UniProtKB - P22303 (ACES_HUMAN)
Acetylcholinesterase
ACHE
Functioni
Catalytic activityi
- EC:3.1.1.7
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 117 | GalanthamineCombined sources | 1 | |
Binding sitei | 117 | Huperzine ACombined sources | 1 | |
Binding sitei | 153 | Huprine W; via amide nitrogenCombined sources | 1 | |
Binding sitei | 164 | Huperzine ACombined sources | 1 | |
Active sitei | 234 | Acyl-ester intermediate | 1 | |
Binding sitei | 234 | Huprine WCombined sources | 1 | |
Active sitei | 365 | Charge relay system | 1 | |
Binding sitei | 368 | GalanthamineCombined sources | 1 | |
Binding sitei | 368 | Huperzine ACombined sources | 1 | |
Binding sitei | 470 | Huprine WCombined sources | 1 | |
Active sitei | 478 | Charge relay system | 1 | |
Binding sitei | 478 | Huprine W; via carbonyl oxygenCombined sources | 1 |
GO - Molecular functioni
- acetylcholine binding Source: HGNC-UCL
- acetylcholinesterase activity Source: HGNC-UCL
- amyloid-beta binding Source: UniProtKB
- carboxylic ester hydrolase activity Source: GO_Central
- cholinesterase activity Source: HGNC-UCL
- collagen binding Source: HGNC-UCL
- hydrolase activity Source: HGNC-UCL
- laminin binding Source: BHF-UCL
- protein homodimerization activity Source: HGNC-UCL
- protein self-association Source: Ensembl
- serine hydrolase activity Source: HGNC-UCL
GO - Biological processi
- acetylcholine catabolic process Source: HGNC-UCL
- acetylcholine catabolic process in synaptic cleft Source: UniProtKB
- acetylcholine receptor signaling pathway Source: Ensembl
- amyloid precursor protein metabolic process Source: UniProtKB
- cell adhesion Source: HGNC-UCL
- negative regulation of synaptic transmission, cholinergic Source: HGNC-UCL
- nervous system development Source: UniProtKB
- neurotransmitter biosynthetic process Source: Reactome
- osteoblast development Source: HGNC-UCL
- phosphatidylcholine biosynthetic process Source: Reactome
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of protein secretion Source: UniProtKB
- receptor internalization Source: Ensembl
- regulation of receptor recycling Source: Ensembl
- retina development in camera-type eye Source: Ensembl
- synapse assembly Source: UniProtKB
Keywordsi
Molecular function | Blood group antigen, Hydrolase, Serine esterase |
Biological process | Neurotransmitter degradation |
Enzyme and pathway databases
BRENDAi | 3.1.1.7, 2681 |
PathwayCommonsi | P22303 |
Reactomei | R-HSA-112311, Neurotransmitter clearance R-HSA-1483191, Synthesis of PC R-HSA-422085, Synthesis, secretion, and deacylation of Ghrelin |
SABIO-RKi | P22303 |
SIGNORi | P22303 |
Protein family/group databases
ESTHERi | human-ACHE, AChE |
MEROPSi | S09.979 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ACHE |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:108, ACHE |
MIMi | 100740, gene+phenotype |
neXtProti | NX_P22303 |
VEuPathDBi | HostDB:ENSG00000087085.13 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity
Extracellular region or secreted
- Secreted By similarity
Other locations
- synapse 2 Publications
Nucleus
Note: Only observed in apoptotic nuclei.
Plasma membrane
- Cell membrane By similarity; GPI-anchor By similarity; Extracellular side By similarity
Extracellular region or secreted
- extracellular region Source: HGNC-UCL
- extracellular space Source: GO_Central
- synaptic cleft Source: GOC
Golgi apparatus
- Golgi apparatus Source: HGNC-UCL
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- anchored component of membrane Source: UniProtKB-KW
- basement membrane Source: HGNC-UCL
- cell surface Source: Ensembl
- membrane Source: HGNC-UCL
- neuromuscular junction Source: Ensembl
- perinuclear region of cytoplasm Source: HGNC-UCL
- synapse Source: HGNC-UCL
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Nucleus, Secreted, SynapsePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 206 | D → N: Misfolding, absence of secretion. 1 Publication | 1 | |
Mutagenesisi | 234 | S → A: Loss of activity. 1 Publication | 1 | |
Mutagenesisi | 365 | E → A: Loss of activity. 1 Publication | 1 | |
Mutagenesisi | 435 | D → N: Misfolding, absence of secretion. 1 Publication | 1 | |
Mutagenesisi | 478 | H → A: Loss of activity. 1 Publication | 1 | |
Mutagenesisi | 611 | C → A: Impairment of interchain disulfide bridge formation. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 43 |
MalaCardsi | ACHE |
MIMi | 100740, gene+phenotype 112100, phenotype |
OpenTargetsi | ENSG00000087085 |
PharmGKBi | PA20 |
Miscellaneous databases
Pharosi | P22303, Tclin |
Chemistry databases
ChEMBLi | CHEMBL220 |
DrugBanki | DB07846, (3,4,8b-Trimethyl-3-oxido-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-3-ium-7-yl) N-(2-ethylphenyl)carbamate DB02673, (4aS,6R,8aS)-11-[8-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)octyl]-6-hydroxy-3-methoxy-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium DB04617, (9S)-9-[(8-AMMONIOOCTYL)AMINO]-1,2,3,4,9,10-HEXAHYDROACRIDINIUM DB04614, (R)-tacrine(10)-hupyridone DB04615, (S)-tacrine(10)-hupyridone DB07756, 1-[3-({[(4-AMINO-5-FLUORO-2-METHYLQUINOLIN-3-YL)METHYL]THIO}METHYL)PHENYL]-2,2,2-TRIFLUOROETHANE-1,1-DIOL DB07701, 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE DB02404, 1-Deoxy-1-Thio-Heptaethylene Glycol DB03814, 2-(N-morpholino)ethanesulfonic acid DB08615, 2-[4-(DIMETHYLAMINO)PHENYL]-6-HYDROXY-3-METHYL-1,3-BENZOTHIAZOL-3-IUM DB02343, 3,6,9,12,15-Pentaoxaheptadecane DB02226, 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-4-Yl]Hexyl]-Phenanthridinium DB03005, 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-5-Yl]Hexyl]-Phenanthridinium DB04114, 3-Chloro-9-Ethyl-6,7,8,9,10,11-Hexahydro-7,11-Methanocycloocta[B]Quinolin-12-Amine DB03128, Acetylcholine DB01122, Ambenonium DB03283, beta-L-fucose DB00411, Carbamoylcholine DB00122, Choline DB14006, Choline salicylate DB01245, Decamethonium DB00944, Demecarium DB08357, Diethylene glycol diethyl ether DB08996, Dimetacrine DB00449, Dipivefrin DB00843, Donepezil DB01010, Edrophonium DB01364, Ephedrine DB00674, Galantamine DB00483, Gallamine triethiodide DB06525, Ganstigmine DB04864, Huperzine A DB03348, Huperzine B DB07555, Hydroxy(oxo)(2-{(1S)-2,2,2-trifluoro-1-[2-(trimethylarsonio)ethoxy]ethyl}phenyl)ammonium DB00677, Isoflurophate DB04924, Itopride DB03359, M-(N,N,N-Trimethylammonio)-2,2,2-Trifluoro-1,1-Dihydroxyethylbenzene DB00358, Mefloquine DB00940, Methantheline DB02825, Methylphosphinate DB02845, Methylphosphinic Acid DB08167, Methylthioninium DB04021, MF268 DB00805, Minaprine DB01805, Monoisopropylphosphorylserine DB03740, N-acetyl-alpha-D-glucosamine DB04556, NAP-226-90 DB01400, Neostigmine DB04892, Phenserine DB00981, Physostigmine DB00733, Pralidoxime DB02166, Propidium DB00545, Pyridostigmine DB00863, Ranitidine DB00989, Rivastigmine DB00382, Tacrine DB04616, TACRINE(8)-4-AMINOQUINOLINE DB01199, Tubocurarine DB13503, Tyrothricin DB04859, Zanapezil |
DrugCentrali | P22303 |
GuidetoPHARMACOLOGYi | 2465 |
Genetic variation databases
BioMutai | ACHE |
DMDMi | 113037 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | Sequence analysisAdd BLAST | 31 | |
ChainiPRO_0000008587 | 32 – 614 | AcetylcholinesteraseAdd BLAST | 583 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Disulfide bondi | 100 ↔ 127 | ||||
Disulfide bondi | 288 ↔ 303 | ||||
Glycosylationi | 296 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 | ||
Glycosylationi | 381 | N-linked (GlcNAc...) asparagineCombined sources4 Publications | 1 | ||
Disulfide bondi | 440 ↔ 560 | ||||
Glycosylationi | 495 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 | ||
Disulfide bondi | 611 | Interchain | |||
Isoform H (identifier: P22303-2) | |||||
Lipidationi | 588 | GPI-anchor amidated glycine1 Publication | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, GPI-anchor, LipoproteinProteomic databases
jPOSTi | P22303 |
MassIVEi | P22303 |
PaxDbi | P22303 |
PeptideAtlasi | P22303 |
PRIDEi | P22303 |
ProteomicsDBi | 53971 [P22303-1] 53972 [P22303-2] 53973 [P22303-3] 53974 [P22303-4] |
2D gel databases
SWISS-2DPAGEi | P22303 |
PTM databases
GlyGeni | P22303, 3 sites |
iPTMneti | P22303 |
PhosphoSitePlusi | P22303 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000087085, Expressed in hypothalamus and 159 other tissues |
ExpressionAtlasi | P22303, baseline and differential |
Genevisiblei | P22303, HS |
Organism-specific databases
HPAi | ENSG00000087085, Group enriched (brain, skeletal muscle) |
Interactioni
Subunit structurei
Interacts with PRIMA1. The interaction with PRIMA1 is required to anchor it to the basal lamina of cells and organize into tetramers (By similarity). Isoform H generates GPI-anchored dimers; disulfide linked. Isoform T generates multiple structures, ranging from monomers and dimers to collagen-tailed and hydrophobic-tailed forms, in which catalytic tetramers are associated with anchoring proteins that attach them to the basal lamina or to cell membranes. In the collagen-tailed forms, isoform T subunits are associated with a specific collagen, COLQ, which triggers the formation of isoform T tetramers, from monomers and dimers. Isoform R may be monomeric.
By similarity2 PublicationsBinary interactionsi
Hide detailsP22303
With | #Exp. | IntAct |
---|---|---|
COLQ [Q9Y215] | 2 | EBI-1637793,EBI-1637847 |
ENO1 [P06733] | 2 | EBI-1637793,EBI-353877 |
RACK1 [P63244] | 2 | EBI-1637793,EBI-296739 |
GO - Molecular functioni
- laminin binding Source: BHF-UCL
- protein homodimerization activity Source: HGNC-UCL
- protein self-association Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 106561, 2 interactors |
DIPi | DIP-1119N |
ELMi | P22303 |
IntActi | P22303, 8 interactors |
MINTi | P22303 |
STRINGi | 9606.ENSP00000303211 |
Chemistry databases
BindingDBi | P22303 |
Miscellaneous databases
RNActi | P22303, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P22303 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P22303 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 233 – 234 | Galanthamine bindingCombined sources | 2 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG4389, Eukaryota |
GeneTreei | ENSGT00940000157637 |
HOGENOMi | CLU_006586_13_0_1 |
InParanoidi | P22303 |
OMAi | PWCPLHT |
OrthoDBi | 754103at2759 |
PhylomeDBi | P22303 |
TreeFami | TF315470 |
Family and domain databases
DisProti | DP01964 |
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR014788, AChE_tetra IPR002018, CarbesteraseB IPR019826, Carboxylesterase_B_AS IPR019819, Carboxylesterase_B_CS IPR000997, Cholinesterase |
Pfami | View protein in Pfam PF08674, AChE_tetra, 1 hit PF00135, COesterase, 1 hit |
PRINTSi | PR00878, CHOLNESTRASE |
SUPFAMi | SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00122, CARBOXYLESTERASE_B_1, 1 hit PS00941, CARBOXYLESTERASE_B_2, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRPPQCLLHT PSLASPLLLL LLWLLGGGVG AEGREDAELL VTVRGGRLRG
60 70 80 90 100
IRLKTPGGPV SAFLGIPFAE PPMGPRRFLP PEPKQPWSGV VDATTFQSVC
110 120 130 140 150
YQYVDTLYPG FEGTEMWNPN RELSEDCLYL NVWTPYPRPT SPTPVLVWIY
160 170 180 190 200
GGGFYSGASS LDVYDGRFLV QAERTVLVSM NYRVGAFGFL ALPGSREAPG
210 220 230 240 250
NVGLLDQRLA LQWVQENVAA FGGDPTSVTL FGESAGAASV GMHLLSPPSR
260 270 280 290 300
GLFHRAVLQS GAPNGPWATV GMGEARRRAT QLAHLVGCPP GGTGGNDTEL
310 320 330 340 350
VACLRTRPAQ VLVNHEWHVL PQESVFRFSF VPVVDGDFLS DTPEALINAG
360 370 380 390 400
DFHGLQVLVG VVKDEGSYFL VYGAPGFSKD NESLISRAEF LAGVRVGVPQ
410 420 430 440 450
VSDLAAEAVV LHYTDWLHPE DPARLREALS DVVGDHNVVC PVAQLAGRLA
460 470 480 490 500
AQGARVYAYV FEHRASTLSW PLWMGVPHGY EIEFIFGIPL DPSRNYTAEE
510 520 530 540 550
KIFAQRLMRY WANFARTGDP NEPRDPKAPQ WPPYTAGAQQ YVSLDLRPLE
560 570 580 590 600
VRRGLRAQAC AFWNRFLPKL LSATDTLDEA ERQWKAEFHR WSSYMVHWKN
610
QFDHYSKQDR CSDL
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J2S3 | C9J2S3_HUMAN | Carboxylic ester hydrolase | ACHE | 397 | Annotation score: | ||
C9JZL6 | C9JZL6_HUMAN | Carboxylic ester hydrolase | ACHE | 434 | Annotation score: | ||
F8WAR7 | F8WAR7_HUMAN | Carboxylic ester hydrolase | ACHE | 359 | Annotation score: | ||
F8WD68 | F8WD68_HUMAN | Carboxylic ester hydrolase | ACHE | 403 | Annotation score: | ||
C9JD78 | C9JD78_HUMAN | Acetylcholinesterase | ACHE | 158 | Annotation score: | ||
A0A498U6H7 | A0A498U6H7_HUMAN | Acetylcholinesterase | ACHE | 28 | Annotation score: | ||
F8WD34 | F8WD34_HUMAN | Acetylcholinesterase | ACHE | 55 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 279 | A → T in BAD97163 (Ref. 5) Curated | 1 | ||
Sequence conflicti | 415 | D → G in BAD97163 (Ref. 5) Curated | 1 | ||
Sequence conflicti | 486 | F → L in AAI43470 (PubMed:15489334).Curated | 1 | ||
Isoform H (identifier: P22303-2) | |||||
Sequence conflicti | 592 | P → R in AAI43470 (PubMed:15489334).Curated | 1 |
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021325 | 34 | R → Q1 PublicationCorresponds to variant dbSNP:rs17881553EnsemblClinVar. | 1 | |
Natural variantiVAR_021326 | 135 | P → A1 PublicationCorresponds to variant dbSNP:rs17885778EnsemblClinVar. | 1 | |
Natural variantiVAR_011934 | 333 | V → E. Corresponds to variant dbSNP:rs8286Ensembl. | 1 | |
Natural variantiVAR_002359 | 353 | H → N in Yt(b) antigen. 2 PublicationsCorresponds to variant dbSNP:rs1799805EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035568 | 357 – 444 | Missing in isoform 4. 1 PublicationAdd BLAST | 88 | |
Alternative sequenceiVSP_001457 | 575 – 614 | DTLDE…RCSDL → ASEAPSTCPGFTHGEAAPRP GLPLPLLLLHQLLLLFLSHL RRL in isoform H. 2 PublicationsAdd BLAST | 40 | |
Alternative sequenceiVSP_035569 | 575 – 603 | DTLDE…KNQFD → GMQGPAGSAGRRGVGARQCN PSLLPLASE in isoform R. 1 PublicationAdd BLAST | 29 | |
Alternative sequenceiVSP_035570 | 604 – 614 | Missing in isoform R. 1 PublicationAdd BLAST | 11 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000241069; ENSP00000241069; ENSG00000087085 [P22303-1] ENST00000302913; ENSP00000303211; ENSG00000087085 [P22303-2] ENST00000411582; ENSP00000404865; ENSG00000087085 [P22303-2] ENST00000412389; ENSP00000394976; ENSG00000087085 [P22303-1] ENST00000419336; ENSP00000403474; ENSG00000087085 [P22303-3] ENST00000428317; ENSP00000414858; ENSG00000087085 [P22303-1] |
GeneIDi | 43 |
KEGGi | hsa:43 |
UCSCi | uc003uxd.4, human [P22303-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
dbRBC/BGMUT Blood group antigen gene mutation database |
Wikipedia Acetylcholinesterase entry |
SeattleSNPs |
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1B41 | X-ray | 2.76 | A | 36-574 | [»] | |
1F8U | X-ray | 2.90 | A | 32-614 | [»] | |
1PUV | model | - | A | 37-574 | [»] | |
1PUW | model | - | A | 37-574 | [»] | |
1VZJ | X-ray | 2.35 | A/B/C/D/E/F/G/H | 575-614 | [»] | |
2CLJ | model | - | A | 32-574 | [»] | |
2X8B | X-ray | 2.95 | A | 32-614 | [»] | |
3LII | X-ray | 3.20 | A/B | 35-574 | [»] | |
4BDT | X-ray | 3.10 | A | 32-614 | [»] | |
4EY4 | X-ray | 2.16 | A/B | 33-574 | [»] | |
4EY5 | X-ray | 2.30 | A/B | 33-574 | [»] | |
4EY6 | X-ray | 2.40 | A/B | 33-574 | [»] | |
4EY7 | X-ray | 2.35 | A/B | 33-574 | [»] | |
4EY8 | X-ray | 2.60 | A | 33-574 | [»] | |
4M0E | X-ray | 2.00 | A/B | 33-574 | [»] | |
4M0F | X-ray | 2.30 | A/B | 33-574 | [»] | |
4PQE | X-ray | 2.90 | A | 32-574 | [»] | |
5FOQ | X-ray | 2.30 | A/B | 32-576 | [»] | |
5FPQ | X-ray | 2.40 | A/B | 33-574 | [»] | |
5HF5 | X-ray | 2.15 | A/B | 33-574 | [»] | |
5HF6 | X-ray | 2.30 | A/B | 33-574 | [»] | |
5HF8 | X-ray | 2.80 | A/B | 33-574 | [»] | |
5HF9 | X-ray | 2.20 | A/B | 33-574 | [»] | |
5HFA | X-ray | 2.20 | A/B | 33-574 | [»] | |
6CQT | X-ray | 2.27 | A/B | 33-574 | [»] | |
6CQU | X-ray | 2.31 | A/B | 33-574 | [»] | |
6CQV | X-ray | 2.60 | A/B | 33-574 | [»] | |
6CQW | X-ray | 2.28 | A/B | 33-574 | [»] | |
6CQX | X-ray | 2.40 | A/B | 33-574 | [»] | |
6CQY | X-ray | 2.45 | A/B | 33-574 | [»] | |
6CQZ | X-ray | 2.22 | A/B | 33-574 | [»] | |
6F25 | X-ray | 3.05 | A/B | 36-574 | [»] | |
6NEA | X-ray | 2.42 | A/B | 33-574 | [»] | |
6NTG | X-ray | 2.65 | A/B | 33-574 | [»] | |
6NTH | X-ray | 2.42 | A/B | 33-574 | [»] | |
6NTK | X-ray | 2.41 | A/B | 33-574 | [»] | |
6NTL | X-ray | 2.25 | A/B | 33-574 | [»] | |
6NTM | X-ray | 2.55 | A/B | 33-574 | [»] | |
6NTN | X-ray | 2.70 | A/B | 33-574 | [»] | |
6NTO | X-ray | 2.05 | A/B | 33-574 | [»] | |
6O4W | X-ray | 2.35 | A/B | 32-578 | [»] | |
6O4X | X-ray | 2.30 | A/B | 32-578 | [»] | |
6O50 | X-ray | 2.35 | A/B | 32-578 | [»] | |
6O52 | X-ray | 3.20 | A/B | 32-578 | [»] | |
6O5R | X-ray | 2.80 | A/B | 32-578 | [»] | |
6O5S | X-ray | 2.80 | A/B | 32-578 | [»] | |
6O5V | X-ray | 2.15 | A/B | 32-578 | [»] | |
6O66 | X-ray | 2.45 | A/B | 32-578 | [»] | |
6O69 | X-ray | 2.08 | A | 33-574 | [»] | |
6U34 | X-ray | 2.40 | A/B | 35-578 | [»] | |
6U37 | X-ray | 2.25 | A/B | 32-578 | [»] | |
6U3P | X-ray | 3.00 | A/B | 32-578 | [»] | |
SMRi | P22303 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 106561, 2 interactors |
DIPi | DIP-1119N |
ELMi | P22303 |
IntActi | P22303, 8 interactors |
MINTi | P22303 |
STRINGi | 9606.ENSP00000303211 |
Chemistry databases
BindingDBi | P22303 |
ChEMBLi | CHEMBL220 |
DrugBanki | DB07846, (3,4,8b-Trimethyl-3-oxido-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-3-ium-7-yl) N-(2-ethylphenyl)carbamate DB02673, (4aS,6R,8aS)-11-[8-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)octyl]-6-hydroxy-3-methoxy-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium DB04617, (9S)-9-[(8-AMMONIOOCTYL)AMINO]-1,2,3,4,9,10-HEXAHYDROACRIDINIUM DB04614, (R)-tacrine(10)-hupyridone DB04615, (S)-tacrine(10)-hupyridone DB07756, 1-[3-({[(4-AMINO-5-FLUORO-2-METHYLQUINOLIN-3-YL)METHYL]THIO}METHYL)PHENYL]-2,2,2-TRIFLUOROETHANE-1,1-DIOL DB07701, 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE DB02404, 1-Deoxy-1-Thio-Heptaethylene Glycol DB03814, 2-(N-morpholino)ethanesulfonic acid DB08615, 2-[4-(DIMETHYLAMINO)PHENYL]-6-HYDROXY-3-METHYL-1,3-BENZOTHIAZOL-3-IUM DB02343, 3,6,9,12,15-Pentaoxaheptadecane DB02226, 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-4-Yl]Hexyl]-Phenanthridinium DB03005, 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-5-Yl]Hexyl]-Phenanthridinium DB04114, 3-Chloro-9-Ethyl-6,7,8,9,10,11-Hexahydro-7,11-Methanocycloocta[B]Quinolin-12-Amine DB03128, Acetylcholine DB01122, Ambenonium DB03283, beta-L-fucose DB00411, Carbamoylcholine DB00122, Choline DB14006, Choline salicylate DB01245, Decamethonium DB00944, Demecarium DB08357, Diethylene glycol diethyl ether DB08996, Dimetacrine DB00449, Dipivefrin DB00843, Donepezil DB01010, Edrophonium DB01364, Ephedrine DB00674, Galantamine DB00483, Gallamine triethiodide DB06525, Ganstigmine DB04864, Huperzine A DB03348, Huperzine B DB07555, Hydroxy(oxo)(2-{(1S)-2,2,2-trifluoro-1-[2-(trimethylarsonio)ethoxy]ethyl}phenyl)ammonium DB00677, Isoflurophate DB04924, Itopride DB03359, M-(N,N,N-Trimethylammonio)-2,2,2-Trifluoro-1,1-Dihydroxyethylbenzene DB00358, Mefloquine DB00940, Methantheline DB02825, Methylphosphinate DB02845, Methylphosphinic Acid DB08167, Methylthioninium DB04021, MF268 DB00805, Minaprine DB01805, Monoisopropylphosphorylserine DB03740, N-acetyl-alpha-D-glucosamine DB04556, NAP-226-90 DB01400, Neostigmine DB04892, Phenserine DB00981, Physostigmine DB00733, Pralidoxime DB02166, Propidium DB00545, Pyridostigmine DB00863, Ranitidine DB00989, Rivastigmine DB00382, Tacrine DB04616, TACRINE(8)-4-AMINOQUINOLINE DB01199, Tubocurarine DB13503, Tyrothricin DB04859, Zanapezil |
DrugCentrali | P22303 |
GuidetoPHARMACOLOGYi | 2465 |
Protein family/group databases
ESTHERi | human-ACHE, AChE |
MEROPSi | S09.979 |
PTM databases
GlyGeni | P22303, 3 sites |
iPTMneti | P22303 |
PhosphoSitePlusi | P22303 |
Genetic variation databases
BioMutai | ACHE |
DMDMi | 113037 |
2D gel databases
SWISS-2DPAGEi | P22303 |
Proteomic databases
jPOSTi | P22303 |
MassIVEi | P22303 |
PaxDbi | P22303 |
PeptideAtlasi | P22303 |
PRIDEi | P22303 |
ProteomicsDBi | 53971 [P22303-1] 53972 [P22303-2] 53973 [P22303-3] 53974 [P22303-4] |
Protocols and materials databases
Antibodypediai | 16701, 764 antibodies |
Genome annotation databases
Ensembli | ENST00000241069; ENSP00000241069; ENSG00000087085 [P22303-1] ENST00000302913; ENSP00000303211; ENSG00000087085 [P22303-2] ENST00000411582; ENSP00000404865; ENSG00000087085 [P22303-2] ENST00000412389; ENSP00000394976; ENSG00000087085 [P22303-1] ENST00000419336; ENSP00000403474; ENSG00000087085 [P22303-3] ENST00000428317; ENSP00000414858; ENSG00000087085 [P22303-1] |
GeneIDi | 43 |
KEGGi | hsa:43 |
UCSCi | uc003uxd.4, human [P22303-1] |
Organism-specific databases
CTDi | 43 |
DisGeNETi | 43 |
GeneCardsi | ACHE |
HGNCi | HGNC:108, ACHE |
HPAi | ENSG00000087085, Group enriched (brain, skeletal muscle) |
MalaCardsi | ACHE |
MIMi | 100740, gene+phenotype 112100, phenotype |
neXtProti | NX_P22303 |
OpenTargetsi | ENSG00000087085 |
PharmGKBi | PA20 |
VEuPathDBi | HostDB:ENSG00000087085.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4389, Eukaryota |
GeneTreei | ENSGT00940000157637 |
HOGENOMi | CLU_006586_13_0_1 |
InParanoidi | P22303 |
OMAi | PWCPLHT |
OrthoDBi | 754103at2759 |
PhylomeDBi | P22303 |
TreeFami | TF315470 |
Enzyme and pathway databases
BRENDAi | 3.1.1.7, 2681 |
PathwayCommonsi | P22303 |
Reactomei | R-HSA-112311, Neurotransmitter clearance R-HSA-1483191, Synthesis of PC R-HSA-422085, Synthesis, secretion, and deacylation of Ghrelin |
SABIO-RKi | P22303 |
SIGNORi | P22303 |
Miscellaneous databases
BioGRID-ORCSi | 43, 113 hits in 1001 CRISPR screens |
ChiTaRSi | ACHE, human |
EvolutionaryTracei | P22303 |
GeneWikii | Acetylcholinesterase |
GenomeRNAii | 43 |
Pharosi | P22303, Tclin |
PROi | PR:P22303 |
RNActi | P22303, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000087085, Expressed in hypothalamus and 159 other tissues |
ExpressionAtlasi | P22303, baseline and differential |
Genevisiblei | P22303, HS |
Family and domain databases
DisProti | DP01964 |
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR014788, AChE_tetra IPR002018, CarbesteraseB IPR019826, Carboxylesterase_B_AS IPR019819, Carboxylesterase_B_CS IPR000997, Cholinesterase |
Pfami | View protein in Pfam PF08674, AChE_tetra, 1 hit PF00135, COesterase, 1 hit |
PRINTSi | PR00878, CHOLNESTRASE |
SUPFAMi | SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00122, CARBOXYLESTERASE_B_1, 1 hit PS00941, CARBOXYLESTERASE_B_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACES_HUMAN | |
Accessioni | P22303Primary (citable) accession number: P22303 Secondary accession number(s): A4D2E2 Q9BXP7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1991 |
Last sequence update: | August 1, 1991 | |
Last modified: | April 7, 2021 | |
This is version 221 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Blood group antigen proteins
Nomenclature of blood group antigens and list of entries - Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families