IL10

Functionⁱ

Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.

GO - Molecular functionⁱ

cytokine activity
Source: BHF-UCL
Non-traceable author statementⁱ
- 10443688
growth factor activity
Source: UniProtKB
Non-traceable author statementⁱ
- 1371884
interleukin-10 receptor binding
Source: UniProtKB
Non-traceable author statementⁱ
- 1847510

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

aging Source: Ensembl
B cell differentiation
Source: UniProtKB
Non-traceable author statementⁱ
- 8228801
B cell proliferation
Source: UniProtKB
Non-traceable author statementⁱ
- 8228801
branching involved in labyrinthine layer morphogenesis Source: Ensembl
cellular response to estradiol stimulus Source: Ensembl
cellular response to hepatocyte growth factor stimulus Source: Ensembl
cellular response to lipopolysaccharide
Source: BHF-UCL
Non-traceable author statementⁱ
- 14971032
cytokine-mediated signaling pathway Source: Reactome
cytoplasmic sequestering of NF-kappaB
Source: UniProtKB
Non-traceable author statementⁱ
- 10975994
defense response to bacterium Source: Ensembl
defense response to protozoan Source: Ensembl
endothelial cell apoptotic process Source: BHF-UCL
hemopoiesis
Source: UniProtKB
Traceable author statementⁱ
- 11244051
inflammatory response
Source: BHF-UCL
Inferred from direct assayⁱ
- 10443688
interleukin-12-mediated signaling pathway Source: Reactome
leukocyte chemotaxis
Source: ProtInc
Traceable author statementⁱ
- 9405662
liver regeneration Source: Ensembl
negative regulation of apoptotic process
Source: UniProtKB
Non-traceable author statementⁱ
- 8312229
negative regulation of B cell proliferation
Source: MGI
Inferred from direct assayⁱ
- 9184696
negative regulation of cell proliferation Source: BHF-UCL
negative regulation of chemokine (C-C motif) ligand 5 production
Source: AgBase
Traceable author statementⁱ
- 19262501
negative regulation of chronic inflammatory response to antigenic stimulus Source: Ensembl
negative regulation of cytokine activity
Source: CACAO
Inferred from mutant phenotypeⁱ
- 9847016
negative regulation of cytokine secretion involved in immune response
Source: BHF-UCL
Inferred from direct assayⁱ
- 10443688
negative regulation of growth of symbiont in host Source: Ensembl
negative regulation of heterotypic cell-cell adhesion Source: BHF-UCL
negative regulation of hydrogen peroxide-induced neuron death Source: ARUK-UCL
negative regulation of inflammatory response
Source: ARUK-UCL
Non-traceable author statementⁱ
- 21857966
negative regulation of interferon-alpha biosynthetic process
Source: UniProtKB
Non-traceable author statementⁱ
- 9637497
negative regulation of interferon-gamma production Source: Ensembl
negative regulation of interleukin-12 production
Source: AgBase
Traceable author statementⁱ
- 19262501
negative regulation of interleukin-18 production
Source: AgBase
Traceable author statementⁱ
- 19262501
negative regulation of interleukin-1 production
Source: AgBase
Traceable author statementⁱ
- 19262501
negative regulation of interleukin-6 production
Source: BHF-UCL
Inferred from direct assayⁱ
- 10443688
negative regulation of interleukin-8 production
Source: AgBase
Traceable author statementⁱ
- 19262501
negative regulation of membrane protein ectodomain proteolysis
Source: BHF-UCL
Inferred from direct assayⁱ
- 18383040
negative regulation of MHC class II biosynthetic process
Source: UniProtKB
Traceable author statementⁱ
- 11244051
negative regulation of mitotic cell cycle Source: BHF-UCL
negative regulation of myeloid dendritic cell activation Source: Ensembl
negative regulation of nitric oxide biosynthetic process Source: Ensembl
negative regulation of sensory perception of pain Source: Ensembl
negative regulation of T cell proliferation
Source: UniProtKB
Non-traceable author statementⁱ
- 8499633
negative regulation of tumor necrosis factor biosynthetic process Source: Ensembl
negative regulation of tumor necrosis factor production
Source: AgBase
Traceable author statementⁱ
- 19262501
negative regulation of vascular smooth muscle cell proliferation Source: BHF-UCL
positive regulation of B cell apoptotic process
Source: MGI
Inferred from direct assayⁱ
- 9184696
positive regulation of cell cycle Source: Ensembl
positive regulation of cytokine secretion
Source: BHF-UCL
Inferred from direct assayⁱ
- 10443688
positive regulation of DNA-binding transcription factor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 7749983
positive regulation of endothelial cell proliferation Source: Ensembl
positive regulation of heterotypic cell-cell adhesion Source: BHF-UCL
positive regulation of macrophage activation Source: Ensembl
positive regulation of MHC class II biosynthetic process Source: Ensembl
positive regulation of pri-miRNA transcription by RNA polymerase II Source: Ensembl
positive regulation of sprouting angiogenesis Source: Ensembl
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 16606666
positive regulation of vascular smooth muscle cell proliferation Source: BHF-UCL
receptor biosynthetic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 10443688
regulation of gene expression
Source: MGI
Inferred from direct assayⁱ
- 9184696
regulation of isotype switching
Source: UniProtKB
Non-traceable author statementⁱ
- 8228801
regulation of response to wounding Source: BHF-UCL
regulation of synapse organization Source: Ensembl
response to activity Source: Ensembl
response to carbon monoxide Source: Ensembl
response to glucocorticoid
Source: BHF-UCL
Inferred from direct assayⁱ
- 10443688
response to inactivity Source: Ensembl
response to insulin Source: Ensembl
response to molecule of bacterial origin
Source: UniProtKB
Inferred from direct assayⁱ
- 17449476
type 2 immune response
Source: UniProtKB
Traceable author statementⁱ
- 11244051

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine

Molecular function

Cytokine

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6783783 Interleukin-10 signaling R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
SignaLinkⁱ	P22301
SIGNORⁱ	P22301

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interleukin-10 Short name: IL-10 Alternative name(s): Cytokine synthesis inhibitory factor Short name: CSIF
Gene namesⁱ	Name:IL10
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000136634.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5962 IL10
MIMⁱ	124092 gene
neXtProtⁱ	NX_P22301

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3586
MalaCards human disease database More...MalaCardsⁱ	IL10
MIMⁱ	614395 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000136634
Orphanetⁱ	117 Behcet disease 238569 Immune dysregulation-inflammatory bowel disease-arthritis-recurrent infections syndrome 536 NON RARE IN EUROPE: Systemic lupus erythematosus
PharmGKBⁱ	PA29778

Chemistry databases

ChEMBLⁱ	CHEMBL3712920
Drug and drug target database More...DrugBankⁱ	DB05066 AV411 DB05744 CRx-139 DB05771 LLL-3348

Polymorphism and mutation databases

BioMutaⁱ	IL10
DMDMⁱ	124292

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 18	1 PublicationAdd BLAST		18
ChainⁱPRO_0000015360	19 – 178	Interleukin-10Add BLAST		160

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	30 ↔ 126	1 Publication
Disulfide bondⁱ	80 ↔ 132	1 Publication
Glycosylationⁱ	134	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P22301
PeptideAtlas More...PeptideAtlasⁱ	P22301
PRIDEⁱ	P22301
ProteomicsDBⁱ	53970

Expressionⁱ

Tissue specificityⁱ

Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types.

Gene expression databases

Bgeeⁱ	ENSG00000136634 Expressed in 81 organ(s), highest expression level in esophagus
CleanExⁱ	HS_IL10
ExpressionAtlasⁱ	P22301 baseline and differential
Genevisibleⁱ	P22301 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB013120

HPAⁱ

CAB013120

Interactionⁱ

Subunit structureⁱ

Homodimer.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
IL10RA	Q13651	9	EBI-1031632,EBI-1031656
IL10RB	Q08334	2	EBI-1031632,EBI-11175900

GO - Molecular functionⁱ

cytokine activity
Source: BHF-UCL
Non-traceable author statementⁱ
- 10443688
growth factor activity
Source: UniProtKB
Non-traceable author statementⁱ
- 1371884
interleukin-10 receptor binding
Source: UniProtKB
Non-traceable author statementⁱ
- 1847510

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109800, 7 interactors
Database of interacting proteins More...DIPⁱ	DIP-3511N
IntActⁱ	P22301, 8 interactors
Molecular INTeraction database More...MINTⁱ	P22301
STRINGⁱ	9606.ENSP00000412237

Chemistry databases

BindingDBⁱ

P22301

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	33 – 36	Combined sources	4
Helixⁱ	37 – 49	Combined sources	13
Helixⁱ	52 – 58	Combined sources	7
Helixⁱ	68 – 75	Combined sources	8
Turnⁱ	76 – 78	Combined sources	3
Helixⁱ	79 – 93	Combined sources	15
Helixⁱ	95 – 99	Combined sources	5
Turnⁱ	103 – 105	Combined sources	3
Helixⁱ	106 – 125	Combined sources	20
Turnⁱ	127 – 129	Combined sources	3
Helixⁱ	131 – 133	Combined sources	3
Helixⁱ	137 – 148	Combined sources	12
Helixⁱ	151 – 159	Combined sources	9
Helixⁱ	161 – 176	Combined sources	16

Show more details

3D structure databases

ProteinModelPortalⁱ	P22301
SMRⁱ	P22301
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P22301

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the IL-10 family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IYFW Eukaryota ENOG4111PXC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000048535
HOGENOMⁱ	HOG000072692
HOVERGENⁱ	HBG004110
InParanoidⁱ	P22301
KEGG Orthology (KO) More...KOⁱ	K05443
OMAⁱ	SLPHMLR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Y3M
PhylomeDBⁱ	P22301
TreeFamⁱ	TF333253

Family and domain databases

InterProⁱ	View protein in InterPro IPR009079 4_helix_cytokine-like_core IPR000098 IL-10 IPR020443 IL-10/19/20/22/24/26_fam IPR020423 IL-10_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00726 IL10, 1 hit
PRINTSⁱ	PR01294 INTRLEUKIN10
SMARTⁱ	View protein in SMART SM00188 IL10, 1 hit
SUPFAMⁱ	SSF47266 SSF47266, 1 hit
PROSITEⁱ	View protein in PROSITE PS00520 INTERLEUKIN_10, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P22301-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MHSSALLCCL VLLTGVRASP GQGTQSENSC THFPGNLPNM LRDLRDAFSR 
        60         70         80         90        100
VKTFFQMKDQ LDNLLLKESL LEDFKGYLGC QALSEMIQFY LEEVMPQAEN 
       110        120        130        140        150
QDPDIKAHVN SLGENLKTLR LRLRRCHRFL PCENKSKAVE QVKNAFNKLQ 
       160        170 
EKGIYKAMSE FDIFINYIEA YMTMKIRN

Length:178

Mass (Da):20,517

Last modified:August 1, 1991 - v1

Checksum:ⁱ6825E9FA4337CDE4

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A286YEX3	A0A286YEX3_HUMAN		Interleukin-10 Interleukin-10	IL10	74	Annotation score:

Polymorphismⁱ

A polymorphism in IL10 promoter region is associated with resistance to graft-versus-host disease (GVHDS) [MIMⁱ:614395]. GVHDS is a major complication of allogeneic bone marrow transplantation, in which mature donor T-cells that contaminate the allogeneic bone marrow recognize the tissues of the recipient as foreign, causing a severe inflammatory disease.1 Publication

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_015883	15	G → R in a family affected by Crohn disease; decreases secretion thereby reducing the anti-inflammatory effect. 1 PublicationCorresponds to variant dbSNP:rs145922845EnsemblClinVar.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M57627 mRNA Translation: AAA63207.1 U16720 Genomic DNA Translation: AAA80104.1 AY029171 mRNA Translation: AAK38162.1 AF418271 Genomic DNA Translation: AAL06594.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1467.1
PIRⁱ	A38580
NCBI Reference Sequences More...RefSeqⁱ	NP_000563.1, NM_000572.2
UniGeneⁱ	Hs.193717

Genome annotation databases

Ensemblⁱ	ENST00000423557; ENSP00000412237; ENSG00000136634
GeneIDⁱ	3586
KEGGⁱ	hsa:3586

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P22301	IL10 protein		HUMAN		178	UniRef100_P22301
Uncharacterized protein		Halomonas sp. ND22Bw		178
IL10 (Fragment)		PANPA		75
Interleukin 10 (Fragment)		HUMAN		160
Interleukin-10 (Fragment)		HUMAN		55
+3

Protein	Similar proteins		Species	Score	Length	Source
P22301	Interleukin-10		CALJA		178	UniRef90_P22301
Interleukin-10		CERAT		178
Interleukin-10		MACFA		178
Interleukin-10		MACMU		178
Interleukin-10		MACNE		178
+42

Protein	Similar proteins		Species	Score	Length	Source
P22301	Interleukin-10		PANTR		178	UniRef50_P22301
Interleukin-10		SAISC		178
Interleukin-10		MACMU		178
Interleukin-10		CERAT		178
Interleukin-10		PAPHA		178
+211

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Interleukin-10 entry

SeattleSNPs

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M57627 mRNA Translation: AAA63207.1 U16720 Genomic DNA Translation: AAA80104.1 AY029171 mRNA Translation: AAK38162.1 AF418271 Genomic DNA Translation: AAL06594.1
CCDSⁱ	CCDS1467.1
PIRⁱ	A38580
RefSeqⁱ	NP_000563.1, NM_000572.2
UniGeneⁱ	Hs.193717

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1ILK	X-ray	1.80	A	28-178	[»]
	1INR	X-ray	2.00	A	19-178	[»]
	1J7V	X-ray	2.90	L	19-178	[»]
	1LK3	X-ray	1.91	A/B	26-178	[»]
	1Y6K	X-ray	2.52	L	19-178	[»]
	2H24	X-ray	2.00	A	19-178	[»]
	2ILK	X-ray	1.60	A	19-178	[»]
ProteinModelPortalⁱ	P22301
SMRⁱ	P22301
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109800, 7 interactors
DIPⁱ	DIP-3511N
IntActⁱ	P22301, 8 interactors
MINTⁱ	P22301
STRINGⁱ	9606.ENSP00000412237

Chemistry databases

BindingDBⁱ	P22301
ChEMBLⁱ	CHEMBL3712920
DrugBankⁱ	DB05066 AV411 DB05744 CRx-139 DB05771 LLL-3348

Polymorphism and mutation databases

BioMutaⁱ	IL10
DMDMⁱ	124292

Proteomic databases

PaxDbⁱ	P22301
PeptideAtlasⁱ	P22301
PRIDEⁱ	P22301
ProteomicsDBⁱ	53970

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3586
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000423557; ENSP00000412237; ENSG00000136634
GeneIDⁱ	3586
KEGGⁱ	hsa:3586

Organism-specific databases

CTDⁱ	3586
DisGeNETⁱ	3586
EuPathDBⁱ	HostDB:ENSG00000136634.5
GeneCardsⁱ	IL10
HGNCⁱ	HGNC:5962 IL10
HPAⁱ	CAB013120
MalaCardsⁱ	IL10
MIMⁱ	124092 gene 614395 phenotype
neXtProtⁱ	NX_P22301
OpenTargetsⁱ	ENSG00000136634
Orphanetⁱ	117 Behcet disease 238569 Immune dysregulation-inflammatory bowel disease-arthritis-recurrent infections syndrome 536 NON RARE IN EUROPE: Systemic lupus erythematosus
PharmGKBⁱ	PA29778
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IYFW Eukaryota ENOG4111PXC LUCA
GeneTreeⁱ	ENSGT00510000048535
HOGENOMⁱ	HOG000072692
HOVERGENⁱ	HBG004110
InParanoidⁱ	P22301
KOⁱ	K05443
OMAⁱ	SLPHMLR
OrthoDBⁱ	EOG091G0Y3M
PhylomeDBⁱ	P22301
TreeFamⁱ	TF333253

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6783783 Interleukin-10 signaling R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
SignaLinkⁱ	P22301
SIGNORⁱ	P22301

Miscellaneous databases

EvolutionaryTraceⁱ	P22301
GeneWikiⁱ	Interleukin_10
GenomeRNAiⁱ	3586
Protein Ontology More...PROⁱ	PR:P22301
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000136634 Expressed in 81 organ(s), highest expression level in esophagus
CleanExⁱ	HS_IL10
ExpressionAtlasⁱ	P22301 baseline and differential
Genevisibleⁱ	P22301 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR009079 4_helix_cytokine-like_core IPR000098 IL-10 IPR020443 IL-10/19/20/22/24/26_fam IPR020423 IL-10_CS
Pfamⁱ	View protein in Pfam PF00726 IL10, 1 hit
PRINTSⁱ	PR01294 INTRLEUKIN10
SMARTⁱ	View protein in SMART SM00188 IL10, 1 hit
SUPFAMⁱ	SSF47266 SSF47266, 1 hit
PROSITEⁱ	View protein in PROSITE PS00520 INTERLEUKIN_10, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IL10_HUMAN
Accessionⁱ	P22301Primary (citable) accession number: P22301
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
	Last sequence update:	August 1, 1991
	Last modified:	November 7, 2018
	This is version 191 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P22301 (IL10_HUMAN)

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Interleukin-10

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ