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Protein

Non-specific lipid-transfer protein

Gene

SCP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis.2 Publications

Catalytic activityi

3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3-alpha,7-alpha,12-alpha-trihydroxy-24-oxo-5-beta-cholestanoyl-CoA.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid transport, Transport
LigandLipid-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS03991-MONOMER
BRENDAi2.3.1.176 2681
ReactomeiR-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-2046106 alpha-linolenic acid (ALA) metabolism
R-HSA-389887 Beta-oxidation of pristanoyl-CoA
R-HSA-9033241 Peroxisomal protein import
R-HSA-9033500 TYSND1 cleaves peroxisomal proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Non-specific lipid-transfer protein (EC:2.3.1.176)
Short name:
NSL-TP
Alternative name(s):
Propanoyl-CoA C-acyltransferase
SCP-chi
SCPX
Sterol carrier protein 2
Short name:
SCP-2
Sterol carrier protein X
Short name:
SCP-X
Gene namesi
Name:SCP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116171.16
HGNCiHGNC:10606 SCP2
MIMi184755 gene
neXtProtiNX_P22307

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Peroxisome

Pathology & Biotechi

Involvement in diseasei

Leukoencephalopathy with dystonia and motor neuropathy (LKDMN)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by leukoencephalopathy, dystonic head tremor, spasmodic torticollis and reduced tendon reflexes in lower extremities. Additional features include hyposmia, pathologic saccadic eye movements, a slight hypoacusis, accumulation of branched-chain pristanic acid in plasma, and the presence of abnormal bile alcohol glucuronides in urine.
See also OMIM:613724

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi528N → D: Strongly reduces sterol carrier and phosphatidylcholine transfer activity; when associated with D-530. 1 Publication1
Mutagenesisi528N → I: Strongly reduces sterol carrier and phosphatidylcholine transfer activity. 1 Publication1
Mutagenesisi530G → D: Strongly reduces sterol carrier and phosphatidylcholine transfer activity; when associated with D-528. 1 Publication1

Organism-specific databases

DisGeNETi6342
MalaCardsiSCP2
MIMi613724 phenotype
OpenTargetsiENSG00000116171
Orphaneti163684 Leukoencephalopathy - dystonia - motor neuropathy
PharmGKBiPA35014

Chemistry databases

ChEMBLiCHEMBL5950

Polymorphism and mutation databases

BioMutaiSCP2
DMDMi2507456

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000340911 – 547Non-specific lipid-transfer proteinAdd BLAST547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3PhosphoserineBy similarity1
Modified residuei132N6-acetyllysine; alternateBy similarity1
Modified residuei132N6-succinyllysine; alternateBy similarity1
Modified residuei168N6-succinyllysineBy similarity1
Modified residuei173N6-acetyllysineBy similarity1
Modified residuei177N6-acetyllysineBy similarity1
Modified residuei183N6-acetyllysine; alternateCombined sources1
Modified residuei183N6-succinyllysine; alternateBy similarity1
Modified residuei282N6-succinyllysineBy similarity1
Modified residuei341N6-acetyllysine; alternateBy similarity1
Modified residuei341N6-succinyllysine; alternateBy similarity1
Modified residuei432N6-acetyllysine; alternateBy similarity1
Modified residuei432N6-succinyllysine; alternateBy similarity1
Modified residuei438N6-acetyllysine; alternateCombined sources1
Modified residuei438N6-succinyllysine; alternateBy similarity1
Modified residuei443N6-acetyllysine; alternateBy similarity1
Modified residuei443N6-succinyllysine; alternateBy similarity1
Modified residuei453N6-acetyllysine; alternateBy similarity1
Modified residuei453N6-succinyllysine; alternateBy similarity1
Modified residuei464N6-succinyllysineBy similarity1
Modified residuei470N6-acetyllysine; alternateCombined sources1
Modified residuei470N6-succinyllysine; alternateBy similarity1
Modified residuei479N6-succinyllysineBy similarity1
Modified residuei491N6-acetyllysineBy similarity1
Modified residuei492N6-succinyllysineBy similarity1
Modified residuei511N6-succinyllysineBy similarity1
Modified residuei516PhosphoserineBy similarity1
Modified residuei522N6-succinyllysineBy similarity1
Modified residuei534N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP22307
MaxQBiP22307
PaxDbiP22307
PeptideAtlasiP22307
PRIDEiP22307
ProteomicsDBi53978
53979 [P22307-2]
53980 [P22307-3]
TopDownProteomicsiP22307-1 [P22307-1]
P22307-2 [P22307-2]
P22307-4 [P22307-4]

2D gel databases

REPRODUCTION-2DPAGEiIPI00026105

PTM databases

iPTMnetiP22307
PhosphoSitePlusiP22307
SwissPalmiP22307

Expressioni

Tissue specificityi

Liver, fibroblasts, and placenta.

Inductioni

Up-regulated by 4-hydroxy-tamoxifen.1 Publication

Gene expression databases

BgeeiENSG00000116171 Expressed in 239 organ(s), highest expression level in liver
CleanExiHS_SCP2
ExpressionAtlasiP22307 baseline and differential
GenevisibleiP22307 HS

Organism-specific databases

HPAiHPA027101
HPA027135
HPA027317

Interactioni

Subunit structurei

Interacts with PEX5.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112246, 40 interactors
ELMiP22307
IntActiP22307, 13 interactors
MINTiP22307
STRINGi9606.ENSP00000360569

Chemistry databases

BindingDBiP22307

Structurei

Secondary structure

1547
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP22307
SMRiP22307
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22307

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini433 – 543SCP2Add BLAST111

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi545 – 547Microbody targeting signalSequence analysis3

Sequence similaritiesi

In the N-terminal section; belongs to the thiolase family.Curated

Phylogenomic databases

eggNOGiKOG1406 Eukaryota
KOG4170 Eukaryota
ENOG410XPRW LUCA
GeneTreeiENSGT00530000062928
HOGENOMiHOG000221741
HOVERGENiHBG006506
InParanoidiP22307
KOiK08764
OMAiVEKMTDV
OrthoDBiEOG091G026S
PhylomeDBiP22307
TreeFamiTF300574

Family and domain databases

Gene3Di3.30.1050.10, 1 hit
3.40.47.10, 1 hit
InterProiView protein in InterPro
IPR003033 SCP2_sterol-bd_dom
IPR036527 SCP2_sterol-bd_dom_sf
IPR016039 Thiolase-like
IPR020615 Thiolase_acyl_enz_int_AS
IPR020617 Thiolase_C
IPR020613 Thiolase_CS
IPR020616 Thiolase_N
PfamiView protein in Pfam
PF02036 SCP2, 1 hit
PF02803 Thiolase_C, 1 hit
PF00108 Thiolase_N, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
SSF55718 SSF55718, 1 hit
PROSITEiView protein in PROSITE
PS00098 THIOLASE_1, 1 hit
PS00737 THIOLASE_2, 1 hit

Sequences (8+)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform SCPx (identifier: P22307-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSSPWEPAT LRRVFVVGVG MTKFVKPGAE NSRDYPDLAE EAGKKALADA
60 70 80 90 100
QIPYSAVDQA CVGYVFGDST CGQRAIYHSL GMTGIPIINV NNNCATGSTA
110 120 130 140 150
LFMARQLIQG GVAECVLALG FEKMSKGSLG IKFSDRTIPT DKHVDLLINK
160 170 180 190 200
YGLSAHPVAP QMFGYAGKEH MEKYGTKIEH FAKIGWKNHK HSVNNPYSQF
210 220 230 240 250
QDEYSLDEVM ASKEVFDFLT ILQCCPTSDG AAAAILASEA FVQKYGLQSK
260 270 280 290 300
AVEILAQEMM TDLPSSFEEK SIIKMVGFDM SKEAARKCYE KSGLTPNDID
310 320 330 340 350
VIELHDCFST NELLTYEALG LCPEGQGATL VDRGDNTYGG KWVINPSGGL
360 370 380 390 400
ISKGHPLGAT GLAQCAELCW QLRGEAGKRQ VPGAKVALQH NLGIGGAVVV
410 420 430 440 450
TLYKMGFPEA ASSFRTHQIE AVPTSSASDG FKANLVFKEI EKKLEEEGEQ
460 470 480 490 500
FVKKIGGIFA FKVKDGPGGK EATWVVDVKN GKGSVLPNSD KKADCTITMA
510 520 530 540
DSDFLALMTG KMNPQSAFFQ GKLKITGNMG LAMKLQNLQL QPGNAKL
Length:547
Mass (Da):58,994
Last modified:November 1, 1997 - v2
Checksum:i29F7551465C7143A
GO
Isoform SCP2 (identifier: P22307-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-404: Missing.

Note: Contains a mitochondrial transit peptide at positions 1-20.Curated
Show »
Length:143
Mass (Da):15,401
Checksum:iDE7FD93BB320BB30
GO
Isoform 3 (identifier: P22307-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-110: Missing.
     362-547: LAQCAELCWQ...LQLQPGNAKL → GHSCS

Show »
Length:322
Mass (Da):34,975
Checksum:iFC4864F7E46C77F7
GO
Isoform 4 (identifier: P22307-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.

Note: Produced by alternative splicing. No experimental confirmation available.
Show »
Length:466
Mass (Da):50,342
Checksum:i47E3BAB70472FF31
GO
Isoform 5 (identifier: P22307-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-404: Missing.
     447-463: EGEQFVKKIGGIFAFKV → IRRLTAQSQWLTQTSWL
     464-547: Missing.

Show »
Length:59
Mass (Da):6,699
Checksum:i8C1F69316F4AF3A9
GO
Isoform 6 (identifier: P22307-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-404: Missing.
     412-414: Missing.

Show »
Length:140
Mass (Da):15,079
Checksum:iB4FED0091257ACC1
GO
Isoform 7 (identifier: P22307-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-110: Missing.

Note: Produced by alternative splicing.
Show »
Length:503
Mass (Da):54,415
Checksum:i26B3C3FC9F326D3E
GO
Isoform 8 (identifier: P22307-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-66: Missing.

Note: Produced by alternative splicing.
Show »
Length:523
Mass (Da):56,497
Checksum:iCC516256338B09FA
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YCB0H0YCB0_HUMAN
Non-specific lipid-transfer protein
SCP2
240Annotation score:
E9PLD1E9PLD1_HUMAN
Non-specific lipid-transfer protein
SCP2
366Annotation score:
H0YF61H0YF61_HUMAN
Non-specific lipid-transfer protein
SCP2
140Annotation score:
H0YD06H0YD06_HUMAN
Non-specific lipid-transfer protein
SCP2
78Annotation score:
H0YEU8H0YEU8_HUMAN
Non-specific lipid-transfer protein
SCP2
32Annotation score:

Sequence cautioni

The sequence AAA03558 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10T → A in AAB41286 (PubMed:7698762).Curated1
Sequence conflicti56A → V in AK308105 (PubMed:14702039).Curated1
Sequence conflicti116V → A in AK308105 (PubMed:14702039).Curated1
Sequence conflicti341K → Q in BAG57810 (PubMed:14702039).Curated1
Sequence conflicti393G → D in AAB41286 (PubMed:7698762).Curated1
Sequence conflicti472A → D in AAB24921 (PubMed:1483685).Curated1
Sequence conflicti482K → Q in AAB24921 (PubMed:1483685).Curated1
Sequence conflicti501D → A in AAB24921 (PubMed:1483685).Curated1
Sequence conflicti522K → P in AAB24921 (PubMed:1483685).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035706155A → D in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0189771 – 404Missing in isoform SCP2, isoform 5 and isoform 6. 5 PublicationsAdd BLAST404
Alternative sequenceiVSP_0451871 – 81Missing in isoform 4. 1 PublicationAdd BLAST81
Alternative sequenceiVSP_04726743 – 66Missing in isoform 8. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_04268667 – 110Missing in isoform 3 and isoform 7. 2 PublicationsAdd BLAST44
Alternative sequenceiVSP_042687362 – 547LAQCA…GNAKL → GHSCS in isoform 3. 1 PublicationAdd BLAST186
Alternative sequenceiVSP_047268412 – 414Missing in isoform 6. 1 Publication3
Alternative sequenceiVSP_047269447 – 463EGEQF…FAFKV → IRRLTAQSQWLTQTSWL in isoform 5. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_047270464 – 547Missing in isoform 5. 1 PublicationAdd BLAST84

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11313
, U11297, U11299, U11300, U11301, U11302, U11303, U11304, U11305, U11306, U11307, U11308, U11309, U11310, U11311, U11312 Genomic DNA Translation: AAB41286.1
M75883 mRNA Translation: AAA03557.1
M75884 mRNA Translation: AAA03558.1 Different initiation.
M55421 mRNA Translation: AAA03559.1
S52450 mRNA Translation: AAB24921.1
AK294631 mRNA Translation: BAG57810.1
AK295214 mRNA Translation: BAG58208.1
AK308105 mRNA No translation available.
CR995014 mRNA No translation available.
AC099677 Genomic DNA No translation available.
AL445183 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06760.1
CH471059 Genomic DNA Translation: EAX06761.1
BC005911 mRNA Translation: AAH05911.1
BC067108 mRNA Translation: AAH67108.1
CB997588 mRNA No translation available.
CCDSiCCDS30719.1 [P22307-5]
CCDS41338.1 [P22307-3]
CCDS44149.1 [P22307-2]
CCDS44150.1 [P22307-6]
CCDS53317.1 [P22307-7]
CCDS53318.1 [P22307-8]
CCDS53319.1 [P22307-4]
CCDS572.1 [P22307-1]
PIRiB40407
I38205
RefSeqiNP_001007099.1, NM_001007098.2 [P22307-3]
NP_001007100.1, NM_001007099.2 [P22307-2]
NP_001007101.1, NM_001007100.2 [P22307-6]
NP_001007251.1, NM_001007250.2 [P22307-5]
NP_001180528.1, NM_001193599.1 [P22307-8]
NP_001180546.1, NM_001193617.1 [P22307-4]
NP_002970.2, NM_002979.4 [P22307-1]
XP_016857535.1, XM_017002046.1
UniGeneiHs.476365

Genome annotation databases

EnsembliENST00000371509; ENSP00000360564; ENSG00000116171 [P22307-7]
ENST00000371513; ENSP00000360568; ENSG00000116171 [P22307-3]
ENST00000371514; ENSP00000360569; ENSG00000116171 [P22307-1]
ENST00000407246; ENSP00000384569; ENSG00000116171 [P22307-8]
ENST00000408941; ENSP00000386214; ENSG00000116171 [P22307-5]
ENST00000430330; ENSP00000406636; ENSG00000116171 [P22307-6]
ENST00000435345; ENSP00000396413; ENSG00000116171 [P22307-2]
ENST00000488965; ENSP00000435783; ENSG00000116171 [P22307-5]
ENST00000528311; ENSP00000434132; ENSG00000116171 [P22307-4]
GeneIDi6342
KEGGihsa:6342
UCSCiuc001cuq.3 human [P22307-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11313
, U11297, U11299, U11300, U11301, U11302, U11303, U11304, U11305, U11306, U11307, U11308, U11309, U11310, U11311, U11312 Genomic DNA Translation: AAB41286.1
M75883 mRNA Translation: AAA03557.1
M75884 mRNA Translation: AAA03558.1 Different initiation.
M55421 mRNA Translation: AAA03559.1
S52450 mRNA Translation: AAB24921.1
AK294631 mRNA Translation: BAG57810.1
AK295214 mRNA Translation: BAG58208.1
AK308105 mRNA No translation available.
CR995014 mRNA No translation available.
AC099677 Genomic DNA No translation available.
AL445183 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06760.1
CH471059 Genomic DNA Translation: EAX06761.1
BC005911 mRNA Translation: AAH05911.1
BC067108 mRNA Translation: AAH67108.1
CB997588 mRNA No translation available.
CCDSiCCDS30719.1 [P22307-5]
CCDS41338.1 [P22307-3]
CCDS44149.1 [P22307-2]
CCDS44150.1 [P22307-6]
CCDS53317.1 [P22307-7]
CCDS53318.1 [P22307-8]
CCDS53319.1 [P22307-4]
CCDS572.1 [P22307-1]
PIRiB40407
I38205
RefSeqiNP_001007099.1, NM_001007098.2 [P22307-3]
NP_001007100.1, NM_001007099.2 [P22307-2]
NP_001007101.1, NM_001007100.2 [P22307-6]
NP_001007251.1, NM_001007250.2 [P22307-5]
NP_001180528.1, NM_001193599.1 [P22307-8]
NP_001180546.1, NM_001193617.1 [P22307-4]
NP_002970.2, NM_002979.4 [P22307-1]
XP_016857535.1, XM_017002046.1
UniGeneiHs.476365

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QNDNMR-A425-547[»]
2C0LX-ray2.30B426-547[»]
ProteinModelPortaliP22307
SMRiP22307
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112246, 40 interactors
ELMiP22307
IntActiP22307, 13 interactors
MINTiP22307
STRINGi9606.ENSP00000360569

Chemistry databases

BindingDBiP22307
ChEMBLiCHEMBL5950

PTM databases

iPTMnetiP22307
PhosphoSitePlusiP22307
SwissPalmiP22307

Polymorphism and mutation databases

BioMutaiSCP2
DMDMi2507456

2D gel databases

REPRODUCTION-2DPAGEiIPI00026105

Proteomic databases

EPDiP22307
MaxQBiP22307
PaxDbiP22307
PeptideAtlasiP22307
PRIDEiP22307
ProteomicsDBi53978
53979 [P22307-2]
53980 [P22307-3]
TopDownProteomicsiP22307-1 [P22307-1]
P22307-2 [P22307-2]
P22307-4 [P22307-4]

Protocols and materials databases

DNASUi6342
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371509; ENSP00000360564; ENSG00000116171 [P22307-7]
ENST00000371513; ENSP00000360568; ENSG00000116171 [P22307-3]
ENST00000371514; ENSP00000360569; ENSG00000116171 [P22307-1]
ENST00000407246; ENSP00000384569; ENSG00000116171 [P22307-8]
ENST00000408941; ENSP00000386214; ENSG00000116171 [P22307-5]
ENST00000430330; ENSP00000406636; ENSG00000116171 [P22307-6]
ENST00000435345; ENSP00000396413; ENSG00000116171 [P22307-2]
ENST00000488965; ENSP00000435783; ENSG00000116171 [P22307-5]
ENST00000528311; ENSP00000434132; ENSG00000116171 [P22307-4]
GeneIDi6342
KEGGihsa:6342
UCSCiuc001cuq.3 human [P22307-1]

Organism-specific databases

CTDi6342
DisGeNETi6342
EuPathDBiHostDB:ENSG00000116171.16
GeneCardsiSCP2
HGNCiHGNC:10606 SCP2
HPAiHPA027101
HPA027135
HPA027317
MalaCardsiSCP2
MIMi184755 gene
613724 phenotype
neXtProtiNX_P22307
OpenTargetsiENSG00000116171
Orphaneti163684 Leukoencephalopathy - dystonia - motor neuropathy
PharmGKBiPA35014
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1406 Eukaryota
KOG4170 Eukaryota
ENOG410XPRW LUCA
GeneTreeiENSGT00530000062928
HOGENOMiHOG000221741
HOVERGENiHBG006506
InParanoidiP22307
KOiK08764
OMAiVEKMTDV
OrthoDBiEOG091G026S
PhylomeDBiP22307
TreeFamiTF300574

Enzyme and pathway databases

BioCyciMetaCyc:HS03991-MONOMER
BRENDAi2.3.1.176 2681
ReactomeiR-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-2046106 alpha-linolenic acid (ALA) metabolism
R-HSA-389887 Beta-oxidation of pristanoyl-CoA
R-HSA-9033241 Peroxisomal protein import
R-HSA-9033500 TYSND1 cleaves peroxisomal proteins

Miscellaneous databases

ChiTaRSiSCP2 human
EvolutionaryTraceiP22307
GeneWikiiSCP2
GenomeRNAii6342
PROiPR:P22307
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116171 Expressed in 239 organ(s), highest expression level in liver
CleanExiHS_SCP2
ExpressionAtlasiP22307 baseline and differential
GenevisibleiP22307 HS

Family and domain databases

Gene3Di3.30.1050.10, 1 hit
3.40.47.10, 1 hit
InterProiView protein in InterPro
IPR003033 SCP2_sterol-bd_dom
IPR036527 SCP2_sterol-bd_dom_sf
IPR016039 Thiolase-like
IPR020615 Thiolase_acyl_enz_int_AS
IPR020617 Thiolase_C
IPR020613 Thiolase_CS
IPR020616 Thiolase_N
PfamiView protein in Pfam
PF02036 SCP2, 1 hit
PF02803 Thiolase_C, 1 hit
PF00108 Thiolase_N, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
SSF55718 SSF55718, 1 hit
PROSITEiView protein in PROSITE
PS00098 THIOLASE_1, 1 hit
PS00737 THIOLASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNLTP_HUMAN
AccessioniPrimary (citable) accession number: P22307
Secondary accession number(s): A6NM69
, B4DGJ9, B4DHP6, C9JC79, D3DQ37, E1B6W5, F2Z3J1, Q15432, Q16622, Q5VVZ1, Q6NXF4, Q99430
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: November 1, 1997
Last modified: October 10, 2018
This is version 209 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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