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UniProtKB - P22303 (ACES_HUMAN)

Entry version 221 (07 Apr 2021)
Sequence version 1 (01 Aug 1991)
Previous versions | rss
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Protein

Acetylcholinesterase

Gene

ACHE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei117GalanthamineCombined sources1
Binding sitei117Huperzine ACombined sources1
Binding sitei153Huprine W; via amide nitrogenCombined sources1
Binding sitei164Huperzine ACombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei234Acyl-ester intermediate1
Binding sitei234Huprine WCombined sources1
Active sitei365Charge relay system1
Binding sitei368GalanthamineCombined sources1
Binding sitei368Huperzine ACombined sources1
Binding sitei470Huprine WCombined sources1
Active sitei478Charge relay system1
Binding sitei478Huprine W; via carbonyl oxygenCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionBlood group antigen, Hydrolase, Serine esterase
Biological processNeurotransmitter degradation

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.1.7, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P22303

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-112311, Neurotransmitter clearance
R-HSA-1483191, Synthesis of PC
R-HSA-422085, Synthesis, secretion, and deacylation of Ghrelin

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P22303

SIGNOR Signaling Network Open Resource

More...SIGNORi		P22303

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...ESTHERi		human-ACHE, AChE

MEROPS protease database

More...MEROPSi		S09.979

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Acetylcholinesterase (EC:3.1.1.7)
Short name:
AChE
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACHE
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:108, ACHE

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		100740, gene+phenotype

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P22303

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000087085.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Nucleus, Secreted, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi206D → N: Misfolding, absence of secretion. 1 Publication1
Mutagenesisi234S → A: Loss of activity. 1 Publication1
Mutagenesisi365E → A: Loss of activity. 1 Publication1
Mutagenesisi435D → N: Misfolding, absence of secretion. 1 Publication1
Mutagenesisi478H → A: Loss of activity. 1 Publication1
Mutagenesisi611C → A: Impairment of interchain disulfide bridge formation. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		43

MalaCards human disease database

More...MalaCardsi		ACHE
MIMi100740, gene+phenotype
112100, phenotype

Open Targets

More...OpenTargetsi		ENSG00000087085

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA20

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P22303, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL220

Drug and drug target database

More...DrugBanki		DB07846, (3,4,8b-Trimethyl-3-oxido-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-3-ium-7-yl) N-(2-ethylphenyl)carbamate
DB02673, (4aS,6R,8aS)-11-[8-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)octyl]-6-hydroxy-3-methoxy-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
DB04617, (9S)-9-[(8-AMMONIOOCTYL)AMINO]-1,2,3,4,9,10-HEXAHYDROACRIDINIUM
DB04614, (R)-tacrine(10)-hupyridone
DB04615, (S)-tacrine(10)-hupyridone
DB07756, 1-[3-({[(4-AMINO-5-FLUORO-2-METHYLQUINOLIN-3-YL)METHYL]THIO}METHYL)PHENYL]-2,2,2-TRIFLUOROETHANE-1,1-DIOL
DB07701, 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE
DB02404, 1-Deoxy-1-Thio-Heptaethylene Glycol
DB03814, 2-(N-morpholino)ethanesulfonic acid
DB08615, 2-[4-(DIMETHYLAMINO)PHENYL]-6-HYDROXY-3-METHYL-1,3-BENZOTHIAZOL-3-IUM
DB02343, 3,6,9,12,15-Pentaoxaheptadecane
DB02226, 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-4-Yl]Hexyl]-Phenanthridinium
DB03005, 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-5-Yl]Hexyl]-Phenanthridinium
DB04114, 3-Chloro-9-Ethyl-6,7,8,9,10,11-Hexahydro-7,11-Methanocycloocta[B]Quinolin-12-Amine
DB03128, Acetylcholine
DB01122, Ambenonium
DB03283, beta-L-fucose
DB00411, Carbamoylcholine
DB00122, Choline
DB14006, Choline salicylate
DB01245, Decamethonium
DB00944, Demecarium
DB08357, Diethylene glycol diethyl ether
DB08996, Dimetacrine
DB00449, Dipivefrin
DB00843, Donepezil
DB01010, Edrophonium
DB01364, Ephedrine
DB00674, Galantamine
DB00483, Gallamine triethiodide
DB06525, Ganstigmine
DB04864, Huperzine A
DB03348, Huperzine B
DB07555, Hydroxy(oxo)(2-{(1S)-2,2,2-trifluoro-1-[2-(trimethylarsonio)ethoxy]ethyl}phenyl)ammonium
DB00677, Isoflurophate
DB04924, Itopride
DB03359, M-(N,N,N-Trimethylammonio)-2,2,2-Trifluoro-1,1-Dihydroxyethylbenzene
DB00358, Mefloquine
DB00940, Methantheline
DB02825, Methylphosphinate
DB02845, Methylphosphinic Acid
DB08167, Methylthioninium
DB04021, MF268
DB00805, Minaprine
DB01805, Monoisopropylphosphorylserine
DB03740, N-acetyl-alpha-D-glucosamine
DB04556, NAP-226-90
DB01400, Neostigmine
DB04892, Phenserine
DB00981, Physostigmine
DB00733, Pralidoxime
DB02166, Propidium
DB00545, Pyridostigmine
DB00863, Ranitidine
DB00989, Rivastigmine
DB00382, Tacrine
DB04616, TACRINE(8)-4-AMINOQUINOLINE
DB01199, Tubocurarine
DB13503, Tyrothricin
DB04859, Zanapezil

DrugCentral

More...DrugCentrali		P22303

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2465

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ACHE

Domain mapping of disease mutations (DMDM)

More...DMDMi		113037

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Sequence analysisAdd BLAST31
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000858732 – 614AcetylcholinesteraseAdd BLAST583

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi100 ↔ 127
Disulfide bondi288 ↔ 303
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi296N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi381N-linked (GlcNAc...) asparagineCombined sources4 Publications1
Disulfide bondi440 ↔ 560
Glycosylationi495N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi611Interchain
Isoform H (identifier: P22303-2)
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi588GPI-anchor amidated glycine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P22303

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P22303

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P22303

PeptideAtlas

More...PeptideAtlasi		P22303

PRoteomics IDEntifications database

More...PRIDEi		P22303

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53971 [P22303-1]
53972 [P22303-2]
53973 [P22303-3]
53974 [P22303-4]

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P22303

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P22303, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P22303

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P22303

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform H is highly expressed in erythrocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000087085, Expressed in hypothalamus and 159 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P22303, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P22303, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000087085, Group enriched (brain, skeletal muscle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PRIMA1. The interaction with PRIMA1 is required to anchor it to the basal lamina of cells and organize into tetramers (By similarity). Isoform H generates GPI-anchored dimers; disulfide linked. Isoform T generates multiple structures, ranging from monomers and dimers to collagen-tailed and hydrophobic-tailed forms, in which catalytic tetramers are associated with anchoring proteins that attach them to the basal lamina or to cell membranes. In the collagen-tailed forms, isoform T subunits are associated with a specific collagen, COLQ, which triggers the formation of isoform T tetramers, from monomers and dimers. Isoform R may be monomeric.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106561, 2 interactors

Database of interacting proteins

More...DIPi		DIP-1119N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P22303

Protein interaction database and analysis system

More...IntActi		P22303, 8 interactors

Molecular INTeraction database

More...MINTi		P22303

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000303211

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P22303

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P22303, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1614
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P22303

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P22303

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni233 – 234Galanthamine bindingCombined sources2

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type-B carboxylesterase/lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4389, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157637

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006586_13_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P22303

Identification of Orthologs from Complete Genome Data

More...OMAi		PWCPLHT

Database of Orthologous Groups

More...OrthoDBi		754103at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P22303

TreeFam database of animal gene trees

More...TreeFami		TF315470

Family and domain databases

Database of protein disorder

More...DisProti		DP01964

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029058, AB_hydrolase
IPR014788, AChE_tetra
IPR002018, CarbesteraseB
IPR019826, Carboxylesterase_B_AS
IPR019819, Carboxylesterase_B_CS
IPR000997, Cholinesterase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08674, AChE_tetra, 1 hit
PF00135, COesterase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00878, CHOLNESTRASE

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53474, SSF53474, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00122, CARBOXYLESTERASE_B_1, 1 hit
PS00941, CARBOXYLESTERASE_B_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform T (identifier: P22303-1) [UniParc]FASTAAdd to basket
Also known as: ACHE-S, synaptic

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRPPQCLLHT PSLASPLLLL LLWLLGGGVG AEGREDAELL VTVRGGRLRG 
        60         70         80         90        100
IRLKTPGGPV SAFLGIPFAE PPMGPRRFLP PEPKQPWSGV VDATTFQSVC 
       110        120        130        140        150
YQYVDTLYPG FEGTEMWNPN RELSEDCLYL NVWTPYPRPT SPTPVLVWIY 
       160        170        180        190        200
GGGFYSGASS LDVYDGRFLV QAERTVLVSM NYRVGAFGFL ALPGSREAPG 
       210        220        230        240        250
NVGLLDQRLA LQWVQENVAA FGGDPTSVTL FGESAGAASV GMHLLSPPSR 
       260        270        280        290        300
GLFHRAVLQS GAPNGPWATV GMGEARRRAT QLAHLVGCPP GGTGGNDTEL 
       310        320        330        340        350
VACLRTRPAQ VLVNHEWHVL PQESVFRFSF VPVVDGDFLS DTPEALINAG 
       360        370        380        390        400
DFHGLQVLVG VVKDEGSYFL VYGAPGFSKD NESLISRAEF LAGVRVGVPQ 
       410        420        430        440        450
VSDLAAEAVV LHYTDWLHPE DPARLREALS DVVGDHNVVC PVAQLAGRLA 
       460        470        480        490        500
AQGARVYAYV FEHRASTLSW PLWMGVPHGY EIEFIFGIPL DPSRNYTAEE 
       510        520        530        540        550
KIFAQRLMRY WANFARTGDP NEPRDPKAPQ WPPYTAGAQQ YVSLDLRPLE 
       560        570        580        590        600
VRRGLRAQAC AFWNRFLPKL LSATDTLDEA ERQWKAEFHR WSSYMVHWKN 
       610 
QFDHYSKQDR CSDL
Length:614
Mass (Da):67,796
Last modified:August 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB9AA84C77831C302
GO
Isoform H (identifier: P22303-2) [UniParc]FASTAAdd to basket
Also known as: ACHE-E, erythrocytic, E4-E5

The sequence of this isoform differs from the canonical sequence as follows:
     575-614: DTLDEAERQW...YSKQDRCSDL → ASEAPSTCPG...LLFLSHLRRL

Show »
Length:617
Mass (Da):67,376
Checksum:i7AC0B2536131A89D
GO
Isoform R (identifier: P22303-4) [UniParc]FASTAAdd to basket
Also known as: ACHE-R, readthrough

The sequence of this isoform differs from the canonical sequence as follows:
     575-603: DTLDEAERQWKAEFHRWSSYMVHWKNQFD → GMQGPAGSAGRRGVGARQCNPSLLPLASE
     604-614: Missing.

Show »
Length:603
Mass (Da):65,560
Checksum:i3B65B9B3390C6AB1
GO
Isoform 4 (identifier: P22303-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     357-444: Missing.

Show »
Length:526
Mass (Da):58,352
Checksum:iFB85F41EDFFF39DB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J2S3C9J2S3_HUMAN
Carboxylic ester hydrolase
ACHE
397Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZL6C9JZL6_HUMAN
Carboxylic ester hydrolase
ACHE
434Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WAR7F8WAR7_HUMAN
Carboxylic ester hydrolase
ACHE
359Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WD68F8WD68_HUMAN
Carboxylic ester hydrolase
ACHE
403Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JD78C9JD78_HUMAN
Acetylcholinesterase
ACHE
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A498U6H7A0A498U6H7_HUMAN
Acetylcholinesterase
ACHE
28Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WD34F8WD34_HUMAN
Acetylcholinesterase
ACHE
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti279A → T in BAD97163 (Ref. 5) Curated1
Sequence conflicti415D → G in BAD97163 (Ref. 5) Curated1
Sequence conflicti486F → L in AAI43470 (PubMed:15489334).Curated1
Isoform H (identifier: P22303-2)
Sequence conflicti592P → R in AAI43470 (PubMed:15489334).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

ACHE is responsible for the Yt blood group system [MIMi:112100]. The molecular basis of the Yt(a)=Yt1/Yt(b)=Yt2 blood group antigens is a single variation in position 353; His-353 corresponds to Yt(a) and the rare variant with Asn-353 to Yt(b).

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02132534R → Q1 PublicationCorresponds to variant dbSNP:rs17881553EnsemblClinVar.1
Natural variantiVAR_021326135P → A1 PublicationCorresponds to variant dbSNP:rs17885778EnsemblClinVar.1
Natural variantiVAR_011934333V → E. Corresponds to variant dbSNP:rs8286Ensembl.1
Natural variantiVAR_002359353H → N in Yt(b) antigen. 2 PublicationsCorresponds to variant dbSNP:rs1799805EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_035568357 – 444Missing in isoform 4. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_001457575 – 614DTLDE…RCSDL → ASEAPSTCPGFTHGEAAPRP GLPLPLLLLHQLLLLFLSHL RRL in isoform H. 2 PublicationsAdd BLAST40
Alternative sequenceiVSP_035569575 – 603DTLDE…KNQFD → GMQGPAGSAGRRGVGARQCN PSLLPLASE in isoform R. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_035570604 – 614Missing in isoform R. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M55040 mRNA Translation: AAA68151.1
S71129 Genomic DNA Translation: AAC60618.1 Sequence problems.
AF334270 mRNA Translation: AAO32948.1
AK291321 mRNA Translation: BAF84010.1
AK223443 mRNA Translation: BAD97163.1
AY750146 Genomic DNA Translation: AAU43801.1
AC011895 Genomic DNA Translation: AAP22364.1
AC011895 Genomic DNA Translation: AAP22365.1
CH236956 Genomic DNA Translation: EAL23812.1
CH236956 Genomic DNA Translation: EAL23813.1
CH471091 Genomic DNA Translation: EAW76461.1
CH471091 Genomic DNA Translation: EAW76463.1
CH471091 Genomic DNA Translation: EAW76462.1
BC036813 mRNA Translation: AAH36813.1
BC105060 mRNA Translation: AAI05061.1
BC105062 mRNA Translation: AAI05063.1
BC143469 mRNA Translation: AAI43470.1
AF312032 Genomic DNA Translation: AAK21003.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5709.1 [P22303-1]
CCDS5710.1 [P22303-2]
CCDS64736.1 [P22303-3]

Protein sequence database of the Protein Information Resource

More...PIRi		A39256

NCBI Reference Sequences

More...RefSeqi		NP_000656.1, NM_000665.4 [P22303-1]
NP_001269378.1, NM_001282449.1 [P22303-3]
NP_001289550.1, NM_001302621.1 [P22303-2]
NP_001289551.1, NM_001302622.1 [P22303-1]
NP_056646.1, NM_015831.2
XP_006716058.1, XM_006715995.2
XP_011514530.1, XM_011516228.2
XP_011514531.1, XM_011516229.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000241069; ENSP00000241069; ENSG00000087085 [P22303-1]
ENST00000302913; ENSP00000303211; ENSG00000087085 [P22303-2]
ENST00000411582; ENSP00000404865; ENSG00000087085 [P22303-2]
ENST00000412389; ENSP00000394976; ENSG00000087085 [P22303-1]
ENST00000419336; ENSP00000403474; ENSG00000087085 [P22303-3]
ENST00000428317; ENSP00000414858; ENSG00000087085 [P22303-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		43

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:43

UCSC genome browser

More...UCSCi		uc003uxd.4, human [P22303-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

Wikipedia

Acetylcholinesterase entry

SeattleSNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55040 mRNA Translation: AAA68151.1
S71129 Genomic DNA Translation: AAC60618.1 Sequence problems.
AF334270 mRNA Translation: AAO32948.1
AK291321 mRNA Translation: BAF84010.1
AK223443 mRNA Translation: BAD97163.1
AY750146 Genomic DNA Translation: AAU43801.1
AC011895 Genomic DNA Translation: AAP22364.1
AC011895 Genomic DNA Translation: AAP22365.1
CH236956 Genomic DNA Translation: EAL23812.1
CH236956 Genomic DNA Translation: EAL23813.1
CH471091 Genomic DNA Translation: EAW76461.1
CH471091 Genomic DNA Translation: EAW76463.1
CH471091 Genomic DNA Translation: EAW76462.1
BC036813 mRNA Translation: AAH36813.1
BC105060 mRNA Translation: AAI05061.1
BC105062 mRNA Translation: AAI05063.1
BC143469 mRNA Translation: AAI43470.1
AF312032 Genomic DNA Translation: AAK21003.1
CCDSiCCDS5709.1 [P22303-1]
CCDS5710.1 [P22303-2]
CCDS64736.1 [P22303-3]
PIRiA39256
RefSeqiNP_000656.1, NM_000665.4 [P22303-1]
NP_001269378.1, NM_001282449.1 [P22303-3]
NP_001289550.1, NM_001302621.1 [P22303-2]
NP_001289551.1, NM_001302622.1 [P22303-1]
NP_056646.1, NM_015831.2
XP_006716058.1, XM_006715995.2
XP_011514530.1, XM_011516228.2
XP_011514531.1, XM_011516229.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B41X-ray2.76A36-574[»]
1F8UX-ray2.90A32-614[»]
1PUVmodel-A37-574[»]
1PUWmodel-A37-574[»]
1VZJX-ray2.35A/B/C/D/E/F/G/H575-614[»]
2CLJmodel-A32-574[»]
2X8BX-ray2.95A32-614[»]
3LIIX-ray3.20A/B35-574[»]
4BDTX-ray3.10A32-614[»]
4EY4X-ray2.16A/B33-574[»]
4EY5X-ray2.30A/B33-574[»]
4EY6X-ray2.40A/B33-574[»]
4EY7X-ray2.35A/B33-574[»]
4EY8X-ray2.60A33-574[»]
4M0EX-ray2.00A/B33-574[»]
4M0FX-ray2.30A/B33-574[»]
4PQEX-ray2.90A32-574[»]
5FOQX-ray2.30A/B32-576[»]
5FPQX-ray2.40A/B33-574[»]
5HF5X-ray2.15A/B33-574[»]
5HF6X-ray2.30A/B33-574[»]
5HF8X-ray2.80A/B33-574[»]
5HF9X-ray2.20A/B33-574[»]
5HFAX-ray2.20A/B33-574[»]
6CQTX-ray2.27A/B33-574[»]
6CQUX-ray2.31A/B33-574[»]
6CQVX-ray2.60A/B33-574[»]
6CQWX-ray2.28A/B33-574[»]
6CQXX-ray2.40A/B33-574[»]
6CQYX-ray2.45A/B33-574[»]
6CQZX-ray2.22A/B33-574[»]
6F25X-ray3.05A/B36-574[»]
6NEAX-ray2.42A/B33-574[»]
6NTGX-ray2.65A/B33-574[»]
6NTHX-ray2.42A/B33-574[»]
6NTKX-ray2.41A/B33-574[»]
6NTLX-ray2.25A/B33-574[»]
6NTMX-ray2.55A/B33-574[»]
6NTNX-ray2.70A/B33-574[»]
6NTOX-ray2.05A/B33-574[»]
6O4WX-ray2.35A/B32-578[»]
6O4XX-ray2.30A/B32-578[»]
6O50X-ray2.35A/B32-578[»]
6O52X-ray3.20A/B32-578[»]
6O5RX-ray2.80A/B32-578[»]
6O5SX-ray2.80A/B32-578[»]
6O5VX-ray2.15A/B32-578[»]
6O66X-ray2.45A/B32-578[»]
6O69X-ray2.08A33-574[»]
6U34X-ray2.40A/B35-578[»]
6U37X-ray2.25A/B32-578[»]
6U3PX-ray3.00A/B32-578[»]
SMRiP22303
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi106561, 2 interactors
DIPiDIP-1119N
ELMiP22303
IntActiP22303, 8 interactors
MINTiP22303
STRINGi9606.ENSP00000303211

Chemistry databases

BindingDBiP22303
ChEMBLiCHEMBL220
DrugBankiDB07846, (3,4,8b-Trimethyl-3-oxido-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-3-ium-7-yl) N-(2-ethylphenyl)carbamate
DB02673, (4aS,6R,8aS)-11-[8-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)octyl]-6-hydroxy-3-methoxy-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
DB04617, (9S)-9-[(8-AMMONIOOCTYL)AMINO]-1,2,3,4,9,10-HEXAHYDROACRIDINIUM
DB04614, (R)-tacrine(10)-hupyridone
DB04615, (S)-tacrine(10)-hupyridone
DB07756, 1-[3-({[(4-AMINO-5-FLUORO-2-METHYLQUINOLIN-3-YL)METHYL]THIO}METHYL)PHENYL]-2,2,2-TRIFLUOROETHANE-1,1-DIOL
DB07701, 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE
DB02404, 1-Deoxy-1-Thio-Heptaethylene Glycol
DB03814, 2-(N-morpholino)ethanesulfonic acid
DB08615, 2-[4-(DIMETHYLAMINO)PHENYL]-6-HYDROXY-3-METHYL-1,3-BENZOTHIAZOL-3-IUM
DB02343, 3,6,9,12,15-Pentaoxaheptadecane
DB02226, 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-4-Yl]Hexyl]-Phenanthridinium
DB03005, 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-5-Yl]Hexyl]-Phenanthridinium
DB04114, 3-Chloro-9-Ethyl-6,7,8,9,10,11-Hexahydro-7,11-Methanocycloocta[B]Quinolin-12-Amine
DB03128, Acetylcholine
DB01122, Ambenonium
DB03283, beta-L-fucose
DB00411, Carbamoylcholine
DB00122, Choline
DB14006, Choline salicylate
DB01245, Decamethonium
DB00944, Demecarium
DB08357, Diethylene glycol diethyl ether
DB08996, Dimetacrine
DB00449, Dipivefrin
DB00843, Donepezil
DB01010, Edrophonium
DB01364, Ephedrine
DB00674, Galantamine
DB00483, Gallamine triethiodide
DB06525, Ganstigmine
DB04864, Huperzine A
DB03348, Huperzine B
DB07555, Hydroxy(oxo)(2-{(1S)-2,2,2-trifluoro-1-[2-(trimethylarsonio)ethoxy]ethyl}phenyl)ammonium
DB00677, Isoflurophate
DB04924, Itopride
DB03359, M-(N,N,N-Trimethylammonio)-2,2,2-Trifluoro-1,1-Dihydroxyethylbenzene
DB00358, Mefloquine
DB00940, Methantheline
DB02825, Methylphosphinate
DB02845, Methylphosphinic Acid
DB08167, Methylthioninium
DB04021, MF268
DB00805, Minaprine
DB01805, Monoisopropylphosphorylserine
DB03740, N-acetyl-alpha-D-glucosamine
DB04556, NAP-226-90
DB01400, Neostigmine
DB04892, Phenserine
DB00981, Physostigmine
DB00733, Pralidoxime
DB02166, Propidium
DB00545, Pyridostigmine
DB00863, Ranitidine
DB00989, Rivastigmine
DB00382, Tacrine
DB04616, TACRINE(8)-4-AMINOQUINOLINE
DB01199, Tubocurarine
DB13503, Tyrothricin
DB04859, Zanapezil
DrugCentraliP22303
GuidetoPHARMACOLOGYi2465

Protein family/group databases

ESTHERihuman-ACHE, AChE
MEROPSiS09.979

PTM databases

GlyGeniP22303, 3 sites
iPTMnetiP22303
PhosphoSitePlusiP22303

Genetic variation databases

BioMutaiACHE
DMDMi113037

2D gel databases

SWISS-2DPAGEiP22303

Proteomic databases

jPOSTiP22303
MassIVEiP22303
PaxDbiP22303
PeptideAtlasiP22303
PRIDEiP22303
ProteomicsDBi53971 [P22303-1]
53972 [P22303-2]
53973 [P22303-3]
53974 [P22303-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		16701, 764 antibodies

Genome annotation databases

EnsembliENST00000241069; ENSP00000241069; ENSG00000087085 [P22303-1]
ENST00000302913; ENSP00000303211; ENSG00000087085 [P22303-2]
ENST00000411582; ENSP00000404865; ENSG00000087085 [P22303-2]
ENST00000412389; ENSP00000394976; ENSG00000087085 [P22303-1]
ENST00000419336; ENSP00000403474; ENSG00000087085 [P22303-3]
ENST00000428317; ENSP00000414858; ENSG00000087085 [P22303-1]
GeneIDi43
KEGGihsa:43
UCSCiuc003uxd.4, human [P22303-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		43
DisGeNETi43

GeneCards: human genes, protein and diseases

More...GeneCardsi		ACHE
HGNCiHGNC:108, ACHE
HPAiENSG00000087085, Group enriched (brain, skeletal muscle)
MalaCardsiACHE
MIMi100740, gene+phenotype
112100, phenotype
neXtProtiNX_P22303
OpenTargetsiENSG00000087085
PharmGKBiPA20
VEuPathDBiHostDB:ENSG00000087085.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4389, Eukaryota
GeneTreeiENSGT00940000157637
HOGENOMiCLU_006586_13_0_1
InParanoidiP22303
OMAiPWCPLHT
OrthoDBi754103at2759
PhylomeDBiP22303
TreeFamiTF315470

Enzyme and pathway databases

BRENDAi3.1.1.7, 2681
PathwayCommonsiP22303
ReactomeiR-HSA-112311, Neurotransmitter clearance
R-HSA-1483191, Synthesis of PC
R-HSA-422085, Synthesis, secretion, and deacylation of Ghrelin
SABIO-RKiP22303
SIGNORiP22303

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		43, 113 hits in 1001 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ACHE, human
EvolutionaryTraceiP22303

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Acetylcholinesterase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		43
PharosiP22303, Tclin

Protein Ontology

More...PROi		PR:P22303
RNActiP22303, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000087085, Expressed in hypothalamus and 159 other tissues
ExpressionAtlasiP22303, baseline and differential
GenevisibleiP22303, HS

Family and domain databases

DisProtiDP01964
Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058, AB_hydrolase
IPR014788, AChE_tetra
IPR002018, CarbesteraseB
IPR019826, Carboxylesterase_B_AS
IPR019819, Carboxylesterase_B_CS
IPR000997, Cholinesterase
PfamiView protein in Pfam
PF08674, AChE_tetra, 1 hit
PF00135, COesterase, 1 hit
PRINTSiPR00878, CHOLNESTRASE
SUPFAMiSSF53474, SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00122, CARBOXYLESTERASE_B_1, 1 hit
PS00941, CARBOXYLESTERASE_B_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACES_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22303
Secondary accession number(s): A4D2E2
, B7ZKZ0, D6W5X7, Q16169, Q29S23, Q2M324, Q504V3, Q53F46, Q86TM9, Q86YX9, Q9BXP7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: April 7, 2021
This is version 221 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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