Interleukin-10

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cytokine activity Source: BHF-UCL <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • 10443688
• growth factor activity Source: UniProtKBNon-traceable author statementⁱ
  • 1371884
• interleukin-10 receptor binding Source: UniProtKBNon-traceable author statementⁱ
  • 1847510

GO - Biological processⁱ

• aging Source: Ensembl
• B cell differentiation Source: UniProtKBNon-traceable author statementⁱ
  • 8228801
• B cell proliferation Source: UniProtKBNon-traceable author statementⁱ
  • 8228801
• branching involved in labyrinthine layer morphogenesis Source: Ensembl
• cellular response to estradiol stimulus Source: Ensembl
• cellular response to hepatocyte growth factor stimulus Source: Ensembl
• cellular response to lipopolysaccharide Source: BHF-UCLNon-traceable author statementⁱ
  • 14971032
• cytokine-mediated signaling pathway Source: Reactome
• cytoplasmic sequestering of NF-kappaB Source: UniProtKBNon-traceable author statementⁱ
  • 10975994
• defense response to bacterium Source: Ensembl
• defense response to protozoan Source: Ensembl
• endothelial cell apoptotic process Source: BHF-UCL
• hemopoiesis Source: UniProtKB <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 11244051
• inflammatory response Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 10443688
• interleukin-12-mediated signaling pathway Source: Reactome
• leukocyte chemotaxis Source: ProtIncTraceable author statementⁱ
  • 9405662
• liver regeneration Source: Ensembl
• negative regulation of apoptotic process Source: UniProtKBNon-traceable author statementⁱ
  • 8312229
• negative regulation of B cell proliferation Source: MGIInferred from direct assayⁱ
  • 9184696
• negative regulation of cell proliferation Source: BHF-UCL
• negative regulation of chemokine (C-C motif) ligand 5 production Source: AgBaseTraceable author statementⁱ
  • 19262501
• negative regulation of chronic inflammatory response to antigenic stimulus Source: Ensembl
• negative regulation of cytokine activity Source: CACAO <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 9847016
• negative regulation of cytokine secretion involved in immune response Source: BHF-UCLInferred from direct assayⁱ
  • 10443688
• negative regulation of growth of symbiont in host Source: Ensembl
• negative regulation of heterotypic cell-cell adhesion Source: BHF-UCL
• negative regulation of hydrogen peroxide-induced neuron death Source: ARUK-UCL
• negative regulation of inflammatory response Source: ARUK-UCLNon-traceable author statementⁱ
  • 21857966
• negative regulation of interferon-alpha biosynthetic process Source: UniProtKBNon-traceable author statementⁱ
  • 9637497
• negative regulation of interferon-gamma production Source: Ensembl
• negative regulation of interleukin-12 production Source: AgBaseTraceable author statementⁱ
  • 19262501
• negative regulation of interleukin-18 production Source: AgBaseTraceable author statementⁱ
  • 19262501
• negative regulation of interleukin-1 production Source: AgBaseTraceable author statementⁱ
  • 19262501
• negative regulation of interleukin-6 production Source: BHF-UCLInferred from direct assayⁱ
  • 10443688
• negative regulation of interleukin-8 production Source: AgBaseTraceable author statementⁱ
  • 19262501
• negative regulation of membrane protein ectodomain proteolysis Source: BHF-UCLInferred from direct assayⁱ
  • 18383040
• negative regulation of MHC class II biosynthetic process Source: UniProtKBTraceable author statementⁱ
  • 11244051
• negative regulation of mitotic cell cycle Source: BHF-UCL
• negative regulation of myeloid dendritic cell activation Source: Ensembl
• negative regulation of nitric oxide biosynthetic process Source: Ensembl
• negative regulation of sensory perception of pain Source: Ensembl
• negative regulation of T cell proliferation Source: UniProtKBNon-traceable author statementⁱ
  • 8499633
• negative regulation of tumor necrosis factor biosynthetic process Source: Ensembl
• negative regulation of tumor necrosis factor production Source: AgBaseTraceable author statementⁱ
  • 19262501
• negative regulation of vascular smooth muscle cell proliferation Source: BHF-UCL
• positive regulation of B cell apoptotic process Source: MGIInferred from direct assayⁱ
  • 9184696
• positive regulation of cell cycle Source: Ensembl
• positive regulation of cytokine secretion Source: BHF-UCLInferred from direct assayⁱ
  • 10443688
• positive regulation of DNA-binding transcription factor activity Source: BHF-UCLInferred from direct assayⁱ
  • 7749983
• positive regulation of endothelial cell proliferation Source: Ensembl
• positive regulation of heterotypic cell-cell adhesion Source: BHF-UCL
• positive regulation of macrophage activation Source: Ensembl
• positive regulation of MHC class II biosynthetic process Source: Ensembl
• positive regulation of pri-miRNA transcription by RNA polymerase II Source: Ensembl
• positive regulation of sprouting angiogenesis Source: Ensembl
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • 16606666
• positive regulation of vascular smooth muscle cell proliferation Source: BHF-UCL
• receptor biosynthetic process Source: BHF-UCLInferred from direct assayⁱ
  • 10443688
• regulation of gene expression Source: MGIInferred from direct assayⁱ
  • 9184696
• regulation of isotype switching Source: UniProtKBNon-traceable author statementⁱ
  • 8228801
• regulation of response to wounding Source: BHF-UCL
• regulation of synapse organization Source: Ensembl
• response to activity Source: Ensembl
• response to carbon monoxide Source: Ensembl
• response to glucocorticoid Source: BHF-UCLInferred from direct assayⁱ
  • 10443688
• response to inactivity Source: Ensembl
• response to insulin Source: Ensembl
• response to molecule of bacterial origin Source: UniProtKBInferred from direct assayⁱ
  • 17449476
• type 2 immune response Source: UniProtKBTraceable author statementⁱ
  • 11244051

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Keywords - Diseaseⁱ

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• cytokine activity Source: BHF-UCLNon-traceable author statementⁱ
  • 10443688
• growth factor activity Source: UniProtKBNon-traceable author statementⁱ
  • 1371884
• interleukin-10 receptor binding Source: UniProtKBNon-traceable author statementⁱ
  • 1847510

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MHSSALLCCL VLLTGVRASP GQGTQSENSC THFPGNLPNM LRDLRDAFSR 
        60         70         80         90        100
VKTFFQMKDQ LDNLLLKESL LEDFKGYLGC QALSEMIQFY LEEVMPQAEN 
       110        120        130        140        150
QDPDIKAHVN SLGENLKTLR LRLRRCHRFL PCENKSKAVE QVKNAFNKLQ 
       160        170 
EKGIYKAMSE FDIFINYIEA YMTMKIRN                         

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismⁱ

Natural variant

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 1
   Human chromosome 1: entries, gene names and cross-references to MIM
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
3. SIMILARITY comments
   Index of protein domains and families
4. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
5. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
6. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot