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Protein

Interleukin-10

Gene

IL10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.

GO - Molecular functioni

  • cytokine activity Source: BHF-UCL
  • growth factor activity Source: UniProtKB
  • interleukin-10 receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-HSA-6783783 Interleukin-10 signaling
R-HSA-6785807 Interleukin-4 and 13 signaling
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
SignaLinkiP22301
SIGNORiP22301

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-10
Short name:
IL-10
Alternative name(s):
Cytokine synthesis inhibitory factor
Short name:
CSIF
Gene namesi
Name:IL10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000136634.5
HGNCiHGNC:5962 IL10
MIMi124092 gene
neXtProtiNX_P22301

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi3586
MalaCardsiIL10
MIMi614395 phenotype
OpenTargetsiENSG00000136634
Orphaneti238569 Autosomal recessive early-onset inflammatory bowel disease
117 Behcet disease
536 Systemic lupus erythematosus
PharmGKBiPA29778

Chemistry databases

ChEMBLiCHEMBL3712920
DrugBankiDB05066 AV411
DB05744 CRx-139
DB05771 LLL-3348

Polymorphism and mutation databases

BioMutaiIL10
DMDMi124292

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000001536019 – 178Interleukin-10Add BLAST160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 1261 Publication
Disulfide bondi80 ↔ 1321 Publication
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP22301
PeptideAtlasiP22301
PRIDEiP22301
ProteomicsDBi53970

Expressioni

Tissue specificityi

Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types.

Gene expression databases

BgeeiENSG00000136634
CleanExiHS_IL10
ExpressionAtlasiP22301 baseline and differential
GenevisibleiP22301 HS

Organism-specific databases

HPAiCAB013120

Interactioni

Subunit structurei

Homodimer.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • cytokine activity Source: BHF-UCL
  • growth factor activity Source: UniProtKB
  • interleukin-10 receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109800, 7 interactors
DIPiDIP-3511N
IntActiP22301, 8 interactors
MINTiP22301
STRINGi9606.ENSP00000412237

Chemistry databases

BindingDBiP22301

Structurei

Secondary structure

1178
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni33 – 36Combined sources4
Helixi37 – 49Combined sources13
Helixi52 – 58Combined sources7
Helixi68 – 75Combined sources8
Turni76 – 78Combined sources3
Helixi79 – 93Combined sources15
Helixi95 – 99Combined sources5
Turni103 – 105Combined sources3
Helixi106 – 125Combined sources20
Turni127 – 129Combined sources3
Helixi131 – 133Combined sources3
Helixi137 – 148Combined sources12
Helixi151 – 159Combined sources9
Helixi161 – 176Combined sources16

3D structure databases

ProteinModelPortaliP22301
SMRiP22301
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22301

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYFW Eukaryota
ENOG4111PXC LUCA
GeneTreeiENSGT00510000048535
HOGENOMiHOG000072692
HOVERGENiHBG004110
InParanoidiP22301
KOiK05443
OMAiPHMLREL
OrthoDBiEOG091G0Y3M
PhylomeDBiP22301
TreeFamiTF333253

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000098 IL-10
IPR020443 IL-10/19/20/22/24/26_fam
IPR020423 IL-10_CS
PfamiView protein in Pfam
PF00726 IL10, 1 hit
PRINTSiPR01294 INTRLEUKIN10
SMARTiView protein in SMART
SM00188 IL10, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00520 INTERLEUKIN_10, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22301-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSSALLCCL VLLTGVRASP GQGTQSENSC THFPGNLPNM LRDLRDAFSR
60 70 80 90 100
VKTFFQMKDQ LDNLLLKESL LEDFKGYLGC QALSEMIQFY LEEVMPQAEN
110 120 130 140 150
QDPDIKAHVN SLGENLKTLR LRLRRCHRFL PCENKSKAVE QVKNAFNKLQ
160 170
EKGIYKAMSE FDIFINYIEA YMTMKIRN
Length:178
Mass (Da):20,517
Last modified:August 1, 1991 - v1
Checksum:i6825E9FA4337CDE4
GO

Polymorphismi

A polymorphism in IL10 promoter region is associated with resistance to graft-versus-host disease (GVHDS) [MIMi:614395]. GVHDS is a major complication of allogeneic bone marrow transplantation, in which mature donor T-cells that contaminate the allogeneic bone marrow recognize the tissues of the recipient as foreign, causing a severe inflammatory disease.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01588315G → R in a family affected by Crohn disease; decreases secretion thereby reducing the anti-inflammatory effect. 1 PublicationCorresponds to variant dbSNP:rs145922845EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57627 mRNA Translation: AAA63207.1
U16720 Genomic DNA Translation: AAA80104.1
AY029171 mRNA Translation: AAK38162.1
AF418271 Genomic DNA Translation: AAL06594.1
CCDSiCCDS1467.1
PIRiA38580
RefSeqiNP_000563.1, NM_000572.2
UniGeneiHs.193717

Genome annotation databases

EnsembliENST00000423557; ENSP00000412237; ENSG00000136634
GeneIDi3586
KEGGihsa:3586

Similar proteinsi

Entry informationi

Entry nameiIL10_HUMAN
AccessioniPrimary (citable) accession number: P22301
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: July 18, 2018
This is version 188 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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