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Protein

Non-specific lipid-transfer protein

Gene

SCP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid transport, Transport
LigandLipid-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:HS03991-MONOMER

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.3.1.176 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-2046106 alpha-linolenic acid (ALA) metabolism
R-HSA-389887 Beta-oxidation of pristanoyl-CoA
R-HSA-9033241 Peroxisomal protein import
R-HSA-9033500 TYSND1 cleaves peroxisomal proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Non-specific lipid-transfer protein (EC:2.3.1.176)
Short name:
NSL-TP
Alternative name(s):
Propanoyl-CoA C-acyltransferase
SCP-chi
SCPX
Sterol carrier protein 2
Short name:
SCP-2
Sterol carrier protein X
Short name:
SCP-X
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SCP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000116171.16

Human Gene Nomenclature Database

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HGNCi
HGNC:10606 SCP2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
184755 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P22307

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Leukoencephalopathy with dystonia and motor neuropathy (LKDMN)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by leukoencephalopathy, dystonic head tremor, spasmodic torticollis and reduced tendon reflexes in lower extremities. Additional features include hyposmia, pathologic saccadic eye movements, a slight hypoacusis, accumulation of branched-chain pristanic acid in plasma, and the presence of abnormal bile alcohol glucuronides in urine.
See also OMIM:613724

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi528N → D: Strongly reduces sterol carrier and phosphatidylcholine transfer activity; when associated with D-530. 1 Publication1
Mutagenesisi528N → I: Strongly reduces sterol carrier and phosphatidylcholine transfer activity. 1 Publication1
Mutagenesisi530G → D: Strongly reduces sterol carrier and phosphatidylcholine transfer activity; when associated with D-528. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
6342

MalaCards human disease database

More...
MalaCardsi
SCP2
MIMi613724 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000116171

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
163684 Leukoencephalopathy-dystonia-motor neuropathy syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA35014

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL5950

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SCP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
2507456

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000340911 – 547Non-specific lipid-transfer proteinAdd BLAST547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei3PhosphoserineBy similarity1
Modified residuei132N6-acetyllysine; alternateBy similarity1
Modified residuei132N6-succinyllysine; alternateBy similarity1
Modified residuei168N6-succinyllysineBy similarity1
Modified residuei173N6-acetyllysineBy similarity1
Modified residuei177N6-acetyllysineBy similarity1
Modified residuei183N6-acetyllysine; alternateCombined sources1
Modified residuei183N6-succinyllysine; alternateBy similarity1
Modified residuei282N6-succinyllysineBy similarity1
Modified residuei341N6-acetyllysine; alternateBy similarity1
Modified residuei341N6-succinyllysine; alternateBy similarity1
Modified residuei432N6-acetyllysine; alternateBy similarity1
Modified residuei432N6-succinyllysine; alternateBy similarity1
Modified residuei438N6-acetyllysine; alternateCombined sources1
Modified residuei438N6-succinyllysine; alternateBy similarity1
Modified residuei443N6-acetyllysine; alternateBy similarity1
Modified residuei443N6-succinyllysine; alternateBy similarity1
Modified residuei453N6-acetyllysine; alternateBy similarity1
Modified residuei453N6-succinyllysine; alternateBy similarity1
Modified residuei464N6-succinyllysineBy similarity1
Modified residuei470N6-acetyllysine; alternateCombined sources1
Modified residuei470N6-succinyllysine; alternateBy similarity1
Modified residuei479N6-succinyllysineBy similarity1
Modified residuei491N6-acetyllysineBy similarity1
Modified residuei492N6-succinyllysineBy similarity1
Modified residuei511N6-succinyllysineBy similarity1
Modified residuei516PhosphoserineBy similarity1
Modified residuei522N6-succinyllysineBy similarity1
Modified residuei534N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P22307

MaxQB - The MaxQuant DataBase

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MaxQBi
P22307

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P22307

PeptideAtlas

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PeptideAtlasi
P22307

PRoteomics IDEntifications database

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PRIDEi
P22307

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53978
53979 [P22307-2]
53980 [P22307-3]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P22307-1 [P22307-1]
P22307-2 [P22307-2]
P22307-4 [P22307-4]

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00026105

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P22307

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P22307

SwissPalm database of S-palmitoylation events

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SwissPalmi
P22307

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Liver, fibroblasts, and placenta.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by 4-hydroxy-tamoxifen.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000116171 Expressed in 239 organ(s), highest expression level in liver

CleanEx database of gene expression profiles

More...
CleanExi
HS_SCP2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P22307 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P22307 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027101
HPA027135
HPA027317

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PEX5.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112246, 40 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P22307

Protein interaction database and analysis system

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IntActi
P22307, 13 interactors

Molecular INTeraction database

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MINTi
P22307

STRING: functional protein association networks

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STRINGi
9606.ENSP00000360569

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P22307

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1547
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P22307

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P22307

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P22307

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini433 – 543SCP2Add BLAST111

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi545 – 547Microbody targeting signalSequence analysis3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the thiolase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1406 Eukaryota
KOG4170 Eukaryota
ENOG410XPRW LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154327

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000221741

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006506

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P22307

KEGG Orthology (KO)

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KOi
K08764

Identification of Orthologs from Complete Genome Data

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OMAi
VEKMTDV

Database of Orthologous Groups

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OrthoDBi
EOG091G026S

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P22307

TreeFam database of animal gene trees

More...
TreeFami
TF300574

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.1050.10, 1 hit
3.40.47.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003033 SCP2_sterol-bd_dom
IPR036527 SCP2_sterol-bd_dom_sf
IPR016039 Thiolase-like
IPR020615 Thiolase_acyl_enz_int_AS
IPR020617 Thiolase_C
IPR020613 Thiolase_CS
IPR020616 Thiolase_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02036 SCP2, 1 hit
PF02803 Thiolase_C, 1 hit
PF00108 Thiolase_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53901 SSF53901, 2 hits
SSF55718 SSF55718, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00098 THIOLASE_1, 1 hit
PS00737 THIOLASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform SCPx (identifier: P22307-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSSPWEPAT LRRVFVVGVG MTKFVKPGAE NSRDYPDLAE EAGKKALADA
60 70 80 90 100
QIPYSAVDQA CVGYVFGDST CGQRAIYHSL GMTGIPIINV NNNCATGSTA
110 120 130 140 150
LFMARQLIQG GVAECVLALG FEKMSKGSLG IKFSDRTIPT DKHVDLLINK
160 170 180 190 200
YGLSAHPVAP QMFGYAGKEH MEKYGTKIEH FAKIGWKNHK HSVNNPYSQF
210 220 230 240 250
QDEYSLDEVM ASKEVFDFLT ILQCCPTSDG AAAAILASEA FVQKYGLQSK
260 270 280 290 300
AVEILAQEMM TDLPSSFEEK SIIKMVGFDM SKEAARKCYE KSGLTPNDID
310 320 330 340 350
VIELHDCFST NELLTYEALG LCPEGQGATL VDRGDNTYGG KWVINPSGGL
360 370 380 390 400
ISKGHPLGAT GLAQCAELCW QLRGEAGKRQ VPGAKVALQH NLGIGGAVVV
410 420 430 440 450
TLYKMGFPEA ASSFRTHQIE AVPTSSASDG FKANLVFKEI EKKLEEEGEQ
460 470 480 490 500
FVKKIGGIFA FKVKDGPGGK EATWVVDVKN GKGSVLPNSD KKADCTITMA
510 520 530 540
DSDFLALMTG KMNPQSAFFQ GKLKITGNMG LAMKLQNLQL QPGNAKL
Length:547
Mass (Da):58,994
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i29F7551465C7143A
GO
Isoform SCP2 (identifier: P22307-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-404: Missing.

Note: Contains a mitochondrial transit peptide at positions 1-20.Curated
Show »
Length:143
Mass (Da):15,401
Checksum:iDE7FD93BB320BB30
GO
Isoform 3 (identifier: P22307-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-110: Missing.
     362-547: LAQCAELCWQ...LQLQPGNAKL → GHSCS

Show »
Length:322
Mass (Da):34,975
Checksum:iFC4864F7E46C77F7
GO
Isoform 4 (identifier: P22307-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.

Note: Produced by alternative splicing. No experimental confirmation available.
Show »
Length:466
Mass (Da):50,342
Checksum:i47E3BAB70472FF31
GO
Isoform 5 (identifier: P22307-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-404: Missing.
     447-463: EGEQFVKKIGGIFAFKV → IRRLTAQSQWLTQTSWL
     464-547: Missing.

Show »
Length:59
Mass (Da):6,699
Checksum:i8C1F69316F4AF3A9
GO
Isoform 6 (identifier: P22307-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-404: Missing.
     412-414: Missing.

Show »
Length:140
Mass (Da):15,079
Checksum:iB4FED0091257ACC1
GO
Isoform 7 (identifier: P22307-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-110: Missing.

Note: Produced by alternative splicing.
Show »
Length:503
Mass (Da):54,415
Checksum:i26B3C3FC9F326D3E
GO
Isoform 8 (identifier: P22307-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-66: Missing.

Note: Produced by alternative splicing.
Show »
Length:523
Mass (Da):56,497
Checksum:iCC516256338B09FA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YCB0H0YCB0_HUMAN
Non-specific lipid-transfer protein
SCP2
240Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLD1E9PLD1_HUMAN
Non-specific lipid-transfer protein
SCP2
366Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YF61H0YF61_HUMAN
Non-specific lipid-transfer protein
SCP2
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YD06H0YD06_HUMAN
Non-specific lipid-transfer protein
SCP2
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEU8H0YEU8_HUMAN
Non-specific lipid-transfer protein
SCP2
32Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA03558 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10T → A in AAB41286 (PubMed:7698762).Curated1
Sequence conflicti56A → V in AK308105 (PubMed:14702039).Curated1
Sequence conflicti116V → A in AK308105 (PubMed:14702039).Curated1
Sequence conflicti341K → Q in BAG57810 (PubMed:14702039).Curated1
Sequence conflicti393G → D in AAB41286 (PubMed:7698762).Curated1
Sequence conflicti472A → D in AAB24921 (PubMed:1483685).Curated1
Sequence conflicti482K → Q in AAB24921 (PubMed:1483685).Curated1
Sequence conflicti501D → A in AAB24921 (PubMed:1483685).Curated1
Sequence conflicti522K → P in AAB24921 (PubMed:1483685).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035706155A → D in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0189771 – 404Missing in isoform SCP2, isoform 5 and isoform 6. 5 PublicationsAdd BLAST404
Alternative sequenceiVSP_0451871 – 81Missing in isoform 4. 1 PublicationAdd BLAST81
Alternative sequenceiVSP_04726743 – 66Missing in isoform 8. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_04268667 – 110Missing in isoform 3 and isoform 7. 2 PublicationsAdd BLAST44
Alternative sequenceiVSP_042687362 – 547LAQCA…GNAKL → GHSCS in isoform 3. 1 PublicationAdd BLAST186
Alternative sequenceiVSP_047268412 – 414Missing in isoform 6. 1 Publication3
Alternative sequenceiVSP_047269447 – 463EGEQF…FAFKV → IRRLTAQSQWLTQTSWL in isoform 5. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_047270464 – 547Missing in isoform 5. 1 PublicationAdd BLAST84

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U11313
, U11297, U11299, U11300, U11301, U11302, U11303, U11304, U11305, U11306, U11307, U11308, U11309, U11310, U11311, U11312 Genomic DNA Translation: AAB41286.1
M75883 mRNA Translation: AAA03557.1
M75884 mRNA Translation: AAA03558.1 Different initiation.
M55421 mRNA Translation: AAA03559.1
S52450 mRNA Translation: AAB24921.1
AK294631 mRNA Translation: BAG57810.1
AK295214 mRNA Translation: BAG58208.1
AK308105 mRNA No translation available.
CR995014 mRNA No translation available.
AC099677 Genomic DNA No translation available.
AL445183 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06760.1
CH471059 Genomic DNA Translation: EAX06761.1
BC005911 mRNA Translation: AAH05911.1
BC067108 mRNA Translation: AAH67108.1
CB997588 mRNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS30719.1 [P22307-5]
CCDS41338.1 [P22307-3]
CCDS44149.1 [P22307-2]
CCDS44150.1 [P22307-6]
CCDS53317.1 [P22307-7]
CCDS53318.1 [P22307-8]
CCDS53319.1 [P22307-4]
CCDS572.1 [P22307-1]

Protein sequence database of the Protein Information Resource

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PIRi
B40407
I38205

NCBI Reference Sequences

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RefSeqi
NP_001007099.1, NM_001007098.2 [P22307-3]
NP_001007100.1, NM_001007099.2 [P22307-2]
NP_001007101.1, NM_001007100.2 [P22307-6]
NP_001007251.1, NM_001007250.2 [P22307-5]
NP_001180528.1, NM_001193599.1 [P22307-8]
NP_001180546.1, NM_001193617.1 [P22307-4]
NP_002970.2, NM_002979.4 [P22307-1]
XP_016857535.1, XM_017002046.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.476365

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000371509; ENSP00000360564; ENSG00000116171 [P22307-7]
ENST00000371513; ENSP00000360568; ENSG00000116171 [P22307-3]
ENST00000371514; ENSP00000360569; ENSG00000116171 [P22307-1]
ENST00000407246; ENSP00000384569; ENSG00000116171 [P22307-8]
ENST00000408941; ENSP00000386214; ENSG00000116171 [P22307-5]
ENST00000430330; ENSP00000406636; ENSG00000116171 [P22307-6]
ENST00000435345; ENSP00000396413; ENSG00000116171 [P22307-2]
ENST00000488965; ENSP00000435783; ENSG00000116171 [P22307-5]
ENST00000528311; ENSP00000434132; ENSG00000116171 [P22307-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6342

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6342

UCSC genome browser

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UCSCi
uc001cuq.3 human [P22307-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11313
, U11297, U11299, U11300, U11301, U11302, U11303, U11304, U11305, U11306, U11307, U11308, U11309, U11310, U11311, U11312 Genomic DNA Translation: AAB41286.1
M75883 mRNA Translation: AAA03557.1
M75884 mRNA Translation: AAA03558.1 Different initiation.
M55421 mRNA Translation: AAA03559.1
S52450 mRNA Translation: AAB24921.1
AK294631 mRNA Translation: BAG57810.1
AK295214 mRNA Translation: BAG58208.1
AK308105 mRNA No translation available.
CR995014 mRNA No translation available.
AC099677 Genomic DNA No translation available.
AL445183 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06760.1
CH471059 Genomic DNA Translation: EAX06761.1
BC005911 mRNA Translation: AAH05911.1
BC067108 mRNA Translation: AAH67108.1
CB997588 mRNA No translation available.
CCDSiCCDS30719.1 [P22307-5]
CCDS41338.1 [P22307-3]
CCDS44149.1 [P22307-2]
CCDS44150.1 [P22307-6]
CCDS53317.1 [P22307-7]
CCDS53318.1 [P22307-8]
CCDS53319.1 [P22307-4]
CCDS572.1 [P22307-1]
PIRiB40407
I38205
RefSeqiNP_001007099.1, NM_001007098.2 [P22307-3]
NP_001007100.1, NM_001007099.2 [P22307-2]
NP_001007101.1, NM_001007100.2 [P22307-6]
NP_001007251.1, NM_001007250.2 [P22307-5]
NP_001180528.1, NM_001193599.1 [P22307-8]
NP_001180546.1, NM_001193617.1 [P22307-4]
NP_002970.2, NM_002979.4 [P22307-1]
XP_016857535.1, XM_017002046.1
UniGeneiHs.476365

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QNDNMR-A425-547[»]
2C0LX-ray2.30B426-547[»]
ProteinModelPortaliP22307
SMRiP22307
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112246, 40 interactors
ELMiP22307
IntActiP22307, 13 interactors
MINTiP22307
STRINGi9606.ENSP00000360569

Chemistry databases

BindingDBiP22307
ChEMBLiCHEMBL5950

PTM databases

iPTMnetiP22307
PhosphoSitePlusiP22307
SwissPalmiP22307

Polymorphism and mutation databases

BioMutaiSCP2
DMDMi2507456

2D gel databases

REPRODUCTION-2DPAGEiIPI00026105

Proteomic databases

EPDiP22307
MaxQBiP22307
PaxDbiP22307
PeptideAtlasiP22307
PRIDEiP22307
ProteomicsDBi53978
53979 [P22307-2]
53980 [P22307-3]
TopDownProteomicsiP22307-1 [P22307-1]
P22307-2 [P22307-2]
P22307-4 [P22307-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6342
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371509; ENSP00000360564; ENSG00000116171 [P22307-7]
ENST00000371513; ENSP00000360568; ENSG00000116171 [P22307-3]
ENST00000371514; ENSP00000360569; ENSG00000116171 [P22307-1]
ENST00000407246; ENSP00000384569; ENSG00000116171 [P22307-8]
ENST00000408941; ENSP00000386214; ENSG00000116171 [P22307-5]
ENST00000430330; ENSP00000406636; ENSG00000116171 [P22307-6]
ENST00000435345; ENSP00000396413; ENSG00000116171 [P22307-2]
ENST00000488965; ENSP00000435783; ENSG00000116171 [P22307-5]
ENST00000528311; ENSP00000434132; ENSG00000116171 [P22307-4]
GeneIDi6342
KEGGihsa:6342
UCSCiuc001cuq.3 human [P22307-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6342
DisGeNETi6342
EuPathDBiHostDB:ENSG00000116171.16

GeneCards: human genes, protein and diseases

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GeneCardsi
SCP2
HGNCiHGNC:10606 SCP2
HPAiHPA027101
HPA027135
HPA027317
MalaCardsiSCP2
MIMi184755 gene
613724 phenotype
neXtProtiNX_P22307
OpenTargetsiENSG00000116171
Orphaneti163684 Leukoencephalopathy-dystonia-motor neuropathy syndrome
PharmGKBiPA35014

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1406 Eukaryota
KOG4170 Eukaryota
ENOG410XPRW LUCA
GeneTreeiENSGT00940000154327
HOGENOMiHOG000221741
HOVERGENiHBG006506
InParanoidiP22307
KOiK08764
OMAiVEKMTDV
OrthoDBiEOG091G026S
PhylomeDBiP22307
TreeFamiTF300574

Enzyme and pathway databases

BioCyciMetaCyc:HS03991-MONOMER
BRENDAi2.3.1.176 2681
ReactomeiR-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-2046106 alpha-linolenic acid (ALA) metabolism
R-HSA-389887 Beta-oxidation of pristanoyl-CoA
R-HSA-9033241 Peroxisomal protein import
R-HSA-9033500 TYSND1 cleaves peroxisomal proteins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SCP2 human
EvolutionaryTraceiP22307

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SCP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6342

Protein Ontology

More...
PROi
PR:P22307

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000116171 Expressed in 239 organ(s), highest expression level in liver
CleanExiHS_SCP2
ExpressionAtlasiP22307 baseline and differential
GenevisibleiP22307 HS

Family and domain databases

Gene3Di3.30.1050.10, 1 hit
3.40.47.10, 1 hit
InterProiView protein in InterPro
IPR003033 SCP2_sterol-bd_dom
IPR036527 SCP2_sterol-bd_dom_sf
IPR016039 Thiolase-like
IPR020615 Thiolase_acyl_enz_int_AS
IPR020617 Thiolase_C
IPR020613 Thiolase_CS
IPR020616 Thiolase_N
PfamiView protein in Pfam
PF02036 SCP2, 1 hit
PF02803 Thiolase_C, 1 hit
PF00108 Thiolase_N, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
SSF55718 SSF55718, 1 hit
PROSITEiView protein in PROSITE
PS00098 THIOLASE_1, 1 hit
PS00737 THIOLASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNLTP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22307
Secondary accession number(s): A6NM69
, B4DGJ9, B4DHP6, C9JC79, D3DQ37, E1B6W5, F2Z3J1, Q15432, Q16622, Q5VVZ1, Q6NXF4, Q99430
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: November 1, 1997
Last modified: December 5, 2018
This is version 211 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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