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Protein

UDP-glucuronosyltransferase 1-1

Gene

UGT1A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.3 Publications

Miscellaneous

The gene is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.26 µM for bilirubin1 Publication
  1. Vmax=1080 pmol/min/mg enzyme with bilirubin as substrate1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • enzyme binding Source: BHF-UCL
  • enzyme inhibitor activity Source: BHF-UCL
  • glucuronosyltransferase activity Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • retinoic acid binding Source: BHF-UCL
  • steroid binding Source: BHF-UCL
  • UDP-glycosyltransferase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.4.1.17 2681
2.4.1.95 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-156588 Glucuronidation
R-HSA-189483 Heme degradation
R-HSA-5579002 Defective UGT1A1 causes hyperbilirubinemia

SABIO-RK: Biochemical Reaction Kinetics Database

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SABIO-RKi
P22309

SIGNOR Signaling Network Open Resource

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SIGNORi
P22309

Protein family/group databases

Carbohydrate-Active enZymes

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CAZyi
GT1 Glycosyltransferase Family 1

Chemistry databases

SwissLipids knowledge resource for lipid biology

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SwissLipidsi
SLP:000001697

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UDP-glucuronosyltransferase 1-1 (EC:2.4.1.17)
Short name:
UDPGT 1-1
Short name:
UGT1*1
Short name:
UGT1-01
Short name:
UGT1.1
Alternative name(s):
Bilirubin-specific UDPGT isozyme 1
Short name:
hUG-BR1
UDP-glucuronosyltransferase 1-A
Short name:
UGT-1A
Short name:
UGT1A
UDP-glucuronosyltransferase 1A1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UGT1A1
Synonyms:GNT1, UGT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000241635.7

Human Gene Nomenclature Database

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HGNCi
HGNC:12530 UGT1A1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
191740 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P22309

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei491 – 507HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Gilbert syndrome (GILBS)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionOccurs as a consequence of reduced bilirubin transferase activity and is often detected in young adults with vague non-specific complaints.
See also OMIM:143500
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02613683F → L in GILBS; displays less than 10% of wild-type bilirubin glucuronidation activity. 2 PublicationsCorresponds to variant dbSNP:rs56059937Ensembl.1
Natural variantiVAR_012283367R → G in GILBS. 2 PublicationsCorresponds to variant dbSNP:rs55750087EnsemblClinVar.1
Transient familial neonatal hyperbilirubinemia (HBLRTFN)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry. The defect has been ascribed to various breast milk substances, but the component or combination of components that is responsible remains unclear. Defects of UGT1A1 are an underlying cause of the prolonged unconjugated hyperbilirubinemia associated with breast milk. One or more components in the milk may trigger the jaundice in infants who have such mutations. Mutations are identical to those detected in patients with Gilbert syndrome, a risk factor of neonatal non-physiologic hyperbilirubinemia and a genetic factor in fasting hyperbilirubinemia.
Disease descriptionA condition characterized by excessive concentration of bilirubin in the blood, which may lead to jaundice. Breast milk jaundice is a common problem in nursing infants.
See also OMIM:237900
Crigler-Najjar syndrome 1 (CN1)10 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionPatients have severe hyperbilirubinemia and usually die of kernicterus (bilirubin accumulation in the basal ganglia and brainstem nuclei) within the first year of life. CN1 inheritance is autosomal recessive.
See also OMIM:218800
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07140236D → N in CN1. 1 Publication1
Natural variantiVAR_02613539H → D in CN1. 1 PublicationCorresponds to variant dbSNP:rs72551339Ensembl.1
Natural variantiVAR_007697177C → R in CN1. 2 PublicationsCorresponds to variant dbSNP:rs72551342Ensembl.1
Natural variantiVAR_007699276G → R in CN1. 2 PublicationsCorresponds to variant dbSNP:rs72551345Ensembl.1
Natural variantiVAR_026138291E → V in CN1. 1 Publication1
Natural variantiVAR_007700292A → V in CN1. 1 Publication1
Natural variantiVAR_007701308G → E in CN1; no enzyme activity. 3 PublicationsCorresponds to variant dbSNP:rs62625011EnsemblClinVar.1
Natural variantiVAR_026141336R → Q in CN1. 1 PublicationCorresponds to variant dbSNP:rs750453538Ensembl.1
Natural variantiVAR_007703357Q → R in CN1. 3 PublicationsCorresponds to variant dbSNP:rs72551351EnsemblClinVar.1
Natural variantiVAR_007704368A → T in CN1. 2 PublicationsCorresponds to variant dbSNP:rs72551352Ensembl.1
Natural variantiVAR_007705375S → F in CN1; no enzyme activity. 5 PublicationsCorresponds to variant dbSNP:rs72551353EnsemblClinVar.1
Natural variantiVAR_007706381S → R in CN1. 2 PublicationsCorresponds to variant dbSNP:rs72551354Ensembl.1
Natural variantiVAR_026146387P → S in CN1. 2 PublicationsCorresponds to variant dbSNP:rs901936528Ensembl.1
Natural variantiVAR_026147395G → V in CN1; has no residual bilirubin glucuronidation activity. 3 PublicationsCorresponds to variant dbSNP:rs367897068Ensembl.1
Natural variantiVAR_007707401A → P in CN1. 2 PublicationsCorresponds to variant dbSNP:rs72551355Ensembl.1
Natural variantiVAR_064960402K → T in CN1; has no residual bilirubin glucuronidation activity; N-glycosylation does take place at this new additional site. 1 Publication1
Natural variantiVAR_007708428K → E in CN1. 2 PublicationsCorresponds to variant dbSNP:rs72551356Ensembl.1
Crigler-Najjar syndrome 2 (CN2)16 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionPatients have less severe hyperbilirubinemia and usually survive into adulthood without neurologic damage. Phenobarbital, which induces the partially deficient glucuronyl transferase, can diminish the jaundice. CN2 inheritance is autosomal dominant.
See also OMIM:606785
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01941015L → R in CN2; mutant protein rapidly degraded by the proteasome owing to its mislocalization in the cell. 4 PublicationsCorresponds to variant dbSNP:rs111033541EnsemblClinVar.1
Natural variantiVAR_02613434P → Q in CN2. 1 Publication1
Natural variantiVAR_00950471G → R in CN2, GILBS and HBLRTFN; has significant residual bilirubin glucuronidation activity of about 25% to 50% of that of the wild-type protein; displays no change in biluribin affinity. 7 PublicationsCorresponds to variant dbSNP:rs4148323Ensembl.1
Natural variantiVAR_064955171Missing in CN2. 1 Publication1
Natural variantiVAR_019411175L → Q in CN2; has low residual bilirubin glucuronidation activity of about 4.6% of that of the wild-type protein. 4 PublicationsCorresponds to variant dbSNP:rs72551341EnsemblClinVar.1
Natural variantiVAR_064956191S → F in CN2; has low residual bilirubin glucuronidation activity of about 5.3% of that of the wild-type protein. 1 Publication1
Natural variantiVAR_007698209R → W in CN2; has low residual bilirubin glucuronidation activity of about 2.9% of that of the wild-type protein. 5 PublicationsCorresponds to variant dbSNP:rs72551343EnsemblClinVar.1
Natural variantiVAR_026137225V → G in CN2. 2 PublicationsCorresponds to variant dbSNP:rs35003977EnsemblClinVar.1
Natural variantiVAR_071403230Y → C in CN2. 1 PublicationCorresponds to variant dbSNP:rs754922685Ensembl.1
Natural variantiVAR_064957279N → Y in CN2. 1 PublicationCorresponds to variant dbSNP:rs397978903EnsemblClinVar.1
Natural variantiVAR_007702331Q → R in CN2; has no residual bilirubin glucuronidation activity. 3 PublicationsCorresponds to variant dbSNP:rs72551348EnsemblClinVar.1
Natural variantiVAR_026142336R → W in CN2; has very low residual bilirubin glucuronidation activity of about 0.4% of that of the wild-type protein. 3 PublicationsCorresponds to variant dbSNP:rs139607673EnsemblClinVar.1
Natural variantiVAR_026143354W → R in CN2. 2 Publications1
Natural variantiVAR_071404367R → C in CN2. 1 PublicationCorresponds to variant dbSNP:rs55750087EnsemblClinVar.1
Natural variantiVAR_064958370I → V in CN2. 1 PublicationCorresponds to variant dbSNP:rs748989741Ensembl.1
Natural variantiVAR_064959387P → H in CN2; has no residual bilirubin glucuronidation activity. 1 Publication1
Natural variantiVAR_019412400N → D in CN2. 1 PublicationCorresponds to variant dbSNP:rs28934877EnsemblClinVar.1
Natural variantiVAR_026148403R → C in CN2. 1 PublicationCorresponds to variant dbSNP:rs778766461EnsemblClinVar.1
Natural variantiVAR_064961443L → P in CN2; has no residual bilirubin glucuronidation activity. 2 PublicationsCorresponds to variant dbSNP:rs758411577Ensembl.1
Natural variantiVAR_026150478A → D in CN2. 1 Publication1
Natural variantiVAR_007709486Y → D in CN2, GILBS and HBLRTFN; displays less than 10% of wild-type bilirubin glucuronidation activity. 7 PublicationsCorresponds to variant dbSNP:rs34993780EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

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DisGeNETi
54658

MalaCards human disease database

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MalaCardsi
UGT1A1
MIMi143500 phenotype
218800 phenotype
237900 phenotype
601816 phenotype
606785 phenotype

Open Targets

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OpenTargetsi
ENSG00000241635

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
79234 Crigler-Najjar syndrome type 1
79235 Crigler-Najjar syndrome type 2
240885 Irinotecan toxicity
357 NON RARE IN EUROPE: Gilbert syndrome
240905 Raltegravir toxicity
2312 Transient familial neonatal hyperbilirubinemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA37181
PA420

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL1287617

Drug and drug target database

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DrugBanki
DB01048 Abacavir
DB00316 Acetaminophen
DB00173 Adenine
DB01076 Atorvastatin
DB06626 Axitinib
DB00586 Diclofenac
DB08930 Dolutegravir
DB06210 Eltrombopag
DB00530 Erlotinib
DB00783 Estradiol
DB00773 Etoposide
DB00973 Ezetimibe
DB04953 Ezogabine
DB01544 Flunitrazepam
DB00712 Flurbiprofen
DB01095 Fluvastatin
DB06741 Gavestinel
DB01050 Ibuprofen
DB05039 Indacaterol
DB00328 Indomethacin
DB00762 Irinotecan
DB00678 Losartan
DB00227 Lovastatin
DB00295 Morphine
DB00688 Mycophenolate mofetil
DB01024 Mycophenolic acid
DB00704 Naltrexone
DB00788 Naproxen
DB04868 Nilotinib
DB06589 Pazopanib
DB00818 Propofol
DB06817 Raltegravir
DB08896 Regorafenib
DB01045 Rifampicin
DB00641 Simvastatin
DB00398 Sorafenib
DB00870 Suprofen
DB01420 Testosterone Propionate
DB00197 Troglitazone

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2990

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
UGT1A1

Domain mapping of disease mutations (DMDM)

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DMDMi
136729

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003600026 – 533UDP-glucuronosyltransferase 1-1Add BLAST508

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi102N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi347N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P22309

PeptideAtlas

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PeptideAtlasi
P22309

PRoteomics IDEntifications database

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PRIDEi
P22309

ProteomicsDB human proteome resource

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ProteomicsDBi
53981

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1873

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P22309

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P22309

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 and isoform 2 are expressed in liver, colon and small intestine. Isoform 2 but not isoform 1 is expressed in kidney. Isoform 1 and isoform 2 are not expressed in esophagus. Not expressed in skin.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000241635 Expressed in 45 organ(s), highest expression level in liver

CleanEx database of gene expression profiles

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CleanExi
HS_UGT1A1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P22309 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P22309 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10. Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120087, 4 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P22309

Protein interaction database and analysis system

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IntActi
P22309, 9 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000304845

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P22309

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P22309

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P22309

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1192 Eukaryota
COG1819 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159677

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000220832

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG004033

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P22309

KEGG Orthology (KO)

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KOi
K00699

Identification of Orthologs from Complete Genome Data

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OMAi
ESHFRRM

Database of Orthologous Groups

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OrthoDBi
EOG091G06JC

Database for complete collections of gene phylogenies

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PhylomeDBi
P22309

TreeFam database of animal gene trees

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TreeFami
TF315472

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS

Pfam protein domain database

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Pfami
View protein in Pfam
PF00201 UDPGT, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00375 UDPGT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P22309-1) [UniParc]FASTAAdd to basket
Also known as: i1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVESQGGRP LVLGLLLCVL GPVVSHAGKI LLIPVDGSHW LSMLGAIQQL
60 70 80 90 100
QQRGHEIVVL APDASLYIRD GAFYTLKTYP VPFQREDVKE SFVSLGHNVF
110 120 130 140 150
ENDSFLQRVI KTYKKIKKDS AMLLSGCSHL LHNKELMASL AESSFDVMLT
160 170 180 190 200
DPFLPCSPIV AQYLSLPTVF FLHALPCSLE FEATQCPNPF SYVPRPLSSH
210 220 230 240 250
SDHMTFLQRV KNMLIAFSQN FLCDVVYSPY ATLASEFLQR EVTVQDLLSS
260 270 280 290 300
ASVWLFRSDF VKDYPRPIMP NMVFVGGINC LHQNPLSQEF EAYINASGEH
310 320 330 340 350
GIVVFSLGSM VSEIPEKKAM AIADALGKIP QTVLWRYTGT RPSNLANNTI
360 370 380 390 400
LVKWLPQNDL LGHPMTRAFI THAGSHGVYE SICNGVPMVM MPLFGDQMDN
410 420 430 440 450
AKRMETKGAG VTLNVLEMTS EDLENALKAV INDKSYKENI MRLSSLHKDR
460 470 480 490 500
PVEPLDLAVF WVEFVMRHKG APHLRPAAHD LTWYQYHSLD VIGFLLAVVL
510 520 530
TVAFITFKCC AYGYRKCLGK KGRVKKAHKS KTH
Length:533
Mass (Da):59,591
Last modified:August 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i19C90231AD0EB547
GO
Isoform 2 (identifier: P22309-2) [UniParc]FASTAAdd to basket
Also known as: i2, UGT1A1s

The sequence of this isoform differs from the canonical sequence as follows:
     435-533: SYKENIMRLS...VKKAHKSKTH → RKKQQSGRQM

Show »
Length:444
Mass (Da):49,368
Checksum:i71E6711DDEFED403
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA61247 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAF03522 differs from that shown. Reason: Erroneous gene model prediction.Curated

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variation in UGT1A1 defines the bilirubin serum levels quantitative trait locus 1 (BILIQTL1) [MIMi:601816]. Variation in serum bilirubin is associated with altered cardiovascular disease risk and drug metabolism.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01941015L → R in CN2; mutant protein rapidly degraded by the proteasome owing to its mislocalization in the cell. 4 PublicationsCorresponds to variant dbSNP:rs111033541EnsemblClinVar.1
Natural variantiVAR_02613434P → Q in CN2. 1 Publication1
Natural variantiVAR_07140236D → N in CN1. 1 Publication1
Natural variantiVAR_02613539H → D in CN1. 1 PublicationCorresponds to variant dbSNP:rs72551339Ensembl.1
Natural variantiVAR_00950471G → R in CN2, GILBS and HBLRTFN; has significant residual bilirubin glucuronidation activity of about 25% to 50% of that of the wild-type protein; displays no change in biluribin affinity. 7 PublicationsCorresponds to variant dbSNP:rs4148323Ensembl.1
Natural variantiVAR_02613683F → L in GILBS; displays less than 10% of wild-type bilirubin glucuronidation activity. 2 PublicationsCorresponds to variant dbSNP:rs56059937Ensembl.1
Natural variantiVAR_007695170Missing in CN1 and CN2; has nearly normal activity at pH 7.6 and is inactive at pH 6.4. 5 Publications1
Natural variantiVAR_064955171Missing in CN2. 1 Publication1
Natural variantiVAR_019411175L → Q in CN2; has low residual bilirubin glucuronidation activity of about 4.6% of that of the wild-type protein. 4 PublicationsCorresponds to variant dbSNP:rs72551341EnsemblClinVar.1
Natural variantiVAR_007697177C → R in CN1. 2 PublicationsCorresponds to variant dbSNP:rs72551342Ensembl.1
Natural variantiVAR_064956191S → F in CN2; has low residual bilirubin glucuronidation activity of about 5.3% of that of the wild-type protein. 1 Publication1
Natural variantiVAR_007698209R → W in CN2; has low residual bilirubin glucuronidation activity of about 2.9% of that of the wild-type protein. 5 PublicationsCorresponds to variant dbSNP:rs72551343EnsemblClinVar.1
Natural variantiVAR_026137225V → G in CN2. 2 PublicationsCorresponds to variant dbSNP:rs35003977EnsemblClinVar.1
Natural variantiVAR_009505229P → Q in CN2 and GILBS; displays 2-fold decrease in biluribin affinity and 61% of wild-type bilirubin glucuronidation activity. 4 PublicationsCorresponds to variant dbSNP:rs35350960EnsemblClinVar.1
Natural variantiVAR_071403230Y → C in CN2. 1 PublicationCorresponds to variant dbSNP:rs754922685Ensembl.1
Natural variantiVAR_007699276G → R in CN1. 2 PublicationsCorresponds to variant dbSNP:rs72551345Ensembl.1
Natural variantiVAR_064957279N → Y in CN2. 1 PublicationCorresponds to variant dbSNP:rs397978903EnsemblClinVar.1
Natural variantiVAR_026138291E → V in CN1. 1 Publication1
Natural variantiVAR_007700292A → V in CN1. 1 Publication1
Natural variantiVAR_026139294I → T in GILBS and CN2; 40-55% normal activity; normal Km for bilirubin; when homozygous far less repressive and generates the mild Gilbert phenotype. 2 PublicationsCorresponds to variant dbSNP:rs72551347Ensembl.1
Natural variantiVAR_007701308G → E in CN1; no enzyme activity. 3 PublicationsCorresponds to variant dbSNP:rs62625011EnsemblClinVar.1
Natural variantiVAR_007702331Q → R in CN2; has no residual bilirubin glucuronidation activity. 3 PublicationsCorresponds to variant dbSNP:rs72551348EnsemblClinVar.1
Natural variantiVAR_026140336R → L in CN1 and CN2. 1 Publication1
Natural variantiVAR_026141336R → Q in CN1. 1 PublicationCorresponds to variant dbSNP:rs750453538Ensembl.1
Natural variantiVAR_026142336R → W in CN2; has very low residual bilirubin glucuronidation activity of about 0.4% of that of the wild-type protein. 3 PublicationsCorresponds to variant dbSNP:rs139607673EnsemblClinVar.1
Natural variantiVAR_026143354W → R in CN2. 2 Publications1
Natural variantiVAR_007703357Q → R in CN1. 3 PublicationsCorresponds to variant dbSNP:rs72551351EnsemblClinVar.1
Natural variantiVAR_071404367R → C in CN2. 1 PublicationCorresponds to variant dbSNP:rs55750087EnsemblClinVar.1
Natural variantiVAR_012283367R → G in GILBS. 2 PublicationsCorresponds to variant dbSNP:rs55750087EnsemblClinVar.1
Natural variantiVAR_007704368A → T in CN1. 2 PublicationsCorresponds to variant dbSNP:rs72551352Ensembl.1
Natural variantiVAR_064958370I → V in CN2. 1 PublicationCorresponds to variant dbSNP:rs748989741Ensembl.1
Natural variantiVAR_007705375S → F in CN1; no enzyme activity. 5 PublicationsCorresponds to variant dbSNP:rs72551353EnsemblClinVar.1
Natural variantiVAR_026144376H → R in CN1 and CN2. 1
Natural variantiVAR_026145377G → V in CN1 and CN2. 1 Publication1
Natural variantiVAR_007706381S → R in CN1. 2 PublicationsCorresponds to variant dbSNP:rs72551354Ensembl.1
Natural variantiVAR_064959387P → H in CN2; has no residual bilirubin glucuronidation activity. 1 Publication1
Natural variantiVAR_026146387P → S in CN1. 2 PublicationsCorresponds to variant dbSNP:rs901936528Ensembl.1
Natural variantiVAR_026147395G → V in CN1; has no residual bilirubin glucuronidation activity. 3 PublicationsCorresponds to variant dbSNP:rs367897068Ensembl.1
Natural variantiVAR_019412400N → D in CN2. 1 PublicationCorresponds to variant dbSNP:rs28934877EnsemblClinVar.1
Natural variantiVAR_007707401A → P in CN1. 2 PublicationsCorresponds to variant dbSNP:rs72551355Ensembl.1
Natural variantiVAR_064960402K → T in CN1; has no residual bilirubin glucuronidation activity; N-glycosylation does take place at this new additional site. 1 Publication1
Natural variantiVAR_026148403R → C in CN2. 1 PublicationCorresponds to variant dbSNP:rs778766461EnsemblClinVar.1
Natural variantiVAR_007708428K → E in CN1. 2 PublicationsCorresponds to variant dbSNP:rs72551356Ensembl.1
Natural variantiVAR_064961443L → P in CN2; has no residual bilirubin glucuronidation activity. 2 PublicationsCorresponds to variant dbSNP:rs758411577Ensembl.1
Natural variantiVAR_026149461W → R in CN1 and CN2. 2 Publications1
Natural variantiVAR_026150478A → D in CN2. 1 Publication1
Natural variantiVAR_007709486Y → D in CN2, GILBS and HBLRTFN; displays less than 10% of wild-type bilirubin glucuronidation activity. 7 PublicationsCorresponds to variant dbSNP:rs34993780EnsemblClinVar.1
Natural variantiVAR_025355511A → P. Corresponds to variant dbSNP:rs1042709Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053958435 – 533SYKEN…KSKTH → RKKQQSGRQM in isoform 2. 1 PublicationAdd BLAST99

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M57899 mRNA Translation: AAA63195.1
M84124, M84122, M84123 Genomic DNA Translation: AAA61247.1 Sequence problems.
M84125 Genomic DNA Translation: AAA61248.1
DQ364247 mRNA Translation: ABC96771.1
AF297093 Genomic DNA Translation: AAG30424.1
AC006985 Genomic DNA Translation: AAF03522.2 Sequence problems.
D87674 Genomic DNA Translation: BAA25600.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2510.1 [P22309-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A39092

NCBI Reference Sequences

More...
RefSeqi
NP_000454.1, NM_000463.2 [P22309-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.554822

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000305208; ENSP00000304845; ENSG00000241635 [P22309-1]
ENST00000360418; ENSP00000353593; ENSG00000241635 [P22309-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54658

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54658

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Glucuronosyltransferase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57899 mRNA Translation: AAA63195.1
M84124, M84122, M84123 Genomic DNA Translation: AAA61247.1 Sequence problems.
M84125 Genomic DNA Translation: AAA61248.1
DQ364247 mRNA Translation: ABC96771.1
AF297093 Genomic DNA Translation: AAG30424.1
AC006985 Genomic DNA Translation: AAF03522.2 Sequence problems.
D87674 Genomic DNA Translation: BAA25600.1
CCDSiCCDS2510.1 [P22309-1]
PIRiA39092
RefSeqiNP_000454.1, NM_000463.2 [P22309-1]
UniGeneiHs.554822

3D structure databases

ProteinModelPortaliP22309
SMRiP22309
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120087, 4 interactors
ELMiP22309
IntActiP22309, 9 interactors
STRINGi9606.ENSP00000304845

Chemistry databases

BindingDBiP22309
ChEMBLiCHEMBL1287617
DrugBankiDB01048 Abacavir
DB00316 Acetaminophen
DB00173 Adenine
DB01076 Atorvastatin
DB06626 Axitinib
DB00586 Diclofenac
DB08930 Dolutegravir
DB06210 Eltrombopag
DB00530 Erlotinib
DB00783 Estradiol
DB00773 Etoposide
DB00973 Ezetimibe
DB04953 Ezogabine
DB01544 Flunitrazepam
DB00712 Flurbiprofen
DB01095 Fluvastatin
DB06741 Gavestinel
DB01050 Ibuprofen
DB05039 Indacaterol
DB00328 Indomethacin
DB00762 Irinotecan
DB00678 Losartan
DB00227 Lovastatin
DB00295 Morphine
DB00688 Mycophenolate mofetil
DB01024 Mycophenolic acid
DB00704 Naltrexone
DB00788 Naproxen
DB04868 Nilotinib
DB06589 Pazopanib
DB00818 Propofol
DB06817 Raltegravir
DB08896 Regorafenib
DB01045 Rifampicin
DB00641 Simvastatin
DB00398 Sorafenib
DB00870 Suprofen
DB01420 Testosterone Propionate
DB00197 Troglitazone
GuidetoPHARMACOLOGYi2990
SwissLipidsiSLP:000001697

Protein family/group databases

CAZyiGT1 Glycosyltransferase Family 1

PTM databases

GlyConnecti1873
iPTMnetiP22309
PhosphoSitePlusiP22309

Polymorphism and mutation databases

BioMutaiUGT1A1
DMDMi136729

Proteomic databases

PaxDbiP22309
PeptideAtlasiP22309
PRIDEiP22309
ProteomicsDBi53981

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
54658
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305208; ENSP00000304845; ENSG00000241635 [P22309-1]
ENST00000360418; ENSP00000353593; ENSG00000241635 [P22309-2]
GeneIDi54658
KEGGihsa:54658

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54658
DisGeNETi54658
EuPathDBiHostDB:ENSG00000241635.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
UGT1A1
HGNCiHGNC:12530 UGT1A1
MalaCardsiUGT1A1
MIMi143500 phenotype
191740 gene
218800 phenotype
237900 phenotype
601816 phenotype
606785 phenotype
neXtProtiNX_P22309
OpenTargetsiENSG00000241635
Orphaneti79234 Crigler-Najjar syndrome type 1
79235 Crigler-Najjar syndrome type 2
240885 Irinotecan toxicity
357 NON RARE IN EUROPE: Gilbert syndrome
240905 Raltegravir toxicity
2312 Transient familial neonatal hyperbilirubinemia
PharmGKBiPA37181
PA420

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1192 Eukaryota
COG1819 LUCA
GeneTreeiENSGT00940000159677
HOGENOMiHOG000220832
HOVERGENiHBG004033
InParanoidiP22309
KOiK00699
OMAiESHFRRM
OrthoDBiEOG091G06JC
PhylomeDBiP22309
TreeFamiTF315472

Enzyme and pathway databases

BRENDAi2.4.1.17 2681
2.4.1.95 2681
ReactomeiR-HSA-156588 Glucuronidation
R-HSA-189483 Heme degradation
R-HSA-5579002 Defective UGT1A1 causes hyperbilirubinemia
SABIO-RKiP22309
SIGNORiP22309

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54658

Protein Ontology

More...
PROi
PR:P22309

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000241635 Expressed in 45 organ(s), highest expression level in liver
CleanExiHS_UGT1A1
ExpressionAtlasiP22309 baseline and differential
GenevisibleiP22309 HS

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUD11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22309
Secondary accession number(s): A6NJC3, B8K286
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: December 5, 2018
This is version 202 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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