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UniProtKB - P22303 (ACES_HUMAN)

Protein

Acetylcholinesterase

Gene

ACHE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.4 Publications

Catalytic activityi

Acetylcholine + H2O = choline + acetate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei117GalanthamineCombined sources1
Binding sitei117Huperzine ACombined sources1
Binding sitei153Huprine W; via amide nitrogenCombined sources1
Binding sitei164Huperzine ACombined sources1
Active sitei234Acyl-ester intermediate1
Binding sitei234Huprine WCombined sources1
Active sitei365Charge relay system1
Binding sitei368GalanthamineCombined sources1
Binding sitei368Huperzine ACombined sources1
Binding sitei470Huprine WCombined sources1
Active sitei478Charge relay system1
Binding sitei478Huprine W; via carbonyl oxygenCombined sources1

GO - Molecular functioni

  • acetylcholine binding Source: HGNC
  • acetylcholinesterase activity Source: HGNC
  • amyloid-beta binding Source: UniProtKB
  • carboxylic ester hydrolase activity Source: GO_Central
  • cholinesterase activity Source: HGNC
  • collagen binding Source: HGNC
  • hydrolase activity Source: HGNC
  • laminin binding Source: BHF-UCL
  • protein homodimerization activity Source: HGNC
  • protein self-association Source: Ensembl
  • serine hydrolase activity Source: HGNC
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionBlood group antigen, Hydrolase, Serine esterase
Biological processNeurotransmitter degradation

Enzyme and pathway databases

BRENDAi3.1.1.7 2681
ReactomeiR-HSA-112311 Neurotransmitter clearance
R-HSA-1483191 Synthesis of PC
R-HSA-422085 Synthesis, secretion, and deacylation of Ghrelin
SABIO-RKiP22303
SIGNORiP22303

Protein family/group databases

ESTHERihuman-ACHE AChE
MEROPSiS09.979

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholinesterase (EC:3.1.1.7)
Short name:
AChE
Gene namesi
Name:ACHE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000087085.13
HGNCiHGNC:108 ACHE
MIMi100740 gene+phenotype
neXtProtiNX_P22303

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Nucleus, Secreted, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi206D → N: Misfolding, absence of secretion. 1 Publication1
Mutagenesisi234S → A: Loss of activity. 1 Publication1
Mutagenesisi365E → A: Loss of activity. 1 Publication1
Mutagenesisi435D → N: Misfolding, absence of secretion. 1 Publication1
Mutagenesisi478H → A: Loss of activity. 1 Publication1
Mutagenesisi611C → A: Impairment of interchain disulfide bridge formation. 1 Publication1

Organism-specific databases

DisGeNETi43
MalaCardsiACHE
MIMi100740 gene+phenotype
112100 phenotype
OpenTargetsiENSG00000087085
PharmGKBiPA20

Chemistry databases

ChEMBLiCHEMBL220
DrugBankiDB04614 (R)-tacrine(10)-hupyridone
DB04615 (S)-tacrine(10)-hupyridone
DB02404 1-Deoxy-1-Thio-Heptaethylene Glycol
DB08357 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE
DB03814 2-(N-Morpholino)-Ethanesulfonic Acid
DB04556 3-[(1s)-1-(Dimethylamino)Ethyl]Phenol
DB03128 Acetylcholine
DB01122 Ambenonium
DB03283 beta-L-fucose
DB00122 Choline
DB01245 Decamethonium
DB00944 Demecarium
DB08996 Dimetacrine
DB00449 Dipivefrin
DB00843 Donepezil
DB01010 Edrophonium
DB01364 Ephedrine
DB00674 Galantamine
DB00483 Gallamine Triethiodide
DB04864 Huperzine A
DB03348 Huperzine B
DB05510 Huperzine-A
DB00677 Isoflurophate
DB00358 Mefloquine
DB09543 Methyl salicylate
DB02845 Methylphosphinic Acid
DB02825 Methylphosphonic Acid Ester Group
DB04021 MF268
DB00805 Minaprine
DB01805 Monoisopropylphosphorylserine
DB03740 N-acetyl-alpha-D-glucosamine
DB01400 Neostigmine
DB04892 Phenserine
DB00981 Physostigmine
DB00733 Pralidoxime
DB02166 Propidium
DB00545 Pyridostigmine
DB00989 Rivastigmine
DB00382 Tacrine
DB04616 TACRINE(8)-4-AMINOQUINOLINE
DB01199 Tubocurarine
DB04859 Zanapezil
GuidetoPHARMACOLOGYi2465

Polymorphism and mutation databases

BioMutaiACHE
DMDMi113037

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000000858732 – 614AcetylcholinesteraseAdd BLAST583

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi100 ↔ 127
Disulfide bondi288 ↔ 303
Glycosylationi296N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi381N-linked (GlcNAc...) asparagineCombined sources4 Publications1
Disulfide bondi440 ↔ 560
Glycosylationi495N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi611Interchain
Isoform H (identifier: P22303-2)
Lipidationi588GPI-anchor amidated glycineCurated1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiP22303
PaxDbiP22303
PeptideAtlasiP22303
PRIDEiP22303
ProteomicsDBi53971
53972 [P22303-2]
53973 [P22303-3]
53974 [P22303-4]

2D gel databases

SWISS-2DPAGEiP22303

PTM databases

iPTMnetiP22303
PhosphoSitePlusiP22303

Expressioni

Tissue specificityi

Isoform H is highly expressed in erythrocytes.1 Publication

Gene expression databases

BgeeiENSG00000087085 Expressed in 145 organ(s), highest expression level in hypothalamus
ExpressionAtlasiP22303 baseline and differential
GenevisibleiP22303 HS

Organism-specific databases

HPAiHPA019704
HPA027098

Interactioni

Subunit structurei

Interacts with PRIMA1. The interaction with PRIMA1 is required to anchor it to the basal lamina of cells and organize into tetramers (By similarity). Isoform H generates GPI-anchored dimers; disulfide linked. Isoform T generates multiple structures, ranging from monomers and dimers to collagen-tailed and hydrophobic-tailed forms, in which catalytic tetramers are associated with anchoring proteins that attach them to the basal lamina or to cell membranes. In the collagen-tailed forms, isoform T subunits are associated with a specific collagen, COLQ, which triggers the formation of isoform T tetramers, from monomers and dimers. Isoform R may be monomeric.By similarity2 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi106561, 2 interactors
DIPiDIP-1119N
ELMiP22303
IntActiP22303, 8 interactors
MINTiP22303
STRINGi9606.ENSP00000303211

Chemistry databases

BindingDBiP22303

Structurei

Secondary structure

1614
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP22303
SMRiP22303
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22303

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni233 – 234Galanthamine bindingCombined sources2

Sequence similaritiesi

Belongs to the type-B carboxylesterase/lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4389 Eukaryota
COG2272 LUCA
GeneTreeiENSGT00760000118946
HOVERGENiHBG008839
InParanoidiP22303
KOiK01049
OMAiHYSKQDR
OrthoDBiEOG091G0I4G
PhylomeDBiP22303
TreeFamiTF315470

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR014788 AChE_tetra
IPR002018 CarbesteraseB
IPR019826 Carboxylesterase_B_AS
IPR019819 Carboxylesterase_B_CS
IPR000997 Cholinesterase
PfamiView protein in Pfam
PF08674 AChE_tetra, 1 hit
PF00135 COesterase, 1 hit
PRINTSiPR00878 CHOLNESTRASE
ProDomiView protein in ProDom or Entries sharing at least one domain
PD415333 AChE_tetra, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00122 CARBOXYLESTERASE_B_1, 1 hit
PS00941 CARBOXYLESTERASE_B_2, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform T (identifier: P22303-1) [UniParc]FASTAAdd to basket
Also known as: ACHE-S, synaptic

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRPPQCLLHT PSLASPLLLL LLWLLGGGVG AEGREDAELL VTVRGGRLRG 
        60         70         80         90        100
IRLKTPGGPV SAFLGIPFAE PPMGPRRFLP PEPKQPWSGV VDATTFQSVC 
       110        120        130        140        150
YQYVDTLYPG FEGTEMWNPN RELSEDCLYL NVWTPYPRPT SPTPVLVWIY 
       160        170        180        190        200
GGGFYSGASS LDVYDGRFLV QAERTVLVSM NYRVGAFGFL ALPGSREAPG 
       210        220        230        240        250
NVGLLDQRLA LQWVQENVAA FGGDPTSVTL FGESAGAASV GMHLLSPPSR 
       260        270        280        290        300
GLFHRAVLQS GAPNGPWATV GMGEARRRAT QLAHLVGCPP GGTGGNDTEL 
       310        320        330        340        350
VACLRTRPAQ VLVNHEWHVL PQESVFRFSF VPVVDGDFLS DTPEALINAG 
       360        370        380        390        400
DFHGLQVLVG VVKDEGSYFL VYGAPGFSKD NESLISRAEF LAGVRVGVPQ 
       410        420        430        440        450
VSDLAAEAVV LHYTDWLHPE DPARLREALS DVVGDHNVVC PVAQLAGRLA 
       460        470        480        490        500
AQGARVYAYV FEHRASTLSW PLWMGVPHGY EIEFIFGIPL DPSRNYTAEE 
       510        520        530        540        550
KIFAQRLMRY WANFARTGDP NEPRDPKAPQ WPPYTAGAQQ YVSLDLRPLE 
       560        570        580        590        600
VRRGLRAQAC AFWNRFLPKL LSATDTLDEA ERQWKAEFHR WSSYMVHWKN 
       610 
QFDHYSKQDR CSDL
Length:614
Mass (Da):67,796
Last modified:August 1, 1991 - v1
Checksum:iB9AA84C77831C302
GO
Isoform H (identifier: P22303-2) [UniParc]FASTAAdd to basket
Also known as: ACHE-E, erythrocytic, E4-E5

The sequence of this isoform differs from the canonical sequence as follows:
     575-614: DTLDEAERQW...YSKQDRCSDL → ASEAPSTCPG...LLFLSHLRRL

Show »
Length:617
Mass (Da):67,376
Checksum:i7AC0B2536131A89D
GO
Isoform R (identifier: P22303-4) [UniParc]FASTAAdd to basket
Also known as: ACHE-R, readthrough

The sequence of this isoform differs from the canonical sequence as follows:
     575-603: DTLDEAERQWKAEFHRWSSYMVHWKNQFD → GMQGPAGSAGRRGVGARQCNPSLLPLASE
     604-614: Missing.

Show »
Length:603
Mass (Da):65,560
Checksum:i3B65B9B3390C6AB1
GO
Isoform 4 (identifier: P22303-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     357-444: Missing.

Note: No experimental confirmation available.
Show »
Length:526
Mass (Da):58,352
Checksum:iFB85F41EDFFF39DB
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JZL6C9JZL6_HUMAN
Carboxylic ester hydrolase
ACHE
434Annotation score:
F8WD68F8WD68_HUMAN
Carboxylic ester hydrolase
ACHE
403Annotation score:
F8WAR7F8WAR7_HUMAN
Carboxylic ester hydrolase
ACHE
359Annotation score:
C9J2S3C9J2S3_HUMAN
Carboxylic ester hydrolase
ACHE
397Annotation score:
C9JD78C9JD78_HUMAN
Acetylcholinesterase
ACHE
158Annotation score:
F8WD34F8WD34_HUMAN
Acetylcholinesterase
ACHE
55Annotation score:
Q6TQD3Q6TQD3_HUMAN
Acetylcholinesterase
ACHE
94Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti279A → T in BAD97163 (Ref. 5) Curated1
Sequence conflicti415D → G in BAD97163 (Ref. 5) Curated1
Sequence conflicti486F → L in AAI43470 (PubMed:15489334).Curated1
Isoform H (identifier: P22303-2)
Sequence conflicti592P → R in AAI43470 (PubMed:15489334).Curated1 Publication1

Polymorphismi

ACHE is responsible for the Yt blood group system [MIMi:112100]. The molecular basis of the Yt(a)=Yt1/Yt(b)=Yt2 blood group antigens is a single variation in position 353; His-353 corresponds to Yt(a) and the rare variant with Asn-353 to Yt(b).

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02132534R → Q1 PublicationCorresponds to variant dbSNP:rs17881553Ensembl.1
Natural variantiVAR_021326135P → A1 PublicationCorresponds to variant dbSNP:rs17885778Ensembl.1
Natural variantiVAR_011934333V → E. Corresponds to variant dbSNP:rs8286Ensembl.1
Natural variantiVAR_002359353H → N in Yt(b) antigen. 2 PublicationsCorresponds to variant dbSNP:rs1799805EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_035568357 – 444Missing in isoform 4. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_001457575 – 614DTLDE…RCSDL → ASEAPSTCPGFTHGEAAPRP GLPLPLLLLHQLLLLFLSHL RRL in isoform H. 2 PublicationsAdd BLAST40
Alternative sequenceiVSP_035569575 – 603DTLDE…KNQFD → GMQGPAGSAGRRGVGARQCN PSLLPLASE in isoform R. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_035570604 – 614Missing in isoform R. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55040 mRNA Translation: AAA68151.1
S71129 Genomic DNA Translation: AAC60618.1 Sequence problems.
AF334270 mRNA Translation: AAO32948.1
AK291321 mRNA Translation: BAF84010.1
AK223443 mRNA Translation: BAD97163.1
AY750146 Genomic DNA Translation: AAU43801.1
AC011895 Genomic DNA Translation: AAP22364.1
AC011895 Genomic DNA Translation: AAP22365.1
CH236956 Genomic DNA Translation: EAL23812.1
CH236956 Genomic DNA Translation: EAL23813.1
CH471091 Genomic DNA Translation: EAW76461.1
CH471091 Genomic DNA Translation: EAW76463.1
CH471091 Genomic DNA Translation: EAW76462.1
BC036813 mRNA Translation: AAH36813.1
BC105060 mRNA Translation: AAI05061.1
BC105062 mRNA Translation: AAI05063.1
BC143469 mRNA Translation: AAI43470.1
AF312032 Genomic DNA Translation: AAK21003.1
CCDSiCCDS5709.1 [P22303-1]
CCDS5710.1 [P22303-2]
CCDS64736.1 [P22303-3]
PIRiA39256
RefSeqiNP_000656.1, NM_000665.4 [P22303-1]
NP_001269378.1, NM_001282449.1 [P22303-3]
NP_001289550.1, NM_001302621.1 [P22303-2]
NP_001289551.1, NM_001302622.1 [P22303-1]
NP_056646.1, NM_015831.2
XP_006716058.1, XM_006715995.2 [P22303-2]
XP_011514530.1, XM_011516228.2 [P22303-2]
XP_011514531.1, XM_011516229.2 [P22303-2]
UniGeneiHs.154495

Genome annotation databases

EnsembliENST00000241069; ENSP00000241069; ENSG00000087085 [P22303-1]
ENST00000302913; ENSP00000303211; ENSG00000087085 [P22303-2]
ENST00000411582; ENSP00000404865; ENSG00000087085 [P22303-2]
ENST00000412389; ENSP00000394976; ENSG00000087085 [P22303-1]
ENST00000419336; ENSP00000403474; ENSG00000087085 [P22303-3]
ENST00000428317; ENSP00000414858; ENSG00000087085 [P22303-1]
GeneIDi43
KEGGihsa:43
UCSCiuc003uxd.4 human [P22303-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

Wikipedia

Acetylcholinesterase entry

SeattleSNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55040 mRNA Translation: AAA68151.1
S71129 Genomic DNA Translation: AAC60618.1 Sequence problems.
AF334270 mRNA Translation: AAO32948.1
AK291321 mRNA Translation: BAF84010.1
AK223443 mRNA Translation: BAD97163.1
AY750146 Genomic DNA Translation: AAU43801.1
AC011895 Genomic DNA Translation: AAP22364.1
AC011895 Genomic DNA Translation: AAP22365.1
CH236956 Genomic DNA Translation: EAL23812.1
CH236956 Genomic DNA Translation: EAL23813.1
CH471091 Genomic DNA Translation: EAW76461.1
CH471091 Genomic DNA Translation: EAW76463.1
CH471091 Genomic DNA Translation: EAW76462.1
BC036813 mRNA Translation: AAH36813.1
BC105060 mRNA Translation: AAI05061.1
BC105062 mRNA Translation: AAI05063.1
BC143469 mRNA Translation: AAI43470.1
AF312032 Genomic DNA Translation: AAK21003.1
CCDSiCCDS5709.1 [P22303-1]
CCDS5710.1 [P22303-2]
CCDS64736.1 [P22303-3]
PIRiA39256
RefSeqiNP_000656.1, NM_000665.4 [P22303-1]
NP_001269378.1, NM_001282449.1 [P22303-3]
NP_001289550.1, NM_001302621.1 [P22303-2]
NP_001289551.1, NM_001302622.1 [P22303-1]
NP_056646.1, NM_015831.2
XP_006716058.1, XM_006715995.2 [P22303-2]
XP_011514530.1, XM_011516228.2 [P22303-2]
XP_011514531.1, XM_011516229.2 [P22303-2]
UniGeneiHs.154495

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B41X-ray2.76A36-574[»]
1F8UX-ray2.90A32-614[»]
1PUVmodel-A37-574[»]
1PUWmodel-A37-574[»]
1VZJX-ray2.35A/B/C/D/E/F/G/H575-614[»]
2CLJmodel-A32-574[»]
2X8BX-ray2.95A32-614[»]
3LIIX-ray3.20A/B35-574[»]
4BDTX-ray3.10A32-614[»]
4EY4X-ray2.16A/B33-574[»]
4EY5X-ray2.30A/B33-574[»]
4EY6X-ray2.40A/B33-574[»]
4EY7X-ray2.35A/B33-574[»]
4EY8X-ray2.60A33-574[»]
4M0EX-ray2.00A/B33-574[»]
4M0FX-ray2.30A/B33-574[»]
4PQEX-ray2.90A32-574[»]
5FOQX-ray2.30A/B32-576[»]
5FPQX-ray2.40A/B33-574[»]
5HF5X-ray2.15A/B33-574[»]
5HF6X-ray2.30A/B33-574[»]
5HF8X-ray2.80A/B33-574[»]
5HF9X-ray2.20A/B33-574[»]
5HFAX-ray2.20A/B33-574[»]
ProteinModelPortaliP22303
SMRiP22303
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106561, 2 interactors
DIPiDIP-1119N
ELMiP22303
IntActiP22303, 8 interactors
MINTiP22303
STRINGi9606.ENSP00000303211

Chemistry databases

BindingDBiP22303
ChEMBLiCHEMBL220
DrugBankiDB04614 (R)-tacrine(10)-hupyridone
DB04615 (S)-tacrine(10)-hupyridone
DB02404 1-Deoxy-1-Thio-Heptaethylene Glycol
DB08357 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE
DB03814 2-(N-Morpholino)-Ethanesulfonic Acid
DB04556 3-[(1s)-1-(Dimethylamino)Ethyl]Phenol
DB03128 Acetylcholine
DB01122 Ambenonium
DB03283 beta-L-fucose
DB00122 Choline
DB01245 Decamethonium
DB00944 Demecarium
DB08996 Dimetacrine
DB00449 Dipivefrin
DB00843 Donepezil
DB01010 Edrophonium
DB01364 Ephedrine
DB00674 Galantamine
DB00483 Gallamine Triethiodide
DB04864 Huperzine A
DB03348 Huperzine B
DB05510 Huperzine-A
DB00677 Isoflurophate
DB00358 Mefloquine
DB09543 Methyl salicylate
DB02845 Methylphosphinic Acid
DB02825 Methylphosphonic Acid Ester Group
DB04021 MF268
DB00805 Minaprine
DB01805 Monoisopropylphosphorylserine
DB03740 N-acetyl-alpha-D-glucosamine
DB01400 Neostigmine
DB04892 Phenserine
DB00981 Physostigmine
DB00733 Pralidoxime
DB02166 Propidium
DB00545 Pyridostigmine
DB00989 Rivastigmine
DB00382 Tacrine
DB04616 TACRINE(8)-4-AMINOQUINOLINE
DB01199 Tubocurarine
DB04859 Zanapezil
GuidetoPHARMACOLOGYi2465

Protein family/group databases

ESTHERihuman-ACHE AChE
MEROPSiS09.979

PTM databases

iPTMnetiP22303
PhosphoSitePlusiP22303

Polymorphism and mutation databases

BioMutaiACHE
DMDMi113037

2D gel databases

SWISS-2DPAGEiP22303

Proteomic databases

EPDiP22303
PaxDbiP22303
PeptideAtlasiP22303
PRIDEiP22303
ProteomicsDBi53971
53972 [P22303-2]
53973 [P22303-3]
53974 [P22303-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000241069; ENSP00000241069; ENSG00000087085 [P22303-1]
ENST00000302913; ENSP00000303211; ENSG00000087085 [P22303-2]
ENST00000411582; ENSP00000404865; ENSG00000087085 [P22303-2]
ENST00000412389; ENSP00000394976; ENSG00000087085 [P22303-1]
ENST00000419336; ENSP00000403474; ENSG00000087085 [P22303-3]
ENST00000428317; ENSP00000414858; ENSG00000087085 [P22303-1]
GeneIDi43
KEGGihsa:43
UCSCiuc003uxd.4 human [P22303-1]

Organism-specific databases

CTDi43
DisGeNETi43
EuPathDBiHostDB:ENSG00000087085.13
GeneCardsiACHE
HGNCiHGNC:108 ACHE
HPAiHPA019704
HPA027098
MalaCardsiACHE
MIMi100740 gene+phenotype
112100 phenotype
neXtProtiNX_P22303
OpenTargetsiENSG00000087085
PharmGKBiPA20
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4389 Eukaryota
COG2272 LUCA
GeneTreeiENSGT00760000118946
HOVERGENiHBG008839
InParanoidiP22303
KOiK01049
OMAiHYSKQDR
OrthoDBiEOG091G0I4G
PhylomeDBiP22303
TreeFamiTF315470

Enzyme and pathway databases

BRENDAi3.1.1.7 2681
ReactomeiR-HSA-112311 Neurotransmitter clearance
R-HSA-1483191 Synthesis of PC
R-HSA-422085 Synthesis, secretion, and deacylation of Ghrelin
SABIO-RKiP22303
SIGNORiP22303

Miscellaneous databases

ChiTaRSiACHE human
EvolutionaryTraceiP22303
GeneWikiiAcetylcholinesterase
GenomeRNAii43
PROiPR:P22303
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000087085 Expressed in 145 organ(s), highest expression level in hypothalamus
ExpressionAtlasiP22303 baseline and differential
GenevisibleiP22303 HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR014788 AChE_tetra
IPR002018 CarbesteraseB
IPR019826 Carboxylesterase_B_AS
IPR019819 Carboxylesterase_B_CS
IPR000997 Cholinesterase
PfamiView protein in Pfam
PF08674 AChE_tetra, 1 hit
PF00135 COesterase, 1 hit
PRINTSiPR00878 CHOLNESTRASE
ProDomiView protein in ProDom or Entries sharing at least one domain
PD415333 AChE_tetra, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00122 CARBOXYLESTERASE_B_1, 1 hit
PS00941 CARBOXYLESTERASE_B_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACES_HUMAN
AccessioniPrimary (citable) accession number: P22303
Secondary accession number(s): A4D2E2
, B7ZKZ0, D6W5X7, Q16169, Q29S23, Q2M324, Q504V3, Q53F46, Q86TM9, Q86YX9, Q9BXP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: November 7, 2018
This is version 202 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  7. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
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Main funding by: National Institutes of Health

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