1D
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UGT1A4Imported
Synonyms:GNT1, UGT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12536, UGT1A4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606429, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P22310

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000244474.5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei492 – 508HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		54657

Open Targets

More...OpenTargetsi		ENSG00000244474

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37179

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P22310, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3619

Drug and drug target database

More...DrugBanki		DB00321, Amitriptyline
DB01217, Anastrozole
DB00714, Apomorphine
DB06216, Asenapine
DB06401, Bazedoxifene
DB05015, Belinostat
DB00363, Clozapine
DB14635, Curcumin sulfate
DB00924, Cyclobenzaprine
DB09183, Dasabuvir
DB09101, Elvitegravir
DB13874, Enasidenib
DB11827, Ertugliflozin
DB00783, Estradiol
DB00977, Ethinylestradiol
DB04953, Ezogabine
DB09054, Idelalisib
DB09262, Imidafenacin
DB00555, Lamotrigine
DB06077, Lumateperone
DB09241, Methylene blue
DB00683, Midazolam
DB00334, Olanzapine
DB09296, Ombitasvir
DB11837, Osilodrostat
DB00910, Paricalcitol
DB12978, Pexidartinib
DB00252, Phenytoin
DB00794, Primidone
DB00503, Ritonavir
DB12020, Tecovirimat
DB00831, Trifluoperazine
DB00197, Troglitazone
DB00313, Valproic acid

DrugCentral

More...DrugCentrali		P22310

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		UGT1A4

Domain mapping of disease mutations (DMDM)

More...DMDMi		136731

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003600329 – 534UDP-glucuronosyltransferase 1A4Add BLAST506

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi142N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi348N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P22310

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P22310

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P22310

PeptideAtlas

More...PeptideAtlasi		P22310

PRoteomics IDEntifications database

More...PRIDEi		P22310

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53982 [P22310-1]
7279

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1876, 2 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P22310, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P22310

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P22310

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in liver (PubMed:1339448, PubMed:18004212). Expressed in kidney, colon and small intestine (PubMed:18004212). Not expressed in esophagus (PubMed:18004212). Not expressed in skin (PubMed:1339448).2 Publications
Expressed in liver, kidney, colon, esophagus and small intestine.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced by phenobarbital.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000244474, Expressed in intestine and 42 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P22310, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000244474, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:17179145). Homooligomer (Probable).

Interacts with UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 to form heterodimers (PubMed:17179145).

Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 (PubMed:20610558).

1 Publication2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120086, 3 interactors

Protein interaction database and analysis system

More...IntActi		P22310, 9 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000362508

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P22310

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P22310, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P22310

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1192, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162976

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_012949_1_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P22310

Identification of Orthologs from Complete Genome Data

More...OMAi		INLAPAM

Database of Orthologous Groups

More...OrthoDBi		508327at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P22310

TreeFam database of animal gene trees

More...TreeFami		TF315472

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002213, UDP_glucos_trans
IPR035595, UDP_glycos_trans_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00201, UDPGT, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00375, UDPGT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P22310-1) [UniParc]FASTAAdd to basket
Also known as: i11 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARGLQVPLP RLATGLLLLL SVQPWAESGK VLVVPTDGSP WLSMREALRE 
        60         70         80         90        100
LHARGHQAVV LTPEVNMHIK EEKFFTLTAY AVPWTQKEFD RVTLGYTQGF 
       110        120        130        140        150
FETEHLLKRY SRSMAIMNNV SLALHRCCVE LLHNEALIRH LNATSFDVVL 
       160        170        180        190        200
TDPVNLCGAV LAKYLSIPAV FFWRYIPCDL DFKGTQCPNP SSYIPKLLTT 
       210        220        230        240        250
NSDHMTFLQR VKNMLYPLAL SYICHTFSAP YASLASELFQ REVSVVDLVS 
       260        270        280        290        300
YASVWLFRGD FVMDYPRPIM PNMVFIGGIN CANGKPLSQE FEAYINASGE 
       310        320        330        340        350
HGIVVFSLGS MVSEIPEKKA MAIADALGKI PQTVLWRYTG TRPSNLANNT 
       360        370        380        390        400
ILVKWLPQND LLGHPMTRAF ITHAGSHGVY ESICNGVPMV MMPLFGDQMD 
       410        420        430        440        450
NAKRMETKGA GVTLNVLEMT SEDLENALKA VINDKSYKEN IMRLSSLHKD 
       460        470        480        490        500
RPVEPLDLAV FWVEFVMRHK GAPHLRPAAH DLTWYQYHSL DVIGFLLAVV 
       510        520        530 
LTVAFITFKC CAYGYRKCLG KKGRVKKAHK SKTH
Length:534
Mass (Da):60,025
Last modified:August 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAB745D46F57538BE
GO
Isoform 2 (identifier: P22310-2) [UniParc]FASTAAdd to basket
Also known as: i21 Publication, UGT1A4s

The sequence of this isoform differs from the canonical sequence as follows:
     436-534: SYKENIMRLS...VKKAHKSKTH → RKKQQSGRQM

Show »
Length:445
Mass (Da):49,802
Checksum:iBB72EF2CDE4C0482
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05984411R → W. Corresponds to variant dbSNP:rs3892221Ensembl.1
Natural variantiVAR_02468424P → T1 PublicationCorresponds to variant dbSNP:rs6755571Ensembl.1
Natural variantiVAR_05858448L → V Increased glucuronosyltransferase activity towards calcidiol. 3 PublicationsCorresponds to variant dbSNP:rs2011425Ensembl.1
Natural variantiVAR_06187068H → Y. Corresponds to variant dbSNP:rs45621441Ensembl.1
Natural variantiVAR_052454176I → F. Corresponds to variant dbSNP:rs45540231Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053960436 – 534SYKEN…KSKTH → RKKQQSGRQM in isoform 2. 2 PublicationsAdd BLAST99

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M84128 Genomic DNA Translation: AAA61249.1
M84124, M84122, M84123 Genomic DNA Translation: AAA61247.1 Sequence problems.
M57951 mRNA Translation: AAA63196.1
AF297093 Genomic DNA Translation: AAG30422.1
AY435139 mRNA Translation: AAR95640.1
AK313623 mRNA Translation: BAG36384.1
DQ364249 mRNA Translation: ABC96773.1
AC006985 Genomic DNA No translation available.
AC114812 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW71061.1
BC139784 mRNA Translation: AAI39785.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33405.1 [P22310-1]

NCBI Reference Sequences

More...RefSeqi		NP_009051.1, NM_007120.2 [P22310-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000373409; ENSP00000362508; ENSG00000244474 [P22310-1]
ENST00000450233; ENSP00000408608; ENSG00000244474 [P22310-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54657

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54657

UCSC genome browser

More...UCSCi		uc002vux.4, human [P22310-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84128 Genomic DNA Translation: AAA61249.1
M84124, M84122, M84123 Genomic DNA Translation: AAA61247.1 Sequence problems.
M57951 mRNA Translation: AAA63196.1
AF297093 Genomic DNA Translation: AAG30422.1
AY435139 mRNA Translation: AAR95640.1
AK313623 mRNA Translation: BAG36384.1
DQ364249 mRNA Translation: ABC96773.1
AC006985 Genomic DNA No translation available.
AC114812 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW71061.1
BC139784 mRNA Translation: AAI39785.1
CCDSiCCDS33405.1 [P22310-1]
RefSeqiNP_009051.1, NM_007120.2 [P22310-1]

3D structure databases

SMRiP22310
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120086, 3 interactors
IntActiP22310, 9 interactors
STRINGi9606.ENSP00000362508

Chemistry databases

BindingDBiP22310
ChEMBLiCHEMBL3619
DrugBankiDB00321, Amitriptyline
DB01217, Anastrozole
DB00714, Apomorphine
DB06216, Asenapine
DB06401, Bazedoxifene
DB05015, Belinostat
DB00363, Clozapine
DB14635, Curcumin sulfate
DB00924, Cyclobenzaprine
DB09183, Dasabuvir
DB09101, Elvitegravir
DB13874, Enasidenib
DB11827, Ertugliflozin
DB00783, Estradiol
DB00977, Ethinylestradiol
DB04953, Ezogabine
DB09054, Idelalisib
DB09262, Imidafenacin
DB00555, Lamotrigine
DB06077, Lumateperone
DB09241, Methylene blue
DB00683, Midazolam
DB00334, Olanzapine
DB09296, Ombitasvir
DB11837, Osilodrostat
DB00910, Paricalcitol
DB12978, Pexidartinib
DB00252, Phenytoin
DB00794, Primidone
DB00503, Ritonavir
DB12020, Tecovirimat
DB00831, Trifluoperazine
DB00197, Troglitazone
DB00313, Valproic acid
DrugCentraliP22310
SwissLipidsiSLP:000001872

Protein family/group databases

CAZyiGT1, Glycosyltransferase Family 1

PTM databases

GlyConnecti1876, 2 N-Linked glycans (1 site)
GlyGeniP22310, 4 sites
iPTMnetiP22310
PhosphoSitePlusiP22310

Genetic variation databases

BioMutaiUGT1A4
DMDMi136731

Proteomic databases

jPOSTiP22310
MassIVEiP22310
PaxDbiP22310
PeptideAtlasiP22310
PRIDEiP22310
ProteomicsDBi53982 [P22310-1]
7279

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		35064, 82 antibodies

Genome annotation databases

EnsembliENST00000373409; ENSP00000362508; ENSG00000244474 [P22310-1]
ENST00000450233; ENSP00000408608; ENSG00000244474 [P22310-2]
GeneIDi54657
KEGGihsa:54657
UCSCiuc002vux.4, human [P22310-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54657
DisGeNETi54657

GeneCards: human genes, protein and diseases

More...GeneCardsi		UGT1A4
HGNCiHGNC:12536, UGT1A4
HPAiENSG00000244474, Tissue enriched (liver)
MIMi606429, gene
neXtProtiNX_P22310
OpenTargetsiENSG00000244474
PharmGKBiPA37179
VEuPathDBiHostDB:ENSG00000244474.5

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1192, Eukaryota
GeneTreeiENSGT00940000162976
HOGENOMiCLU_012949_1_3_1
InParanoidiP22310
OMAiINLAPAM
OrthoDBi508327at2759
PhylomeDBiP22310
TreeFamiTF315472

Enzyme and pathway databases

BioCyciMetaCyc:HS11970-MONOMER
BRENDAi2.4.1.17, 2681
PathwayCommonsiP22310
ReactomeiR-HSA-156588, Glucuronidation
R-HSA-189483, Heme degradation
R-HSA-5579016, Defective UGT1A4 causes hyperbilirubinemia
SABIO-RKiP22310
SIGNORiP22310

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54657, 3 hits in 790 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		UGT1A4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54657
PharosiP22310, Tbio

Protein Ontology

More...PROi		PR:P22310
RNActiP22310, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000244474, Expressed in intestine and 42 other tissues
GenevisibleiP22310, HS

Family and domain databases

InterProiView protein in InterPro
IPR002213, UDP_glucos_trans
IPR035595, UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201, UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375, UDPGT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUD14_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22310
Secondary accession number(s): B2R937, B8K288, Q5DT00
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: February 10, 2021
This is version 204 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with genetic variants
    List of human entries with genetic variants
  2. Human variants curated from literature reports
    Index of human variants curated from literature reports
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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